Microwave-assisted solid-phase organic synthesis (MASPOS) as a key step for an indole library construction

Organic Letters

Volumn 5, Issue 16, 2003, Pages 2919-2922

  Dai, Wei Min ^a   Guo, Dian Shun ^a   Sun, Li Ping ^a   Huang, Xiang Hong ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ANILIDE; COPPER COMPLEX; INDOLE DERIVATIVE; PALLADIUM COMPLEX; RESIN;

ARTICLE; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; RING CLOSING METATHESIS; SOLID; SYNTHESIS;

EID: 0141743549     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0350543     Document Type: Article

References (68)

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50. Microwave-assisted solid-phase organic synthesis (MASPOS) is used here for the organic reactions of resin-bound substrates performed in solvent at defined temperature under microwave irradiation. Microwave-assisted organic synthesis with inorganic supports, dry media, or under solventless conditions falls into a different category.
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65. f tag cannot be archived after exposure to microwave if the tag vertically sits in a 2-mL process vial. The reason is not known. Photos of the reaction vials are found in the Supporting Information.
66. van Esseveldt, B. C. J.; van Delft, F. L.; de Gelder, R.; Rutjes, F. P. J. T. Org. Lett. 2003, 5, 1717-1720 and references therein.
67. Decomposition of the resin at the reaction temperatures as high as 200°C was not observed. Also, see refs 6g,n and 7c,d.
68. For a recent solid-phase indole synthesis with microwave irradiation, see ref 7e.