An efficient combination of microwave dielectric heating and the use of solid-supported triphenylphosphine for Wittig reactions

Organic Letters

Volumn 3, Issue 23, 2001, Pages 3745-3747

  Westman, Jacob ^a  

^a Personal Chemistry AB   (Sweden)

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ARTICLE;

EID: 0001104765     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0167053     Document Type: Article

References (23)

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21. 3 in 2 mL of MeOH. The mixture was heated in a Smith synthesizer (available from Personal Chemistry) in 5 min at 150°C. The residue was then filtered through a short plug of silica gel and washed. The solution was concentrated and purified by RF-HPLC to give the compound with purity higher than 98% based on NMR analysis.
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23. (17) Purity of the compounds after preparative HPLC was determined by LC/MS-ELSD analysis.