Microwave-Accelerated SPOT-synthesis on cellulose supports

Organic Letters

Volumn 6, Issue 12, 2004, Pages 2019-2022

  Bowman, Matthew D ^a   Jeske, Ryan C ^a   Blackwell, Helen E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULOSE;

ACCELERATION; ARTICLE; COMBINATORIAL LIBRARY; MEMBRANE; METHODOLOGY; MICROWAVE RADIATION; MOLECULE; REACTION ANALYSIS; SCALE UP; SOLID; SYNTHESIS;

EID: 3042708379     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol049313f     Document Type: Article

References (32)

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13. 2).
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24. Functionalization levels were determined by quantitation of Fmoc-derivatized amino-support 3 using UV spectroscopy (at 296 nm).
25. All MW-assisted reactions on cellulose supports were performed in a Milestone Ethos Microsynth multimodal reactor using power (wattage) control. Temperature control was not possible due to the low solvent volumes used. Supports were washed with various solvents and dried routinely between each synthesis step; see the Supporting Information.
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29. Control SPOT reactions (30 min, 25°C) generated chalcones in low yields (ca. 10%); see the Supporting Information.
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31. Perloza MT-100 is commercially available from Iontosorb Co.
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