Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction

Organic and Biomolecular Chemistry

Volumn 2, Issue 6, 2004, Pages 813-815

  Tye, Heather ^a   Whittaker, Mark ^a  

^a EVOTEC UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; COLUMN CHROMATOGRAPHY; MICROWAVES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PURIFICATION; REACTION KINETICS;

DESIGN OF EXPERIMENTS (DOE); MULTI-COMPONENT REACTIONS;

ORGANIC ACIDS;

EID: 1842482531     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b400298a     Document Type: Article

References (12)

1. Microwaves in Organic Synthesis; ed. A. Loupy, Wiley-VCH, Weinheim, 2002.
2. www.cem.com.
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4. C. Jamieson, M. S. Congreve, D. F. Emiabata-Smith, S. V. Ley and J. J. Scicinski, Org. Process Res. Develop., 2002, 6, 823-825.
5. M. D. Evans, X. Ring, A. Schoen, A. Bell, P. Edwards, D. Berthelot, R. Nicewonger and C. M. Baldino, Tetrahedron Lett., 2003, 44, 9337-9341.
6. S. M. Ireland, H. Tye and M. Whittaker, Tetrahedron Lett., 2003, 44, 4369.
7. N. J. McLean, H. Tye and M. Whittaker, Tetrahedron Lett., 2004, 45, 993-995.
8. G. C. B. Harriman, Tetrahedron Lett., 1997, 38, 5591-5594.
9. www.umetrics.com.
10. Many protocols for performing Ugi 4cc and 3cc reactions employ an imine pre-formation step.
11. 2 > 0.5 is desirable.
12. Experimental designs which support non-linear responses are generally of the central composite type requiring a larger number of experiments to be carried out.