-
1
-
-
0028757621
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(1994)
Endeavour
, vol.18
, pp. 115-122
-
-
Ugi, I.1
Dömling, A.2
Hörl, W.3
-
2
-
-
0000512227
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(1996)
Acc. Chem. Res.
, vol.29
, pp. 123-131
-
-
Armstrong, R.W.1
Combs, A.P.2
Tempest, P.A.3
Brown, S.D.4
Keating, T.5
-
3
-
-
0032087839
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(1998)
Curr Opin. Chem. Biol.
, vol.2
, pp. 363-371
-
-
Tietze, L.F.1
Lieb, M.E.2
-
4
-
-
0032035067
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(1998)
Comb. Chem. High Throughput Screening
, vol.1
, pp. 1-22
-
-
Dömling, A.1
-
5
-
-
0032925557
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(1999)
Curr. Med. Chem.
, vol.6
, pp. 255-270
-
-
Dax, S.L.1
McNally, J.J.2
Youngman, M.A.3
-
6
-
-
0033947531
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(2000)
Med. Res. Rev.
, vol.20
, pp. 304-322
-
-
Tietze, L.F.1
Modi, A.2
-
7
-
-
0034665244
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(2000)
Chem. Eur. J.
, vol.6
, pp. 3321-3329
-
-
Bienayme, H.1
Hulme, C.2
Oddon, G.3
Schmitt, P.4
-
8
-
-
0035030563
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(2001)
Comb. High Throughput Screening
, vol.4
, pp. 1-34
-
-
Ugi, I.1
Heck, S.2
-
9
-
-
0037079610
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(2002)
Drug Disc. Today
, vol.7
, pp. 143-147
-
-
Weber1
-
10
-
-
0036603766
-
-
For reviews on multicomponent reactions, see the following: I. Ugi, A. Dömling, W. Hörl, Endeavour 1994, 18, 115-122; R. W. Armstrong, A. P. Combs, P. A. Tempest, S. D. Brown, T. Keating, Acc. Chem. Res. 1996, 29, 123-131; L. F. Tietze, M. E. Lieb, Curr Opin. Chem. Biol. 1998, 2, 363-371; A. Dömling, Comb. Chem. High Throughput Screening 1998, 1, 1-22; S. L. Dax, J. J. McNally, M. A. Youngman, Curr. Med. Chem. 1999, 6, 255-270; L. F. Tietze, A. Modi, Med. Res. Rev. 2000, 20, 304-322; H. Bienayme, C. Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329; I. Ugi, S. Heck, Comb. High Throughput Screening 2001, 4, 1-34; Weber, Drug Disc. Today 2002, 7, 143-147; A. Dömling, Curr. Opin. Chem. Biol. 2002, 6, 306-313.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 306-313
-
-
Dömling, A.1
-
11
-
-
0000176059
-
-
P. Biginelli, Gazz. Chim. Ital. 1893, 23, 360-413. In this 54 page long article (!), Biginelli comments that his research was inspired by earlier work on bimolecular urea-aldehyde and urea-β-ketoester condensations, respectively.
-
(1893)
Gazz. Chim. Ital.
, vol.23
, pp. 360-413
-
-
Biginelli, P.1
-
12
-
-
0043030213
-
-
In earlier publications, Biginelli originally proposed a linear-type structure instead of the correct DHPM structure 4: P. Biginelli, Gazz. Chim. Ital. 1891, 21, 497-500; P. Biginelli, Chem. Ber. 1891, 24, 1317-1319.
-
(1891)
Gazz. Chim. Ital.
, vol.21
, pp. 497-500
-
-
Biginelli, P.1
-
13
-
-
84981754351
-
-
In earlier publications, Biginelli originally proposed a linear-type structure instead of the correct DHPM structure 4: P. Biginelli, Gazz. Chim. Ital. 1891, 21, 497-500; P. Biginelli, Chem. Ber. 1891, 24, 1317-1319.
-
(1891)
Chem. Ber.
, vol.24
, pp. 1317-1319
-
-
Biginelli, P.1
-
14
-
-
0027205552
-
-
For an extensive review of the first 100 years of the Biginelli reaction, see: C. O. Kappe, Tetrahedron 1993, 49, 6937-6963.
-
(1993)
Tetrahedron
, vol.49
, pp. 6937-6963
-
-
Kappe, C.O.1
-
15
-
-
0034518876
-
-
For a more recent update on the Biginelli reaction, see: C. O. Kappe, Acc. Chem. Res. 2000, 33, 879-888.
-
(2000)
Acc. Chem. Res.
, vol.33
, pp. 879-888
-
-
Kappe, C.O.1
-
16
-
-
0033615746
-
-
K. Singh, J. Singh, P. K. Deb, H. Singh, Tetrahedron 1999, 55, 12873-12880.
-
(1999)
Tetrahedron
, vol.55
, pp. 12873-12880
-
-
Singh, K.1
Singh, J.2
Deb, P.K.3
Singh, H.4
-
17
-
-
0035796960
-
-
A. Dondoni, A. Massi, S. Sabbatini, Tetrahedron Lett. 2001, 42, 4495-4497; A. Dondoni, A. Massi, S. Sabbatini, V. Bertolasi, J. Org. Chem. 2002, 67, 6979-6944.
-
(2001)
Tetrahedron Lett.
, vol.42
, pp. 4495-4497
-
-
Dondoni, A.1
Massi, A.2
Sabbatini, S.3
-
18
-
-
0037019968
-
-
A. Dondoni, A. Massi, S. Sabbatini, Tetrahedron Lett. 2001, 42, 4495-4497; A. Dondoni, A. Massi, S. Sabbatini, V. Bertolasi, J. Org. Chem. 2002, 67, 6979-6944.
-
(2002)
J. Org. Chem.
, vol.67
, pp. 6979-6944
-
-
Dondoni, A.1
Massi, A.2
Sabbatini, S.3
Bertolasi, V.4
-
20
-
-
0141549304
-
-
R. Pérez, T. Beryozkina, O. I. Zbruyev, W. Haas, C. O. Kappe, J. Comb. Chem. 2002, 4, 501-510.
-
(2002)
J. Comb. Chem.
, vol.4
, pp. 501-510
-
-
Pérez, R.1
Beryozkina, T.2
Zbruyev, O.I.3
Haas, W.4
Kappe, C.O.5
-
21
-
-
0043030201
-
-
K. K. Mayer, S. Dove, H. Pongratz, M. Ertan, W. Wiegrebe, Heterocycles 1998, 48, 1169-1183.
-
(1998)
Heterocycles
, vol.48
, pp. 1169-1183
-
-
Mayer, K.K.1
Dove, S.2
Pongratz, H.3
Ertan, M.4
Wiegrebe, W.5
-
22
-
-
0042529282
-
-
D. I. Brahmbhatt, G. B. Raolji, S. U. Pandya, U. Shashi, U. R. Pandya, Ind. J. Chem. B. 1999, 35, 317-324.
-
(1999)
Ind. J. Chem. B
, vol.35
, pp. 317-324
-
-
Brahmbhatt, D.I.1
Raolji, G.B.2
Pandya, S.U.3
Shashi, U.4
Pandya, U.R.5
-
23
-
-
18544397955
-
-
J. C. Barrow, P. G. Nantermet, H. G. Selnick, K. L. Glass, K. E. Rittle, K. F. Gilbert, T. G. Steele, C. F. Homnick, R. M. Freidinger, R. W. Ransom, P. Kling, D. Reiss, T. P. Broten, T. W. Schorn, R. S. L. Chang, S. S. O'Malley, T. V. Olah, J. D. Ellis, A. Barrish, K. Kassahun, P. Leppert, D. Nagarathnam, C. Forray, C. J. Med. Chem. 2000, 43, 2703-2718.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2703-2718
-
-
Barrow, J.C.1
Nantermet, P.G.2
Selnick, H.G.3
Glass, K.L.4
Rittle, K.E.5
Gilbert, K.F.6
Steele, T.G.7
Homnick, C.F.8
Freidinger, R.M.9
Ransom, R.W.10
Kling, P.11
Reiss, D.12
Broten, T.P.13
Schorn, T.W.14
Chang, R.S.L.15
O'Malley, S.S.16
Olah, T.V.17
Ellis, J.D.18
Barrish, A.19
Kassahun, K.20
Leppert, P.21
Nagarathnam, D.22
Forray, C.23
more..
-
24
-
-
4243525059
-
-
For a review on the use of nitroacetone in the Biginelli reaction, see: G. Y. Remenikov, Khim. Geterotsikl. Soedin. 1997, 1587-1602.
-
(1997)
Khim. Geterotsikl. Soedin
, pp. 1587-1602
-
-
Remenikov, G.Y.1
-
25
-
-
0000482661
-
-
J. J. Vanden Eynde, N. Audiart, V. Canonne, S. Michel, Y. Van Haverbeke, C. O. Kappe, Heterocycles 1997, 45, 1967-1978.
-
(1997)
Heterocycles
, vol.45
, pp. 1967-1978
-
-
Vanden Eynde, J.J.1
Audiart, N.2
Canonne, V.3
Michel, S.4
Van Haverbeke, Y.5
Kappe, C.O.6
-
26
-
-
0035945997
-
-
J. J. Vanden Eynde, N. Hecq, O. Kataeva, C. O. Kappe, Tetrahedron 2001, 57, 1785-1791.
-
(2001)
Tetrahedron
, vol.57
, pp. 1785-1791
-
-
Vanden Eynde, J.J.1
Hecq, N.2
Kataeva, O.3
Kappe, C.O.4
-
27
-
-
0024818583
-
-
K. S. Atwal, G. C. Rovnyak, B. C. O'Reilly, J. Schwartz, J. Org. Chem. 1989, 54, 5898-5907.
-
(1989)
J. Org. Chem.
, vol.54
, pp. 5898-5907
-
-
Atwal, K.S.1
Rovnyak, G.C.2
O'Reilly, B.C.3
Schwartz, J.4
-
28
-
-
85192675440
-
-
note
-
1) have not been reported, however.
-
-
-
-
29
-
-
85192678896
-
-
note
-
Literature search conducted with SciFinder Scholar in February 2003 in the CAPLUS database. The > 10,000 hits are linked to ca 200 publications and 40 patents.
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-
-
-
30
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0042028468
-
-
in press
-
For a tabular literature survey of all published DHPMs of type 8 prepared via three-component Biginelli condensation, see: C. O. Kappe, A. Stadler, Org. React. 2004, in press.
-
(2004)
Org. React.
-
-
Kappe, C.O.1
Stadler, A.2
-
31
-
-
0032524801
-
-
E. H. Hu, D. R. Sidler, U.-H. Dolling, J. Org. Chem. 1998, 63, 3454-3457.
-
(1998)
J. Org. Chem.
, vol.63
, pp. 3454-3457
-
-
Hu, E.H.1
Sidler, D.R.2
Dolling, U.-H.3
-
33
-
-
0034674776
-
-
Y. Ma, C. Qian, L. Wang, M. Yang, J. Org. Chem. 2000, 65, 3864-3868.
-
(2000)
J. Org. Chem.
, vol.65
, pp. 3864-3868
-
-
Ma, Y.1
Qian, C.2
Wang, L.3
Yang, M.4
-
34
-
-
0030732273
-
-
For a detailed meachanistic study on the Biginelli reaction, see: C. O. Kappe, J. Org. Chem. 1997, 62, 7201-7204. The reaction mechanism can be classified as an α-amidoalkylation, or more specifically as an α-ureidoalkylation. For more information on the latter type of reaction, see: H. Petersen, Synthesis 1973, 243-292.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 7201-7204
-
-
Kappe, C.O.1
-
35
-
-
85055598769
-
-
For a detailed meachanistic study on the Biginelli reaction, see: C. O. Kappe, J. Org. Chem. 1997, 62, 7201-7204. The reaction mechanism can be classified as an α-amidoalkylation, or more specifically as an α-ureidoalkylation. For more information on the latter type of reaction, see: H. Petersen, Synthesis 1973, 243-292.
-
(1973)
Synthesis
, pp. 243-292
-
-
Petersen, H.1
-
36
-
-
0001858454
-
-
K. Lewandowski, P. Murer, F. Svec, J. M. J. Fréchet, Chem. Commun. 1998, 2237-2238; K. Lewandowski, P. Murer, F. Svec, J. M. J. Fréchet, J. Comb. Chem. 1999, 1, 105-112.
-
(1998)
Chem. Commun.
, pp. 2237-2238
-
-
Lewandowski, K.1
Murer, P.2
Svec, F.3
Fréchet, J.M.J.4
-
37
-
-
0032600765
-
-
K. Lewandowski, P. Murer, F. Svec, J. M. J. Fréchet, Chem. Commun. 1998, 2237-2238; K. Lewandowski, P. Murer, F. Svec, J. M. J. Fréchet, J. Comb. Chem. 1999, 1, 105-112.
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 105-112
-
-
Lewandowski, K.1
Murer, P.2
Svec, F.3
Fréchet, J.M.J.4
-
38
-
-
11144305702
-
-
M. Nüchter, B. Ondruschka, A. Tied, W. Lautenschläger, K. Borowski, K. J. Am. Genomic/Proteomic Techn. 2001, 1, 34-39; For an earlier microwave-assisted parallel DHPM synthesis, see: C. O. Kappe, D. Kumar, R. S. Varma, Synthesis 1999, 1799-1803.
-
(2001)
Am. Genomic/Proteomic Techn.
, vol.1
, pp. 34-39
-
-
Nüchter, M.1
Ondruschka, B.2
Tied, A.3
Lautenschläger, W.4
Borowski, K.5
-
39
-
-
0032847541
-
-
M. Nüchter, B. Ondruschka, A. Tied, W. Lautenschläger, K. Borowski, K. J. Am. Genomic/Proteomic Techn. 2001, 1, 34-39; For an earlier microwave-assisted parallel DHPM synthesis, see: C. O. Kappe, D. Kumar, R. S. Varma, Synthesis 1999, 1799-1803.
-
(1999)
Synthesis
, pp. 1799-1803
-
-
Kappe, C.O.1
Kumar, D.2
Varma, R.S.3
-
40
-
-
0041461964
-
-
For use of microwaves in combinatorial chemistry, see the following review articles: A. Lew, P. O. Krutzik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; P. Lidstrom, J. Westman, A. Lewis, Comb. Chem. High Throughput Screen. 2002, 5, 441-458.
-
(2002)
J. Comb. Chem.
, vol.4
, pp. 95-105
-
-
Lew, A.1
Krutzik, P.O.2
Hart, M.E.3
Chamberlin, A.R.4
-
41
-
-
0036603599
-
-
For use of microwaves in combinatorial chemistry, see the following review articles: A. Lew, P. O. Krutzik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; P. Lidstrom, J. Westman, A. Lewis, Comb. Chem. High Throughput Screen. 2002, 5, 441-458.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 314-320
-
-
Kappe, C.O.1
-
42
-
-
0038066071
-
-
For use of microwaves in combinatorial chemistry, see the following review articles: A. Lew, P. O. Krutzik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; P. Lidstrom, J. Westman, A. Lewis, Comb. Chem. High Throughput Screen. 2002, 5, 441-458.
-
(2002)
Comb. Chem. High Throughput Screen
, vol.5
, pp. 441-458
-
-
Lidstrom, P.1
Westman, J.2
Lewis, A.3
-
44
-
-
0004127585
-
-
(Eds. K. C. Nicolaou, R. Hanko, W. Hartwig), Wiley-VCH, Weinheim
-
Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials (Eds. K. C. Nicolaou, R. Hanko, W. Hartwig), Wiley-VCH, Weinheim, 2002.
-
(2002)
Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials
-
-
-
46
-
-
85192670234
-
-
Tahoe City, CA, USA, January 19-24
-
L. K. Hamaker, K. Yang, J. A. Drane, M. L. Peterson, Proceedings of the Second Lake Tahoe Symposium on Molecular Diversity, Tahoe City, CA, USA, January 19-24, 1998.
-
(1998)
Proceedings of the Second Lake Tahoe Symposium on Molecular Diversity
-
-
Hamaker, L.K.1
Yang, K.2
Drane, J.A.3
Peterson, M.L.4
-
49
-
-
0642316448
-
-
American Chemical Society: Washington, DC; ORGN 122
-
L. D. Robinett, K. M. Yager, J. C. Phelan, J. C. 211th National Meeting of the American Chemical Society, New Orleans, 1996; American Chemical Society: Washington, DC, 1996; ORGN 122.
-
(1996)
211th National Meeting of the American Chemical Society, New Orleans, 1996
-
-
Robinett, L.D.1
Yager, K.M.2
Phelan, J.C.3
-
51
-
-
0033578612
-
-
J. Simpson, D. L. Rathbone, D. C. Billington, Tetrahedron Lett. 1999, 40, 7031-7033. For an application of this catalyst to the high-throughput generation of enones of type 5, see: G. A. Strohmeier, C. O. Kappe, manuscript in preparation.
-
(1999)
Tetrahedron Lett.
, vol.40
, pp. 7031-7033
-
-
Simpson, J.1
Rathbone, D.L.2
Billington, D.C.3
-
52
-
-
85192683468
-
-
manuscript in preparation
-
J. Simpson, D. L. Rathbone, D. C. Billington, Tetrahedron Lett. 1999, 40, 7031-7033. For an application of this catalyst to the high-throughput generation of enones of type 5, see: G. A. Strohmeier, C. O. Kappe, manuscript in preparation.
-
-
-
Strohmeier, G.A.1
Kappe, C.O.2
-
53
-
-
85192681858
-
-
Louvain-la-Neuve, Belgium, July 5-9
-
J. J. Vanden Eynde, N. Labuche, Y. Van Haverbeke, Belgian Organic Chemistry Symposium (BOSS-7), Louvain-la-Neuve, Belgium, July 5-9, 1998.
-
(1998)
Belgian Organic Chemistry Symposium (BOSS-7)
-
-
Vanden Eynde, J.J.1
Labuche, N.2
Van Haverbeke, Y.3
-
54
-
-
0031040133
-
-
D. Obrecht, C. Albrecht, A. Grieder, J. M. Villalgordo, Helv. Chim. Acta 1997, 80, 65-72.
-
(1997)
Helv. Chim. Acta
, vol.80
, pp. 65-72
-
-
Obrecht, D.1
Albrecht, C.2
Grieder, A.3
Villalgordo, J.M.4
-
55
-
-
0003415079
-
-
(Ed. H. Feniri), Oxford University Press, Oxford
-
D. P. Curran, S. Hadida, A. Studer, M. He, S.-Y. Kim, Z. L., M. Larhed, A. Hallberg, B. Linclau in Combinatorial Chemistry (Ed. H. Feniri), Oxford University Press, Oxford, 2000, p. 327-352.
-
(2000)
Combinatorial Chemistry
, pp. 327-352
-
-
Curran, D.P.1
Hadida, S.2
Studer, A.3
He, M.4
Kim, S.-Y.5
Larhed, M.6
Hallberg, A.7
Linclau, B.8
-
56
-
-
0031029886
-
-
A. Studer, S. Hadida, R. Ferritto, S.-Y. Kim, P. Jeger, P. Wipf, P. D. P. Curran, Science 1997, 275, 823-826; A. Studer, P. Jeger, P. Wipf, D. P. Curran, J. Org. Chem. 1997, 62, 2917-2924.
-
(1997)
Science
, vol.275
, pp. 823-826
-
-
Studer, A.1
Hadida, S.2
Ferritto, R.3
Kim, S.-Y.4
Jeger, P.5
Wipf, P.6
Curran, P.D.P.7
-
57
-
-
0001591221
-
-
A. Studer, S. Hadida, R. Ferritto, S.-Y. Kim, P. Jeger, P. Wipf, P. D. P. Curran, Science 1997, 275, 823-826; A. Studer, P. Jeger, P. Wipf, D. P. Curran, J. Org. Chem. 1997, 62, 2917-2924.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 2917-2924
-
-
Studer, A.1
Jeger, P.2
Wipf, P.3
Curran, D.P.4
-
58
-
-
0036811238
-
-
and references cited therein
-
T. J. Dickerson, N. N. Reed, K. D. Janda, Chem. Rev. 2002, 102, 3325-3343 and references cited therein.
-
(2002)
Chem. Rev.
, vol.102
, pp. 3325-3343
-
-
Dickerson, T.J.1
Reed, N.N.2
Janda, K.D.3
-
59
-
-
0037152294
-
-
M. Xia, Y.-G. Wang, Tetrahedron Lett. 2002, 43, 7703-7705; M. Xia, Y.-G. Wang, Synthesis 2003, 262-266.
-
(2002)
Tetrahedron Lett.
, vol.43
, pp. 7703-7705
-
-
Xia, M.1
Wang, Y.-G.2
-
60
-
-
0037286355
-
-
M. Xia, Y.-G. Wang, Tetrahedron Lett. 2002, 43, 7703-7705; M. Xia, Y.-G. Wang, Synthesis 2003, 262-266.
-
(2003)
Synthesis
, pp. 262-266
-
-
Xia, M.1
Wang, Y.-G.2
-
61
-
-
0032542189
-
-
T. G. Steele, C. A. Coburn, M. A. Patane, M. G. Bock, Tetrahedron Lett. 1998, 39, 9315-9318.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 9315-9318
-
-
Steele, T.G.1
Coburn, C.A.2
Patane, M.A.3
Bock, M.G.4
-
62
-
-
0035910539
-
-
For a review on the use of dendrimers and hyperbranched polymers as supports in organic synthesis, see: R. Haag, Chem. Eur. J. 2001, 7, 327-335.
-
(2001)
Chem. Eur. J.
, vol.7
, pp. 327-335
-
-
Haag, R.1
-
63
-
-
0033550242
-
-
For a previous report on the use of Boltorn polymers as supports for organic synthesis, see: A. B. Kantchev, J. R. Parquette, Tetrahedron Lett. 1999, 40, 8049-8052.
-
(1999)
Tetrahedron Lett.
, vol.40
, pp. 8049-8052
-
-
Kantchev, A.B.1
Parquette, J.R.2
-
66
-
-
0033525821
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(1999)
J. Org. Chem.
, vol.64
, pp. 1512-1519
-
-
Franklin, A.S.1
Ly, S.L.2
Mackin, G.H.3
Overman, L.E.4
Shaka, A.J.5
-
67
-
-
0033619847
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(1999)
Org. Lett.
, vol.1
, pp. 2169-2172
-
-
Cohen, F.1
Overman, L.E.2
Ly, S.L.3
-
68
-
-
0028939869
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(1995)
J. Am. Chem Soc.
, vol.117
, pp. 2657-2658
-
-
Overman, L.E.1
Rabinowitz, M.H.2
Renhowe, P.A.3
-
69
-
-
0033612744
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 6944-6945
-
-
Coffey, D.S.1
McDonald, A.I.2
Overman, L.E.3
Stappenbeck, F.4
-
70
-
-
0034709447
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 4904-4914
-
-
Coffey, D.S.1
Overman, L.E.2
Stappenbeck, F.3
-
71
-
-
0034709386
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 4893-4903
-
-
Coffey, D.S.1
McDonald, A.I.2
Overman, L.E.3
Rabinowitz, M.H.4
Renhowe, P.A.5
-
72
-
-
0042028454
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 10782-10783
-
-
Coffey, D.S.1
Overman, L.E.2
-
73
-
-
0035804953
-
-
A. S. Franklin, S. L. Ly, G. H. Mackin, L. E. Overman, A. J. Shaka, J. Org. Chem. 1999, 64, 1512-1519; F. Cohen, L. E. Overman, S. L. Ly, Org. Lett. 1999, 1, 2169-2172; L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 1995, 117, 2657-2658; D. S. Coffey, A. I. McDonald, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 1999, 121, 6944-6945; D. S. Coffey, L. E. Overman, F. Stappenbeck, J. Am. Chem. Soc. 2000, 122, 4904-4914; D. S. Coffey, A. I. McDonald, L. E. Overman, M. H. Rabinowitz, P. A. Renhowe, J. Am. Chem. Soc. 2000, 122, 4893-4903; D. S. Coffey, L. E. Overman, J. Am. Chem. Soc. 2001, 123, 10782-10783; L. E. Overman, J. P. Wolfe, J. Org. Chem. 2001, 66, 3167-3175.
-
(2001)
J. Org. Chem.
, vol.66
, pp. 3167-3175
-
-
Overman, L.E.1
Wolfe, J.P.2
-
74
-
-
0034400884
-
-
For a review on the synthesis and biological properties of these alkaloids, see: L. Heys, C. G. Moore, P. J. Murphy, Chem. Soc. Rev. 2000, 29, 57-67.
-
(2000)
Chem. Soc. Rev.
, vol.29
, pp. 57-67
-
-
Heys, L.1
Moore, C.G.2
Murphy, P.J.3
-
75
-
-
0037660637
-
-
G. Byk, H. Gottlieb, J. Herscovici, F. Mirkin, J. Comb. Chem. 2000, 2, 732-735.
-
(2000)
J. Comb. Chem.
, vol.2
, pp. 732-735
-
-
Byk, G.1
Gottlieb, H.2
Herscovici, J.3
Mirkin, F.4
-
76
-
-
26844487901
-
-
C. O. Kappe, S. F. Falsone, Synlett 1998, 718-720; C. O. Kappe, F. S. Falsone, W. M. F. Fabian, F. Belaj, Heterocycles 1999, 51, 77-84; V. I. Saloutin, Ya. V. Burgat, O. G. Kuzueva, C. O. Kappe, O. N. Chupakhin, J. Fluorine Chem. 2000, 103, 17-23; C. V. Reddy, M. Mahesh, P. V. K. Raju, T. R. Babu, V. V. N. Reddy, Tetrahedron Lett. 2002, 43, 2657-2659.
-
(1998)
Synlett
, pp. 718-720
-
-
Kappe, C.O.1
Falsone, S.F.2
-
77
-
-
0032854156
-
-
C. O. Kappe, S. F. Falsone, Synlett 1998, 718-720; C. O. Kappe, F. S. Falsone, W. M. F. Fabian, F. Belaj, Heterocycles 1999, 51, 77-84; V. I. Saloutin, Ya. V. Burgat, O. G. Kuzueva, C. O. Kappe, O. N. Chupakhin, J. Fluorine Chem. 2000, 103, 17-23; C. V. Reddy, M. Mahesh, P. V. K. Raju, T. R. Babu, V. V. N. Reddy, Tetrahedron Lett. 2002, 43, 2657-2659.
-
(1999)
Heterocycles
, vol.51
, pp. 77-84
-
-
Kappe, C.O.1
Falsone, F.S.2
Fabian, W.M.F.3
Belaj, F.4
-
78
-
-
0002035865
-
-
C. O. Kappe, S. F. Falsone, Synlett 1998, 718-720; C. O. Kappe, F. S. Falsone, W. M. F. Fabian, F. Belaj, Heterocycles 1999, 51, 77-84; V. I. Saloutin, Ya. V. Burgat, O. G. Kuzueva, C. O. Kappe, O. N. Chupakhin, J. Fluorine Chem. 2000, 103, 17-23; C. V. Reddy, M. Mahesh, P. V. K. Raju, T. R. Babu, V. V. N. Reddy, Tetrahedron Lett. 2002, 43, 2657-2659.
-
(2000)
J. Fluorine Chem.
, vol.103
, pp. 17-23
-
-
Saloutin, V.I.1
Burgat, Ya.V.2
Kuzueva, O.G.3
Kappe, C.O.4
Chupakhin, O.N.5
-
79
-
-
0036532558
-
-
C. O. Kappe, S. F. Falsone, Synlett 1998, 718-720; C. O. Kappe, F. S. Falsone, W. M. F. Fabian, F. Belaj, Heterocycles 1999, 51, 77-84; V. I. Saloutin, Ya. V. Burgat, O. G. Kuzueva, C. O. Kappe, O. N. Chupakhin, J. Fluorine Chem. 2000, 103, 17-23; C. V. Reddy, M. Mahesh, P. V. K. Raju, T. R. Babu, V. V. N. Reddy, Tetrahedron Lett. 2002, 43, 2657-2659.
-
(2002)
Tetrahedron Lett.
, vol.43
, pp. 2657-2659
-
-
Reddy, C.V.1
Mahesh, M.2
Raju, P.V.K.3
Babu, T.R.4
Reddy, V.V.N.5
-
80
-
-
0034708729
-
-
For an in depth discussion of solid-state (X-ray), solution phase (NMR) and calculated (semiempirical, ab initio, DFT) structures and geometries of DHPM derivatives, see the following: C. O. Kappe, O. V. Shishkin, G. Uray, P. Verdino, Tetrahedron 2000, 56, 1859-1862; W. M. F. Fabian, M.A. Semones, C. O. Kappe, J. Mol. Struct. (Theochem), 1998, 432, 219-229; C. O. Kappe, W. M. F. Fabian, M. A. Semones, Tetrahedron, 1997, 53, 2803-2816.
-
(2000)
Tetrahedron
, vol.56
, pp. 1859-1862
-
-
Kappe, C.O.1
Shishkin, O.V.2
Uray, G.3
Verdino, P.4
-
81
-
-
0040577516
-
-
For an in depth discussion of solid-state (X-ray), solution phase (NMR) and calculated (semiempirical, ab initio, DFT) structures and geometries of DHPM derivatives, see the following: C. O. Kappe, O. V. Shishkin, G. Uray, P. Verdino, Tetrahedron 2000, 56, 1859-1862; W. M. F. Fabian, M.A. Semones, C. O. Kappe, J. Mol. Struct. (Theochem), 1998, 432, 219-229; C. O. Kappe, W. M. F. Fabian, M. A. Semones, Tetrahedron, 1997, 53, 2803-2816.
-
(1998)
J. Mol. Struct. (Theochem)
, vol.432
, pp. 219-229
-
-
Fabian, W.M.F.1
Semones, M.A.2
Kappe, C.O.3
-
82
-
-
0031584880
-
-
For an in depth discussion of solid-state (X-ray), solution phase (NMR) and calculated (semiempirical, ab initio, DFT) structures and geometries of DHPM derivatives, see the following: C. O. Kappe, O. V. Shishkin, G. Uray, P. Verdino, Tetrahedron 2000, 56, 1859-1862; W. M. F. Fabian, M.A. Semones, C. O. Kappe, J. Mol. Struct. (Theochem), 1998, 432, 219-229; C. O. Kappe, W. M. F. Fabian, M. A. Semones, Tetrahedron, 1997, 53, 2803-2816.
-
(1997)
Tetrahedron
, vol.53
, pp. 2803-2816
-
-
Kappe, C.O.1
Fabian, W.M.F.2
Semones, M.A.3
-
83
-
-
85192674243
-
-
U.S. Patent 1986, 4,608,494
-
J. J. Baldwin, D. A. Claremon, D. E. McClure, U.S. Patent 1986, 4,608,494; J. Svetlik, V. Hanus, J. Bella, J. Chem. Res., Synop. 1991, 4-5; R. Rehani, A. C. Shah, V. P. Arya, Ind. J. Chem. 1994, 33B, 775-778; N.-Y. Fu, Y.-F. Yuan, Z. Cao, S.-W. Wang, J.-T. Wang, C. Peppe, Tetrahedron 2002, 58, 4801-4807.
-
-
-
Baldwin, J.J.1
Claremon, D.A.2
McClure, D.E.3
-
84
-
-
0009498125
-
-
J. J. Baldwin, D. A. Claremon, D. E. McClure, U.S. Patent 1986, 4,608,494; J. Svetlik, V. Hanus, J. Bella, J. Chem. Res., Synop. 1991, 4-5; R. Rehani, A. C. Shah, V. P. Arya, Ind. J. Chem. 1994, 33B, 775-778; N.-Y. Fu, Y.-F. Yuan, Z. Cao, S.-W. Wang, J.-T. Wang, C. Peppe, Tetrahedron 2002, 58, 4801-4807.
-
(1991)
J. Chem. Res., Synop.
, pp. 4-5
-
-
Svetlik, J.1
Hanus, V.2
Bella, J.3
-
85
-
-
0009528349
-
-
J. J. Baldwin, D. A. Claremon, D. E. McClure, U.S. Patent 1986, 4,608,494; J. Svetlik, V. Hanus, J. Bella, J. Chem. Res., Synop. 1991, 4-5; R. Rehani, A. C. Shah, V. P. Arya, Ind. J. Chem. 1994, 33B, 775-778; N.-Y. Fu, Y.-F. Yuan, Z. Cao, S.-W. Wang, J.-T. Wang, C. Peppe, Tetrahedron 2002, 58, 4801-4807.
-
(1994)
Ind. J. Chem.
, vol.33 B
, pp. 775-778
-
-
Rehani, R.1
Shah, A.C.2
Arya, V.P.3
-
86
-
-
0037054171
-
-
J. J. Baldwin, D. A. Claremon, D. E. McClure, U.S. Patent 1986, 4,608,494; J. Svetlik, V. Hanus, J. Bella, J. Chem. Res., Synop. 1991, 4-5; R. Rehani, A. C. Shah, V. P. Arya, Ind. J. Chem. 1994, 33B, 775-778; N.-Y. Fu, Y.-F. Yuan, Z. Cao, S.-W. Wang, J.-T. Wang, C. Peppe, Tetrahedron 2002, 58, 4801-4807.
-
(2002)
Tetrahedron
, vol.58
, pp. 4801-4807
-
-
Fu, N.-Y.1
Yuan, Y.-F.2
Cao, Z.3
Wang, S.-W.4
Wang, J.-T.5
Peppe, C.6
-
88
-
-
85192679511
-
-
American Chemical Society: Washington, DC; MEDI-379
-
Y.-Z. Zhao, L. Huang, X. Yue, Z. Fang, W. Ma, 224th National Meeting of the American Chemical Society, Boston, MA, 2002; American Chemical Society: Washington, DC, 2002; MEDI-379.
-
(2002)
224th National Meeting of the American Chemical Society, Boston, MA, 2002
-
-
Zhao, Y.-Z.1
Huang, L.2
Yue, X.3
Fang, Z.4
Ma, W.5
-
89
-
-
0034519777
-
-
A recent review summarizes the biological activities reported for DHPM derivatives. The interested reader is refered to the following account: C. O. Kappe, Eur. J. Med. Chem. 2000, 35, 1043-1052.
-
(2000)
Eur. J. Med. Chem.
, vol.35
, pp. 1043-1052
-
-
Kappe, C.O.1
-
90
-
-
0026065919
-
-
K. S. Atwal, B. N. Swanson, S. E. Unger, D. M. Floyd, S. Moreland, A. Hedberg, B. C. O'Reilly, J. Med. Chem. 1991, 34, 806-811.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 806-811
-
-
Atwal, K.S.1
Swanson, B.N.2
Unger, S.E.3
Floyd, D.M.4
Moreland, S.5
Hedberg, A.6
O'Reilly, B.C.7
-
91
-
-
0029036894
-
-
G. C. Rovnyak, S. D. Kimball, B. Beyer, G. Gucinotta, J. D. DiMarco, J. Gougoutas, A. Hedberg, M. Malley, J. P. McCarthy, R. Zhang, S. Moreland, J. Med. Chem. 1995, 38, 119-129.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 119-129
-
-
Rovnyak, G.C.1
Kimball, S.D.2
Beyer, B.3
Gucinotta, G.4
DiMarco, J.D.5
Gougoutas, J.6
Hedberg, A.7
Malley, M.8
McCarthy, J.P.9
Zhang, R.10
Moreland, S.11
-
92
-
-
0033615357
-
-
T. U. Mayer, T. M. Kapoor, S. J. Haggarty, R. W. King, S. L. Schreiber, T. J. Mitchison, Science 1999, 286, 971-974; S. J. Haggarty, T. U. Mayer, D. T. Miyamoto, R. Fathi, R. W. King, T. J. Mitchison, S. L. Schreiber, Chem. Biol. 2000, 7, 275-286.
-
(1999)
Science
, vol.286
, pp. 971-974
-
-
Mayer, T.U.1
Kapoor, T.M.2
Haggarty, S.J.3
King, R.W.4
Schreiber, S.L.5
Mitchison, T.J.6
-
93
-
-
0034177962
-
-
T. U. Mayer, T. M. Kapoor, S. J. Haggarty, R. W. King, S. L. Schreiber, T. J. Mitchison, Science 1999, 286, 971-974; S. J. Haggarty, T. U. Mayer, D. T. Miyamoto, R. Fathi, R. W. King, T. J. Mitchison, S. L. Schreiber, Chem. Biol. 2000, 7, 275-286.
-
(2000)
Chem. Biol.
, vol.7
, pp. 275-286
-
-
Haggarty, S.J.1
Mayer, T.U.2
Miyamoto, D.T.3
Fathi, R.4
King, R.W.5
Mitchison, T.J.6
Schreiber, S.L.7
-
94
-
-
0036752261
-
-
Z. Maliga, T. M. Kapoor, T. J. Mitchison, Chem. Biol. 2002, 9, 989-996; S. DeBonis, J.-P. Simorre, I. Crevel, L. Lebeau, D. A. Skoufias, A. Blangy, C. Ebel, P. Gans, R. Cross, D. D. Hackney, R. H. Wade, F. Kozielski, Biochemistry 2003, 42, 338-349.
-
(2002)
Chem. Biol.
, vol.9
, pp. 989-996
-
-
Maliga, Z.1
Kapoor, T.M.2
Mitchison, T.J.3
-
95
-
-
0037457808
-
-
Z. Maliga, T. M. Kapoor, T. J. Mitchison, Chem. Biol. 2002, 9, 989-996; S. DeBonis, J.-P. Simorre, I. Crevel, L. Lebeau, D. A. Skoufias, A. Blangy, C. Ebel, P. Gans, R. Cross, D. D. Hackney, R. H. Wade, F. Kozielski, Biochemistry 2003, 42, 338-349.
-
(2003)
Biochemistry
, vol.42
, pp. 338-349
-
-
DeBonis, S.1
Simorre, J.-P.2
Crevel, I.3
Lebeau, L.4
Skoufias, D.A.5
Blangy, A.6
Ebel, C.7
Gans, P.8
Cross, R.9
Hackney, D.D.10
Wade, R.H.11
Kozielski, F.12
-
96
-
-
0026776479
-
-
C. O. Kappe, G. Uray, P. Roschger, W. Lindner, C. Kratky, W. Keller, Tetrahedron 1992, 48, 5473-5480.
-
(1992)
Tetrahedron
, vol.48
, pp. 5473-5480
-
-
Kappe, C.O.1
Uray, G.2
Roschger, P.3
Lindner, W.4
Kratky, C.5
Keller, W.6
-
97
-
-
0026759681
-
-
G. C. Rovnyak, K. S. Atwal, A. Hedberg, S. D. Kimball, S. Moreland, J. Z. Gougoutas, B. C. O'Reilly, J. Schwartz, M. F. Malley, J. Med. Chem. 1992, 35, 3254-3263; D. Nagarathnam, S. W. Miao, B. Lagu, G. Chiu, J. Fang, T. G. M. Dhar, J. Zhang, S. Tyagarajan, M. R. Marzabadi, F. Q. Zhang, W. C. Wong, W. Y. Sun, D. Tian, J. M. Wetzel, C. Forray, R. S. L. Chang, T. P. Broten, R. W. Ransom, T. W. Schorn, T. B. Chen, S. O'Malley, P. Kling, K. Schneck, R. Benedesky, C. M. Harrell, K. P. Vyas, C. Gluchowski, J. Med. Chem. 1999, 42, 4764-4777; A. Dondoni, A. Massi, S. Sabbatini, Tetrahedron Lett. 2002, 43, 5913-5916.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3254-3263
-
-
Rovnyak, G.C.1
Atwal, K.S.2
Hedberg, A.3
Kimball, S.D.4
Moreland, S.5
Gougoutas, J.Z.6
O'Reilly, B.C.7
Schwartz, J.8
Malley, M.F.9
-
98
-
-
0344146598
-
-
G. C. Rovnyak, K. S. Atwal, A. Hedberg, S. D. Kimball, S. Moreland, J. Z. Gougoutas, B. C. O'Reilly, J. Schwartz, M. F. Malley, J. Med. Chem. 1992, 35, 3254-3263; D. Nagarathnam, S. W. Miao, B. Lagu, G. Chiu, J. Fang, T. G. M. Dhar, J. Zhang, S. Tyagarajan, M. R. Marzabadi, F. Q. Zhang, W. C. Wong, W. Y. Sun, D. Tian, J. M. Wetzel, C. Forray, R. S. L. Chang, T. P. Broten, R. W. Ransom, T. W. Schorn, T. B. Chen, S. O'Malley, P. Kling, K. Schneck, R. Benedesky, C. M. Harrell, K. P. Vyas, C. Gluchowski, J. Med. Chem. 1999, 42, 4764-4777; A. Dondoni, A. Massi, S. Sabbatini, Tetrahedron Lett. 2002, 43, 5913-5916.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4764-4777
-
-
Nagarathnam, D.1
Miao, S.W.2
Lagu, B.3
Chiu, G.4
Fang, J.5
Dhar, T.G.M.6
Zhang, J.7
Tyagarajan, S.8
Marzabadi, M.R.9
Zhang, F.Q.10
Wong, W.C.11
Sun, W.Y.12
Tian, D.13
Wetzel, J.M.14
Forray, C.15
Chang, R.S.L.16
Broten, T.P.17
Ransom, R.W.18
Schorn, T.W.19
Chen, T.B.20
O'Malley, S.21
Kling, P.22
Schneck, K.23
Benedesky, R.24
Harrell, C.M.25
Vyas, K.P.26
Gluchowski, C.27
more..
-
99
-
-
0037136153
-
-
G. C. Rovnyak, K. S. Atwal, A. Hedberg, S. D. Kimball, S. Moreland, J. Z. Gougoutas, B. C. O'Reilly, J. Schwartz, M. F. Malley, J. Med. Chem. 1992, 35, 3254-3263; D. Nagarathnam, S. W. Miao, B. Lagu, G. Chiu, J. Fang, T. G. M. Dhar, J. Zhang, S. Tyagarajan, M. R. Marzabadi, F. Q. Zhang, W. C. Wong, W. Y. Sun, D. Tian, J. M. Wetzel, C. Forray, R. S. L. Chang, T. P. Broten, R. W Ransom, T. W. Schorn, T. B. Chen, S. O'Malley, P. Kling, K. Schneck, R. Benedesky, C. M. Harrell, K. P. Vyas, C. Gluchowski, J. Med. Chem. 1999, 42, 4764-4777; A. Dondoni, A. Massi, S. Sabbatini, Tetrahedron Lett. 2002, 43, 5913-5916.
-
(2002)
Tetrahedron Lett.
, vol.43
, pp. 5913-5916
-
-
Dondoni, A.1
Massi, A.2
Sabbatini, S.3
-
100
-
-
0034073769
-
-
B. Schnell, U. T. Strauss, P. Verdino, K. Faber, C. O. Kappe, Tetrahedron: Asymmetry 2000, 11, 1449-1453; B. Schnell, W. Krenn, K. Faber, C. O. Kappe, J. Chem. Soc., Perkin Trans. 1, 2000, 4382-4389; D. R. Sidler, N. Barta, W. Li, E. Hu, L. Matty, N. Ikemoto, J. S. Campbell, M. Chartrain, K. Gbewonyo, R. Boyd, E. G. Corley, R. G. Ball, R. D. Larsen, P. J. Reider, Can. J. Chem. 2002, 80, 646-652.
-
(2000)
Tetrahedron: Asymmetry
, vol.11
, pp. 1449-1453
-
-
Schnell, B.1
Strauss, U.T.2
Verdino, P.3
Faber, K.4
Kappe, C.O.5
-
101
-
-
0034700664
-
-
B. Schnell, U. T. Strauss, P. Verdino, K. Faber, C. O. Kappe, Tetrahedron: Asymmetry 2000, 11, 1449-1453; B. Schnell, W. Krenn, K. Faber, C. O. Kappe, J. Chem. Soc., Perkin Trans. 1, 2000, 4382-4389; D. R. Sidler, N. Barta, W. Li, E. Hu, L. Matty, N. Ikemoto, J. S. Campbell, M. Chartrain, K. Gbewonyo, R. Boyd, E. G. Corley, R. G. Ball, R. D. Larsen, P. J. Reider, Can. J. Chem. 2002, 80, 646-652.
-
(2000)
J. Chem. Soc., Perkin Trans. 1
, pp. 4382-4389
-
-
Schnell, B.1
Krenn, W.2
Faber, K.3
Kappe, C.O.4
-
102
-
-
18544379145
-
-
B. Schnell, U. T. Strauss, P. Verdino, K. Faber, C. O. Kappe, Tetrahedron: Asymmetry 2000, 11, 1449-1453; B. Schnell, W. Krenn, K. Faber, C. O. Kappe, J. Chem. Soc., Perkin Trans. 1, 2000, 4382-4389; D. R. Sidler, N. Barta, W. Li, E. Hu, L. Matty, N. Ikemoto, J. S. Campbell, M. Chartrain, K. Gbewonyo, R. Boyd, E. G. Corley, R. G. Ball, R. D. Larsen, P. J. Reider, Can. J. Chem. 2002, 80, 646-652.
-
(2002)
Can. J. Chem.
, vol.80
, pp. 646-652
-
-
Sidler, D.R.1
Barta, N.2
Li, W.3
Hu, E.4
Matty, L.5
Ikemoto, N.6
Campbell, J.S.7
Chartrain, M.8
Gbewonyo, K.9
Boyd, R.10
Corley, E.G.11
Ball, R.G.12
Larsen, R.D.13
Reider, P.J.14
-
103
-
-
0031008496
-
-
O. P. Kleidernigg, C. O. Kappe, Tetrahedron: Asymmetry 1997, 8, 2057-2067; W. Krenn, P. Verdino, G. Uray, K. Faber, C. O. Kappe, Chirality 1999, 11, 659-662; D. Kontrec, V. Vinkovic, V. Sunjic, B. Schuiki, W. M. F. Fabian, C. O. Kappe, Chirality 2003, in press.
-
(1997)
Tetrahedron: Asymmetry
, vol.8
, pp. 2057-2067
-
-
Kleidernigg, O.P.1
Kappe, C.O.2
-
104
-
-
0032879265
-
-
O. P. Kleidernigg, C. O. Kappe, Tetrahedron: Asymmetry 1997, 8, 2057-2067; W. Krenn, P. Verdino, G. Uray, K. Faber, C. O. Kappe, Chirality 1999, 11, 659-662; D. Kontrec, V. Vinkovic, V. Sunjic, B. Schuiki, W. M. F. Fabian, C. O. Kappe, Chirality 2003, in press.
-
(1999)
Chirality
, vol.11
, pp. 659-662
-
-
Krenn, W.1
Verdino, P.2
Uray, G.3
Faber, K.4
Kappe, C.O.5
-
105
-
-
85192682119
-
-
in press
-
O. P. Kleidernigg, C. O. Kappe, Tetrahedron: Asymmetry 1997, 8, 2057-2067; W. Krenn, P. Verdino, G. Uray, K. Faber, C. O. Kappe, Chirality 1999, 11, 659-662; D. Kontrec, V. Vinkovic, V. Sunjic, B. Schuiki, W. M. F. Fabian, C. O. Kappe, Chirality 2003, in press.
-
(2003)
Chirality
-
-
Kontrec, D.1
Vinkovic, V.2
Sunjic, V.3
Schuiki, B.4
Fabian, W.M.F.5
Kappe, C.O.6
-
106
-
-
0034000447
-
-
F. Wang, T. D. Loughlin, T. Dowling, G. Bicker, J. Wyvratt, J. Chromatogr. A 2000, 872, 279-288; O. Lecnik, M. G. Schmid, C. O. Kappe, G. Gübitz, Electrophoresis, 2001, 22, 3198-3202.
-
(2000)
J. Chromatogr. A
, vol.872
, pp. 279-288
-
-
Wang, F.1
Loughlin, T.D.2
Dowling, T.3
Bicker, G.4
Wyvratt, J.5
-
107
-
-
0034795024
-
-
F. Wang, T. D. Loughlin, T. Dowling, G. Bicker, J. Wyvratt, J. Chromatogr. A 2000, 872, 279-288; O. Lecnik, M. G. Schmid, C. O. Kappe, G. Gübitz, Electrophoresis, 2001, 22, 3198-3202.
-
(2001)
Electrophoresis
, vol.22
, pp. 3198-3202
-
-
Lecnik, O.1
Schmid, M.G.2
Kappe, C.O.3
Gübitz, G.4
-
108
-
-
0035812731
-
-
G. Uray, P. Verdino, F. Belaj, C. O. Kappe, W. M. F. Fabian, J. Org. Chem. 2001, 66, 6685-6694.
-
(2001)
J. Org. Chem.
, vol.66
, pp. 6685-6694
-
-
Uray, G.1
Verdino, P.2
Belaj, F.3
Kappe, C.O.4
Fabian, W.M.F.5
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