Synthesis of Δ3-pyrrolines and Δ3-tetrahydropyridines via microwave-accelerated ring-closing metathesis

Tetrahedron Letters

Volumn 44, Issue 26, 2003, Pages 4899-4901

  Grigg, Ronald ^a   Martin, William ^b   Morris, James ^a   Sridharan, Visuvanthar ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDINE DERIVATIVE; PYRROLINE DERIVATIVE;

ACCELERATION; ARTICLE; CATALYSIS; CATALYST; CHEMICAL BOND; CYCLOADDITION; ELECTRON; MICROWAVE RADIATION; REDUCTION; RING CLOSING METATHESIS; SYNTHESIS;

EID: 0037534871     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01080-3     Document Type: Article

References (16)

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14. 2 (4 ml) were combined in a microwave pressure vial, containing a small magnetic stirrer bar, to afford solutions of either 1.5 or 3.0 mM. Catalyst was then added to this solution and the pressure vial immediately sealed and subjected to microwave irradiation (Smith Creator model). The solvent was then removed and the product conversion measured by 500 MHz NMR analysis. Passing the crude product through a small pad of silica, eluting with ether/petrol, afforded the product.
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