Rapid synthesis of α-ketoamides using microwave irradiation- simultaneous cooling method

Tetrahedron Letters

Volumn 44, Issue 49, 2003, Pages 8873-8876

  Chen, Jack J ^a   Deshpande, Seema V ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Isocyanide chemistry; Microwave synthesis; ketoamide

Indexed keywords

AMIDE; CALCIUM CARBONATE; CHLORIDE; ISONITRILE DERIVATIVE;

ARTICLE; COOLING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; MICROWAVE IRRADIATION; POLYMERIZATION;

EID: 0242266536     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.09.180     Document Type: Article

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28. Reaction with neat reagents and conventional heating also provided similar results, but still required total 4 h reaction time.
29. The Discovery™ microwave synthesizer features the option of heating along with spontaneous air-cooling. A similar approach has been mentioned in Chapter 5 of Ref. 11a.
30. +.