Microwave-assisted scavenging of electrophiles utilizing polymer-supported sequestration reagents. Application to the synthesis of N3-acylated dihydropyrimidine libraries

Molecular Diversity

Volumn 7, Issue 2-4, 2003, Pages 229-245

  Dallinger, Doris ^a   Gorobets, Nikolay Yu ^a   Kappe, C Oliver ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Combinatorial chemistry; Microwave chemistry; N3 acylated dihydropyrimidines; Scavenging; Solid phase extraction

Indexed keywords

ACID ANHYDRIDE; CHLORIDE; DIAMINE; DIETHYLENETRIAMINE; DIHYDROPYRIMIDINE DERIVATIVE; METHYLAMINE; POLYMER; POLYSTYRENE; PYRIMIDINE DERIVATIVE; REAGENT; SCAVENGER; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; COMBINATORIAL CHEMISTRY; HEATING; IMMOBILIZATION; MICROWAVE RADIATION; PRIORITY JOURNAL; PURIFICATION; REACTION TIME; SOLID PHASE EXTRACTION; SYNTHESIS;

ACIDS; CHEMISTRY, ORGANIC; CHLORIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; DIMERIZATION; GENE LIBRARY; ISOCYANATES; KINETICS; MICROWAVES; MODELS, CHEMICAL; POLYMERS; POLYSTYRENES; PYRIMIDINES; TEMPERATURE; TIME FACTORS;

EID: 0346456935     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MODI.0000006865.59065.bf     Document Type: Article

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20. Within the scope of these microwave exposure/temperature stability investigations, we have also studied the thermal stability of standard polypropylene IRORI MicroKans, which are very common platforms in modem solid-supported chemistry. 15 min exposure at 150 °C of the polypropylene Kans to microwave irradiation in MeCN led to apparent deformations and to a partial melt down of the polypropylene mesh.