High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: In vitro enzyme inhibition and antibacterial properties

Journal of the American Chemical Society

Volumn 125, Issue 6, 2003, Pages 1575-1586

  Pirrung, Michael C ^a   Tumey, L Nathan ^a   McClerren, Amanda L ^b   Raetz, Christian R H ^b  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; ESCHERICHIA COLI; LIPIDS;

ANTIBACTERIAL ACTIVITY;

ENZYME INHIBITION;

ALKYL GROUP; AMIDASE; HYDROXAMIC ACID DERIVATIVE; L 159692; L 161240; LIPID A; OXAZOLINE DERIVATIVE; PROTEIN LPXC; RESIN; UNCLASSIFIED DRUG; ZINC ION;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CHEMICAL STRUCTURE; CORRELATION FUNCTION; ENZYME INHIBITION; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; PSEUDOMONAS AERUGINOSA; PURIFICATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; ESCHERICHIA COLI; HYDROXAMIC ACIDS; MICROBIAL SENSITIVITY TESTS; OXAZOLONE; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037433247     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0209114     Document Type: Article

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