Utilization of molybdenum- and palladium-catayzed dynamic kinetic asymmetric transformations for the preparation of tertiary and quaternary stereogenic centers: A concise synthesis of Tipranavir

Journal of the American Chemical Society

Volumn 124, Issue 48, 2002, Pages 14320-14321

  Trost, Barry M ^a   Andersen, Neil G ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLYBDENUM; PALLADIUM; PROTEINASE INHIBITOR; TIPRANAVIR;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; HUMAN IMMUNODEFICIENCY VIRUS 1; KINETICS; NONHUMAN; STEREOCHEMISTRY; VIRUS RESISTANCE;

CATALYSIS; HIV PROTEASE INHIBITORS; KINETICS; MOLYBDENUM; PALLADIUM; PYRIDINES; PYRONES; STEREOISOMERISM;

EID: 0037021514     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja028497v     Document Type: Article

References (14)

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8. (a) Trost, B. M.; Dogra, K.; Hachiya, I.; Emura, T.; Hughes, D. L.; Krska, S.; Reamer, R. A.; Palucki, M.; Yasuda, N.; Reider, P. J. Angew. Chem., Int. Ed. 2002, 41 (11), 1929.
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12. Microwave heating was carried out in a Smith Workstation manufactured by Personal Chemistry.
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14. Dr. Bruce Pearlman (Pharmacia Corp.) is thanked for providing a research sample of 5-trifluoromethyl-1H-pyridine-2-thione (7).