Microwave-assisted soluble polymer-supported synthesis of benzopiperazinones

Synlett

Volumn , Issue 11, 2003, Pages 1688-1692

  Chang, Wong Jin ^a   Yeh, Wen Ben ^a   Sun, Chung Ming ^a  

^a NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Combinatorial synthesis; Microwave assisted; Quinoxaline 2 ones

Indexed keywords

FLUORIDE; NITRO DERIVATIVE; PIPERAZINE DERIVATIVE; POLYMER; QUINOXALINE DERIVATIVE;

AMINATION; ARTICLE; COMBINATORIAL CHEMISTRY; CYCLIZATION; DRUG SYNTHESIS; ESTERIFICATION; LIQUID; MICROWAVE IRRADIATION; MICROWAVE OVEN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD; REDUCTION; SOLUBILITY; STOICHIOMETRY;

EID: 0042912871     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-41427     Document Type: Article

References (35)

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35. 2O and dried in vacuum. Polymer support of 8m was cleaved by exposing it to microwave (150 W) for 10 min in sodium methoxide solution. Progress of cleavage was monitored on TLC [solvent: EtOAc-n-hexane (1:2)]. Separation of 2-arm PEG from the desired products was achieved by precipitation in ethanol to give crude mixtures of compounds 9m and 10m in 90% combined yield and 93% (53% and 40%) HPLC purity (UV detection at λ = 254 nm. Column: Sphereclone 5u Si (250 x 4.6 nm); gradient: 50% EtOAc/n-hexane; flow rate: 1 mL/min).