Microwave-assisted C-H bond activation: A rapid entry into functionalized heterocycles

Organic Letters

Volumn 5, Issue 12, 2003, Pages 2131-2134

  Tan, Kian L ^a   Vasudevan, Anil ^c   Bergman, Robert G ^a,b   Ellman, Jonathan A ^a   Souers, Andrew J ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; BENZIMIDAZOLE; HETEROCYCLIC COMPOUND; RHODIUM;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL BOND; CHEMICAL REACTION; MICROWAVE IRRADIATION; MOLECULAR INTERACTION; PURIFICATION; REACTION ANALYSIS;

ALKENES; BENZIMIDAZOLES; CATALYSIS; CYCLIZATION; HETEROCYCLIC COMPOUNDS; MICROWAVES; ORGANOMETALLIC COMPOUNDS; RHODIUM;

EID: 0141630581     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol030050j     Document Type: Article

References (19)

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15. Both toluene and THF have low values of tan ∈, making them poor microwave solvents. Hayes, B. L. Microwave Synthesis: Chemistry at the Speed of Light; CEM Publishing: Matthews, NC, 2002; pp 29-62.
16. Reactions with THF and toluene solutions were aborted above temperatures of 180°C due to pressure maxima.
17. Though the phosphine hydrochloride is stable to air oxidation, the salt is hydroscopic and should be handled accordingly.
18. 2.
19. 1H NMR of the crude reaction mixture.