The multifaceted roles of glycogen synthase kinase 3β in cellular signaling

Progress in Neurobiology

Volumn 65, Issue 4, 2001, Pages 391-426

  Grimes, Carol A ^a   Jope, Richard S ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Tel: +1 205 934 7023 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; AMYLOID; AMYLOID PRECURSOR PROTEIN; APC; BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK TRANSCRIPTION FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LITHIUM; MYELIN BASIC PROTEIN; NERVE CELL ADHESION MOLECULE; NUCLEAR FACTOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PRESENILIN 1; PROTEIN; PYRUVATE DEHYDROGENASE; SERINE; STRUCTURAL PROTEIN; TAU PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR MYC; TYROSINE; UNCLASSIFIED DRUG; WNT PROTEIN;

AFFECTIVE NEUROSIS; ALZHEIMER DISEASE; APOPTOSIS; CELL SURVIVAL; CELLULAR DISTRIBUTION; COMPLEX FORMATION; DEGENERATIVE DISEASE; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; HUMAN; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; NERVE CELL PLASTICITY; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SENILE PLAQUE; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; BIPOLAR DISORDER; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL PHYSIOLOGY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0034859101     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(01)00011-9     Document Type: Review

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257. Transcription factors of the NFAT family: Regulation and function
258. Identification and characterization of an IκB kinase
259. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
260. Control of glycogen synthase by hierarchal protein phosphorylation
261. Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphorylation
262. Glycogen synthase kinase 3 is an insulin-regulated C/EBPα kinase
263. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
264. Stabilization of β-catenin by genetic defects in melanoma cell lines
265. Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein
266. Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody
267. Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase
268. Lithium inhibits glycogen synthase kinase-3 by competition for magnesium
269. The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells
270. Bridging of β-catenin and glycogen synthase-3β by axin and inhibition of β-catenin-mediated transcription
271. Activation of protein kinase C increases phosphorylation of the L-Myc trans-activator domain at a GSK-3 target site
272. Phosphorylation and dephosphorylation in the proline-rich C-terminal domain of microtubule-associated protein 2
273. Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function
274. Biochemical interactions in the wnt pathway
275. Inducibility of kappa immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
276. Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5
277. A phosphorylation site located in the NH2-domain of c-Myc increases transactivation of gene expression
278. Identification of a putative regulator of early T cell activation genes
279. Further evidence that the inhibition of glycogen synthase kinase-3β by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
280. 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2
281. CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
282. 2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases
283. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
284. CREB and memory
285. Modulation of rabbit reticulocyte guanine nucleotide exchange factor activity by casein kinases 1 and 2 and glycogen synthase kinase 3
286. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
287. Glycogen synthase kinase-3β phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice
288. Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
289. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
290. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant
291. Inactivation of glycogen synthase kinase-3β by phosphorylation: New kinase connections in insulin and growth-factor signalling
292. Tau protein kinase I is essential for amyloid β-protein-induced neurotoxicity
293. Amyloid β peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3β in rat hippocampal neurons
294. Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the inactivation of phosphatidylinositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β
295. Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25-35) enhances phosphorylation of tau in hippocampal neurons
296. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
297. The transcriptional coactivator CBP interacts with β-catenin to activate gene expression
298. Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis
299. Phosphorylation of nerve growth factor receptor proteins in sympathetic neurons and PC12 cells. In vitro phosphorylation by the cAMP-independent protein kinase FA/GSK-3
300. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
301. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and β-catenin
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303. Inactivation of glycogen synthase kinase-3 by protein kinase Cδ: Implications for regulation of tau phosphorylation
304. NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit
305. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
306. Lithium chloride promotes short-term survival of PC12 cells after serum and NGF deprivation
307. LiCl promotes survival of GABAergic neurons from cerebellum and cerebral cortex: LiCl induces survival of GABAergic neurons
308. Nuclear translocation and DNA recognition signals colocalized within the bZIP domain of cyclic adenosine 3′,5′-monophosphate response element-binding protein CREB
309. Is CREB a key to neuronal survival?
310. CCAAT-enhancer binding protein α is expressed in activated microglial cells after brain injury
311. CREB phosphorylation promotes nerve cell survival
312. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
313. Glycogen synthase kinase-3β is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation
314. Isoform differences in substrate recognition by glycogen synthase kinases 3α and 3β in the phosphorylation of phosphatase inhibitor 2
315. Use of a synthetic peptide as a selective substrate for glycogen synthase kinase 3
316. Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells
317. Eukaryotic initiation factor 2B (eIF2B)
318. β-Amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment
319. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB
320. Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B
321. T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3
322. Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase
323. Regulation of eukaryotic initiation factor eIF2B: Glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation
324. The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max (p20/22) in human neuroblastoma cells
325. Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)
326. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis
327. Mechanisms of Wnt signaling in development
328. Molecular cloning and expression of glycogen synthase kinase-3/factor A
329. cDNA cloning and properties of glycogen synthase kinase-3
330. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
331. Enhancement of interleukin 2 production in human and Gibbon T cells after in vitro treatment with lithium
332. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells
333. Glycogen synthase kinase 3β negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1
334. Hyperphosphorylation of heat shock transcription factor 1 is correlated with transcriptional competence and slow dissociation of active factor trimers
335. 32P-labeled in vivo
336. The interrelationship between selective tau phosphorylation and microtubule association
337. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
338. Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II
339. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3β and β-catenin and inhibits axis formation of Xenopus embryos
340. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3β regulates its stability
341. Identification of the ATP.Mg-dependent protein phosphatase activator (FA) as a myelin basic protein kinase in the brain
342. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
343. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
344. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
345. Protein kinase FA/glycogen synthase kinase-3 predominantly phosphorylates the in vivo site Thr97-Pro in brain myelin basic protein: Evidence for Thr-Pro and Ser-Arg-X-X-Ser as consensus sequence motifs
346. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin
347. Lithium stimulates gene expression through the AP-1 transcription factor pathway
348. 2+/calmodulin kinase activation in hippocampal neurons
349. DNA-binding and dimerization domains of adenosine 3′,5′-cyclic monophosphate-responsive protein CREB reside in the carboxyl-terminal 66 amino acids
350. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
351. Presenilin 1 interaction in the brain with a novel member of the Armadillo family