Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells

Journal of Neurochemistry

Volumn 73, Issue 6, 1999, Pages 2278-2285

  Kovacs, Dora M ^a   Mancini, Ronald ^a   Henderson, John ^a   Na, Sang J ^a   Schmidt, Stephen D ^a   Kim, Tae Wan ^a   Tanzi, Rudolph E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Caspase; Presenilin

Indexed keywords

CASPASE 3; PRESENILIN 1;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; APOPTOSIS; BRAIN NEOPLASMS; CASPASE 3; CASPASES; ENZYME ACTIVATION; ENZYME PRECURSORS; GLIOMA; HUMANS; MEMBRANE PROTEINS; POINT MUTATION; POLY(ADP-RIBOSE) POLYMERASES; PRESENILIN-1; RECOMBINANT FUSION PROTEINS; STAUROSPORINE; TRANSFECTION;

EID: 0032727864     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0732278.x     Document Type: Article

References (40)

1. Barnes N. Y., Li L., Yoshikawa K., Schwartz L. M., Oppenheim R. W., and Milligan C. E. (1998) Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J. Neurosci. 18, 5869-5880.
2. Capell A., Grunberg J., Pesold B., Diehlmann A., Citron M., Nixon R., Beyreuther K., Selkoe D. J., and Haass C. (1998) The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J. Biol. Chem. 273, 3205-3211.
3. Cohen G. M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16.
4. Deng G., Pike C. J., and Cotman C. W. (1996) Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 397, 50-54.
5. Doan A., Thinakaran G., Borchelt D. R., Slunt H. H., Ratovitsky T., Podlisny M., Selkoe D. J., Seeger M., Candy S. E., Price D. L., and Sisodia S. S. (1996) Protein topology of presenilin 1. Neuron 17, 1023-1030.
6. Grunberg J., Walter J., Loetscher H., Deuschle U., Jacobsen H., and Haass C. (1998) Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family. Biochemistry 37, 2263-2270.
7. Guo Q., Furukawa K., Sopher B. L., Pham D. G., Xie J., Robinson N., Martin G. M., and Mattson M. P. (1996) Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. Neuroreport 8, 379-383.
8. Guo Q., Sopher B. L., Furukawa K., Pham D. G., Robinson N., Martin G. M., and Mattson M. P. (1997) Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17, 4212-4222.
9. Guo Q., Christakos S., Robinson N., and Mattson M. P. (1998) Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1 : reduced oxidative stress and preserved mitochondrial function. Proc. Natl. Acad. Sci. USA 95, 3227-3232.
10. Hendriks L., Thinakaran G., Harris C. L., De Jonghe C., Martin J. J., Sisodia S. S., and Van Broeckhoven C. (1997) Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls. Neuroreport 8, 1717-1721.
11. Holtzman D. M. and Deshmukh M. (1997) Caspases: a treatment target for neurodegenerative disease? Nat. Med. 3, 954-955.
12. Janicki S. and Monteiro M. J. (1997) Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N1411). J. Cell Biol. 139, 485-495.
13. Keller J. N., Go Q., Holtsberg F. W., Bruce-Keller A. J., and Mattson M. P. (1998) Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J. Neurosci. 18, 4439-4450.
14. Kim T.-W., Pettingell W. H., Jung Y.-K., Kovacs D. M., and Tanzi R. E. (1997a) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by caspase-3 family protease. Science 277, 373-376.
15. Kim T.-W., Pettingell W. H., Hallmark O. G., Moir R. D., Wasco W., and Tanzi R. E. (1997b) Endoproteolylic processing and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 272, 11006-11010.
16. Kovacs D. M., Fausett H. J., Page K. J., Kim T.-W., Mori R. D., Merriam D. E., Hollister R. D., Hallmark O. G., Mancini R., Felsenstein K. M., Hyman B. T., Tanzi R. E., and Wasco W. (1996) Alzheimer associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med 2, 224-229.
17. Lee M. K., Borchelt D. R., Kim G., Thinakaran G., Slunt H. H., Ratovitski T. R., Martin L. J., Kittur A., Gandy S., Levey A. I., Jenkins N., Copeland N., Price D. L., and Sisodia S. S. (1997) Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nat. Med. 3, 756-760.
18. Lehmann S., Chiesa R., and Harris D. A. (1997) Evidence for a six-transmembrane domain structure of presenilin 1. J. Biol. Chem. 272, 12047-12051.
19. Levy-Lahad E., Wasco W., Poorkaj P., Romano D. M., Oshima J. M., Pettingell W. H., Yu C., Jondro P. D., Schmidt S. D., Wang K., Crowley A. C., Fu Y.-H., Guenette S. Y., Galas D., Nemens E., Wijsman E. M., Bird T. D., Schellenberg G. D., and Tanzi R. E. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
20. Loetscher H., Deuschle U., Brockhaus M., Reinhardt D., Nelboeck P., Mous J., Grunberg J., Haass C., and Jacobsen H. (1997) Presenilins are processed by caspase-type proteases. J. Biol. Chem. 272, 20655-20659.
21. Lunkes A. and Mandel J. L. (1998) A cellular model that recapitulates major pathogenic steps of Huntington's disease. Hum. Mol. Genet. 7, 1355-1361.
22. Mercken M., Takahashi H., Honda T., Sato K., Murayama M., Nakazato Y., Noguchi K., Imahori K., and Takashima A. (1996) Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: evidence that Alzheimer mutations affect proteolytic processing. FEBS Lett. 389, 297-303.
23. Murayama O., Honda T., Mercken M., Murayama M., Yasutake K., Nihonmatsu N., Nakazato Y., Michel G., Song S., Sato K., Takahashi H., and Takashima A. (1997) Different effects of Alzheimer-associated mutations of presenilin 1 on its processing. Neurosci. Lett. 229, 61-64.
24. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K. J., Yuan J., and Moskowitz M. A. (1998) Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 18, 3659-3668.
25. Okochi M., Ishii K., Usami M., Sahara N., Kametani F., Tanaka K., Fraser P. E., Ikeda M., Saunders A. M., Hendriks L., Shoji S. I., Nee L. E., Martin J. J., Van Broeckhoven C., St. George-Hyslop P. H., Roses A. D., and Mori H. (1997) Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations. FEBS Lett. 418, 162-166.
26. Podlisny M. B., Citron M., Amarante P., Sherrington R., Xia W., Zhang J., Diehl T., Levesque G., Fraser P., Haass C., Koo E. H., Seubert P., St. George-Hyslop P., Teplow D. B., and Selkoe D. J. (1997) Presenilin proteins undergo heterogenous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol. Dis. 3, 325-337.
27. Rogaev E. I., Sherrington R., Rogaeva E. A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., Mar L., Sorbi S., Nacmias B., Piacentini S., Amaducci L., Chumakov I., Cohen D., Lannfelt L., Fraser P. E., Rommens J. M., and St. George-Hyslop P. H. (1995) Familial Alzheimer's disease in kindreds with missense mutation in a gene on chomosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
28. Roperch J.-P., Alvaro V., Prieur S., Tuynder M., Nemani M., Lethrosne F., Piouffre L., Gendron M.-C., Israeli D., Dausset J., et al. (1998) Inhibition of presenilin 1 expression is promoted by p53 and p21 WAF-1 and results in apoptosis and tumor suppression. Nat. Med. 4, 835-838.
29. Seeger M., Nordstedt C., Petanceska S., Kovacs D. M., Gouras G. K., Hahne S., Fraser P., Levesque L., Czernik A. J., St. George-Hyslop P., Sisodia S. S., Thinakaran G., Tanzi R. E., Greengard P., and Gandy S. (1997) Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc. Natl. Acad. Sci. USA 94, 5090-5094.
30. Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A. C., Montesi M. P., Sorbi S., Rainere I., Pinessi L., Nee L., Chumakov Y., Pollen D., Wasco W., Hainus J. L., Da Silva R., Pericak-Vance M., Tanzi R. E., Roses A. D., Fraser P. E., Rommens J. M., and St. George-Hyslop P. H. (1995) Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer disease. Nature 375, 754-760.
31. Shirotani K., Takahashi K., Ozawa K., Kunishita T., and Tabira T. (1997) Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines, Biochem. Biophys. Res. Commun. 240, 728-731.
32. Slee E. A., Harte M. T., Kluck R. M., Wolf B. B., Casiano C. A., Newmeyer D. D., Wang H.-G., Reed J. C., Nicholson D. W., Alnemri E. S., Green D. R., and Martin S. J. (1999) Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J. Cell biol. 144, 281-292.
33. Tesco G., Kim T.-W., Diehlmann A., Beyreuther K., and Tanzi R. E. (1998) Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J. Biol. Chem. 273, 33909-33914.
34. Thinakaran G., Borchelt D., Lee M., Slunt H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A. I., Gandy S. E., Jenkins N. A., Copeland N. G., Price D. L., and Sisodia S. S. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190.
35. Thinakaran G., Regard J. B., Bouton C. M. L., Harris C. L., Price D. L., Borchelt D. R., and Sisodia S. S. (1998) Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiol. Dis. 4, 438-453.
36. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271, 521-524.
37. Vito P., Ghayurt T., and D'Adamio L. (1997) Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proleolysis, and caspase-3 cleavage. J. Biol. Chem. 272, 28315-28320.
38. Wellington C. L., Ellerby L. M., Hackam A. S., Margolis R. L., Trifiro M. A., Singaraja R., McCutcheon K., Salvesen G. S., Propp S. S., Bromm M., et al. (1998) Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem. 273, 9158-9167.
39. Wolozin B., Iwasaki K., Vito P., Ganjei K., Lacana E., Sunderland T., Zhao B., Kusiak J. W., Wasco W., and D'Adamio L. (1996) PS2 participates in cellular apoptosis: constitutive activity conferred by Alzheimer mutation. Science 274, 1710-1713.
40. Xia W., Zhang J., Kholodenko D., Citron M., Podlisny M. B., Teplow D. B., Haass C., Seubert P., Koo E. H., and Selkoe D. J. (1997) Enhanced production and oligomerization of the 42-residue amyloid beta protein by Chinese hamster ovary cells stably expressing mutant presenilins. J. Biol. Chem. 272, 7977-7982.