L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

Nature

Volumn 401, Issue 6754, 1999, Pages 703-708

  Graef, Isabella A ^a   Mermelstein, Paul G ^b   Stankunas, Kryn ^a   Hellson, Joel R ^a   Delsseroth, Karl ^b   Tsien, Richard W ^b   Crabtree, Gerald R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; CALCIUM CHANNEL; GSK 3; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NF ATC4; UNCLASSIFIED DRUG;

ARTICLE; HIPPOCAMPUS; MEMORY; NERVE CELL PLASTICITY; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM;

BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCINEURIN; CALCIUM; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CELL NUCLEUS; CELLS, CULTURED; CYTOPLASM; DNA-BINDING PROTEINS; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; LUMINESCENT PROTEINS; NEURONS; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033554699     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/44378     Document Type: Article

References (30)

1. Mulkey, R. M, Endo, S., Shenolikar, S. & Malenka, R. C. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature 369, 486-488 (1994).
2. Lu, Y. F., Hayashi, Y., Moriwaki, A., Tomizawa, K. & Matsui, H. FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor inhibits the induction of long-term potentiation in the rat hippocampus. Neurosci. Lett. 205, 103-106 (1996).
3. Winder, D. G., Mansuy, I. M., Osman, M., Moallem, T. M. & Kandel, E. R. Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92, 25-37 (1998).
4. Mansuy, I. M., Mayford, M., Jacob, B., Kandel, E. R. & Bach, M. E. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92, 39-49 (1998).
5. Klee, C. B., Crouch, T. H. & Krinks, M. H. Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc. Natl Acad. Sci. USA 76, 6270-4273 (1979).
6. Flanagan, W. M., Corthesy, B., Bram, R. J. & Crabtree, G. R. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A [see comments]. Nature 352, 803-807 (1991).
7. Liu, J. et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815 (1991).
8. Shaw, J.-P. et al. Identification of a putative regulator of early T cell activation genes. Science 241, 202-205 (1988).
9. Clipstone, N. A. & Crabtree, G. R. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697 (1992).
10. Hoey, T., Sun, Y.-L., Willamson, K. & Xu, X. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2, 461-472 (1995).
11. Crabtree, G. R. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell 96, 611-614 (1999).
12. Jain, J. et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365, 352-355 (1993).
13. Beals, C. R., Clipstone, N. A., Ho, S. N. & Crabtree, G. R. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev. 11, 824-834 (1997).
14. Timmerman, L. A., Clipstone, N. A., Ho, S. N., Northrop, J. P. & Crabtree, G. R. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 383, 837-840 (1996).
15. Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P. & Crabtree, G. R. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275, 1930-1934 (1997).
16. Chow, C. W., Rincon M., Cavanagh, J., Dickens, M. & Davis, R. J. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278, 1638-1641 (1997).
17. Zhu, J. et al. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKKI. Cell 93, 851-861 (1998).
18. He, X., Saint-Jeannet, J. P., Woodgett, J. R., Varmus, H. E. & Dawid, I. B. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos [published erratum appears in Nature 375, 253 (1995)]. Nature 374, 617-622 (1995).
19. Genazzani, A. A., Carafoli, E. & Guerini, D. Calcineurin controls inositol 1,4,5-trisphosphate type I receptor expression in neurons. Proc. Natl Acad. Sci. USA 96, 5797-5801 (1999).
20. Crabtree, G. R. Contingent genetic regulatory events in T lymphocyte activation. Science 243, 355-361 (1989).
21. Zhou, P., Sun, L. J., Dotsch, V., Wagner, G. & Verdine, G. L. Solution structure of the core NFATCI/ DNA complex. Cell 92, 687-696 (1998).
22. Bito, H., Deisseroth, K. & Tsien, R. W. Ca2+-dependent regulation in neuronal gene expression. Curr. Opin. Neurobiol. 7, 419-429 (1997).
23. Ghosh, A. & Greenberg, M. E. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268, 239-247 (1995).
24. Inoue, T., Kato, K., Kohda, K. & Mikoshiba, K. Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons. J. Neurosci. 18, 5366-5373 (1998).
25. Kasono, K. & Hirano, T. Involvement of inositol trisphosphate in cerebellar long-term depression. NeuroReport 6, 569-572 (1995).
26. Reyes, M. & Stanton, P. K. Induction of hippocampal long-term depression requires release of Ca2+ from separate presynaptic and postsynaptic intracellular stores. J. Neurosci. 16, 5951-5960 (1996).
27. Nguyen, P. V., Abel, T. & Kandel, E. R. Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265, 1104-1107 (1994).
28. Flexner, L. B., Flexner, J. B. & Roberts, R. B. Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory. Science 155, 1377-1383 (1967).
29. Deisseroth, K., Heist, E. K. & Tsien, R. W. Translocaton of cabmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 392, 198-202 (1998).
30. Bito, H., Deisseroth, K. & Tsien, R. W. CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell 87, 1203-1214 (1996).