β-Amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment

European Journal of Pharmacology

Volumn 392, Issue 3, 2000, Pages 117-123

  Wei, Huafeng ^a   Leeds, Peter R ^a   Qian, Yanning ^a   Wei, Wenlin ^a   Chen, Ren wu ^a   Chuang, De Maw ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Alzheimer's disease; Bcl 2; Lithium chloride; Amyloid

Indexed keywords

AMYLOID BETA PEPTIDE[1-42]; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[25-35]; LITHIUM; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL STRAIN; CHROMAFFIN CELL; CONTROLLED STUDY; DOSE RESPONSE; GRANULE CELL; IN VITRO STUDY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN; ANIMALS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; LITHIUM CHLORIDE; NEURONS; OXIDATION-REDUCTION; PC12 CELLS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS;

EID: 0034737575     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00127-8     Document Type: Article

References (26)

1. Alvarez G., Muñoz-Montaño J.R., Satrústegui J., Avila J., Bogónez E., Díaz-Nido J. Lithium protects cultured neurons against β-amyloid-induced neurodegeneration. FEBS Lett. 453:1999;260-264.
2. Behl C., Davis J.B., Cole G.M., Schubert D. Vitamin E protects nerve cells from amyloid β protein toxicity. Biochem. Biophys. Res. Commun. 186:1992;944-950.
3. Behl C., Hovery L. III, Krajewski S., Schubert D., Reed J.C. Bcl-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein. Biochem. Biophys. Res. Commun. 197:1993;949-956.
4. Chalecka-Franaszek E., Chuang D.-M. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. USA. 96:1999;8745-8750.
5. Chen R.W., Chuang D.-M. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotecion against excitotoxicity. J. Biol. Chem. 274:1999;6039-6042.
6. Colom L.V., Diaz M.E., Beers D.R., Neely A., Xie W.J., Appel S.H. Role of potassium channels in amyloid-induced cell death. J. Neurochem. 70:1998;1925-1934.
7. Goodman Y., Mattson M.P. Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury. Exp. Neurol. 128:1994;1-12.
8. + protection of cerebellar granule neurons switched to non-depolarizing medium. Eur. J. Pharmacol. 315:1996;111-114.
9. Hong M., Chen D.C.R., Klein P.S., Lee V.M.Y. Lithium reduces Tau phosphorylation by inhibition of glycogen synthase kinase-3. J. Biol. Chem. 272:1997;25326-25332.
10. Ishitani R., Sunaga K., Hirano A., Saunders P., Katsube N., Chuang D.-M. Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture. J. Neurochem. 66:1996;928-935.
11. Koh J.Y., Yang L.L., Cotman C.W. β-Amyloid protein increases the vulnerability of cultured neurons to excitotoxic damage. Brain Res. 533:1990;315-320.
12. 2+ homeostasis in Alzheimer's disease. Trends Neurosci. 16:1993;409-414.
13. Muñoz-Montaño J.R., Moreno F.J., Avila J., Díaz-Nido J. Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. FEBS Lett. 411:1997;183-188.
14. Nonaka S., Chuang D.-M. Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats. NeuroReport. 9:1998;2081-2084.
15. Nonaka S., Hough C.J., Chuang D.-M. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proc. Natl. Acad. Sci. USA. 95:1998;2642-2647.
16. Nonaka S., Katsube N., Chuang D.-M. Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine. J. Pharmacol. Exp. Ther. 286:1998;539-547.
17. Paradis E., Douillard H., Koutroumanis M., Goodyer C., LeBlanc A. Amyloid β peptide of Alzheimer's disease downregulates Bcl-2 and upregulate Bax expression in human neurons. J. Neurosci. 16:1996;7533-7539.
18. Price D.L., Tanzi R.E., Borchelt D.R., Sisodia S.S. Alzheimer's disease: genetic studies and transgenic models. Annu. Rev. Genet. 32:1998;461-493.
19. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron. 6:1991;487-498.
20. Shearman M.S., Ragan C.I., Iversen L.L. Inhibition of PC 12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc. Natl. Acad. Sci. USA. 91:1994;1470-1474.
21. Sky A.J., Grossberg G.T. The use of psychotropic medication in the management of problem behaviors in the patient with Alzheimer's disease. Med. Clin. North Am. 78:1994;811-822.
22. Tanzi R., Gaston S., Bush A., Romano D., Pettingell W., Peppercorn J., Paradis M., Gurubhagavatula S., Jenkins B., Wasco W. Genetic-heterogeneity of gene defects responsible for familial Alzheimer-disease. Genetica. 91:1993;255-263.
23. Tomiyama T., Shoji A., Kataoka K.I., Suwa Y., Asano S., Kaneko H., Endo N. Inhibition of amyloid β protein aggregation and neurotoxicity by rifampicin. J. Biol. Chem. 271:1996;6839-8644.
24. Volonté C., Rukenstein A. Lithium promotes short-term survival of PC 12 cells after serum and NGF deprivation. Lithium. 4:1993;211-219.
25. Wei H., Hough C.J., Leng Y., Chen R.-W., Chuang D.-M. Protracted lithium treatment inhibits PC-12 cell death induced by thapsigargin and high KCl. Soc. Neurosci. Abstr. 24:1998;998. (390.9).
26. Wei H., Qian Y., Wei W., Leeds P.R., Nonaka S., Chuang D.-M. β-Amyloid-induced death of PC 12 cells is inhibited by long-term lithium treatment. Soc. Neurosci. Abstr. 25:1999;343. (136.3).