Neuroprotective signal transduction: Relevance to stroke

Neuroscience and Biobehavioral Reviews

Volumn 21, Issue 2, 1997, Pages 193-206

  Mattson, Mark P ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Amyloid precursor protein; Antioxidant enzymes; Basic fibroblast growth factor; Calcium; Cerebral ischemia; Excitotoxicity; Hippocampus; Neurotrophic factors; Platelet derived growth factor; Protease nexin; Reactive oxygen species; Receptor tyrosine kinase; Thrombin; Tumor necrosis factor

Indexed keywords

AMYLOID BETA PROTEIN; BASIC FIBROBLAST GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM ION; FREE RADICAL; K 252A; LYMPHOTOXIN; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; PLATELET DERIVED GROWTH FACTOR; PROTEASE NEXIN I; STAUROSPORINE; THROMBIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CALCIUM CELL LEVEL; CEREBROVASCULAR DISEASE; DEGENERATIVE DISEASE; FEEDBACK SYSTEM; GENE INDUCTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STROKE;

ANIMALS; CEREBROVASCULAR DISORDERS; GROWTH SUBSTANCES; NEUROPROTECTIVE AGENTS; SIGNAL TRANSDUCTION;

EID: 0031048002     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(96)00010-3     Document Type: Article

References (129)

1. Armitage R.J., Fanslow W.C., Strockbine L., Sato T.A., Clifford K.N., Macduff B.M., Anderson D.M., Gimpel S.D., Davis-Smith T., Maliszewski C.R., Clark E.A., Smith C.A., Grabstein K.H., Cosman D., Spriggs M.K. Molecular and biological characterization of murine ligand for CD40. Nature. 357:1992;82-82.
2. Barger S.W., Fiscus R.R., Ruth P., Hofmann F., Mattson M.P. Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of β amyloid precursor. J. Neurochem. 64:1995;2087-2096.
3. Barger S.W., Horster D., Furukawa K., Goodman Y., Krieglstein J., Mattson M.P. TNFs protect hippocampal neurons against amyloid β-peptide toxicity: involvement of NFkB and attenuation of peroxide and calcium accumulation. Proc. Natl. Acad. Sci. U.S.A. 92:1995;9328-9332.
4. Barger, S.W.; Mattson, M.P. Excitatory amino acids and growth factors: biological and molecular interactions regulating neuronal survival and plasticity. In: Stone, T.W., ed. CNS Neurotransmitters and Neuromodulators. Boca Raton: CRC Press; 1995: 2:273-294.
5. Barger S.W., Mattson M.P. Secreted form of the Alzheimer's β-amyloid precursor induces neuroprotective kB-dependent transcription. Molec. Brain Res. 40:1996;116-126.
6. Barger S.W., Van Eldik L.J., Mattson M.P. S100β protects hippocampal neurons from damage induced by glucose deprivation. Brain Res. 677:1995;167-170.
7. Bowes M.P., Masliah E., Otero D.A., Zivin J.A., Saitoh T. Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model. Exp. Neurol. 129:1994;112-129.
8. Bruce A.J., Boling W., Kindy M.S., Peschon J., Kraemer P.J., Carpenter M.K., Holtsberg F.W., Mattson M.P. Altered neuronal and microglial responses to brain injury in mice lacking TNF receptors. Nature Medicine. 2:1996;788-794.
9. Chao M.V. Neurotrophin receptors: a window into neuronal differentiation. Neuron. 9:1992;583-593.
10. Cheng B., Barger S.W., Mattson M.P. Staurosporine, K-252a and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose. J. Neurochem. 62:1994;1319-1329.
11. Cheng B., Christakos S., Mattson M.P. Tumor necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis. Neuron. 12:1994;139-153.
12. Cheng B., Goodman Y., Begley J.G., Mattson M.P. Neurotrophin 4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury. Brain Res. 650:1994;331-335.
13. Cheng B., Mattson M.P. NGF and bFGF protect rat and human central neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron. 7:1991;1031-1041.
14. Cheng B., Mattson M.P. IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemia damage. J. Neurosci. 12:1992;1558-1566.
15. Cheng B., Mattson M.P. NT-3 and BDNF protect hippocampal, septal, and cortical neurons against metabolic compromise. Brain Res. 640:1994;56-67.
16. Cheng B., Mattson M.P. PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways. J. Neurosci. 15:1995;7095-7104.
17. Cheng B., McMahon D., Mattson M.P. Modulation of calcium current, intracellular calcium levels and cell survival by hypoglycemia, NGF and bFGF in cultured hippocampal neurons. Brain Res. 607:1993;275-285.
18. Collazo D., Takahashi H., McKay R.D.G. Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus. Neuron. 9:1992;643-656.
19. Dobrowsky R.T., Werner M.H., Castellino A.M., Chao M.V., Hannun Y.A. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science. 265:1994;1596-1599.
20. Dykens J.A., Stern A., Trenkner E. Mechanism of kainate toxicity to cerebellar neurons in vitro is analagous to reperfusion tissue injury. J. Neurochem. 49:1987;1222-1228.
21. Endoh M., Pulsinelli W.A., Wagner J.A. Transient global ischemia induces dynamic changes in the expression of bFGF and the FGF receptor. Molec. Brain Res. 22:1993;76-88.
22. Fenton J.W. II, Ofosu F.A., Brezniak D.V., Hassouna H.I. Understanding thrombin and hemostasis. Hematol. Oncol. Clin. North Am. 7:1993;1107-1119.
23. Finklestein S.P., Apostolides P.J., Caday C.G., Prosser J., Phillips M.G., Klagsbrun M. Increased basic fibroblast growth factor immunoreactivity at the site of focal brain wounds. Brain Res. 460:1988;253-259.
24. Floyd R.A., Carney J.M. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32:1992;S22-S27.
25. Folbergrova J., Kiyota Y., Pahlmark K., Memezawa H., Smith M.L., Siesjo B.K. Does ischemia with reperfusion lead to oxidative damage to proteins in the brain? J. Cereb. Blood Flow Metab. 13:1993;145-152.
26. Freese A., Finklestein S.P., DiFiglia M. Basic fibroblast growth factor protects striatal neurons in vitro from NMDA receptor-mediated excitotoxicity. Brain Res. 575:1992;351-355.
27. Friden P.M. Receptor-mediated transport of therapeutics across the blood-brain barrier. Neurosurgery. 35:1994;294-298.
28. + channels and suppression of neuronal activity by secreted β-amyloid precursor protein. Nature. 379:1996;74-78.
29. i. Exp. Neurol. In press; 1995.
30. Gall C., Isackson P.J. Limbic seizures increase neuronal production of mRNA for nerve growth factor. Science. 245:1989;758-761.
31. Geschwind M.D., Kessler J.A., Geller A.I., Federoff H.J. Transfer of nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Molec. Brain Res. 24:1994;327-335.
32. Ghosh A., Greenberg M.E. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science. 268:1995;239-247.
33. Ginsberg M.D., Pulsinelli W.A. The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke. Ann. Neurol. 36:1994;553-554.
34. Goodman Y., Mattson M.P. Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury. Exp. Neurol. 128:1994;1-12.
35. Goodman Y., Mattson M.P. Staurosporine and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury. Brain Res. 650:1994;170-174.
36. Goodman Y., Mattson M.P. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid β-peptide toxicity. J. Neurochem. 66:1996;869-872.
37. Gurwitz D., Cunningham D.D. Neurie outgrowth activity of protease nexin-1 on neuroblastoma cells requires thrombin inhibition. J. Cell. Physiol. 142:1990;155-162.
38. Hall E.D., Braughler J.M., Yonkers P.A., Smith S.L., Linseman K.L., Means E.D., Scherch H.M., Von Voightlander P.F., Lahti R.A., Jacobsen E.J. U-7817F: a potent inhibitor lipid peroxidation with activity in experimental brain injury and ischemia. J. Pharmac. Exp. Ther. 258:1991;688-694.
39. Hall E.D., Yonkers P.A., Andrus P.K., Cox J.W., Anderson D.K. Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury. J. Neurotrauma. 9:1992;S425-S442.
40. Heller R.A., Song K., Onash M., Fisher W.H., Chang D.J., Ringold G.M. Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor. Proc. Natl. Acad. Sci. USA. 87:1990;6151-6155.
41. Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F., Floyd R., Butterfield D.A. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 91:1994;3270-3274.
42. Hoffman M.C., Nitsch C., Scotti A.L., Reinhard E., Monard D. The prolonged presence of glia-derived nexin an endogenous protease inhibitor in the hippocampus after ischemia-induced delayed neuronal death. Neuroscience. 49:1992;397-408.
43. Houenou L.J., Turner P.L., Li L., Oppenheim R.W., Festoff B.W. A serine protease inhibitor, protease nexin-1, rescues motoneurons from naturally occurring and axotomy-induced cell death. Proc. Natl. Acad. Sci. USA. 92:1995;895-899.
44. Hutchins J.B., Jefferson V.E. Developmental distribution of platelet-derived growth factor in the mouse central nervous system. Dev. Brain Res. 67:1992;121-135.
45. Hutchins J.B., Zhang X. Platelet-derived growth factor (PDGF) receptors in the developing mouse optic pathway. Vis. Neurosci. 11:1994;33-40.
46. Iacopino A., Christakos S., German D., Sonsalla P.K., Altar C.A. Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity. Molec. Brain Res. 13:1992;251-261.
47. Iihara K., Sasahara M., Hashimoto N., Uemura Y., Kikuchi H., Hazama F. Ischemia induces the expression of the platelet-derived growth factor-B chain in neurons and brain macrophages in vivo. J. Cereb. Blood Flow Metab. 14:1994;818-824.
48. Jarrett J.T., Lansbury P.T. Seeding one dimensional crystallization of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell. 73:1993;1055-1058.
49. Kearns C.M., Gash D.M. GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res. 672:1995;104-111.
50. Koketsu N., Berlove D.J., Moskowitz M.A., Kowall N.W., Caday C.G., Finklestein S.P. Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats. Ann. Neurol. 35:1994;451-457.
51. Korsmeyer S.J. Regulators of cell death. Trends Genet. 11:1995;101-105.
52. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
53. Lee T.H., Abe K., Aoki M., Nakamura M., Kogure K., Itoyama Y. The protective effect of L-threo-3,4-dihydroxyphenylserine on ischemic hippocampal neuronal death in gerbils. Stroke. 25:1994;1425-1431.
54. Li Y., Chopp M., Jiang N., Zaloga C. In situ detection of DNA fragmentation after focal cerebral ischemia in mice. Molec. Brain Rec. 28:1995;164-168.
55. Lindvall O., Ernfors P., Bengzon J., Kokaia Z., Smith M.-L., Siesjo B.K., Persson H. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotropic factor, and neurotropin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc. Natl. Acad. Sci. USA. 89:1992;648-652.
56. Liou H.C., Baltimore D. Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr. Opin. Cell Biol. 5:1993;477-487.
57. Lipton S.A., Stamler J.S. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology. 33:1994;1229-1233.
58. Liu H.M., Chen H.H. c-fos protein expression and ischemic changes in neurons vulnerable to ischemia/hypoxia, correlated with basic fibroblast growth factor immunoreactivity. J. Neuropathol. Exp. Neurol. 53:1994;598-605.
59. Liu Y., Kato H., Nakata N., Kogure K. Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia. Brain Res. 586:1992;121-124.
60. 2+ homeostasis and cell death. J. Neurosci. 15:1995;6239-6249.
61. Mattson M.P. Secreted forms of β-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons. J. Neurobiol. 25:1994;439-450.
62. Mattson M.P. Calcium and neuronal injury in Alzheimer's disease. Contributions of β-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise. Ann. N. Y. Acad. Sci. 747:1994;50-76.
63. Mattson M.P., Barger S.W., Cheng B., Lieberburg I., Smith-Swintosky V.L., Rydel R.E. β-amyloid precursor protein metabolites and loss of neuronal calcium homeostasis in Alzheimer's disease. Trends Neurosci. 16:1993;409-415.
64. Mattson, M.P.; Barger, S.W. Programmed cell life: neuroprotective signal transduction and ischemic brain injury. Proceedings of the Nineteenth Princeton Conference (Butterworth, Stoneham, MA) 271-290; 1995.
65. Mattson M.P., Cheng B. Growth factors protect neurons against excitotoxic/ischemic damage by stabilizing calcium homeostasis. Eighteenth Princeton Conference. Stroke. 24:1993;I136-I140.
66. Mattson, M.P.; Cheng, B.; Baldwin, S.; Smith-Swintosky, V.L.; Keller, J.; Geddes, J.W.; Scheff, S.W.; Christakos, S. Brain injury and tumor necrosis factors induce expression of calbindin D-28k in astrocytes: a cytoprotective response. J. Neurosci. Res. 42: In press; 1995.
67. Mattson M.P., Cheng B., Culwell A., Esch F., Lieberburg I., Rydel R.E. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of β-amyloid precursor protein. Neuron. 10:1993;243-254.
68. Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., Rydel R.E. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:1992;376-389.
69. Mattson M.P., Cheng B., Smith-Swintosky V.L. Growth factor-mediated protection from excitotoxicity and disturbances in calcium and free radical metabolism. Seminars Neurosci. 5:1993;295-307.
70. Mattson M.P., Goodman Y. Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium. Brain Res. 676:1995;219-224.
71. Mattson M.P., Kumar K., Cheng B., Wang H., Michaelis E.K. Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in cultured hippocampal neurons. J. Neurosci. 13:1993;4575-4588.
72. i and neurotoxicity, and increase antioxidant enzyme activities in hippocampal neurons. J. Neurochem. 65:1995;1740-1751.
73. Mattson M.P., Murrain M., Guthrie P.B., Kater S.B. Fibroblast growth factor and glutamate: opposing actions in the generation and degeneration of hippocampal neuroarchitecture. J. Neurosci. 9:1989;3728-3740.
74. Mattson M.P., Rychlik B., Chu C., Christakos S. Evidence for calcium-reducing and excitoprotective roles for the calcium binding protein (calbindin-D28k) in cultured hippocampal neurons. Neuron. 6:1991;41-51.
75. Mattson M.P., Scheff S.W. Endogenous neuroprotection factors and traumatic brain injury: mechanisms of action and implications for therapies. J. Neurotrauma. 11:1994;3-33.
76. Mattson M.P., Tomaselli K., Rydel R.E. Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF. Brain Res. 621:1993;35-49.
77. Mattson M.P., Zhang Y., Bose S. Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose. Exp. Neurol. 121:1993;1-13.
78. McDonald N.Q., Hendrickson W.A. A structural superfamily of growth factors containing a cystine knot motif. Cell. 73:1993;421-424.
79. Minami M., Kuraishi Y., Satoh M. Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain. Biochem. Biophys. Res. Commun. 176:1993;593-598.
80. Monard D., Niday E., Limat A., Solomon F. Inhibition of protease activity can lead to neurite extension in neuroblastoma cells. Progr. Brain Res. 58:1983;359-364.
81. Monyer H., Goldberg M.P., Choi D.W. Glucose deprivation neuronal injury in cortical culture. Brain Res. 483:1989;347-354.
82. Morrison R.S., Sharma A., De Vellis J., Bradshaw R.A. Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. Proc. Natl. Acad. Sci. USA. 83:1986;7537-7541.
83. Morshead C.M., Reynolds B.A., Craig C.G., McBurney M.W., Staines W.A., Morassutti D., Weiss S., van der Kooy D. Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of ependymal cells. Neuron. 13:1994;1071-1082.
84. Nabeshima T., Nitta A., Fuji K., Kameyama T., Hasegawa T. Oral administration of NGF synthesis stimulators recovers reduced brain NGF content in aged rats and cognitive dysfunction in basal forebrain lesioned rats. Gerontology. 40:(S2):1994;46-56.
85. Nakata N., Kato H., Kogure K. Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil. Brain Res. 605:1993;35-356.
86. Nikkhah G., Odin P., Smits A., Tingstrom A., Othberg A., Brundin P., Funa K., Lindvall O. Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture. Exp. Brain Res. 92:1993;516-523.
87. Nitatori T., Sato N., Waguri S., Karasawa Y., Araki H., Shibanai K., Kominami E., Uchiyama Y. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci. 15:1995;1001-1011.
88. Nitsch R.M., Slack B.E., Growdon J.H., Wurtman R.J. Release of amyloid β-protein precursor derivatives by electrical depolarization or rat hippocampal slices. Proc. Natl. Acad. Sci. USA. 90:1993;5191-5193.
89. Noble M., Murray K., Stroobant P., Waterfield M.D., Riddle P. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of oligodendrocyte/type-2 astrocyte progenitor cell. Nature. 333:1988;560-562.
90. Nozaki K., Finklestein S.P., Beal M.F. Basicfibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats. J. Cereb. Blood Flow Metab. 13:1993;221-228.
91. Pan Z., Perez-Polo R. Role of nerve growth factor in oxidant homeostasis: glutathione metabolism. J. Neurochem. 61:1993;1713-1721.
92. Perlmutter L.S. Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Molec. Neurobiol. 9:1994;33-40.
93. Prehn J.H.M., Backhaub C., Krieglstein J. Transforming growth factor-β1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse from ischemic injury in vivo. J. Cereb. Blood Flow Metab. 13:1993;521-525.
94. Pringle N.P., Mudhar H.S., Collarini E.J., Richardson W.D. PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development. 115:1992;535-551.
95. Pulsinelli W. Pathophysiology of acute ischaemic stroke. Lancet. 339:1992;533-536.
96. Raff M.C., Lillien L.E., Richardson W.D., Burne J.F., Noble M.D. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature. 333:1988;562-565.
97. Reinhard E., Suidan H.S., Pavlik A., Monard D. Glia-derived nexin/protease nexin-1 is expressed by a subset of neurons in the rat brain. J. Neurosci. Res. 37:1994;256-270.
98. Roberts G.W., Gentleman S.M., Lynch A., Graham D.I. βA4 amyloid protein deposition in brain after head injury. Lancet. 338:1991;1422-1423.
99. Roch J.M., Masliah E., Roch-Levecq A.C., Sundsmo M.P., Otero D.A., Veinbergs I., Saitoh T. Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc. Natl. Acad. Sci. USA. 91:1994;7450-7454.
100. Rosenblatt D.E., Cotman C.W., Nieto-Sampedro M., Rowe J.W., Knauer D.J. Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-1. Brain Res. 415:1987;40-48.
101. Rothman S.M. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J. Neurosci. 4:1984;1884-1891.
102. Rozemuller A.J., Roos R.A., Bots G.T., Kamphorst W., Eikelenboom P., Van Nostrand W.E. Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease. Am. J. Pathol. 142:1993;1449-1457.
103. Saido T.C., Yokota M., Maruyama K., Yamao-Harigaya W., Tani E., Ihara Y., Kawashima S. Spatial resolution of the primary amyloidogenic process induced in postischemic hippocampus. J. Biol. Chem. 269:1994;15,253-15,257.
104. Sampath D., Jackson G.R., Werrbach-Perez K., Perez-Polo J.R. Effects of nerve growth factor on glutathione peroxidase and catalase in PC12 cells. J. Neurochem. 62:1994;2476-2479.
105. Sasahara M., Fries J.W.U., Raines E.W., Gown A.M., Westrum L.E., Frosch M.P., Bonthron D.T., Ross R., Collins T. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell. 64:1991;217-227.
106. Scharfman H.E., Schwartzkroin P.A. Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation. Science. 246:1989;257-260.
107. Schulze-Osthoff K., Krammer P.H., Droge W. Divergent signaling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J. 13:1994;4587-4596.
108. Selkoe D.J. Physiological production of the b-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci. 16:1993;403-409.
109. Selmaj K.W., Raine C.S. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23:1988;339-346.
110. Shigeno T., Mima T., Takakura K., Graham D.I., Kato G., Hashimoto Y., Furukawa S. Amelioration of delayed neuronal death in the hippocampus by nerve growth factor. J. Neurosci. 11:1991;2914-2919.
111. Siman R., Noszek J.C. Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron. 1:1988;279-287.
112. Smith-Swintosky, V.L.; Kraemer, P.J.; McCants, N.; Maki, A.; Brown, R.W.; Keller, J.; Goodman, Y.; Mattson, M.P. Bacterial alkaloids mitigate seizure-induced hippocampal damage and memory deficits. Ann. Neurol. Submitted; 1995.
113. Smith-Swintosky V.L., Pettigrew L.C., Craddock S.D., Culwell A.R., Rydel R.E., Mattson M.P. Secreted forms of β-amyloid precursor protein protect against ischemic brain injury. J. Neurochem. 63:1994;781-784.
114. 2+ homeostasis and sensitivity to glucose deprivation-induced injury. J. Neurosci. 15: In press; 1995.
115. Smith-Swintosky V.L., Zimmer S., Fenton J.W. II, Mattson M.P. Opposing actions of thrombin and protease nexin-1 on amyloid β-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons. J. Neurochem. 65:1995;1415-1418.
116. Spina M.B., Squinto S.P., Miller J., Lindsay R.M., Hyman C. Brain-derived neurotropic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system. J. Neurochem. 59:1992;99-106.
117. Stein-Behrens B., Mattson M.P., Chang I., Yeh M., Sapolsky R.M. Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus. J. Neurosci. 14:1994;5373-5380.
118. Thomas, K.A. Biochemistry and molecular biology of fibroblast growth factors. In Loughlin, S.E.; Fallon, J.H., eds. Neurotrophic Factors. San Diego: Academic Press; 1993:285-312.
119. Tortosa A., Rivera R., Ferrer I. Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia. J. Neurol. Sci. 121:1994;10-17.
120. 2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo. Neuron. 11:1993;221-235.
121. Vaughan P.J., Cunningham D.D. Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors. J. Biol. Chem. 268:1993;3720-3727.
122. Walicke P., Cowan W.M., Ueno N., Baird A., Guillemin R. Fibroblast growth factor promotes survival of dissociated hippocampal neurons and promotes neurite extension. Proc. Natl. Acad. Sci. USA. 83:1986;3012-3016.
123. Wang, X.; Yue, T.L.; Barone, F.C.; White, R.F.; Gagnon, R. C.; Feuerstein, G.Z. Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia. Molec. Chem. Neuropathol. 23:103-114.
124. Watson B.D., Ginsberg M.D. Ischemic injury in the brain. Role of oxygen radical-mediated processes. Ann. N.Y. Acad. Sci. 559:1989;269-281.
125. Weinstein J.R., Gold S.J., Cunningham D.D., Gall C.M. Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J. Neurosci. 15:1995;2906-2919.
126. Weiss J.H., Hartley D.M., Koh J., Choi D.W. The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity. Science. 247:1990;1474-1477.
127. Wilde G.J.C., Pringle A.K., Sundstrom L.E., Iannotti F. Tumor necrosis factor α attenuates hypoxic/hypoglycaemic damage in organotypic hippocampal cultures. J. Cereb. Blood Flow Metab. 15:1995;S263.
128. Yeh H.J., Silos-Santiago I., Wang Y.X., George R.J., Snider W.D., Deuel T.F. Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system. Proc. Natl. Acad. Sci. USA. 90:1993;1952-1956.
129. Zhang R.L., Chopp M., Li Y., Zaloga C., Jiang N., Jones M.L., Miyasaka M., Ward P.A. Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology. 44:1994;1747-1751.