p300 and CBP: Partners for life and death

Journal of Cellular Physiology

Volumn 181, Issue 2, 1999, Pages 218-230

  Giordano, Antonio ^a   Avantaggiati, Maria Laura ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN;

APOPTOSIS; CELL DIFFERENTIATION; CELL GROWTH; CHROMATIN STRUCTURE; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CREB-BINDING PROTEIN; HUMANS; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 0032829090     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199911)181:2<218::AID-JCP4>3.0.CO;2-5     Document Type: Review

References (116)

1. Ait-Si-Ali S, Ramirez S, Barre FX, Dkhissi F, Magnaghi-Jaulin L, Girault JA, Robin P, Knibiehler M, Pritchard LL, Ducommun B, Trouche D, Harel-Bellan A. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature 396:184-186.
2. Akimaru H, Hou DX, Ishii S. 1997. Drosophila CBP is required for dorsal-dependent twist gene expression. Nat Genet 17:211-214.
3. Arias J, Alberts AS, Brindle P, Claret XS, Smeal T, Karin, M, Feramisco J, Montminy M. 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370:226-229.
4. Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, Livingston DM. 1996. An essential role for p300/ CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 93:12969-12973.
5. Arany Z, Newsome D, Oldread E, Livingston DM, Eckner R. 1995. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature 374:81-84.
6. Avantaggiati, ML, Carbone, M, Graessman, A, Nakatani, Y, Howard, B, Levine, AS. 1996. The SV40 Large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional coactivator p300. Embo J 15:2236-2248.
7. Avantaggiati ML, Ogrykko, V, Gardner, K, Giordano, A, Levine, AS, Kelly, K. 1997. Recrutment of p300/CBP in p53-dependent signal pathways. Cell 89, 1175-1184.
8. Bannister AJ, Oehler T, Wilhelm D, Angel P, Kouzarides T, Bannister AJ, Kouzarides T. 1996. The CBP co-activator is a histone acetyltransferase. Nature 384:641-643.
9. Bannister AJ, Oehler T, Wilhelm D, Angel P, Kouzarides T. 1995. Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11:2509-2514.
10. Bannister AJ, Kouzarides T. 1995. CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J 14:4758-4762.
11. Baylies MK, Bate M, Ruiz Gomez M. 1998. Myogenesis: a view from Drosophila. Cell 93:921-927.
12. Bengal E, Ransone L, Scharfmann R, Dwarki VJ, Tapscott SJ, Weintraub H, Verma IM. 1992. Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell 68:507-519.
13. Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston DM. 1996. Cooperation of Stat2 and p300/ CBP in signalling induced by interferon-alpha. Nature 383:344-347.
14. Borrow J, Stanton VP Jr, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Discteche C, Dube I, Frichauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE. 1996. The translocation t(8;16) (p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet 14:33-41.
15. Boyes J, Byfield P, Nakatani Y, Ogryzko V. 1998. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396:594-598.
16. Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601.
17. Brownell JE, Allis CD. 1996. Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation. Curr Opin Genet Dev 6:176-184.
18. Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL. 1996. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol 16:593-602.
19. Carey M. 1998. The enhanceosome and transcriptional synergy. Cell 92:5-8.
20. Chakravarti D, Ogryzko V, Hung-Ying Kao, Nash A, Chen H, Nakatani Y, Evans RM. 1999. A Viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell 96:393-403.
21. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. 1997. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569-580.
22. Chiou SK, White E. 1997. p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis. J Virol 71:3515-3525.
23. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. 1993. Phoshorylated CREB binds specifically to the nuclear protein . Nature 359:328-330.
24. Dai P, Akimaru H, Tanaka Y, Hou DX, Yasukawa T, Kanei-Ishii C, Takahashi T, Ishii S. 1996. CBP as a transcriptional coactivator of c-Myb. Genes Dev 10:528-540.
25. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215-221.
26. Eckner R. 1996. p300 and CBP as transcriptional regulators and targets of oncogenic events. Biol Chem 377:685-688.
27. Eckner R, Yao TP, Oldread E, Livingston DM. 1996a. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes & Dev. 10:2478-2490.
28. Eckner R, Ludlow JW, Lill NL, Oldread E, Arany Z, Modjtahedi N, De Caprio JA, Livingston DM. 1996b. Association of p300 and CBP with simian virus 40 large T antigen. Mol. Cell. Biol. 16:3454-3464.
29. Eckner R, Ewen ME, Newsome D, Gerdes M, De Caprio JA, Lawrence JB, Livingston DM. 1994. Molecular cloning and functional analysis of the adenovirus E1aA-associated 300-KD protein reveals a protein with properties of a transcriptional adaptor. Genes Dev 7:869-884.
30. Feng XH, Zhang Y, Wu RY, Derynck R. 1998. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev 12:2153-2163.
31. Giles RH, Peters DJ, Breuning MH. 1998. Conjunction dysfunction: CBP/p300 in human disease. Trends Genet 14:178-181.
32. Gottlieb TM, Oren M. 1996. p53 in growth control and neoplasia. Biochim Biophys Acta 1287:77-102.
33. Gregory, PD, Schmid, A, Zavari, M, Lui, L, Berger, SL, Horz, W. 1998. Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast. Mol. Cell 1:495-505.
34. Grossman SR, Perez M, Kung AL., Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM. 1998. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell 2:405-415.
35. Gu, W, Shi, X-L, Roeder, RG. 1997. Synergistic activation of transcription by CBP and p53. Nature 387:819-822.
36. Gu W, Roeder RG. 1997. Activation of p53 sequence-specific DNA binding by acetylation on the C-terminal domain. Cell 90:595-606.
37. Hamamori Y, Sartorelli V, Ogryzko V, Puri PL, Wu HY, Wang JYJ, Nakatani Y, Kedes L. 1999. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell 96:405-413.
38. Horvai AE, Xu L, Korzus E, Brard G, Kalafus D, Mullen TM, Rose DW, Rosenfeld MG, Glass CK. 1997. Nuclear integration of JAK/ STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci USA 94:1074-1079.
39. Hottiger MO, Felzien LK, Nabel GJ. 1998. Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300. EMBO J 17:3124-3134.
40. Hupp, TR, Meee, DW, Midgley, CA, Lane DP. 1992. Regulation of specific DNA binding function of p53. Cell 71:875-886.
41. Ida K, Kitabayashi I, Taki T, Taniwaki M, Noro K, Yamamoto M, Ohki M, Hayashi Y. 1997. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). Blood 90:4699-4704.
42. Imhof A, Yang XJ, Ogryzko VV, Nakatani Y, Wolffe AP, Ge H. 1997. Acetylation of general transcription factors by histone acetyltransferases. Curr Biol 7:689-692.
43. Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L. 1998. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J 17:6573-6586.
44. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK. 1996. A CBP integrator complex mediates transcriptional activation and API inhibition by nuclear receptors. Cell 85:403-414.
45. Kawasaki H, Song J, Eckner R, Ugai H, Chiu R, Taira K, Shi Y, Jones N, Yokoyama KK. 1998a. p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Genes Dev 12:233-245.
46. Kawasaki H, Eckner R, Yao TP, Taira K, Chiu R, Livingston DM, Yokoyama KK. 1998b. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature 393: 284-289.
47. Kee BL, Arias J, Montminy MR. 1996. Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J Biol Chem 271:2373-2375.
48. Kijima M, Yoshida M, Sugita K, Horinouchi S, Beppu T. 1993. Trapoxin, an anti-tumor cyclic tetrapeptide is an irreversible inhibitor of mammalian histone-deacetylase. J Biol Chem 268:22429-22435.
49. Kim TK, Kim TH, Maniatis T. 1998. Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. Proc Natl Acad Sci USA 95:12191-12196.
50. Kitabayashi I, Eckner R, Arany Z, Chiu R, Gachelin G, Livingston DM, Yokoyama KK. 1995. Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells. EMBO J 14:3496-3509.
51. Ko LJ, Prives C. 1996. p53: puzzle and paradigm. Genes Dev. 10: 1054-1072.
52. Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG. 1998. Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279:703-707.
53. Kuo MH, Zhou J, Jambeck P, Churchill ME, Allis DC. 1998. Histone acetyltransferase activity of yeast Gcn5 is required for the activation of target genes. Genes Dev 12:627-639.
54. Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH. 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370:223-226.
55. Janknecht R, Wells NJ, Hunter T. 1998. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev 12:2114-2119.
56. Janknecht R, Hunter T. 1996. Versatile molecular glue. Transcriptional control. Curr Biol 1;6:951-954.
57. Janknecht R, Nordheim A. 1996. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem Biophys Res Commun 228:831-837.
58. Jones SN, Roe AE, Donehower LA, Bradley A. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378:206-208.
59. Lambert PF, Kashanchi F, Radonovich MF, Shiekhattar R, Brady JN. 1998. Phosphorylation of p53 serine 15 increases interaction with CBP. J Biol Chem 273:33048-53.
60. Lane DP, Hall PA. 1997. MDM2: arbiter of p53's destruction. Trends Biochem Sci 22:372-374.
61. Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN. 1997. Histone deacetylases associated with the mSin3 corepressor mediate Mad transcriptional repression. Cell 89:349-356.
62. Lee CW, Sorensen TS, Shikama N, La Thangue NB. 1998. Functional interplay between p53 and E2F through co-activator p300. Oncogene 16:2695-2710.
63. Lill, NL, Grossman, SR, Ginsberg, D, De Caprio, J, Livingston, DM. 1997a. Binding and modulation of p53 by p300/cbp coactivators. Nature 387:823-827.
64. Lill NL, Tevethia MJ, Eckner R, Livingston DM, Modjtahedi N. 1997b. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. J Virol 71:129-137.
65. Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL. 1999. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol. 19:1202-1209.
66. Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, Gansmuller A, Chambon P. 1994. Function of the retinoic acid receptors (RARs) during development (I).Craniofacial and skeletal abnormalities in RAR double mutants. Development 120:2723-2748.
67. Lundblad JR, Kwok RP, Laurance ME, Harter ML, Goodman RH. 1995. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374:85-88.
68. Luo RX, Postigo AA, Dean DC. 1998. Rb interacts with histone deacetylase to repress transcription. Cell 92:463-473.
69. Lurger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ. 1997. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389(6648):251-260.
70. Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, Troalen F, Trouche D, Harel-Bellan A. 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-605.
71. Maione R, Amati P. 1997. Interdependence between muscle differentiation and cell-cycle control. Biochim Biophys Acta 1332:M19-30.
72. Mizzen CA, Yang XJ, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman J, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD. 1996. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell 87:1261-1270.
73. Merika M, Williams AJ, Chen G, Collins T, Thanos D. 1998. Recruitment of p300/CBP by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol Cell 1:277-287.
74. Montes de Oca Luna R, Wagner DS, Lozano G. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378:203-206.
75. Moran E. 1993. Interaction of aolenovizol proteins with pRb and p53. IASEB J 7:880-885.
76. Muraoka, M, Konishi, M, Kikuchi, -Yanoshita, R, Tanaka, K, Shitara, N, Chong, JM, Iwama, T, Miyaki, M. 1996. p300 gene alterations in colorectal and gastric carcinomas. Oncogene 12:1565-1569.
77. Nakajima T, Uchida C, Anderson SF, Lee CG, Hurwitz J, Parvin JD, Montminy M. 1997. RNA helicase A mediates association of CBP with RNA polymerase II. Cell 90:1107-1112.
78. Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR. 1996. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 86:465-474.
79. Ogryzko W, Kotani T, Zhang X, Schlitz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y 1998.Histone-like TAFs within the PCAF histone acetylase complex. Cell 94:35-44.
80. Ogryzko, VV, Schiltz, RL, Russanova, V, Howard, B, Nakatani, Y. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959.
81. Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. 1998. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell 2:353-359.
82. Perkins ND, Felzien LK, Betts JC, Leung K, Beach DH, Nabel GJ. 1997. Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523-527.
83. Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ, et al. 1995. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 376:348-351.
84. Prives C. 1998. Signaling to p53: breaking the MDM2-p53 circuit. Cell 95:5-8.
85. Puri PL, Avantaggiati ML, Balsano C, Sang N, Graessmann A, Giordano A, Levrero M. 1997. p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription. EMBO J 16: 369-383.
86. Puri PL, Sartorelli V, Yang X-J, Hamamori Y, Ogryzko V, Howard BH, Kedes L, Wang JYJ, Graessmann A, Nakatani Y, Levrero M. 1998. Differential roles of p300 and P/CAF acetyltransferases in muscle differentiation. Mol Cell 1:35-46.
87. Radhakrishnan I, Perez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE.1997. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell 91:741-752.
88. Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, Jacks T. 1995. A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 10:175-180.
89. Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E. 1998. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12:2831-2841.
90. Sang N, Avantaggiati ML, Giordano A. 1997. Roles of p300, pocket proteins, and hTBP in E1a-mediated transcriptional regulation and inhibition of p53 transactivation activity. J Cell Biochem 66:277-285.
91. Sartorelli V, Huang J, Hamamori Y, Kedes L. 1997. Molecular mechanisms of myogenic coactivation by p300 direct interaction with the activation domain of MyoD and with the MADS box MEF2C. Mol. Cell. Biol. 7:1010-1026.
92. Scolnick DM, Chehab NH, Stavridi ES, Lien MC, Caruso L, Moran E, Berger SL, Halazonetis TD. 1997. CREB-binding protein and p300/ CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res 57:3693-3696.
93. Shen X, Hu PP, Liberati NT, Datto MB, Frederick JP, Wang XF. 1998. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol Biol Cell 9:3309-3319.
94. Shieh SY, Ikeda M, Taya Y, Prives C. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334.
95. Shikama, N, Lyon, L, La Tangue, NB. 1997. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell. Biol 7:230-236.
96. Skapek SX, Rhee J, Spicer DB, Lassar AB. 1995. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 267:1022-1024.
97. Sobulo OM, Borrow J, Tomek R, Reshmi S, Harden A, Schlegelberger B, Housman D, Doggett NA, Rowley JD, Zeleznik-Le NJ. 1997. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3). Proc Natl Acad Sci USA 94:8732-8737.
98. Somasundaram K, El-Deiry WS. 1997. Inhibition of p53-mediated transactivation and cell cycle arrest byE1A through its p300/CBP-interacting region. Oncogene 14:1047-1057.
99. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW. 1997. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389:194-198.
100. Struhl K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev 12:599-606.
101. Tanaka Y, Naruse I, Maekawa T, Masuya H, Shiroishi T, Ishii S. 1997. Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc Natl Acad Sci USA 94:10215-10220.
102. Taunton J, Hassig CA, Schreiber SL. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
103. Thomas A, White E. 1998. Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function. Genes Dev 12:1975-1985.
104. Tsukiyama T, Wu C. 1997. Chromatin remodeling and transcription. Curr Opin Genet Dev 7:182-191.
105. Wang, LA, Mizzen, C, Ying, C, Candau, R, Barlev, N, Brownell, JE, Allis, CD, and Berger, SL. 1997. Histone acetyltransferase activity is conserved between yeast and human Gcn5 and is required for complementation of growth and transcriptional activation. Mol. Cell Biol 17:519-527.
106. Whyte, P, Williamson, NM, Harlow, E. 1989. Cellular targets for transformation by the adenovirus E1a. Cell 53:67-75.
107. Wolffe, AP, Pruss, D. 1996. Targeting chromatin disruption: transcription regulators that acetylate histones. Cell 86:817-819.
108. Yaciuk P, Moran E. 1991. Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification. Mol Cell Biol 11:5389-5397.
109. Yang, XJ, Ogryzko, VV, Nishikawa J, Howard, BH, and Nakatani, Y. 1996. A p300/CBP assoaciated factor that competes with the adenoviral oncoprotein E1a. Nature 382:319-324.
110. Yang, C, Shapiro, LH, Rivera, M, Kumar, A, Brindle, PK. 1998. A role for CREBbinding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol 18:2218-2229.
111. Yao TP, Oh SP, Fuchs M, Zhou ND, Ch'ng LE, Newsome D, Bronson RT, Li E, Livingston DM, Eckner R. 1998. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93:361-372.
112. Yoshida, M, Horinouchi, S, Beppu, T. 1995. Thricostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. BioEssays 5:423-430.
113. Yuan W Condorelli G Caruso M Felsani A Giordano A. 1996. Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem 271:9009-9013.
114. Zhang W, Bone JR, Edmondson DG, Turner BM, Roth SY. 1998. Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the GcnSp acetyltransferase. EMBO J 17:3155-3167.
115. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D. 1997. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89:357-364.
116. Zhang JJ, Vinkemeier U, Gu W, Chakravarti D, Horvath CM, Darnell JE Jr. 1996. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc Natl Acad Sci USA 93:15092-15096.