CREB phosphorylation promotes nerve cell survival

Journal of Neurochemistry

Volumn 73, Issue 5, 1999, Pages 1836-1842

  Walton, Marshall ^a   Woodgate, Ann Marie ^a   Muravlev, Alexander ^a   Xu, Ruian ^a   During, Matthew J ^a   Dragunow, Michael ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Apoptosis; Cyclic AMP responsive element binding protein; Neuroprotection; Okadaic acid; Survival

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; OKADAIC ACID; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENETIC TRANSFECTION; NERVE CELL; NEUROPROTECTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

EID: 0032692571     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.01836.x     Document Type: Article

References (43)

1. Arias J., Alberts A. S., Brindle P., Claret F. X., Smeal T., Karin M., Feramisco J., and Montminy M. (1994) Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370, 226-229.
2. Barton K., Muthusamy N., Chanyangam M., Fischer C., Clendenin C., and Leiden J. M. (1996) Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379, 81-85.
3. Beiter-Johnson D. and Millhorn D. E. (1998) Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism. J. Biol. Chem. 273, 19834-19839.
4. Bito H., Deisseroth K., and Tsien R. W. (1996) CREB phosphorylation and dephosphorylation: a calcium and stimulus duration dependent switch for hippocampal gene expression. Cell 87, 1203-1214.
5. Bonni A., Ginty D. D., Dudek H., and Greenberg M. E. (1995) Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. Mol. Cell. Neurosci. 6, 168-183.
6. Brindle P., Linke S., and Montminy M. (1993) Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. Nature 364, 821-824.
7. Bruening W., Giasson B., Mushynski W., and Durham H. D. (1998) Activation of stress-activated MAP protein kinase upregulates expression of transgenes driven by the cytomegalovirus immediate/early promoter. Nucleic Acids Res. 26, 486-489.
8. Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., Montminy M., and Goodman R. H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859.
9. Du K. and Montminy M. (1998) CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem. 273, 32377-32379.
10. Dudek H., Datta S. R., Franke T. F., Birnbaum M. J., Yao R., Cooper G. M., Segal R. A., Kaplan D. R., and Greenberg M. E. (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-664.
11. 2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. J. Biol. Chem. 269, 15520-15527.
12. Finkbeiner S., Tavazoie S. F., Maloratsky A., Jacobs K. M., Harris K. M., and Greenberg M. E. (1997) CREB: a major mediator of neuronal neurotrophin responses. Neuron 19, 1031-1047.
13. 129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J. Biol. Chem. 269, 32187-32193.
14. Friedman A. D., Landschulz W. H., and McKnight S. L. (1989) CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3, 1314-1322.
15. Ginty D. D., Kornhauser J. M., Thompson M. A., Bading H., Mayo K. E., Takahashi J. S., and Greenberg M. E. (1993) Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and circadian clock. Science 260, 238-260.
16. Ginty D. D., Bonni A., and Greenberg M. E. (1994) Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 77, 713-725.
17. Gonzalez G. A., Menzel P., Leonard J., Fischer W. H., and Montminy M. R. (1991) Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol. Cell. Biol. 11, 1306-1312.
18. Hanson M. G., Shen S., Wiemelt A. P., McMorris F. A., and Barres B. A. (1998) Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J. Neurosci. 18, 7361-7371.
19. Hu B. R., Fux C. M., Martone M. E., Zivin J. A., and Ellisman M. H. (1999) Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain. Neuroscience 89, 437-452.
20. Imaki J., Yoshida K., and Yamashita K. (1994) A developmental study of cyclic AMP-response element binding protein (CREB) by in situ hybridization, histochemistry and immunocytochemistry in the rat neocortex. Brain Res. 651, 269-274.
21. Jean D., Harbison M., McConkey D. J., Ronai Z., and Bar-Eli M. (1998) CREB and its associated proteins act as survival factors for human melanoma cells. J. Biol. Chem. 273, 24884-24890.
22. Kwok R. P. S., Lundblad J. P., Chrivia J. C., Richards J. P., Bachinger P., Brennan R. G., Roberts S., Green M. R., and Goodman R. H. (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370, 223-226.
23. Lamph W. W., Dwarki V. J., Ofir R., Montminy M., and Verma I. M. (1990) Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. Proc. Natl. Acad. Sci. USA 87, 4320-4324.
24. Liu F.-C., and Graybiel A. M. (1996) Spatiotemporal dynamics of CREB phosphorylation: transient versus sustained phosphorylation in the developing striatum. Neuron 17, 1133-1144.
25. MacGibbon G. A., Cooper G. J. S., and Dragunow M. (1997) Acute application of human amylin, unlike beta-amyloid peptides, kills undifferentiated PC12 cells by apoptosis. Neuroreport 8, 3945-3950.
26. Masquilier D. and Sassone-Corsi P. (1992) Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun. J. Biol. Chem. 267, 22460-22466.
27. Matthews R. P., Guthrie C. R., Wailes L. M., Zhao X., Means A. R., and McKnight G. S. (1994) Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expressions. Mol. Cell. Biol. 14, 6107-6116.
28. Moore A. N., Waxham M. N., and Dash P. K. (1996) Neuronal activity increases the phosphorylation of the transcription factor cAMP response element-binding protein (CREB) in rat hippocampus and cortex. J. Biol. Chem. 271, 14214-14220.
29. Sheng M., Thompson M. A., and Greenberg M. E. (1991) CREB: a calcium-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252, 1427-1430.
30. +-induced apoptosis of cerebellar granule neurons. Dev. Brain Res. 101, 197-206.
31. Silva A. J., Kogan J. H., Frankland P. W., and Kida S. (1998) CREB and memory. Annu. Rev. Neurosci. 21, 127-148.
32. Struthers R. S., Vale W. W., Arias C., Sawchenko P. E., and Montminy M. R. (1991) Somatotroph hypoplasia in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350, 622-624.
33. Tanaka K., Nagata E., Suzuki S., Dembo T., Nogawa S., and Fukuuchi Y. (1999) Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia in rats. Brain Res. 818, 520-526.
34. Tao X., Finkbeiner S., Arnold D. B., Shaywitz A. J., and Greenberg M. E. (1997) Calcium influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20, 709-726.
35. Walton M., Sirimanne E., Williams C., Gluckman P., and Dragunow M. (1996) The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair. Mol. Brain Res. 43, 21-29.
36. Walton M., MacGibbon G., Young D., Sirimanne E., Williams C., Gluckman P., and Dragunow M. (1998a) Do c-Jun, c-Fos, and amyloid precursor protein play a role in neuronal death or survival? J. Neurosci. Res. 53, 330-342.
37. Walton M., Woodgate A.-M., Sirimanne E., Gluckman P., and Dragunow M. (1998b) ATF-2 phosphorylation in apoptotic neuronal death. Mol. Brain Res. 63, 198-204.
38. Walton M., Connor B., Lawlor P., Young D., Sirimanne E., Gluckman P., Cole G., and Dragunow M. (1999) Neuronal death and survival in two models of hypoxic-ischemic brain damage. Brain Res. Rev. 29, 137-168.
39. Wilson B. E., Mochon E., and Boxer L. M. (1996) Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol. Cell Biol. 16, 5546-5556.
40. Woodgate A., Walton M., MacGibbon G., and Dragunow M. (1999) Inducible transcription factor expression in a cell culture model of apoptosis. Mol. Brain Res. 66, 211-216.
41. Xing J., Ginty D. D., and Greenberg M. E. (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273, 959-963.
42. Yamamoto K. K., Gonzalez G. A., Biggs W. H., and Montminy M. R. (1988) Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature 334, 494-498.
43. Yang Y. M., Dolan L. R., and Ronai Z. (1996) Expression of dominant negative CREB reduces resistance to radiation of human melanoma cells. Oncogene 12, 2223-2233.