Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB

Journal of Neuroscience

Volumn 19, Issue 13, 1999, Pages 5360-5369

  Weihl, Conrad C ^a   Ghadge, Ghanashyam D ^a   Kennedy, Scott G ^b   Hay, Nissim ^b   Miller, Richard J ^a   Roos, Raymond P ^a,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

Adenoviral vectors; Akt PKB; Alzheimer's disease; Apoptosis; Hippocampal neurons; Presenilin

Indexed keywords

BETA CATENIN; CASEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; MUTANT PROTEIN; PRESENILIN 1; PRESENILIN 2; PROTEIN AKT PKB; PROTEIN SERINE THREONINE KINASE; S6 KINASE; UNCLASSIFIED DRUG;

ADENOVIRUS; ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; FAMILIAL DISEASE; FETUS; HIPPOCAMPUS; NERVE CELL NECROSIS; NONHUMAN; PATHOGENESIS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0033168352     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-13-05360.1999     Document Type: Article

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