Lithium inhibits glycogen synthase kinase-3 by competition for magnesium

Biochemical and Biophysical Research Communications

Volumn 280, Issue 3, 2001, Pages 720-725

  Ryves, W J ^a   Harwood, A J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASEIN KINASE; CASEIN KINASE III; ISOENZYME; LITHIUM; MAGNESIUM; METAL ION; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL LEVEL; CHELATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DEPRESSION; DICTYOSTELIUM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034805180     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4169     Document Type: Article

References (36)

1. Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
2. Separation and characterisation of glycogen synthase kinase 3, glycogen synthase kinase 4 and glycogen synthase kinase 5 from rabbit skeletal muscle
3. Glycogen synthase kinases
4. ATP-Mg-dependent protein phosphatase from rabbit muscle. Purification of the activating factor and its regulation as a bi-functional protein also displaying synthase kinase activity
5. Purification of glycogen synthase kinase 3 from rabbit skeletal muscle
6. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
7. Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain
8. Molecular cloning and expression of glycogen synthase kinase-3/factor A
9. 2+ subfamily
10. Wingless signaling acts through Zeste-White 3, the Drosophila homolog of glycogen-synthase kinase-3, to regulate engrailed and establish cell fate
11. Glycogen synthase kinase-3: Functions in oncogenesis and development
12. Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant
13. Glycogen synthase kinase 3 regulates cell fate in Dictyostelium
14. 'Insulin-like' effects of lithium ion on isolated rat adipocytes. II. Specific activation of glycogen synthase
15. A molecular mechanism for the effect of lithium on development
16. Neurobiology of lithium: An update
17. Key treatment studies of lithium in manic-depressive illness: Efficacy and side effects
18. Tau domains, phosphorylation, and interactions with microtubules
19. Inhibition of GSK-3b leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium
20. An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts
21. Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein
22. Inactivation of glycogen synthase kinase-3b by phosphorylation: New kinase connections in insulin and growth-factor signalling
23. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
24. Activation of the Wnt signaling pathway: A molecular mechanism for lithium action
25. Rubidium chloride in the treatment of major depression
26. Exploration of the clinical profile of rubidium chloride in depression: A systematic open trial
27. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
28. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
29. Nucleotide metabolism during differentiation in Dictyostelium discoideum
30. The AMP-activated protein kinase-fuel gauge of the mammalian cell?
31. 2+ concentrations
32. Adenine nucleotide metabolism and compartmentalization in isolated adult rat heart cells
33. Evaluation of three simple methods for predicting therapeutic lithium doses