A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

Nature

Volumn 388, Issue 6642, 1997, Pages 548-554

  Didonato, Joseph A ^a   Hayakawa, Makio ^a   Rothwarf, David M ^a   Zandi, Ebrahim ^a   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PROTEIN KINASE; TRANSCRIPTION FACTOR; AUTACOID; CHUK PROTEIN, HUMAN; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL MATURATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE MAPPING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; ENZYME SPECIFICITY; GENETICS; HELA CELL; HUMAN; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; ENZYME ACTIVATION; HELA CELLS; HUMANS; I-KAPPA B KINASE; INFLAMMATION MEDIATORS; KINETICS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SUBSTRATE SPECIFICITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030610362     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/41493     Document Type: Article

References (31)

1. Beg, A. A. & Baldwin, A. S. Jr The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7, 2064-2070 (1993).
2. Gilmore, T. D. & Morin, P. J. The IκB proteins: members of a multifunctional family. Trends Genet. 9, 427-433 (1993).
3. Brockman, J. A. et al. Coupling of a signal response domain in IκB to multiple pathways for NF-κB activation. Mol. Cell. Biol. 15, 2809-2818 (1995).
4. Brown, K., Gerstberger, F. S., Carlson, L., Franzoso, G. & Siebenlist, U. Control of IκBαt proteolysis by site-specific, signal-induced phosphorylation. Science 267, 1485-1491 (1995).
5. Traenckner, E. B. et al. Phosphorylation of human IκB on serines 32 and 36 controls IκB proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14, 2876-2883 (1995).
6. Whiteside, T. et al. N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NF-κB activity. Mol. Cell. Biol. 15, 5339-5345 (1995).
7. DiDonato, J. A. et al. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16, 1295-1304 (1996).
8. Chen, Z. et al. Signal-induced site-specific phosphorylation targets IκB to the ubiquitin-proteasome pathway. Genes Dev. 9, 1586-1597 (1995).
9. Scherer, D. C., Brockman, J., Chen, Z., Maniatis, T. & Ballard, D. Signal-induced degradation of IκBα requires site-specific ubiquitination. Proc. Natl Acad. Sci. USA 92, 11259-11263 (1995).
10. Hershko, A. & Cienchanover, A. The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61, 761-807 (1992).
11. Alkalay, I. et al. In vivo stimulation of IκB phosphorylation is not sufficient to activate NF-κB. Mol. Cell. Biol. 15, 1294-1301 (1995).
12. DiDonato, J. A., Mercurio, F. & Karin, M. Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NF-κB. Mol. Cell. Biol. 15, 1302-1311 (1995).
13. Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D. & Miyamoto, S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9, 2723-2735 (1995).
14. Sun, S. C., Maggirwar, S. B. & Harhaj, E. Activation of NF-&B by phsophatase inhibitors involves the phosphorylation of IκBα at phosphatase 2A-sensitive sites. J. Biol. Chem. 270, 18347-18351 (1995).
15. Chen, Z. J., Parent, L. & Maniatis, T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84, 853-862 (1996).
16. Haystead, C. M., Gregory, P., Sturgill, T. W. & Haystead, T. A. γ-Phosphate-linked ATP-Sepharose for the affinity purification of protein kinases. Rapid purification to homogeneity of skeletal muscle mitogen-activated protein kinase kinase. Eur. J. Biochem. 214, 459-467 (1993).
17. Connely, M. A. & Marcu, K. B. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell. Mol. Biol. Res. 41, 537-549 (1995).
18. Baeuerle, P. A. & Henkel, T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179 (1994).
19. Barnes, P. J. & Karin, M. Nuclear factor-κB - A pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 336, 1066-1071 (1997).
20. Baeuerle, P. A. & Baltimore, D. NF-κB: ten years after. Cell 87, 13-20 (1996).
21. Rothe, M., Wong, S. C., Henzel, W. J. & Goeddel, D. V. A novel family of putative signal transducers associated with the cytoplamic domain of the 75 kDa tumor necrosis factor receptor. Cell 78, 681-692 (1994).
22. Hsu, H., Xiong, J. & Goeddel, D. V. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81, 495-504 (1995).
23. Hsu, H., Shu, B. H., Pan, M. G. & Goeddel, D. V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308 (1996).
24. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. & Goeddel, D. V. TRAF6 in a signal transducer for interleukin-1. Science 383, 443-446 (1996).
25. Cao, Z., Henzel, W. J. & Gao, X. IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128-1131 (1996).
26. Liu, Z.-G., Hu, H., Goeddel, D. V. & Karin, M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis, while NF-κB activation prevents cell death. Cell 87, 565-576 (1996).
27. Lee, F. S., Hagler, J., Chen, Z. J. & Maniatis, T. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88, 213-222 (1997).
28. Kallunki, T., Deng, T., Hibi, M. & Karin, M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87, 929-939 (1996).
29. Thompson, J. E., Philips, R. J., Erdjument-Bromage, H., Tempst, P. & Ghosh, S. IκBβ regulates the persistent response in a biphasic activation of NF-κB. Cell 80, 573-582 (1995).
30. Kallunki, T. et al. JNK2 ocntains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8, 2996-3007 (1994).
31. Helmberg, A., Auphan, N., Gaelles, C. & Karin, M. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor EMBO J. 14, 452-460 (1995).