IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation

Science

Volumn 278, Issue 5339, 1997, Pages 860-866

  Mercurio, Frank ^a   Zhu, Hengyi ^a   Murray, Brion W ^a   Shevchenko, Andrej ^b   Bennett, Brydon L ^a   Li, Jian Wu ^a   Young, David B ^a   Barbosa, Miguel ^a   Mann, Matthias ^b   Manning, Anthony ^a   Rao, Anjana ^c  

^a CELGENE CORPORATION   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUCINE ZIPPER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

CELL CYCLE PROTEINS; CLONING, MOLECULAR; ENZYME ACTIVATION; HELA CELLS; HELIX-LOOP-HELIX MOTIFS; HUMANS; I-KAPPA B KINASE; IMMEDIATE-EARLY PROTEINS; LEUCINE ZIPPERS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0030685825     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5339.860     Document Type: Article

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53. We thank I. Verma and R. Mueller for the gift of the IκB-α COOH-terminus construct and helpful discussions; J. DiDonato for the IκB-α vectors; H. Raymon and N. Richard for assistance with immunocytochemistry; S. Kim, A. LaPointe, and B. Lee for technical assistance; K. Davis and E. Carlson for help with compiling the manuscript and figures; and D. Anderson and A. Lewis for helpful comments and support. A.R. contributed to this work during a sabbatical at Signal Pharmaceuticals.