Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

Journal of Neurochemistry

Volumn 77, Issue 1, 2001, Pages 94-102

  Cross, Darren A E ^a   Culbert, Ainsley A ^a   Chalmers, Katy A ^a   Facci, Laura ^a   Skaper, Stephen D ^a   Reith, Alastair D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Beta catenin; Glycogen synthase kinase 3; Kinase inhibitors; Neuronal survival; Protein kinase B; Tau

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; ENZYME ACTIVITY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0035087123     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.t01-1-00251.x     Document Type: Article

References (46)

1. Mechanism of activation and function of protein kinase B
2. Effects of lithium treatment and its discontinuation in bipolar manic depressive disorders
3. Neural and developmental actions of lithium: A unifying hypothesis
4. Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3b in cellular and animal models of neuronal degeneration
5. Regulation of cell death protease caspase-9 by phosphorylation
6. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
7. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
8. The development and therapeutic potential of protein kinase inhibitors
9. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
10. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
11. Glycogen synthase kinase-3β activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal
12. Akt phosphorylation of BAD couples survival signals to the cell- Intrinsic death machinery
13. Specificity and mechanism of action of some commonly used protein kinase inhibitors
14. Differential regulation of glycogen synthase kinase 3b by insulin and wnt signalling
15. Regulation of neuronal survival by the serine-threonine protein kinase Akt
16. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
17. Potassium deprivation-induced apoptosis of cerebellar granule neurons: Cytochrome c release in the absence of altered expression of Bcl-2 family proteins
18. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
19. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal
20. Axin a negative regulator of the wnt signalling pathway, forms a complex with GSK-3-beta and beta-catenin and promotes GSK-3-beta-dependent phosphorylation of beta-catenin
21. Roles of axin in the Wnt signalling pathway
22. A molecular mechanism for the effect of lithium on development
23. Forkhead transcription factors: New insights into protein kinase B (c-akt) signalling
24. Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons
25. The nerve growth factor 35 years later
26. An automated colorimetric assay for neurotrophic factors
27. Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor 1-mediated survival of cerebellar granule cells
28. Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats
29. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
30. Phosphorylation of the Drosophila adherens junction protein armadillo - Roles for wingless signal and zeste-white 3 kinase
31. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
32. Programmed cell death and the control of cell survival - Lessons from the nervous system
33. Potassium deprivation-induced apoptosis of cerebellar granule neurons: A sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species
34. Intracellular signalling pathways activated by neurotrophic factors
35. Culture and use of primary and clonal neural cells
36. Glycogen synthase kinase-3-beta phosphorylates tau protein at multiple sites in intact cells
37. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
38. Observations on rat cerebellar cells in vitro: Influence of substratum, potassium concentration and relationship between neurones and astrocytes
39. A GSK-3-binding peptide from FRAT1 selectively inhibits the GSK-3-catalyzed phosphorylation of Axin and β-catenin
40. Tau is phosphorylated by GSK-3 at several sites found in Alzheimer-disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase
41. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation - Characterisation of dominant-negative mutant of PKB
42. Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts
43. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
44. Lithium activates the c-Jun NH2-terminal kinases in vitro and in the CNS in vivo
45. Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation
46. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis