Lithium reduces tau phosphorylation: Effects in living cells and in neurons at therapeutic concentrations

Biological Psychiatry

Volumn 45, Issue 8, 1999, Pages 995-1003

  Lovestone, Simon ^a   Davis, Danny R ^a   Webster, Marie Therese ^a   Kaech, Stefanie ^b   Brion, Jean Pierre ^c   Matus, Andrew ^b   Anderton, Brian H ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Glycogen synthase kinase 3; Lithium; Microtubules; Neuron; Phosphorylation; Tau

Indexed keywords

LITHIUM; PROTEIN KINASE; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; IMMUNOHISTOCHEMISTRY; MICROTUBULE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIMANIC AGENTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL CULTURE TECHNIQUES; CELL MOVEMENT; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN SYNTHASE KINASES; HIPPOCAMPUS; LITHIUM; MICROTUBULES; NEURONS; PHOSPHORYLATION; RATS; TAU PROTEINS;

EID: 0033561207     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00183-8     Document Type: Article

References (37)

1. Atack J.R., Broughton H.B., Pollack S.J. Inositol monophosphatase - A putative target for Li+ in the treatment of bipolar disorder. Trends Neurosci. 18:1995;343-349.
2. Azhderian E.M., Hefner D., Lin C.H., Kaczmarek L.K., Forscher P. Cyclic AMP modulates fast axonal transport in Aplysia bag cell neurons by increasing the probability of single organelle movement. Neuron. 12:1994;1223-1233.
3. Batty I.H., Downes C.P. The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+. J Neurochem. 65:1995;2279-2289.
4. Caceres A., Potrebic S., Kosik K.S. The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons. J Neurosci. 11:1991;1515-1523.
5. Couchie D., Charriere-Bertrand C., Nunez J. Expression of the mRNA for tau proteins during brain development and in cultured neurons and astroglial cells. J Neurochem. 50:1988;1894-1899.
6. Davis D.R., Brion J.-P., Couck A.-M., Gallo J.-M., Hanger D.P., Ladhani K., et al. The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and β-amyloid in primary rat cortical neuronal cultures. Biochem J. 309:1995;941-949.
7. Drubin D.G., Feinstein S.C., Shooter E.M., Kirschner M.W. Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J Cell Biol. 101:1985;1799-1807.
8. Esmaeli-Azad B., McCarty J.H., Feinstein S.C. Sense and antisense transfection analysis of tau function Tau influences net microtubule assembly, neurite outgrowth and neuritic stability . J Cell Sci. 107:1994;869-879.
9. Gallo J.M., Hanger D.P., Twist E.C., Kosik K.S., Anderton B.H. Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells. Biochem J. 286:1992;399-404.
10. Garver T.D., Harris K.A., Lehman R.A., Lee V.M., Trojanowski J.Q., Billingsley M.L. Tau phosphorylation in human, primate, and rat brain Evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro . J Neurochem. 63:1994;2279-2287.
11. Gur E., Lerer B., Newman M.E. Acute or chronic lithium does not affect agonist-stimulated inositol trisphosphate formation in rat brain in vivo. Neuroreport. 7:1996;393-396.
12. Hanger D.P., Hughes K., Woodgett J.R., Brion J.-P., Anderton B.H. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci Lett. 147:1992;58-62.
13. Harvey B., Carstens M., Taljaard J. Lithium modulation of cortical cyclic nucleotides Evidence for the yin-yang hypothesis . Eur J Pharmacol. 175:1990;129-136.
14. Hong M., Lee V.M.Y. Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem. 272:1997;19547-19553.
15. Hong M., Chen D.C., Klein P.S., Lee V.M. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem. 272:1997;25326-25332.
16. Itoh K., Tang T.L., Neel B.G., Sokol S.Y. Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase. Development. 121:1995;3979-3988.
17. Jope R.S., Song L., Kolasa K. Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures. Biol Psychiatry. 31:1992;505-514.
18. Jope R.S., Song L., Li P.P., Young L.T., Kish S.J., Pacheco M.A., et al. The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. J Neurochem. 66:1996;2402-2409.
19. Kaech S., Ludin B., Matus A. Cytoskeletal plasticity in cells expressing neuronal microtubule-associated proteins. Neuron. 17:1996;1189-1199.
20. Kanai Y., Takemura R., Oshima T., Mori H., Ihara Y., Yanagisawa M., et al. Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. J Cell Biol. 109:1989;1173-1184.
21. Klein P.S., Melton D.A. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA. 93:1996;8455-8459.
22. Li X., Jope R.S. Selective inhibition of the expression of signal transduction proteins by lithium in nerve growth factor-differentiated PC12 cells. J Neurochem. 65:1995;2500-2508.
23. Li P.P., Young L.T., Tam Y.K., Sibony D., Warsh J.J. Effects of chronic lithium and carbamazepine treatment on G-protein subunit expression in rat cerebral cortex. Biol Psychiatry. 34:1993;162-170.
24. Lindwall G., Cole R.D. Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem. 259:1984;5301-5305.
25. Los G.V., Artemenko I.P., Hokin L.E. Time-dependent effects of lithium on the agonist-stimulated accumulation of second messenger inositol 1,4,5-trisphosphate in SH-SY5Y human neuroblastoma cells. Biochem J. 311:1995;225-232.
26. Lovestone S., Reynolds C.H. The phosphorylation of tau A critical stage in neurodevelopmental and neurodegenerative processes . Neuroscience. 78:1997;309-324.
27. Lovestone S., Reynolds C.H., Latimer D., Davis D.R., Anderton B.H., Gallo J.-M., et al. Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol. 4:1994;1077-1086.
28. Lovestone S., Hartley C.L., Pearce J., Anderton B.H. Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on organisation and stability of microtubules. Neuroscience. 73:1996;1145-1157.
29. Mangin G., Couchie D., Charriere-Bertrand C., Nunez J. Timing and expression of tau and its encoding mRNAs in developing cerbral neocortex and cerebellum of the mouse. J Neurochem. 53:1989;45-50.
30. Manji H.K., Etcheberrigaray R., Chen G., Olds J.L. Lithium decreases membrane-associated protein kinase C in hippocampus Selectivity for the alpha isozyme . J Neurochem. 61:1993;2303-2310.
31. Matsuo E.S., Shin R.-W., Billingsley M.L., Van DeVoorde A O., 'Connor M., Trojanowski J.Q., et al. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron. 13:1994;989-1002.
32. Mawal Dewan M., Henley J., Van de Voorde A., Trojanowski J.Q., Lee V.M. The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases. J Biol Chem. 269:1994;30981-30987.
33. Munoz-Montano J.R., Moreno F.J., Avila J., Diaz Nido J. Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. FEBS Lett. 411:1997;183-188.
34. Ruel L., Bourouis M., Heitzler P., Pantesco V., Simpson P. Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch. Nature. 362:1993;557-560.
35. Sato Harada R., Okabe S., Umeyama T., Kanai Y., Hirokawa N. Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transports. Cell Struct Funct. 21:1996;283-295.
36. Schubert T., Stoll L., Muller W.E. Therapeutic concentrations of lithium and carbamazepine inhibit cGMP accumulation in human lymphocytes. A clinical model for a possible common mechanism of action? Psychopharmacology (Berl). 104:1991;45-50.
37. Stambolic V., Ruel L., Woodgett J.R. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol. 6:1996;1664-1668.