Phosphorylation of CREB at ser-133 induces complex formation with CREB-binding protein via a direct mechanism

Molecular and Cellular Biology

Volumn 16, Issue 2, 1996, Pages 694-703

  Parker, D ^a   Ferreri, K ^a   Nakajima, T ^a   LaMorte, V J ^a   Evans, R ^a   Koerber, S C ^a   Hoeger, C ^a   Montminy, M R ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEOXYCHOLIC ACID; GLUTATHIONE TRANSFERASE; GLYCINE; PHOSPHOSERINE; SERINE; SODIUM CHLORIDE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; COMPLEX FORMATION; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CIRCULAR DICHROISM; CREB-BINDING PROTEIN; CROSS-LINKING REAGENTS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SERINE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0030058682     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.2.694     Document Type: Article

References (17)

1. Arias, J., A. Alberts, P. Brindle, F. Claret, T. Smeal, M. Karin, J. Feramisco, and M. Montminy. 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature (London) 370:226-228.
2. Brindle, P., S. Linke, and M. Montminy. 1993. Analysis of a PK-A dependent activator in CREB reveals a new role for the CREM family of repressors. Nature (London) 364:821-824.
3. Chang, C. T., S. Wu, and J. Yang. 1978. Circular dichroic analysis of protein conformation: inclusion of the β-turns. Anal. Biochem. 92:13-31.
4. Chrivia, J. C., R. P. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature (London) 365:855-859.
5. II complexes. Nucleic Acids Res. 20:2497-2502.
6. Eckner, R., M. E. Ewen, D. Newsome, M. Gerdes, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston. 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8:869-884
7. Gonzalez, G. A., and M. R. Montminy. 1989. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675-680.
8. Hagiwara, M., P. Brindle, A. Harootunian, R. Armstrong, J. Rivier, W. Vale, R. Tsien, and M. R. Montminy. 1993. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol. Cell. Biol. 13:4852-4859.
9. Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375-387.
10. Hurley, J., A. Dean, J. Sohl, D. Koshland, and R. Stroud. 1990. Regulation of an enzyme by phosphorylation at the active site. Science 249:1012-1016.
11. Kwok, R. P., J. R. Lundblad, J. C. Chrivia, J. P. Richards, H. Bachinger, R. Brennan, S. Roberts, M. Green, and R. H. Goodman. 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature (London) 370:223-226.
12. Leung, D. W., E. Chen, and D. Goeddel. 1989. A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction. Technique 1:11-15.
13. Mathews, L., and W. Vale. 1991. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65:973-982.
14. Meinkoth, J., A. Alberts, and J. Feramisco. 1990. Generation of mammalian cell lines with indicator genes driven by regulated promoters. Ciba Found. Symp. 150:47-56.
15. 14a. Montminy, M., I. Radhakrishnan, and P. Wright. Unpublished data.
16. Pawson, T., and G. Gish. 1992. SH2 and SH3 domains: from structure to function. Cell 71:359-362.
17. Sprang, S. R., K. R. Acharya, E. J. Goldsmith, D. I. Stuart, K. Varvill, R. J. Flettrick, N. B. Madsen, and L. N. Johnson. 1988. Structural changes in glycogen phosphorylase induced by phosphorylation. Nature (London) 336: 215-221.