The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

Journal of Neurochemistry

Volumn 72, Issue 2, 1999, Pages 879-882

  Chen, Guang ^a   Zeng, Wei Zhang ^a   Yuan, Pei Xiong ^a   Huang, Li Dong ^a   Jiang, Yi Ming ^a   Zhao, Zhen Hua ^a   Manji, Husseini K ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bcl 2; Differential display; Lithium; Manic depressive illness; Polyomavirus enhancer binding protein 2; Transcription factors; Valproate

Indexed keywords

DNA; DNA BINDING PROTEIN; LITHIUM CARBONATE; POLYOMAVIRUS ENHANCER BINDING PROTEIN; PROTEIN BCL 2; SODIUM CHLORIDE; STABILIZING AGENT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VALPROIC ACID;

AFFECTIVE NEUROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA BINDING; DRUG EFFECT; FRONTAL CORTEX; GENE EXPRESSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOOD; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

AFFECT; ANIMALS; ANTIMANIC AGENTS; BRAIN CHEMISTRY; FRONTAL LOBE; GENE EXPRESSION; LITHIUM; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED WKY; RNA, MESSENGER; TRANSCRIPTION FACTORS; VALPROIC ACID;

EID: 0032956630     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.720879.x     Document Type: Article

References (24)

1. Bruno V., Sortino M. A., Scapagnini U., Nicoletti F., and Canonico P. (1995) Antidegenerative effects of Mg(2+)-valproate in cultured cerebellar neurons. Funct. Neurol. 10, 121-130.
2. Chen D. F., Schneider G. E., Martinou J. C., and Tonegawa S. (1997) Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 385, 434-439.
3. Chen G., Yuan P.-X., Jiang Y.-M., Huang L-D., and Manji H. K. (1998) Lithium increases tyrosine hydroxylase levels both in vivo and in vitro. J. Neurochem. 70, 1768-1771.
4. Drevets W. C., Price J. L., Simpson J. R. Jr., Todd R. D., Reich T., Vannier M., and Raichle M. E. (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature 38, 824-827.
5. Duman R. S., Heninger G. R., and Nestler E. J. (1997) A molecular and cellular theory of depression. Arch. Gen. Psychiatry 54, 597-606.
6. Goodwin F. K. and Jamison K. R. (1990) Manic-Depressive Illness. Oxford University Press, New York.
7. Hsu S. M., Raine L., and Fanger H. (1981) Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29, 577-580.
8. Hyman S. E. and Nestler E. J. (1996) Initiation and adaptation: a paradigm for understanding psychotropic drug action. Am. J. Psychiatry 153, 151-162.
9. Jacobson M. D. and Raff M. (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374, 814-816.
10. Jope R. S. and Williams M. B. (1994) Lithium and brain signal transduction systems. Biochem. Pharmacol. 77, 429-441.
11. Kanno T., Kanno Y., Chen L. F., Ogawa E., Kim W. Y., and Ito Y. (1998) Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhanced binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit. Mol. Cell. Biol. 18, 2444-2454.
12. Ketter T. A., George M. S., Kimbrell T. A., Willis M., Wills M. W., Benson B. E., and Post R. M. (1997) Bipolar Disorder: Biological Models and Their Clinical Application, pp. 179-217. Marcel Dekker, New York.
13. Klampfer L., Zhang J., Zelenetz A. O., Uchida H., and Nimer S. D. (1996) The AML1/ETO fusion protein activates transcription of Bcl-2. Proc. Natl. Acad. Sci. USA 26, 14059-14064.
14. Lawrence M. S., Ho D. Y., Sun G. H., Steinberg G. K., and Sapolsky R. M. (1996) Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J. Neurosci. 16, 486-496.
15. Liang P., Bauer D., Averboukh L., Warthoe P., Rohrwild M., Muller H., Strauss M., and pardee A. B. (1995) Analysis of altered gene expression by differential display. Methods Enzymol. 254, 304-321.
16. Liu P., Tarle S. A., Hajra A., Claxton D. F., Marlton P., Freedman M., Siciliano M. J., and Collins F. S. (1993) Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261, 1041-1044.
17. Manji H. K., Potter W. Z., and Lenox R. H. (1995) Signal transduction pathways. Molecular targets for lithium's actions. Arch. Gen. Psychiatry 52, 531-543.
18. Merry D. E. and Korsmeyer S. J. (1997) Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20, 245-267.
19. Nonaka S., Hough C. J., and Chuang D. M. (1998) Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proc. Natl. Acad. Sci. USA 95, 2642-2647.
20. Ogawa E., Inuzuka M., Maruyama M., Satake M., Naito-Fujimoto M., Ito Y., and Shigesada K. (1993) Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology 194, 314-331.
21. Rajkowska G. (1997) Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patients. Ann. NY Acad. Sci. 836, 253-268.
22. Smith M. A., Makino S., Altemus M., Michelson D., Hong S. K., Kvetnansky R., and Post R. M. (1995) Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus. Proc. Natl. Acad. Sci. USA 92, 8788-8792.
23. Wang Q., Stacy T., Miller J. D., Lewis A. F., Gu T. L., Huang X., Bushweller J. H., Bories J. C. Alt F. W., Ryan G., Liu P. P., Wynshaw-Boris A., Binder M., Marin-Padilla M., Sharpe A. H., and Speck N. A. (1996) The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 87, 697-708.
24. Wang S., Wang Q., Crute B. E., Melnikova I. N., Keller S. R., and Speck N. A. (1993) Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol. Cell. Biol. 13, 3324-3339.