Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

Neuroscience Letters

Volumn 203, Issue 1, 1996, Pages 33-36

  Takashima, Akihiko ^a   Noguchi, Kaori ^a   Michel, Gilles ^a   Mercken, Marc ^a   Hoshi, Minako ^a   Ishiguro, Koichi ^a   Imahori, Kazutomo ^a  

^a Mistubishi Chem Inst of Life Sci   (Japan)

Author keywords

Alzheimer's disease; Amyloid (25 35); Paired helical filaments; Phosphatidyl inositol 3 kinase; Tau protein kinase I glycogen synthase kinase 3

Indexed keywords

AMYLOID BETA PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; TAU PROTEIN; WORTMANNIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; HIPPOCAMPUS; NONHUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANDROSTADIENES; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLYCOGEN SYNTHASE; HIPPOCAMPUS; PHOSPHOTRANSFERASES; RATS; TAU PROTEINS;

EID: 0030044463     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(95)12257-5     Document Type: Article

References (19)

1. Arcaro, A. and Wymann, M., Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses, Biochem. J., 296 (1993) 297-301.
2. Busciglio, J., Lorenzo, A., Yeh, J. and Yankner, B.A., β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron, 14 (1995) 879-888.
3. Elder-Finkelman, H., Seger, R., Vandenheede, J.R. and Krebs, E.G., Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/ p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells, J. Biol. Chem., 270 (1995) 987-990.
4. Hardy, J.A. and Higgins, G.A., Alzheimer's disease: the amyloid cascade hypothesis, Science, 256 (1992) 184-185.
5. Kimura, K., Hattori, S., Kabuyama, Y., Shizawa, Y., Takayanagi, J., Nakamura, S., Toki, S., Matsuda, Y., Onodera, K. and Fukui, Y., Neunte outgrowth of PC12 cells is suppressed by Wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase, J. Biol. Chem., 269 (1994) 18961-18967.
6. Latimer, D.A., Gallo, J.-M., Lovestone, S., Miller, C.C.J., Reynolds, C.H., Marquardt, B., Stabel, S., Woodgett, J.R. and Anderton, B.H., Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau, FEBS Lett., 365 (1995) 42-46.
7. Lint, J.V., Khandelwal, R.L., Merlevede, W. and Vandenheede, J.R., A specific immunoprecipitation assay for the protein kinase FA/glycogen synthase kinase 3, Anal. Biochem., 208 (1993) 132-137.
8. Mattson, M.P. and Rydel, R.E., β-amyloid precursor protein and Alzheimer's disease: the peptide plot thickens, Neurobiol. Aging, 13 (1992) 617-622.
9. Mattson, M.P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I. and Rydel, R.E., β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity, J. Neurosci., 12 (1992) 376-379.
10. Pike, C.J., Cummings, B.J. and Cotman, C.W., β-Amyloid induces neuritic dystrophy in vitro: similarlities with Alzheimer's pathology, NeuroReport, 3 (1992) 1676-1687.
11. Pike, C.J., Walencewicz, A.J., Kosmoski, J., Cribbs, D.H., Glabe, C.G. and Cotman, C. W., Structure-activity analyses of β-amyloid peptides: contributions of the β25-35 region to aggregation and neurotoxicity, J. Neurochem., 64 (1995) 253-265.
12. Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G. and Cotman, C.W., Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci., 13 (1993) 1676-1687.
13. Saito, Y., Vandenheede, J.R. and Cohen, P., The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells., Biochem. J., 303 (1994) 27-31.
14. Takashima, A., Ishiguro, K., Noguchi, K., Michel, G., Hoshi, M., Sato, K., Takahashi, M., Hoshino, T., Uchida, T. and Imahori, K., Amyloid β peptide (25-35) induces tau phosphorylation and decrease the ability of microtubule formation in rat hippocampal culture, Neurosci. Meeting Abstr., 671 (1995) 17.
15. Takashima, A., Noguchi, K., Hoshino, T. and Imahori, K., Tau protein kinase 1 is essential for amyloid β-protein-induced neurotoxicity, Proc. Natl. Acad. Sci. USA, 90 (1993) 7789-7793.
16. Welsh, G.I. and Proud, C.G., Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B, Biochem. J., 294 (1993) 625-629.
17. Welsh, G.I., Foultone, E.J., Young, S.W., Tavare, J.M. and Proud, C.G., Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase, Biochem. J., 303 (1994) 15-20.
18. Yankner, B.A., Duffy, L.K. and Kirshner, D.A., Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides, Science, 250 (1990) 279-282.
19. Yao, R. and Cooper, G.M., Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor, Science, 267 (1995) 2003-2005.