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Volumn 10, Issue 9, 2018, Pages

The common cytokine receptor γ chain family of cytokines

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 2 RECEPTOR GAMMA;

EID: 85053661017     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a028449     Document Type: Review
Times cited : (138)

References (345)
  • 1
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    • Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weiss-man IL. 1997. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89: 1033–1041.
    • (1997) Cell , vol.89 , pp. 1033-1041
    • Akashi, K.1    Kondo, M.2    von Freeden-Jeffry, U.3    Murray, R.4    Weiss-Man, I.L.5
  • 4
    • 10544246077 scopus 로고    scopus 로고
    • CDNA cloning and characterization of the human interleukin 13 receptor α chain
    • Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ. 1996. cDNA cloning and characterization of the human interleukin 13 receptor α chain. J Biol Chem 271: 29265–29270.
    • (1996) J Biol Chem , vol.271 , pp. 29265-29270
    • Aman, M.J.1    Tayebi, N.2    Obiri, N.I.3    Puri, R.K.4    Modi, W.S.5    Leonard, W.J.6
  • 6
    • 0026743905 scopus 로고
    • Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling
    • Arima N, Kamio M, Imada K, Hori T, Hattori T, Tsudo M, Okuma M, Uchiyama T. 1992. Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling. J Exp Med 176: 1265–1272.
    • (1992) J Exp Med , vol.176 , pp. 1265-1272
    • Arima, N.1    Kamio, M.2    Imada, K.3    Hori, T.4    Hattori, T.5    Tsudo, M.6    Okuma, M.7    Uchiyama, T.8
  • 7
    • 0028798403 scopus 로고
    • IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation
    • Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH. 1995. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154: 483–490.
    • (1995) J Immunol , vol.154 , pp. 483-490
    • Armitage, R.J.1    Macduff, B.M.2    Eisenman, J.3    Paxton, R.4    Grabstein, K.H.5
  • 9
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: The common γ-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K. 2001. Cutting edge: The common γ-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 167: 1–5.
    • (2001) J Immunol , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3    Ishii, N.4    Tsuchiya, S.5    Foster, D.6    Sugamura, K.7
  • 11
    • 49649120932 scopus 로고    scopus 로고
    • IL-21-induced isotype switching to IgG and IgA by human naïve B cells is differentially regulated by IL-4
    • Avery DT, Bryant VL, Ma CS, de Waal Malefyt R, Tangye SG. 2008. IL-21-induced isotype switching to IgG and IgA by human naïve B cells is differentially regulated by IL-4. J Immunol 181: 1767–1779.
    • (2008) J Immunol , vol.181 , pp. 1767-1779
    • Avery, D.T.1    Bryant, V.L.2    Ma, C.S.3    de Waal Malefyt, R.4    Tangye, S.G.5
  • 12
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato A, Leon B, Graf BA, Moquin A, Adams PS, Lund FE, Randall TD. 2012. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36: 847–856.
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1    Leon, B.2    Graf, B.A.3    Moquin, A.4    Adams, P.S.5    Lund, F.E.6    Randall, T.D.7
  • 13
    • 0028363377 scopus 로고
    • The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-acti-vated killer cells
    • Bamford RN, Grant AJ, Burton JD, Peters C, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA. 1994. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-acti-vated killer cells. Proc Natl Acad Sci 91: 4940–4944.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 4940-4944
    • Bamford, R.N.1    Grant, A.J.2    Burton, J.D.3    Peters, C.4    Kurys, G.5    Goldman, C.K.6    Brennan, J.7    Roessler, E.8    Waldmann, T.A.9
  • 15
  • 18
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • Bazan JF. 1990. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci 87: 6934–6938.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 6934-6938
    • Bazan, J.F.1
  • 27
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with anti-body-cytokine immune complexes
    • Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J. 2006. Selective stimulation of T cell subsets with anti-body-cytokine immune complexes. Science 311: 1924–1927.
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3    Surh, C.D.4    Sprent, J.5
  • 28
    • 0345257344 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell activation and maturation
    • Brandt K, Bulfone-Paus S, Foster DC, Ruckert R. 2003. Interleukin-21 inhibits dendritic cell activation and maturation. Blood 102: 4090–4098.
    • (2003) Blood , vol.102 , pp. 4090-4098
    • Brandt, K.1    Bulfone-Paus, S.2    Foster, D.C.3    Ruckert, R.4
  • 31
    • 79952698207 scopus 로고    scopus 로고
    • Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: Longterm outcomes
    • Buckley RH. 2011. Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: Longterm outcomes. Immunol Res 49: 25–43.
    • (2011) Immunol Res , vol.49 , pp. 25-43
    • Buckley, R.H.1
  • 33
    • 0028276796 scopus 로고
    • A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lympho-kine-activated killer cells
    • Burton JD, Bamford RN, Peters C, Grant AJ, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA. 1994. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lympho-kine-activated killer cells. Proc Natl Acad Sci 91: 4935– 4939.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 4935-4939
    • Burton, J.D.1    Bamford, R.N.2    Peters, C.3    Grant, A.J.4    Kurys, G.5    Goldman, C.K.6    Brennan, J.7    Roessler, E.8    Waldmann, T.A.9
  • 35
    • 84874957237 scopus 로고    scopus 로고
    • Interleukin-6 receptor blockade selectively re- duces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis
    • Carbone G, Wilson A, Diehl SA, Bunn J, Cooper SM, Rincon M. 2013. Interleukin-6 receptor blockade selectively re- duces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis. Int J Biol Sci 9: 279– 288.
    • (2013) Int J Biol Sci , vol.9 , pp. 279-288
    • Carbone, G.1    Wilson, A.2    Diehl, S.A.3    Bunn, J.4    Cooper, S.M.5    Rincon, M.6
  • 37
    • 84957309656 scopus 로고    scopus 로고
    • Natural killer cell memory in infection, inflammation and cancer
    • Cerwenka A, Lanier LL. 2016. Natural killer cell memory in infection, inflammation and cancer. Nat Rev Immunol 16: 112–123.
    • (2016) Nat Rev Immunol , vol.16 , pp. 112-123
    • Cerwenka, A.1    Lanier, L.L.2
  • 38
    • 85023618354 scopus 로고    scopus 로고
    • IL-4Rα inhibitor for atopic disease
    • Chang HY, Nadeau KC. 2017. IL-4Rα inhibitor for atopic disease. Cell 170: 222.
    • (2017) Cell , vol.170 , pp. 222
    • Chang, H.Y.1    Nadeau, K.C.2
  • 44
    • 79956116032 scopus 로고    scopus 로고
    • RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuro-inflammation
    • Codarri L, Gyulveszi G, Tosevski V, Hesske L, Fontana A, Magnenat L, Suter T, Becher B. 2011. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuro-inflammation. Nat Immunol 12: 560–567.
    • (2011) Nat Immunol , vol.12 , pp. 560-567
    • Codarri, L.1    Gyulveszi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6    Suter, T.7    Becher, B.8
  • 49
    • 84908148200 scopus 로고    scopus 로고
    • T follicular helper cell differentiation, function, and roles in disease
    • Crotty S. 2014. T follicular helper cell differentiation, function, and roles in disease. Immunity 41: 529–542.
    • (2014) Immunity , vol.41 , pp. 529-542
    • Crotty, S.1
  • 52
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE Jr, Kerr IM, Stark GR. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415–1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 54
    • 0029785080 scopus 로고    scopus 로고
    • A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9
    • Demoulin JB, Uyttenhove C, Van Roost E, DeLestre B, Donckers D, Van Snick J, Renauld JC. 1996. A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol 16: 4710–4716.
    • (1996) Mol Cell Biol , vol.16 , pp. 4710-4716
    • Demoulin, J.B.1    Uyttenhove, C.2    van Roost, E.3    Delestre, B.4    Donckers, D.5    van Snick, J.6    Renauld, J.C.7
  • 55
    • 0033520477 scopus 로고    scopus 로고
    • Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9
    • Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC. 1999. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 274: 25855–25861.
    • (1999) J Biol Chem , vol.274 , pp. 25855-25861
    • Demoulin, J.B.1    van Roost, E.2    Stevens, M.3    Groner, B.4    Renauld, J.C.5
  • 57
    • 0025083360 scopus 로고
    • Functional and biochemical characterization of mouse P40/ IL-9 receptors
    • Druez C, Coulie P, Uyttenhove C, Van Snick J. 1990. Functional and biochemical characterization of mouse P40/ IL-9 receptors. J Immunol 145: 2494–2499.
    • (1990) J Immunol , vol.145 , pp. 2494-2499
    • Druez, C.1    Coulie, P.2    Uyttenhove, C.3    van Snick, J.4
  • 58
    • 0036826914 scopus 로고    scopus 로고
    • IL-15Rα recycles and presents IL-15 in trans to neighboring cells
    • Dubois S, Mariner J, Waldmann TA, Tagaya Y. 2002. IL-15Rα recycles and presents IL-15 in trans to neighboring cells. Immunity 17: 537–547.
    • (2002) Immunity , vol.17 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 60
    • 0023225411 scopus 로고
    • A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors
    • Dukovich M, Wano Y, Le thi Bich T, Katz P, Cullen BR, Kehrl JH, Greene WC. 1987. A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature 327: 518–522.
    • (1987) Nature , vol.327 , pp. 518-522
    • Dukovich, M.1    Wano, Y.2    Le Thi Bich, T.3    Katz, P.4    Cullen, B.R.5    Kehrl, J.H.6    Greene, W.C.7
  • 61
    • 84994802422 scopus 로고    scopus 로고
    • Functions of murine dendritic cells
    • Durai V, Murphy KM. 2016. Functions of murine dendritic cells. Immunity 45: 719–736.
    • (2016) Immunity , vol.45 , pp. 719-736
    • Durai, V.1    Murphy, K.M.2
  • 64
    • 85020377962 scopus 로고    scopus 로고
    • Inflammation and metabolism in tissue repair and regeneration
    • Eming SA, Wynn TA, Martin P. 2017. Inflammation and metabolism in tissue repair and regeneration. Science 356: 1026–1030.
    • (2017) Science , vol.356 , pp. 1026-1030
    • Eming, S.A.1    Wynn, T.A.2    Martin, P.3
  • 67
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142–1151.
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 68
    • 0027717408 scopus 로고
    • Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice
    • Gessner A, Blum H, Rollinghoff M. 1993. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology 189: 419–435.
    • (1993) Immunobiology , vol.189 , pp. 419-435
    • Gessner, A.1    Blum, H.2    Rollinghoff, M.3
  • 69
  • 73
    • 79953107993 scopus 로고    scopus 로고
    • A brief history of IL-9
    • Goswami R, Kaplan MH. 2011. A brief history of IL-9. J Immunol 186: 3283–3288.
    • (2011) J Immunol , vol.186 , pp. 3283-3288
    • Goswami, R.1    Kaplan, M.H.2
  • 76
    • 84922588496 scopus 로고    scopus 로고
    • Regulatory T-cells in autoimmune diseases: Challenges, controversies and—yet—unanswered questions
    • Grant CR, Liberal R, Mieli-Vergani G, Vergani D, Longhi MS. 2015. Regulatory T-cells in autoimmune diseases: Challenges, controversies and—yet—unanswered questions. Autoimmun Rev 14: 105–116.
    • (2015) Autoimmun Rev , vol.14 , pp. 105-116
    • Grant, C.R.1    Liberal, R.2    Mieli-Vergani, G.3    Vergani, D.4    Longhi, M.S.5
  • 80
    • 0024403321 scopus 로고
    • Interleukin-2 receptor β chain gene: Generation of three receptor forms by cloned human α and β chain cDNA’s
    • Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T. 1989. Interleukin-2 receptor β chain gene: Generation of three receptor forms by cloned human α and β chain cDNA’s. Science 244: 551–556.
    • (1989) Science , vol.244 , pp. 551-556
    • Hatakeyama, M.1    Tsudo, M.2    Minamoto, S.3    Kono, T.4    Doi, T.5    Miyata, T.6    Miyasaka, M.7    Taniguchi, T.8
  • 81
    • 0030018826 scopus 로고    scopus 로고
    • + T cells, but not natural killer cells
    • + T cells, but not natural killer cells. J Exp Med 184: 289–293.
    • (1996) J Exp Med , vol.184 , pp. 289-293
    • He, Y.W.1    Malek, T.R.2
  • 83
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D, Brown TP, Liang S, Young DA, Collins M, Du-nussi-Joannopoulos K. 2007. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 178: 3822–3830.
    • (2007) J Immunol , vol.178 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Du-Nussi-Joannopoulos, K.6
  • 84
    • 84875432419 scopus 로고    scopus 로고
    • Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
    • Herold KC, Vignali DA, Cooke A, Bluestone JA. 2013. Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 13: 243–256.
    • (2013) Nat Rev Immunol , vol.13 , pp. 243-256
    • Herold, K.C.1    Vignali, D.A.2    Cooke, A.3    Bluestone, J.A.4
  • 89
    • 14044276352 scopus 로고    scopus 로고
    • The Wiskott–Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-κB (RelA) independently of its role in filamentous actin polymerization and actin cyto-skeletal rearrangement
    • Huang W, Ochs HD, Dupont B, Vyas YM. 2005. The Wiskott–Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-κB (RelA) independently of its role in filamentous actin polymerization and actin cyto-skeletal rearrangement. J Immunol 174: 2602–2611.
    • (2005) J Immunol , vol.174 , pp. 2602-2611
    • Huang, W.1    Ochs, H.D.2    Dupont, B.3    Vyas, Y.M.4
  • 90
    • 0025306952 scopus 로고
    • Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9)
    • Hultner L, Druez C, Moeller J, Uyttenhove C, Schmitt E, Rude E, Dormer P, Van Snick J. 1990. Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9). Eur J Immunol 20: 1413– 1416.
    • (1990) Eur J Immunol , vol.20 , pp. 1413-1416
    • Hultner, L.1    Druez, C.2    Moeller, J.3    Uyttenhove, C.4    Schmitt, E.5    Rude, E.6    Dormer, P.7    van Snick, J.8
  • 92
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium; Well-come Trust Case Control Consortium; Sawcer S, Hellen-thal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsi-anas L, Dilthey A, Su Z, et al. 2011. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: 214–219.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1    Hellen-Thal, G.2    Pirinen, M.3    Spencer, C.C.4    Patsopoulos, N.A.5    Moutsi-Anas, L.6    Dilthey, A.7    Su, Z.8
  • 94
    • 0020031839 scopus 로고
    • T cell-derived B cell differentiation factor(S). Effect on the isotype switch of murine B cells
    • Isakson PC, Pure E, Vitetta ES, Krammer PH. 1982. T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells. J Exp Med 155: 734–748.
    • (1982) J Exp Med , vol.155 , pp. 734-748
    • Isakson, P.C.1    Pure, E.2    Vitetta, E.S.3    Krammer, P.H.4
  • 96
    • 55249106981 scopus 로고    scopus 로고
    • FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
    • Jensen CT, Kharazi S, Boiers C, Cheng M, Lubking A, Sit-nicka E, Jacobsen SE. 2008. FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis. Blood 112: 2297–2304.
    • (2008) Blood , vol.112 , pp. 2297-2304
    • Jensen, C.T.1    Kharazi, S.2    Boiers, C.3    Cheng, M.4    Lubking, A.5    Sit-Nicka, E.6    Jacobsen, S.E.7
  • 98
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimu-lation, growth arrest, or Bim-dependent apoptosis
    • Jin H, Carrio R, Yu A, Malek TR. 2004. Distinct activation signals determine whether IL-21 induces B cell costimu-lation, growth arrest, or Bim-dependent apoptosis. J Immunol 173: 657–665.
    • (2004) J Immunol , vol.173 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 104
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. 2003. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 4: 1191–1198.
    • (2003) Nat Immunol , vol.4 , pp. 1191-1198
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5    Ahmed, R.6
  • 106
    • 84928584195 scopus 로고    scopus 로고
    • The development and in vivo function of T helper 9 cells
    • Kaplan MH, Hufford MM, Olson MR. 2015. The development and in vivo function of T helper 9 cells. Nat Rev Immunol 15: 295–307.
    • (2015) Nat Rev Immunol , vol.15 , pp. 295-307
    • Kaplan, M.H.1    Hufford, M.M.2    Olson, M.R.3
  • 109
    • 0029115353 scopus 로고
    • Critical role of the interleukin 2 (IL-2) receptor γ-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction
    • Kawahara A, Minami Y, Miyazaki T, Ihle JN, Taniguchi T. 1995. Critical role of the interleukin 2 (IL-2) receptor γ-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Proc Natl Acad Sci 92: 8724–8728.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 8724-8728
    • Kawahara, A.1    Minami, Y.2    Miyazaki, T.3    Ihle, J.N.4    Taniguchi, T.5
  • 111
    • 0029147621 scopus 로고
    • The IL-9 receptor gene (IL9R): Genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter
    • Kermouni A, Van Roost E, Arden KC, Vermeesch JR, Weiss S, Godelaine D, Flint J, Lurquin C, Szikora JP, Higgs DR, et al. 1995. The IL-9 receptor gene (IL9R): Genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter. Genomics 29: 371–382.
    • (1995) Genomics , vol.29 , pp. 371-382
    • Kermouni, A.1    van Roost, E.2    Arden, K.C.3    Vermeesch, J.R.4    Weiss, S.5    Godelaine, D.6    Flint, J.7    Lurquin, C.8    Szikora, J.P.9    Higgs, D.R.10
  • 114
    • 84986285566 scopus 로고    scopus 로고
    • NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics
    • Kiniwa T, Enomoto Y, Terazawa N, Omi A, Miyata N, Ishi-wata K, Miyajima A. 2016. NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics. Proc Natl Acad Sci 113: 10139–10144.
    • (2016) Proc Natl Acad Sci , vol.113 , pp. 10139-10144
    • Kiniwa, T.1    Enomoto, Y.2    Terazawa, N.3    Omi, A.4    Miyata, N.5    Ishi-Wata, K.6    Miyajima, A.7
  • 115
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T, Okada T. 2011. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34: 961–972.
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1    Moriyama, S.2    Ando, Y.3    Hikida, M.4    Mori, Y.5    Kurosaki, T.6    Okada, T.7
  • 116
    • 0027731604 scopus 로고
    • Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4
    • Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K. 1993. Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262: 1874–1877.
    • (1993) Science , vol.262 , pp. 1874-1877
    • Kondo, M.1    Takeshita, T.2    Ishii, N.3    Nakamura, M.4    Watanabe, S.5    Arai, K.6    Sugamura, K.7
  • 123
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn R, Rajewsky K, Muller W. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254: 707–710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1    Rajewsky, K.2    Muller, W.3
  • 124
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman D, Schofield B, Wills-Karp M, Grusby MJ. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 187: 939–948.
    • (1998) J Exp Med , vol.187 , pp. 939-948
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 128
    • 0034663813 scopus 로고    scopus 로고
    • Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18
    • Lauwerys BR, Garot N, Renauld JC, Houssiau FA. 2000. Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18. J Immunol 165: 1847–1853.
    • (2000) J Immunol , vol.165 , pp. 1847-1853
    • Lauwerys, B.R.1    Garot, N.2    Renauld, J.C.3    Houssiau, F.A.4
  • 130
    • 84864508237 scopus 로고    scopus 로고
    • Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
    • Lee LF, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, Rajpal A, Brown C, et al. 2012. Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci 109: 12674–12679.
    • (2012) Proc Natl Acad Sci , vol.109 , pp. 12674-12679
    • Lee, L.F.1    Logronio, K.2    Tu, G.H.3    Zhai, W.4    Ni, I.5    Mei, L.6    Dilley, J.7    Yu, J.8    Rajpal, A.9    Brown, C.10
  • 132
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
    • Lenardo MJ. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353: 858–861.
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 133
    • 0029924265 scopus 로고    scopus 로고
    • The molecular basis of X-linked severe combined immunodeficiency: Defective cytokine receptor signaling
    • Leonard WJ. 1996. The molecular basis of X-linked severe combined immunodeficiency: Defective cytokine receptor signaling. Annu Rev Med 47: 229–239.
    • (1996) Annu Rev Med , vol.47 , pp. 229-239
    • Leonard, W.J.1
  • 134
    • 0035752146 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases
    • Leonard WJ. 2001. Cytokines and immunodeficiency diseases. Nat Rev Immunol 1: 200–208.
    • (2001) Nat Rev Immunol , vol.1 , pp. 200-208
    • Leonard, W.J.1
  • 135
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard WJ, O’Shea JJ. 1998. Jaks and STATs: Biological implications. Annu Rev Immunol 16: 293–322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O’Shea, J.J.2
  • 139
    • 84978634373 scopus 로고    scopus 로고
    • T cell receptor signalling in the control of regulatory T cell differentiation and function
    • Li MO, Rudensky AY. 2016. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol 16: 220–233.
    • (2016) Nat Rev Immunol , vol.16 , pp. 220-233
    • Li, M.O.1    Rudensky, A.Y.2
  • 141
    • 84971254846 scopus 로고    scopus 로고
    • EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
    • Li J, Lu E, Yi T, Cyster JG. 2016. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature 533: 110–114.
    • (2016) Nature , vol.533 , pp. 110-114
    • Li, J.1    Lu, E.2    Yi, T.3    Cyster, J.G.4
  • 142
    • 54549103162 scopus 로고    scopus 로고
    • Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor α-chain expression
    • Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ. 2008. Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor α-chain expression. Nat Immunol 9: 1288– 1296.
    • (2008) Nat Immunol , vol.9 , pp. 1288-1296
    • Liao, W.1    Schones, D.E.2    Oh, J.3    Cui, Y.4    Cui, K.5    Roh, T.Y.6    Zhao, K.7    Leonard, W.J.8
  • 143
    • 79956085895 scopus 로고    scopus 로고
    • Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
    • Liao W, Lin JX, Wang L, Li P, Leonard WJ. 2011. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol 12: 551– 559.
    • (2011) Nat Immunol , vol.12 , pp. 551-559
    • Liao, W.1    Lin, J.X.2    Wang, L.3    Li, P.4    Leonard, W.J.5
  • 144
    • 84872790689 scopus 로고    scopus 로고
    • Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
    • Liao W, Lin JX, Leonard WJ. 2013. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 38: 13–25.
    • (2013) Immunity , vol.38 , pp. 13-25
    • Liao, W.1    Lin, J.X.2    Leonard, W.J.3
  • 145
    • 84895806505 scopus 로고    scopus 로고
    • Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression
    • Liao W, Spolski R, Li P, Du N, West EE, Ren M, Mitra S, Leonard WJ. 2014. Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression. Proc Natl Acad Sci 111: 3508– 3513.
    • (2014) Proc Natl Acad Sci , vol.111 , pp. 3508-3513
    • Liao, W.1    Spolski, R.2    Li, P.3    Du, N.4    West, E.E.5    Ren, M.6    Mitra, S.7    Leonard, W.J.8
  • 147
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin JX, Migone TS, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, et al. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2: 331–339.
    • (1995) Immunity , vol.2 , pp. 331-339
    • Lin, J.X.1    Migone, T.S.2    Tsang, M.3    Friedmann, M.4    Weatherbee, J.A.5    Zhou, L.6    Yamauchi, A.7    Bloom, E.T.8    Mietz, J.9    John, S.10
  • 148
    • 84859968982 scopus 로고    scopus 로고
    • Critical role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function
    • Lin JX, Li P, Liu D, Jin HT, He J, Ata Ur Rasheed M, Rochman Y, Wang L, Cui K, Liu C, et al. 2012. Critical role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity 36: 586–599.
    • (2012) Immunity , vol.36 , pp. 586-599
    • Lin, J.X.1    Li, P.2    Liu, D.3    Jin, H.T.4    He, J.5    Ata Ur Rasheed, M.6    Rochman, Y.7    Wang, L.8    Cui, K.9    Liu, C.10
  • 149
    • 0031859134 scopus 로고    scopus 로고
    • STAT6 is required for IL-4-induced germ-line Ig gene transcription and switch recombination
    • Linehan LA, Warren WD, Thompson PA, Grusby MJ, Ber-ton MT. 1998. STAT6 is required for IL-4-induced germ-line Ig gene transcription and switch recombination. J Immunol 161: 302–310.
    • (1998) J Immunol , vol.161 , pp. 302-310
    • Linehan, L.A.1    Warren, W.D.2    Thompson, P.A.3    Grusby, M.J.4    Ber-Ton, M.T.5
  • 151
    • 44449136105 scopus 로고    scopus 로고
    • + T cells prevents development of experimental autoimmune diseases
    • + T cells prevents development of experimental autoimmune diseases. J Immunol 180: 6070–6076.
    • (2008) J Immunol , vol.180 , pp. 6070-6076
    • Liu, X.1    Lee, Y.S.2    Yu, C.R.3    Egwuagu, C.E.4
  • 152
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S, Ma A. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9: 669–676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5    Trettin, S.6    Ma, A.7
  • 153
    • 33646580769 scopus 로고    scopus 로고
    • The structure of the interleukin-15α receptor and its implications for ligand binding
    • Lorenzen I, Dingley AJ, Jacques Y, Grotzinger J. 2006. The structure of the interleukin-15α receptor and its implications for ligand binding. J Biol Chem 281: 6642–6647.
    • (2006) J Biol Chem , vol.281 , pp. 6642-6647
    • Lorenzen, I.1    Dingley, A.J.2    Jacques, Y.3    Grotzinger, J.4
  • 157
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: At the interface between tolerance and immunity
    • Malek TR, Castro I. 2010. Interleukin-2 receptor signaling: At the interface between tolerance and immunity. Immunity 33: 153–165.
    • (2010) Immunity , vol.33 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 158
    • 0034654319 scopus 로고    scopus 로고
    • Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors
    • Malek TR, Porter BO, Codias EK, Scibelli P, Yu A. 2000. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J Immunol 164: 2905–2914.
    • (2000) J Immunol , vol.164 , pp. 2905-2914
    • Malek, T.R.1    Porter, B.O.2    Codias, E.K.3    Scibelli, P.4    Yu, A.5
  • 159
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2
    • Malek TR, Yu A, Vincek V, Scibelli P, Kong L. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17: 167–178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 161
    • 0031715301 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells
    • Maraskovsky E, Peschon JJ, McKenna H, Teepe M, Strasser A. 1998. Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells. Int Immunol 10: 1367–1375.
    • (1998) Int Immunol , vol.10 , pp. 1367-1375
    • Maraskovsky, E.1    Peschon, J.J.2    McKenna, H.3    Teepe, M.4    Strasser, A.5
  • 163
    • 32044471648 scopus 로고    scopus 로고
    • + T cell differentiation is induced following activation in the absence of γ-chain-dependent cytokine signals
    • + T cell differentiation is induced following activation in the absence of γ-chain-dependent cytokine signals. J Immunol 176: 2059–2063.
    • (2006) J Immunol , vol.176 , pp. 2059-2063
    • Mayack, S.R.1    Berg, L.J.2
  • 164
    • 33846632842 scopus 로고    scopus 로고
    • Interleukin-7 receptor expression: Intelligent design
    • Mazzucchelli R, Durum SK. 2007. Interleukin-7 receptor expression: Intelligent design. Nat Rev Immunol 7: 144– 154.
    • (2007) Nat Rev Immunol , vol.7 , pp. 144-154
    • Mazzucchelli, R.1    Durum, S.K.2
  • 173
    • 0018589972 scopus 로고
    • Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors
    • Mizel SB, Farrar JJ. 1979. Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors. Cell Immunol 48: 433–436.
    • (1979) Cell Immunol , vol.48 , pp. 433-436
    • Mizel, S.B.1    Farrar, J.J.2
  • 177
    • 0017199306 scopus 로고
    • Selective in vitro growth of T lymphocytes from normal human bone marrows
    • Morgan DA, Ruscetti FW, Gallo R. 1976. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193: 1007–1008.
    • (1976) Science , vol.193 , pp. 1007-1008
    • Morgan, D.A.1    Ruscetti, F.W.2    Gallo, R.3
  • 182
    • 0028286628 scopus 로고
    • Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation
    • Nelson BH, Lord JD, Greenberg PD. 1994. Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation. Nature 369: 333– 336.
    • (1994) Nature , vol.369 , pp. 333-336
    • Nelson, B.H.1    Lord, J.D.2    Greenberg, P.D.3
  • 191
  • 193
    • 0023124410 scopus 로고
    • Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage
    • Ohara J, Paul WE. 1987. Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 325: 537–540.
    • (1987) Nature , vol.325 , pp. 537-540
    • Ohara, J.1    Paul, W.E.2
  • 194
    • 84875498856 scopus 로고    scopus 로고
    • Development and maintenance of regulatory T cells
    • Ohkura N, Kitagawa Y, Sakaguchi S. 2013. Development and maintenance of regulatory T cells. Immunity 38: 414–423.
    • (2013) Immunity , vol.38 , pp. 414-423
    • Ohkura, N.1    Kitagawa, Y.2    Sakaguchi, S.3
  • 197
    • 0034633734 scopus 로고    scopus 로고
    • Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain
    • Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ. 2000. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci 97: 11439– 11444.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 11439-11444
    • Ozaki, K.1    Kikly, K.2    Michalovich, D.3    Young, P.R.4    Leonard, W.J.5
  • 201
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai SY, Truitt ML, Ho IC. 2004. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci 101: 1993–1998.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 206
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses
    • Parrish-Novak J, Foster DC, Holly RD, Clegg CH. 2002. Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses. J Leukoc Biol 72: 856–863.
    • (2002) J Leukoc Biol , vol.72 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 207
    • 84938974323 scopus 로고    scopus 로고
    • History of interleukin-4
    • Paul WE. 2015. History of interleukin-4. Cytokine 75: 3–7.
    • (2015) Cytokine , vol.75 , pp. 3-7
    • Paul, W.E.1
  • 211
    • 0027180597 scopus 로고
    • Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes
    • Petit-Frere C, Dugas B, Braquet P, Mencia-Huerta JM. 1993. Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes. Immunology 79: 146–151.
    • (1993) Immunology , vol.79 , pp. 146-151
    • Petit-Frere, C.1    Dugas, B.2    Braquet, P.3    Mencia-Huerta, J.M.4
  • 213
    • 74549216531 scopus 로고    scopus 로고
    • Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
    • Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A. 2010. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32: 79–90.
    • (2010) Immunity , vol.32 , pp. 79-90
    • Pipkin, M.E.1    Sacks, J.A.2    Cruz-Guilloty, F.3    Lichtenheld, M.G.4    Bevan, M.J.5    Rao, A.6
  • 214
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinate-ly act together to promote differentiation of IL-10-pro-ducing Tr1 cells
    • Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, et al. 2009. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinate-ly act together to promote differentiation of IL-10-pro-ducing Tr1 cells. J Immunol 183: 797–801.
    • (2009) J Immunol , vol.183 , pp. 797-801
    • Pot, C.1    Jin, H.2    Awasthi, A.3    Liu, S.M.4    Lai, C.Y.5    Madan, R.6    Sharpe, A.H.7    Karp, C.L.8    Miaw, S.C.9    Ho, I.C.10
  • 216
    • 84927607970 scopus 로고    scopus 로고
    • The varieties of immunological experience: Of pathogens, stress, and dendritic cells
    • Pulendran B. 2015. The varieties of immunological experience: Of pathogens, stress, and dendritic cells. Annu Rev Immunol 33: 563–606.
    • (2015) Annu Rev Immunol , vol.33 , pp. 563-606
    • Pulendran, B.1
  • 217
    • 84949024607 scopus 로고    scopus 로고
    • Common γ chain cytokines in combinatorial immune strategies against cancer
    • Pulliam SR, Uzhachenko RV, Adunyah SE, Shanker A. 2016. Common γ chain cytokines in combinatorial immune strategies against cancer. Immunol Lett 169: 61–72.
    • (2016) Immunol Lett , vol.169 , pp. 61-72
    • Pulliam, S.R.1    Uzhachenko, R.V.2    Adunyah, S.E.3    Shanker, A.4
  • 219
    • 84984848116 scopus 로고    scopus 로고
    • T follicular helper cells in space-time
    • Qi H. 2016. T follicular helper cells in space-time. Nat Rev Immunol 16: 612–625.
    • (2016) Nat Rev Immunol , vol.16 , pp. 612-625
    • Qi, H.1
  • 221
    • 0029057858 scopus 로고
    • Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
    • Quelle FW, Shimoda K, Thierfelder W, Fischer C, Kim A, Ruben SM, Cleveland JL, Pierce JH, Keegan AD, Nelms K, et al. 1995. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol 15: 3336–3343.
    • (1995) Mol Cell Biol , vol.15 , pp. 3336-3343
    • Quelle, F.W.1    Shimoda, K.2    Thierfelder, W.3    Fischer, C.4    Kim, A.5    Ruben, S.M.6    Cleveland, J.L.7    Pierce, J.H.8    Keegan, A.D.9    Nelms, K.10
  • 225
    • 77957879962 scopus 로고    scopus 로고
    • Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis
    • Rasmussen TK, Andersen T, Hvid M, Hetland ML, Horslev-Petersen K, Stengaard-Pedersen K, Holm CK, Deleuran B. 2010. Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol 37: 2014–2020.
    • (2010) J Rheumatol , vol.37 , pp. 2014-2020
    • Rasmussen, T.K.1    Andersen, T.2    Hvid, M.3    Hetland, M.L.4    Horslev-Petersen, K.5    Stengaard-Pedersen, K.6    Holm, C.K.7    Deleuran, B.8
  • 226
    • 0035892899 scopus 로고    scopus 로고
    • IL-7 enhances the survival and maintains the size of naïve T cells
    • Rathmell JC, Farkash EA, Gao W, Thompson CB. 2001. IL-7 enhances the survival and maintains the size of naïve T cells. J Immunol 167: 6869–6876.
    • (2001) J Immunol , vol.167 , pp. 6869-6876
    • Rathmell, J.C.1    Farkash, E.A.2    Gao, W.3    Thompson, C.B.4
  • 227
    • 84944681622 scopus 로고    scopus 로고
    • The interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells
    • Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, et al. 2015. The interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells. Immunity 43: 690–702.
    • (2015) Immunity , vol.43 , pp. 690-702
    • Ray, J.P.1    Staron, M.M.2    Shyer, J.A.3    Ho, P.C.4    Marshall, H.D.5    Gray, S.M.6    Laidlaw, B.J.7    Araki, K.8    Ahmed, R.9    Kaech, S.M.10
  • 231
    • 0030576990 scopus 로고    scopus 로고
    • IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells
    • Rolling C, Treton D, Pellegrini S, Galanaud P, Richard Y. 1996. IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells. FEBS Lett 393: 53–56.
    • (1996) FEBS Lett , vol.393 , pp. 53-56
    • Rolling, C.1    Treton, D.2    Pellegrini, S.3    Galanaud, P.4    Richard, Y.5
  • 232
    • 84902191817 scopus 로고    scopus 로고
    • IL-2: The first effective immunotherapy for human cancer
    • Rosenberg SA. 2014. IL-2: The first effective immunotherapy for human cancer. J Immunol 192: 5451–5458.
    • (2014) J Immunol , vol.192 , pp. 5451-5458
    • Rosenberg, S.A.1
  • 237
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253–261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 238
    • 84937635672 scopus 로고    scopus 로고
    • T follicular regulatory cells in the regulation of B cell responses
    • Sage PT, Sharpe AH. 2015. T follicular regulatory cells in the regulation of B cell responses. Trends Immunol 36: 410– 418.
    • (2015) Trends Immunol , vol.36 , pp. 410-418
    • Sage, P.T.1    Sharpe, A.H.2
  • 239
    • 84963593799 scopus 로고    scopus 로고
    • T follicular regulatory cells
    • Sage PT, Sharpe AH. 2016. T follicular regulatory cells. Immunol Rev 271: 246–259.
    • (2016) Immunol Rev , vol.271 , pp. 246-259
    • Sage, P.T.1    Sharpe, A.H.2
  • 241
    • 0035655578 scopus 로고    scopus 로고
    • IL-15-induced conversion of monocytes to mature dendritic cells
    • Saikh KU, Khan AS, Kissner T, Ulrich RG. 2001. IL-15-induced conversion of monocytes to mature dendritic cells. Clin Exp Immunol 126: 447–455.
    • (2001) Clin Exp Immunol , vol.126 , pp. 447-455
    • Saikh, K.U.1    Khan, A.S.2    Kissner, T.3    Ulrich, R.G.4
  • 242
    • 0025718931 scopus 로고
    • Biochemical evidence for a third chain of the interleukin-2 receptor
    • Saito Y, Tada H, Sabe H, Honjo T. 1991. Biochemical evidence for a third chain of the interleukin-2 receptor. J Biol Chem 266: 22186–22191.
    • (1991) J Biol Chem , vol.266 , pp. 22186-22191
    • Saito, Y.1    Tada, H.2    Sabe, H.3    Honjo, T.4
  • 243
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151–1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 247
    • 0034689009 scopus 로고    scopus 로고
    • The interleukin 7 receptor is required for T cell receptor γ locus accessibility to the V(D)J recombinase
    • Schlissel MS, Durum SD, Muegge K. 2000. The interleukin 7 receptor is required for T cell receptor γ locus accessibility to the V(D)J recombinase. J Exp Med 191: 1045–1050.
    • (2000) J Exp Med , vol.191 , pp. 1045-1050
    • Schlissel, M.S.1    Durum, S.D.2    Muegge, K.3
  • 248
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    • Schluns KS, Kieper WC, Jameson SC, Lefrancois L. 2000. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol 1: 426–432.
    • (2000) Nat Immunol , vol.1 , pp. 426-432
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrancois, L.4
  • 251
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621–624.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 252
    • 15444374646 scopus 로고    scopus 로고
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 201: 723–735.
    • (2005) J Exp Med , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 254
    • 0023010578 scopus 로고
    • Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions
    • Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ. 1986. Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 234: 859–863.
    • (1986) Science , vol.234 , pp. 859-863
    • Sharon, M.1    Klausner, R.D.2    Cullen, B.R.3    Chizzonite, R.4    Leonard, W.J.5
  • 255
    • 84927580933 scopus 로고    scopus 로고
    • STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflamma-tion
    • Sheng W, Yang F, Zhou Y, Yang H, Low PY, Kemeny DM, Tan P, Moh A, Kaplan MH, Zhang Y, et al. 2014. STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflamma-tion. Cell Res 24: 1387–1402.
    • (2014) Cell Res , vol.24 , pp. 1387-1402
    • Sheng, W.1    Yang, F.2    Zhou, Y.3    Yang, H.4    Low, P.Y.5    Kemeny, D.M.6    Tan, P.7    Moh, A.8    Kaplan, M.H.9    Zhang, Y.10
  • 256
    • 44649178270 scopus 로고    scopus 로고
    • Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation
    • Shi M, Lin TH, Appell KC, Berg LJ. 2008. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28: 763–773.
    • (2008) Immunity , vol.28 , pp. 763-773
    • Shi, M.1    Lin, T.H.2    Appell, K.C.3    Berg, L.J.4
  • 258
    • 85013129835 scopus 로고    scopus 로고
    • Daclizumab: A review in relapsing multiple sclerosis
    • Shirley M. 2017a. Daclizumab: A review in relapsing multiple sclerosis. Drugs 77: 447–458.
    • (2017) Drugs , vol.77 , pp. 447-458
    • Shirley, M.1
  • 259
    • 85019707765 scopus 로고    scopus 로고
    • Dupilumab: First global approval
    • Shirley M. 2017b. Dupilumab: First global approval. Drugs 77: 1115–1121.
    • (2017) Drugs , vol.77 , pp. 1115-1121
    • Shirley, M.1
  • 260
    • 0023230069 scopus 로고
    • The IL-2 receptor β chain (P70): Role in mediating signals for LAK, NK, and proliferative activities
    • Siegel JP, Sharon M, Smith PL, Leonard WJ. 1987. The IL-2 receptor β chain (p70): Role in mediating signals for LAK, NK, and proliferative activities. Science 238: 75–78.
    • (1987) Science , vol.238 , pp. 75-78
    • Siegel, J.P.1    Sharon, M.2    Smith, P.L.3    Leonard, W.J.4
  • 261
    • 84961722011 scopus 로고    scopus 로고
    • Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling
    • Smith GA, Uchida K, Weiss A, Taunton J. 2016. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol 12: 373–379.
    • (2016) Nat Chem Biol , vol.12 , pp. 373-379
    • Smith, G.A.1    Uchida, K.2    Weiss, A.3    Taunton, J.4
  • 263
    • 0033988447 scopus 로고    scopus 로고
    • DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites
    • Soldaini E, John S, Moro S, Bollenbacher J, Schindler U, Leonard WJ. 2000. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. Mol Cell Biol 20: 389–401.
    • (2000) Mol Cell Biol , vol.20 , pp. 389-401
    • Soldaini, E.1    John, S.2    Moro, S.3    Bollenbacher, J.4    Schindler, U.5    Leonard, W.J.6
  • 265
    • 84899979288 scopus 로고    scopus 로고
    • Interleukin-21: A double-edged sword with therapeutic potential
    • Spolski R, Leonard WJ. 2014. Interleukin-21: A double-edged sword with therapeutic potential. Nat Rev Drug Discov 13: 379–395.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 379-395
    • Spolski, R.1    Leonard, W.J.2
  • 266
    • 52949091915 scopus 로고    scopus 로고
    • IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
    • Spolski R, Kashyap M, Robinson C, Yu Z, Leonard WJ. 2008. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc Natl Acad Sci 105: 14028–14033.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 14028-14033
    • Spolski, R.1    Kashyap, M.2    Robinson, C.3    Yu, Z.4    Leonard, W.J.5
  • 267
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski R, Kim HP, Zhu W, Levy DE, Leonard WJ. 2009. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 182: 2859–2867.
    • (2009) J Immunol , vol.182 , pp. 2859-2867
    • Spolski, R.1    Kim, H.P.2    Zhu, W.3    Levy, D.E.4    Leonard, W.J.5
  • 268
    • 79956105098 scopus 로고    scopus 로고
    • Normal T cell homeostasis: The conversion of naïve cells into memory-phenotype cells
    • Sprent J, Surh CD. 2011. Normal T cell homeostasis: The conversion of naïve cells into memory-phenotype cells. Nat Immunol 12: 478–484.
    • (2011) Nat Immunol , vol.12 , pp. 478-484
    • Sprent, J.1    Surh, C.D.2
  • 272
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naïve and memory T cells
    • Surh CD, Sprent J. 2008. Homeostasis of naïve and memory T cells. Immunity 29: 848–862.
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 273
    • 0037114638 scopus 로고    scopus 로고
    • Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cɛ transcription of IL-4-stimulated B cells
    • Suto A, Nakajima H, Hirose K, Suzuki K, Kagami S, Seto Y, Hoshimoto A, Saito Y, Foster DC, Iwamoto I. 2002. Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cɛ transcription of IL-4-stimulated B cells. Blood 100: 4565–4573.
    • (2002) Blood , vol.100 , pp. 4565-4573
    • Suto, A.1    Nakajima, H.2    Hirose, K.3    Suzuki, K.4    Kagami, S.5    Seto, Y.6    Hoshimoto, A.7    Saito, Y.8    Foster, D.C.9    Iwamoto, I.10
  • 275
    • 0025298471 scopus 로고
    • An associated molecule, p64, with high-affinity interleukin 2 receptor
    • Takeshita T, Asao H, Suzuki J, Sugamura K. 1990. An associated molecule, p64, with high-affinity interleukin 2 receptor. Int Immunol 2: 477–480.
    • (1990) Int Immunol , vol.2 , pp. 477-480
    • Takeshita, T.1    Asao, H.2    Suzuki, J.3    Sugamura, K.4
  • 278
    • 84925120155 scopus 로고    scopus 로고
    • Advances in IL-21 biology—Enhancing our understanding of human disease
    • Tangye SG. 2015. Advances in IL-21 biology—Enhancing our understanding of human disease. Curr Opin Immunol 34: 107–115.
    • (2015) Curr Opin Immunol , vol.34 , pp. 107-115
    • Tangye, S.G.1
  • 280
    • 85006377210 scopus 로고    scopus 로고
    • Discovery of a JAK3-selective inhibitor: Functional differentiation of JAK3-se-lective inhibition over pan-JAK or JAK1-selective inhibition
    • Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, Moy E, Balbo P, Li W, Zhao Y, et al. 2016. Discovery of a JAK3-selective inhibitor: Functional differentiation of JAK3-se-lective inhibition over pan-JAK or JAK1-selective inhibition. ACS Chem Biol 11: 3442–3451.
    • (2016) ACS Chem Biol , vol.11 , pp. 3442-3451
    • Telliez, J.B.1    Dowty, M.E.2    Wang, L.3    Jussif, J.4    Lin, T.5    Li, L.6    Moy, E.7    Balbo, P.8    Li, W.9    Zhao, Y.10
  • 282
    • 0023140359 scopus 로고
    • Interleukin 2 high-affinity receptor expression requires two distinct binding proteins
    • Teshigawara K, Wang HM, Kato K, Smith KA. 1987. Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med 165: 223–238.
    • (1987) J Exp Med , vol.165 , pp. 223-238
    • Teshigawara, K.1    Wang, H.M.2    Kato, K.3    Smith, K.A.4
  • 284
    • 0033696860 scopus 로고    scopus 로고
    • IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    • Townsend JM, Fallon GP, Matthews JD, Smith P, Jolin EH, McKenzie NA. 2000. IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity 13: 573–583.
    • (2000) Immunity , vol.13 , pp. 573-583
    • Townsend, J.M.1    Fallon, G.P.2    Matthews, J.D.3    Smith, P.4    Jolin, E.H.5    McKenzie, N.A.6
  • 285
    • 85012974126 scopus 로고    scopus 로고
    • “Final common pathway” of human cancer immunotherapy: Targeting random somatic mutations
    • Tran E, Robbins PF, Rosenberg SA. 2017. “Final common pathway” of human cancer immunotherapy: Targeting random somatic mutations. Nat Immunol 18: 255–262.
    • (2017) Nat Immunol , vol.18 , pp. 255-262
    • Tran, E.1    Robbins, P.F.2    Rosenberg, S.A.3
  • 286
    • 0022908286 scopus 로고
    • Demonstration of a non-Tac peptide that binds interleukin 2: A potential participant in a multichain interleukin 2 receptor complex
    • Tsudo M, Kozak RW, Goldman CK, Waldmann TA. 1986. Demonstration of a non-Tac peptide that binds interleukin 2: A potential participant in a multichain interleukin 2 receptor complex. Proc Natl Acad Sci 83: 9694–9698.
    • (1986) Proc Natl Acad Sci , vol.83 , pp. 9694-9698
    • Tsudo, M.1    Kozak, R.W.2    Goldman, C.K.3    Waldmann, T.A.4
  • 289
    • 0023739985 scopus 로고
    • Functional and structural characterization of P40, a mouse glycopro-tein with T-cell growth factor activity
    • Uyttenhove C, Simpson RJ, Van Snick J. 1988. Functional and structural characterization of P40, a mouse glycopro-tein with T-cell growth factor activity. Proc Natl Acad Sci 85: 6934–6938.
    • (1988) Proc Natl Acad Sci , vol.85 , pp. 6934-6938
    • Uyttenhove, C.1    Simpson, R.J.2    van Snick, J.3
  • 291
    • 84875544506 scopus 로고    scopus 로고
    • Interleukin-4-and inter-leukin-13-mediated alternatively activated macrophages: Roles in homeostasis and disease
    • Van Dyken SJ, Locksley RM. 2013. Interleukin-4-and inter-leukin-13-mediated alternatively activated macrophages: Roles in homeostasis and disease. Annu Rev Immunol 31: 317–343.
    • (2013) Annu Rev Immunol , vol.31 , pp. 317-343
    • van Dyken, S.J.1    Locksley, R.M.2
  • 296
    • 0031032852 scopus 로고    scopus 로고
    • The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y
    • Vermeesch JR, Petit P, Kermouni A, Renauld JC, Van Den Berghe H, Marynen P. 1997. The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y. Hum Mol Genet 6: 1–8.
    • (1997) Hum Mol Genet , vol.6 , pp. 1-8
    • Vermeesch, J.R.1    Petit, P.2    Kermouni, A.3    Renauld, J.C.4    van Den Berghe, H.5    Marynen, P.6
  • 298
    • 0029903770 scopus 로고    scopus 로고
    • DNA binding of in vitro activated Stat1 α, Stat1 β and truncated Stat1: Interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites
    • Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, Darnell JE Jr. 1996. DNA binding of in vitro activated Stat1 α, Stat1 β and truncated Stat1: Interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J 15: 5616–5626.
    • (1996) EMBO J , vol.15 , pp. 5616-5626
    • Vinkemeier, U.1    Cohen, S.L.2    Moarefi, I.3    Chait, B.T.4    Kuriyan, J.5    Darnell, J.E.6
  • 299
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino-terminal protein interaction domain of STAT-4
    • Vinkemeier U, Moarefi I, Darnell JE Jr, Kuriyan J. 1998. Structure of the amino-terminal protein interaction domain of STAT-4. Science 279: 1048–1052.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell, J.E.3    Kuriyan, J.4
  • 301
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Bur-dach SE, Murray R. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181: 1519–1526.
    • (1995) J Exp Med , vol.181 , pp. 1519-1526
    • von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Bur-Dach, S.E.5    Murray, R.6
  • 302
    • 12444295407 scopus 로고    scopus 로고
    • Roles for common cytokine receptor γ-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo
    • Vosshenrich CA, Ranson T, Samson SI, Corcuff E, Colucci F, Rosmaraki EE, Di Santo JP. 2005. Roles for common cytokine receptor γ-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol 174: 1213–1221.
    • (2005) J Immunol , vol.174 , pp. 1213-1221
    • Vosshenrich, C.A.1    Ranson, T.2    Samson, S.I.3    Corcuff, E.4    Colucci, F.5    Rosmaraki, E.E.6    Di Santo, J.P.7
  • 304
    • 33746547247 scopus 로고    scopus 로고
    • The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design
    • Waldmann TA. 2006. The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design. Nat Rev Immunol 6: 595–601.
    • (2006) Nat Rev Immunol , vol.6 , pp. 595-601
    • Waldmann, T.A.1
  • 305
    • 84961554501 scopus 로고    scopus 로고
    • The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplas-tic lymphocytes: Implications for cancer therapy
    • Waldmann TA. 2015. The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplas-tic lymphocytes: Implications for cancer therapy. Cancer Immunol Res 3: 219–227.
    • (2015) Cancer Immunol Res , vol.3 , pp. 219-227
    • Waldmann, T.A.1
  • 313
    • 0025297840 scopus 로고
    • Severe combined immunodeficiency due to a specific defect in the production of interleukin-2
    • Weinberg K, Parkman R. 1990. Severe combined immunodeficiency due to a specific defect in the production of interleukin-2. N Engl J Med 322: 1718–1723.
    • (1990) N Engl J Med , vol.322 , pp. 1718-1723
    • Weinberg, K.1    Parkman, R.2
  • 316
    • 84964573673 scopus 로고    scopus 로고
    • Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: A randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial
    • Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, Pirozzi G, Sutherland ER, Evans RR, Joish VN, et al. 2016. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: A randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet 388: 31–44.
    • (2016) Lancet , vol.388 , pp. 31-44
    • Wenzel, S.1    Castro, M.2    Corren, J.3    Maspero, J.4    Wang, L.5    Zhang, B.6    Pirozzi, G.7    Sutherland, E.R.8    Evans, R.R.9    Joish, V.N.10
  • 319
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521–530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 320
    • 85014097983 scopus 로고    scopus 로고
    • The emerging safety profile of JAK inhibitors in rheumatic disease
    • Winthrop KL. 2017. The emerging safety profile of JAK inhibitors in rheumatic disease. Nat Rev Rheumatol 13: 234–243.
    • (2017) Nat Rev Rheumatol , vol.13 , pp. 234-243
    • Winthrop, K.L.1
  • 321
    • 0024581767 scopus 로고
    • Effects of IL-4 on macrophage functions: Increased uptake and killing of a protozoan parasite (Trypanosoma cruzi)
    • Wirth JJ, Kierszenbaum F, Zlotnik A. 1989. Effects of IL-4 on macrophage functions: Increased uptake and killing of a protozoan parasite (Trypanosoma cruzi). Immunology 66: 296–301.
    • (1989) Immunology , vol.66 , pp. 296-301
    • Wirth, J.J.1    Kierszenbaum, F.2    Zlotnik, A.3
  • 322
    • 27644461409 scopus 로고    scopus 로고
    • Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity
    • Wu Z, Kim HP, Xue HH, Liu H, Zhao K, Leonard WJ. 2005. Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol 25: 9741–9752.
    • (2005) Mol Cell Biol , vol.25 , pp. 9741-9752
    • Wu, Z.1    Kim, H.P.2    Xue, H.H.3    Liu, H.4    Zhao, K.5    Leonard, W.J.6
  • 324
    • 84960437624 scopus 로고    scopus 로고
    • Macrophages in tissue repair, regeneration, and fibrosis
    • Wynn TA, Vannella KM. 2016. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44: 450–462.
    • (2016) Immunity , vol.44 , pp. 450-462
    • Wynn, T.A.1    Vannella, K.M.2
  • 325
    • 77949301468 scopus 로고    scopus 로고
    • Daclizumab in active relapsing multiple sclerosis (CHOICE study): A phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon β
    • Wynn D, Kaufman M, Montalban X, Vollmer T, Simon J, Elkins J, O’Neill G, Neyer L, Sheridan J, Wang C, et al. 2010. Daclizumab in active relapsing multiple sclerosis (CHOICE study): A phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon β. Lancet Neurol 9: 381–390.
    • (2010) Lancet Neurol , vol.9 , pp. 381-390
    • Wynn, D.1    Kaufman, M.2    Montalban, X.3    Vollmer, T.4    Simon, J.5    Elkins, J.6    O’Neill, G.7    Neyer, L.8    Sheridan, J.9    Wang, C.10
  • 326
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn TA, Chawla A, Pollard JW. 2013. Macrophage biology in development, homeostasis and disease. Nature 496: 445–455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 327
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
    • Xu X, Sun YL, Hoey T. 1996. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273: 794–797.
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.L.2    Hoey, T.3
  • 328
    • 84929103800 scopus 로고    scopus 로고
    • Intratumoral delivery of IL-21 overcomes anti-Her2/Neu resistance through shifting tumor-associ-ated macrophages from M2 to M1 phenotype
    • Xu M, Liu M, Du X, Li S, Li H, Li X, Li Y, Wang Y, Qin Z, Fu YX, et al. 2015. Intratumoral delivery of IL-21 overcomes anti-Her2/Neu resistance through shifting tumor-associ-ated macrophages from M2 to M1 phenotype. J Immunol 194: 4997–5006.
    • (2015) J Immunol , vol.194 , pp. 4997-5006
    • Xu, M.1    Liu, M.2    Du, X.3    Li, S.4    Li, H.5    Li, X.6    Li, Y.7    Wang, Y.8    Qin, Z.9    Fu, Y.X.10
  • 333
    • 0035652459 scopus 로고    scopus 로고
    • The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation
    • Ye SK, Agata Y, Lee HC, Kurooka H, Kitamura T, Shimizu A, Honjo T, Ikuta K. 2001. The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation. Immunity 15: 813–823.
    • (2001) Immunity , vol.15 , pp. 813-823
    • Ye, S.K.1    Agata, Y.2    Lee, H.C.3    Kurooka, H.4    Kitamura, T.5    Shimizu, A.6    Honjo, T.7    Ikuta, K.8
  • 338
    • 84928586624 scopus 로고    scopus 로고
    • Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes
    • Yu A, Snowhite I, Vendrame F, Rosenzwajg M, Klatzmann D, Pugliese A, Malek TR. 2015. Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64: 2172–2183.
    • (2015) Diabetes , vol.64 , pp. 2172-2183
    • Yu, A.1    Snowhite, I.2    Vendrame, F.3    Rosenzwajg, M.4    Klatzmann, D.5    Pugliese, A.6    Malek, T.R.7
  • 344
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • Zhu J, Cote-Sierra J, Guo L, Paul WE. 2003. Stat5 activation plays a critical role in Th2 differentiation. Immunity 19: 739–748.
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.