The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

Immunity

Volumn 43, Issue 4, 2015, Pages 690-702

  Ray, John P ^a   Staron, Matthew M ^a   Shyer, Justin A ^a   Ho, Ping Chih ^a   Marshall, Heather D ^a   Gray, Simon M ^a   Laidlaw, Brian J ^a   Araki, Koichi ^c   Ahmed, Rafi ^c   Kaech, Susan M ^a,b   Craft, Joe ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CD4 ANTIGEN; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR NFAT; AKT1 PROTEIN, MOUSE; GLUCOSE; IL2RA PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR ALPHA; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PRDM1 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CELL FATE; CELL METABOLISM; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GLYCOLYSIS; HELPER CELL; INTRACELLULAR SIGNALING; LYMPHOCYTE DIFFERENTIATION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TH1 CELL; VIRUS INFECTION; ANIMAL; APOPTOSIS; BIOSYNTHESIS; C57BL MOUSE; CALCIUM SIGNALING; CELL CYCLE; CELL DIVISION; CYTOLOGY; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; METABOLISM; OXYGEN CONSUMPTION; PHYSIOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; VIROLOGY;

ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CELL CYCLE; CELL DIVISION; ENZYME ACTIVATION; GLUCOSE; GLYCOLYSIS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; NFATC TRANSCRIPTION FACTORS; OXYGEN CONSUMPTION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84944681622     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.08.017     Document Type: Article

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