-
2
-
-
84859416933
-
Regulatory T cells: Mechanisms of differentiation and function
-
Josefowicz, S. Z., Lu, L. F. & Rudensky, A. Y. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30, 531-564 (2012).
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 531-564
-
-
Josefowicz, S.Z.1
Lu, L.F.2
Rudensky, A.Y.3
-
3
-
-
43949105866
-
Regulatory T cells and immune tolerance
-
Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Regulatory T cells and immune tolerance. Cell 133, 775-787 (2008).
-
(2008)
Cell
, vol.133
, pp. 775-787
-
-
Sakaguchi, S.1
Yamaguchi, T.2
Nomura, T.3
Ono, M.4
-
4
-
-
0014667395
-
Thymus and reproduction: Sex-linked dysgnesia of the gonad after neonatal thymectomy in mice
-
Nishizuka, Y. Thymus and reproduction: sex-linked dysgnesia of the gonad after neonatal thymectomy in mice. Science 166, 753-755 (1969).
-
(1969)
Science
, vol.166
, pp. 753-755
-
-
Nishizuka, Y.1
-
5
-
-
0021997185
-
Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; Deficit of a T cell subset as a possible cause of autoimmune disease
-
Sakaguchi, S., Fukuma, K., Kuribayashi, K. & Masuda, T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161, 72-87 (1985).
-
(1985)
J. Exp. Med.
, vol.161
, pp. 72-87
-
-
Sakaguchi, S.1
Fukuma, K.2
Kuribayashi, K.3
Masuda, T.4
-
6
-
-
0034679560
-
+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
-
+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 303-310
-
-
Takahashi, T.1
-
7
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995).
-
(1995)
J. Immunol.
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
10
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
13
-
-
15244354286
-
Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
-
Fontenot, J. D. et al. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22, 329-341 (2005).
-
(2005)
Immunity
, vol.22
, pp. 329-341
-
-
Fontenot, J.D.1
-
14
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin, M. A. et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445, 771-775 (2007).
-
(2007)
Nature
, vol.445
, pp. 771-775
-
-
Gavin, M.A.1
-
15
-
-
33947600584
-
Regulatory T cell development in the absence of functional Foxp3
-
Lin, W. et al. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8,359-368 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 359-368
-
-
Lin, W.1
-
16
-
-
84886947397
-
Transcriptional control of regulatory T cell development and function
-
Luo, C. T. & Li, M. O. Transcriptional control of regulatory T cell development and function. Trends Immunol. 34, 531-539 (2013).
-
(2013)
Trends Immunol.
, vol.34
, pp. 531-539
-
-
Luo, C.T.1
Li, M.O.2
-
17
-
-
79958251745
-
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
-
Moran, A. E. et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208, 1279-1289 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1279-1289
-
-
Moran, A.E.1
-
18
-
-
33645102841
-
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
-
Hsieh, C. S., Zheng, Y., Liang, Y., Fontenot, J. D. & Rudensky, A. Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7, 401-410 (2006).
-
(2006)
Nat. Immunol.
, vol.7
, pp. 401-410
-
-
Hsieh, C.S.1
Zheng, Y.2
Liang, Y.3
Fontenot, J.D.4
Rudensky, A.Y.5
-
19
-
-
0028102655
-
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
-
Lafaille, J. J., Nagashima, K., Katsuki, M. & Tonegawa, S. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78, 399-408 (1994).
-
(1994)
Cell
, vol.78
, pp. 399-408
-
-
Lafaille, J.J.1
Nagashima, K.2
Katsuki, M.3
Tonegawa, S.4
-
20
-
-
0035320679
-
+ regulatory T cells induced by an agonist self-peptide
-
+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
-
(2001)
Nat. Immunol.
, vol.2
, pp. 301-306
-
-
Jordan, M.S.1
-
21
-
-
0036345337
-
Origin of regulatory T cells with known specificity for antigen
-
Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 756-763
-
-
Apostolou, I.1
Sarukhan, A.2
Klein, L.3
Von Boehmer, H.4
-
22
-
-
80052572177
-
+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion
-
+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion. Proc. Natl Acad. Sci. USA 108, 14890-14895 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 14890-14895
-
-
Cozzo Picca, C.1
-
23
-
-
84866524744
-
A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self
-
Lee, H. M., Bautista, J. L., Scott-Browne, J., Mohan, J. F. & Hsieh, C. S. A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity 37, 475-486 (2012).
-
(2012)
Immunity
, vol.37
, pp. 475-486
-
-
Lee, H.M.1
Bautista, J.L.2
Scott-Browne, J.3
Mohan, J.F.4
Hsieh, C.S.5
-
24
-
-
84876216209
-
Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery
-
Paiva, R. S. et al. Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. Proc. Natl Acad. Sci. USA 110, 6494-6499 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 6494-6499
-
-
Paiva, R.S.1
-
25
-
-
2542420993
-
In vivo instruction of suppressor commitment in naive T cells
-
Apostolou, I. & von Boehmer, H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199, 1401-1408 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1401-1408
-
-
Apostolou, I.1
Von Boehmer, H.2
-
26
-
-
29244435493
-
Inducing and expanding regulatory T cell populations by foreign antigen
-
Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6, 1219-1227 (2005).
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1219-1227
-
-
Kretschmer, K.1
-
27
-
-
77955391804
-
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
-
Gottschalk, R. A., Corse, E. & Allison, J. P. TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J. Exp. Med. 207, 1701-1711 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1701-1711
-
-
Gottschalk, R.A.1
Corse, E.2
Allison, J.P.3
-
28
-
-
84874562592
-
+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB
-
+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J. Exp. Med. 210, 269-285 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 269-285
-
-
Daley, S.R.1
Hu, D.Y.2
Goodnow, C.C.3
-
29
-
-
84875257845
-
Murine thymic selection quantified using a unique method to capture deleted T cells
-
Stritesky, G. L. et al. Murine thymic selection quantified using a unique method to capture deleted T cells. Proc. Natl Acad. Sci. USA 110, 4679-4684 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 4679-4684
-
-
Stritesky, G.L.1
-
30
-
-
25844504653
-
Developmental regulation of Foxp3 expression during ontogeny
-
Fontenot, J. D., Dooley, J. L., Farr, A. G. & Rudensky, A. Y. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202, 901-906 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 901-906
-
-
Fontenot, J.D.1
Dooley, J.L.2
Farr, A.G.3
Rudensky, A.Y.4
-
31
-
-
84878662471
-
+ thymocyte development
-
+ thymocyte development. J. Exp. Med. 210, 675-681 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 675-681
-
-
Cowan, J.E.1
-
33
-
-
34248598295
-
+ medullary thymic epithelial cells
-
+ medullary thymic epithelial cells. Nat. Immunol. 8, 351-358 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 351-358
-
-
Aschenbrenner, K.1
-
34
-
-
84928581675
-
Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
-
Yang, S., Fujikado, N., Kolodin, D., Benoist, C. & Mathis, D. Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science 348, 589-594 (2015).
-
(2015)
Science
, vol.348
, pp. 589-594
-
-
Yang, S.1
Fujikado, N.2
Kolodin, D.3
Benoist, C.4
Mathis, D.5
-
35
-
-
77956894327
-
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function
-
Tanaka, S. et al. Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J. Immunol. 185, 2295-2305 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 2295-2305
-
-
Tanaka, S.1
-
36
-
-
37049019860
-
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
-
Siggs, O. M. et al. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 27, 912-926 (2007).
-
(2007)
Immunity
, vol.27
, pp. 912-926
-
-
Siggs, O.M.1
-
37
-
-
70449721003
-
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity
-
Hsu, L. Y., Tan, Y. X., Xiao, Z., Malissen, M. & Weiss, A. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J. Exp. Med. 206, 2527-2541 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2527-2541
-
-
Hsu, L.Y.1
Tan, Y.X.2
Xiao, Z.3
Malissen, M.4
Weiss, A.5
-
39
-
-
77149154686
-
Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
-
Fu, G. et al. Phospholipase Cγ1 is essential for T cell development, activation, and tolerance. J. Exp. Med. 207, 309-318 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 309-318
-
-
Fu, G.1
-
40
-
-
40949123088
-
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance
-
Oh-hora, M. et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat. Immunol. 9, 432-443 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 432-443
-
-
Oh-Hora, M.1
-
41
-
-
1842480966
-
+ regulatory and natural killer-like T cells on signals leading to NF-κB activation
-
+ regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proc. Natl Acad. Sci. USA 101, 4566-4571 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 4566-4571
-
-
Schmidt-Supprian, M.1
-
42
-
-
54349086262
-
Differential requirement of PKC-θ in the development and function of natural regulatory T cells
-
Gupta, S. et al. Differential requirement of PKC-θ in the development and function of natural regulatory T cells. Mol. Immunol. 46, 213-224 (2008).
-
(2008)
Mol. Immunol.
, vol.46
, pp. 213-224
-
-
Gupta, S.1
-
43
-
-
60549113390
-
Differential requirement for CARMA1 in agonist-selected T-cell development
-
Medoff, B. D. et al. Differential requirement for CARMA1 in agonist-selected T-cell development. Eur. J. Immunol. 39, 78-84 (2009).
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 78-84
-
-
Medoff, B.D.1
-
44
-
-
65549114796
-
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery
-
Barnes, M. J. et al. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol. 7, e51 (2009).
-
(2009)
PLoS Biol.
, vol.7
, pp. e51
-
-
Barnes, M.J.1
-
45
-
-
44449127238
-
Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice
-
Chen, X., Priatel, J. J., Chow, M. T. & Teh, H. S. Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice. J. Immunol. 180, 5973-5982 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 5973-5982
-
-
Chen, X.1
Priatel, J.J.2
Chow, M.T.3
Teh, H.S.4
-
46
-
-
38449088381
-
Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development
-
Willoughby, J. E. et al. Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. J. Immunol. 179, 6836-6844 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 6836-6844
-
-
Willoughby, J.E.1
-
47
-
-
84889263101
-
Diacylglycerol kinase ξ limits the generation of natural regulatory T cells
-
Schmidt, A. M. et al. Diacylglycerol kinase ξ limits the generation of natural regulatory T cells. Sci. Signal. 6, ra101 (2013).
-
(2013)
Sci. Signal.
, vol.6
, pp. ra101
-
-
Schmidt, A.M.1
-
48
-
-
84889254459
-
The ξ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated Ras signaling
-
Joshi, R. P. et al. The ξ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated Ras signaling. Sci. Signal. 6, ra102 (2013).
-
(2013)
Sci. Signal.
, vol.6
, pp. ra102
-
-
Joshi, R.P.1
-
49
-
-
71749088574
-
Nuclear factor-κB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
-
Long, M., Park, S.-G., Strickland, I., Hayden, M. S. & Ghosh, S. Nuclear factor-κB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31, 921-931 (2009).
-
(2009)
Immunity
, vol.31
, pp. 921-931
-
-
Long, M.1
Park, S.-G.2
Strickland, I.3
Hayden, M.S.4
Ghosh, S.5
-
50
-
-
84857989935
-
Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
-
Fassett, M. S., Jiang, W., D'Alise, A. M., Mathis, D. & Benoist, C. Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc. Natl Acad. Sci. USA 109, 3891-3896 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 3891-3896
-
-
Fassett, M.S.1
Jiang, W.2
D'Alise, A.M.3
Mathis, D.4
Benoist, C.5
-
51
-
-
84870284512
-
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
-
Hwang, S. et al. Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J. Exp. Med. 209, 1781-1795 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1781-1795
-
-
Hwang, S.1
-
52
-
-
84962327530
-
SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex
-
Park, Y. et al. SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Nat. Immunol. 17, 286-296 (2016).
-
(2016)
Nat. Immunol.
, vol.17
, pp. 286-296
-
-
Park, Y.1
-
54
-
-
33750807672
-
+ regulatory T cells
-
+ regulatory T cells. J. Immunol. 177, 6598-6602 (2006).
-
(2006)
J. Immunol.
, vol.177
, pp. 6598-6602
-
-
Patton, D.T.1
-
55
-
-
84862137469
-
Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation
-
Chang, X., Lazorchak, A. S., Liu, D. & Su, B. Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation. Eur. J. Immunol. 42, 1639-1647 (2012).
-
(2012)
Eur. J. Immunol.
, vol.42
, pp. 1639-1647
-
-
Chang, X.1
Lazorchak, A.S.2
Liu, D.3
Su, B.4
-
56
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
Sauer, S. et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl Acad. Sci. USA 105, 7797-7802 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 7797-7802
-
-
Sauer, S.1
-
57
-
-
77953811224
-
+ regulatory T cells
-
+ regulatory T cells. Nat. Immunol. 11, 618-627 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 618-627
-
-
Ouyang, W.1
-
58
-
-
37849009964
-
Two-step process for thymic regulatory T cell development
-
Lio, C.-W. J. & Hsieh, C.-S. A. Two-step process for thymic regulatory T cell development. Immunity 28, 100-111 (2008).
-
(2008)
Immunity
, vol.28
, pp. 100-111
-
-
Lio, C.-W.J.1
Hsieh, C.-S.A.2
-
60
-
-
65749120321
-
Intraclonal competition limits the fate determination of regulatory T cells in the thymus
-
Bautista, J. L. et al. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat. Immunol. 10, 610-617 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 610-617
-
-
Bautista, J.L.1
-
62
-
-
67651158788
-
The impact of negative selection on thymocyte migration in the medulla
-
Le Borgne, M. et al. The impact of negative selection on thymocyte migration in the medulla. Nat. Immunol. 10, 823-830 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 823-830
-
-
Le Borgne, M.1
-
64
-
-
78650731638
-
Foxo: In command of T lymphocyte homeostasis and tolerance
-
Ouyang, W. & Li, M. O. Foxo: in command of T lymphocyte homeostasis and tolerance. Trends Immunol. 32, 26-33 (2011).
-
(2011)
Trends Immunol.
, vol.32
, pp. 26-33
-
-
Ouyang, W.1
Li, M.O.2
-
65
-
-
71749094333
-
+ regulatory T cells is driven by the c-Rel enhanceosome
-
+ regulatory T cells is driven by the c-Rel enhanceosome. Immunity 31, 932-940 (2009).
-
(2009)
Immunity
, vol.31
, pp. 932-940
-
-
Ruan, Q.1
-
66
-
-
84867088968
-
+ regulatory T cells
-
+ regulatory T cells. Proc. Natl Acad. Sci. USA 109, 16258-16263 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 16258-16263
-
-
Vaeth, M.1
-
67
-
-
84896848164
-
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
-
Gomez-Rodriguez, J. et al. Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. J. Exp. Med. 211, 529-543 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 529-543
-
-
Gomez-Rodriguez, J.1
-
68
-
-
84907033007
-
IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function
-
Huang, W., Jeong, A. R., Kannan, A. K., Huang, L. & August, A. IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function. J. Immunol. 193, 2267-2272 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 2267-2272
-
-
Huang, W.1
Jeong, A.R.2
Kannan, A.K.3
Huang, L.4
August, A.5
-
69
-
-
84860237060
-
Regulation and function of mTOR signalling in T cell fate decisions
-
Chi, H. Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12, 325-338 (2012).
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 325-338
-
-
Chi, H.1
-
70
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe, G. M. et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832-844 (2009).
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
-
71
-
-
0035236095
-
The Goldilocks conditions applied to T cell development
-
Yun, T. J. & Bevan, M. J. The Goldilocks conditions applied to T cell development. Nat. Immunol. 2, 13-14 (2001).
-
(2001)
Nat. Immunol.
, vol.2
, pp. 13-14
-
-
Yun, T.J.1
Bevan, M.J.2
-
72
-
-
13944260538
-
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
-
Tai, X., Cowan, M., Feigenbaum, L. & Singer, A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6, 152-162 (2005).
-
(2005)
Nat. Immunol.
, vol.6
, pp. 152-162
-
-
Tai, X.1
Cowan, M.2
Feigenbaum, L.3
Singer, A.4
-
73
-
-
82155170171
-
B7/CD28 in central tolerance: Costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion
-
Hinterberger, M., Wirnsberger, G. & Klein, L. B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion. Front. Immunol. 2, 30 (2011).
-
(2011)
Front. Immunol.
, vol.2
, pp. 30
-
-
Hinterberger, M.1
Wirnsberger, G.2
Klein, L.3
-
74
-
-
84878646386
-
+ regulatory T cell development via the CD27-CD70 pathway
-
+ regulatory T cell development via the CD27-CD70 pathway. J. Exp. Med. 210, 715-728 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 715-728
-
-
Coquet, J.M.1
-
75
-
-
84899475568
-
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
-
Mahmud, S. A. et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat. Immunol. 15, 473-481 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 473-481
-
-
Mahmud, S.A.1
-
76
-
-
34547769253
-
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
-
Benson, M. J., Pino-Lagos, K., Rosemblatt, M. & Noelle, R. J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204, 1765-1774 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1765-1774
-
-
Benson, M.J.1
Pino-Lagos, K.2
Rosemblatt, M.3
Noelle, R.J.4
-
77
-
-
70249146894
-
+ cells in the absence of CD5 signaling
-
+ cells in the absence of CD5 signaling. Eur. J. Immunol. 39, 2233-2247 (2009).
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 2233-2247
-
-
Ordonez-Rueda, D.1
-
78
-
-
84924988088
-
CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens
-
Henderson, J. G., Opejin, A., Jones, A., Gross, C. & Hawiger, D. CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens. Immunity 42, 471-483 (2015).
-
(2015)
Immunity
, vol.42
, pp. 471-483
-
-
Henderson, J.G.1
Opejin, A.2
Jones, A.3
Gross, C.4
Hawiger, D.5
-
79
-
-
33644835247
-
+ regulatory cells
-
+ regulatory cells. J. Immunol. 176, 3321-3329 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 3321-3329
-
-
Zheng, S.G.1
-
80
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco, L. M. et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. Exp. Med. 206, 3015-3029 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 3015-3029
-
-
Francisco, L.M.1
-
81
-
-
77953267301
-
Transforming growth factor-β signaling curbs thymic negative selection promoting regulatory T cell development
-
Ouyang, W., Beckett, O., Ma, Q. & Li, M. O. Transforming growth factor-β signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 32, 642-653 (2010).
-
(2010)
Immunity
, vol.32
, pp. 642-653
-
-
Ouyang, W.1
Beckett, O.2
Ma, Q.3
Li, M.O.4
-
82
-
-
84879601640
-
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals
-
Tai, X. et al. Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity 38, 1116-1128 (2013).
-
(2013)
Immunity
, vol.38
, pp. 1116-1128
-
-
Tai, X.1
-
83
-
-
44049087148
-
+ regulatory T cells
-
+ regulatory T cells. Nat. Immunol. 9, 632-640 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 632-640
-
-
Liu, Y.1
-
84
-
-
0348223787
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp3
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
-
85
-
-
34247564147
-
Nonredundant roles for Stat5a/b in directly regulating Foxp3
-
Yao, Z. et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109, 4368-4375 (2007).
-
(2007)
Blood
, vol.109
, pp. 4368-4375
-
-
Yao, Z.1
-
86
-
-
48449086316
-
TGF-β: A master of all T cell trades
-
Li, M. O. & Flavell, R. A. TGF-β: a master of all T cell trades. Cell 134, 392-404 (2008).
-
(2008)
Cell
, vol.134
, pp. 392-404
-
-
Li, M.O.1
Flavell, R.A.2
-
87
-
-
84872790689
-
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
-
Liao, W., Lin, J. X. & Leonard, W. J. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 38, 13-25 (2013).
-
(2013)
Immunity
, vol.38
, pp. 13-25
-
-
Liao, W.1
Lin, J.X.2
Leonard, W.J.3
-
88
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
Zheng, Y. et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808-812 (2010).
-
(2010)
Nature
, vol.463
, pp. 808-812
-
-
Zheng, Y.1
-
89
-
-
73949090725
-
+ CD4 regulatory T cells
-
+ CD4 regulatory T cells. J. Exp. Med. 206, 3001-3014 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 3001-3014
-
-
Isomura, I.1
-
90
-
-
77954395996
-
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
-
Harada, Y. et al. Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J. Exp. Med. 207, 1381-1391 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1381-1391
-
-
Harada, Y.1
-
91
-
-
84870928198
-
NS protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
-
NS protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 37, 998-1008 (2012).
-
(2012)
Immunity
, vol.37
, pp. 998-1008
-
-
Schuster, M.1
-
92
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
Tone, Y. et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol. 9, 194-202 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 194-202
-
-
Tone, Y.1
-
93
-
-
85027932757
-
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
-
Sekiya, T. et al. Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. Nat. Immunol. 14, 230-237 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 230-237
-
-
Sekiya, T.1
-
94
-
-
84930834791
-
Dynamic changes in E-protein activity regulate T reg cell development
-
Gao, P. et al. Dynamic changes in E-protein activity regulate T reg cell development. J. Exp. Med. 211, 2651-2668 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 2651-2668
-
-
Gao, P.1
-
95
-
-
84904260731
-
Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation
-
Liu, C. et al. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J. Immunol. 193, 663-672 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 663-672
-
-
Liu, C.1
-
96
-
-
78650309487
-
H17 cells by the DNA-binding inhibitor Id3
-
H17 cells by the DNA-binding inhibitor Id3. Nat. Immunol. 12, 86-95 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 86-95
-
-
Maruyama, T.1
-
97
-
-
84949192008
-
A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance
-
Feng, Y. et al. A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature 528, 132-136 (2015).
-
(2015)
Nature
, vol.528
, pp. 132-136
-
-
Feng, Y.1
-
98
-
-
84866975037
-
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
-
Samstein, R. M. et al. Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell 151, 153-166 (2012).
-
(2012)
Cell
, vol.151
, pp. 153-166
-
-
Samstein, R.M.1
-
99
-
-
84869148187
-
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
-
Ohkura, N. et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 37, 785-799 (2012).
-
(2012)
Immunity
, vol.37
, pp. 785-799
-
-
Ohkura, N.1
-
100
-
-
34447265236
-
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
-
Kim, H. P. & Leonard, W. J. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J. Exp. Med. 204, 1543-1551 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1543-1551
-
-
Kim, H.P.1
Leonard, W.J.2
-
101
-
-
33846980131
-
Epigenetic control of the foxp3 locus in regulatory T cells
-
Floess, S. et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 5, e38 (2007).
-
(2007)
PLoS Biol.
, vol.5
, pp. e38
-
-
Floess, S.1
-
102
-
-
65549100376
-
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1
-
Josefowicz, S. Z., Wilson, C. B. & Rudensky, A. Y. Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J. Immunol. 182, 6648-6652 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 6648-6652
-
-
Josefowicz, S.Z.1
Wilson, C.B.2
Rudensky, A.Y.3
-
103
-
-
84888057006
-
DNMT1-interacting RNAs block gene-specific DNA methylation
-
Di Ruscio, A. et al. DNMT1-interacting RNAs block gene-specific DNA methylation. Nature 503, 371-376 (2013).
-
(2013)
Nature
, vol.503
, pp. 371-376
-
-
Di Ruscio, A.1
-
104
-
-
84859388345
-
Selection of self-reactive T cells in the thymus
-
Stritesky, G. L., Jameson, S. C. & Hogquist, K. A. Selection of self-reactive T cells in the thymus. Annu. Rev. Immunol. 30, 95-114 (2012).
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 95-114
-
-
Stritesky, G.L.1
Jameson, S.C.2
Hogquist, K.A.3
-
105
-
-
66949171924
-
+ T cells expressing the FoxP3 transcription factor
-
+ T cells expressing the FoxP3 transcription factor. Immunity 30, 899-911 (2009).
-
(2009)
Immunity
, vol.30
, pp. 899-911
-
-
Miyara, M.1
-
106
-
-
10744221289
-
+ regulatory T cells
-
+ regulatory T cells. J. Exp. Med. 199, 303-313 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 303-313
-
-
Huehn, J.1
-
107
-
-
84892502529
-
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
-
Smigiel, K. S. et al. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J. Exp. Med. 211, 121-136 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 121-136
-
-
Smigiel, K.S.1
-
108
-
-
79959664629
-
The light and dark sides of intestinal intraepithelial lymphocytes
-
Cheroutre, H., Lambolez, F. & Mucida, D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 11, 445-456 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 445-456
-
-
Cheroutre, H.1
Lambolez, F.2
Mucida, D.3
-
109
-
-
84906243997
-
The self-obsession of T cells: How TCR signaling thresholds affect fate 'decisions' and effector function
-
Hogquist, K. A. & Jameson, S. C. The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function. Nat. Immunol. 15, 815-823 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 815-823
-
-
Hogquist, K.A.1
Jameson, S.C.2
-
112
-
-
84861880306
-
+ T cells
-
+ T cells. Blood 119, 5155-5163 (2012).
-
(2012)
Blood
, vol.119
, pp. 5155-5163
-
-
Tai, X.1
-
114
-
-
84956616968
-
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity
-
Luo, C. T., Liao, W., Dadi, S., Toure, A. & Li, M. O. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature 529, 532-536 (2016).
-
(2016)
Nature
, vol.529
, pp. 532-536
-
-
Luo, C.T.1
Liao, W.2
Dadi, S.3
Toure, A.4
Li, M.O.5
-
115
-
-
84355162741
-
Response to self antigen imprints regulatory memory in tissues
-
Rosenblum, M. D. et al. Response to self antigen imprints regulatory memory in tissues. Nature 480, 538-542 (2011).
-
(2011)
Nature
, vol.480
, pp. 538-542
-
-
Rosenblum, M.D.1
-
116
-
-
84908123494
-
Continuous requirement for the TCR in regulatory T cell function
-
Levine, A. G., Arvey, A., Jin, W. & Rudensky, A. Y. Continuous requirement for the TCR in regulatory T cell function. Nat. Immunol. 15, 1070-1078 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 1070-1078
-
-
Levine, A.G.1
Arvey, A.2
Jin, W.3
Rudensky, A.Y.4
-
117
-
-
84912113033
-
Continuous T cell receptor signals maintain a functional regulatory T cell pool
-
Vahl, J. C. et al. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity 41, 722-736 (2014).
-
(2014)
Immunity
, vol.41
, pp. 722-736
-
-
Vahl, J.C.1
-
118
-
-
84908403082
-
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
-
Feng, Y. et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell 158, 749-763 (2014).
-
(2014)
Cell
, vol.158
, pp. 749-763
-
-
Feng, Y.1
-
119
-
-
84908401913
-
Function of a Foxp3 cis-element in protecting regulatory T cell identity
-
Li, X., Liang, Y., LeBlanc, M., Benner, C. & Zheng, Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. Cell 158, 734-748 (2014).
-
(2014)
Cell
, vol.158
, pp. 734-748
-
-
Li, X.1
Liang, Y.2
LeBlanc, M.3
Benner, C.4
Zheng, Y.5
-
120
-
-
77951902637
-
The role of the LAT-PLC-γ1 interaction in T regulatory cell function
-
Chuck, M. I., Zhu, M., Shen, S. & Zhang, W. The role of the LAT-PLC-γ1 interaction in T regulatory cell function. J. Immunol. 184, 2476-2486 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 2476-2486
-
-
Chuck, M.I.1
Zhu, M.2
Shen, S.3
Zhang, W.4
-
121
-
-
84859900589
-
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells
-
Chang, J. H. et al. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat. Immunol. 13, 481-490 (2012).
-
(2012)
Nat. Immunol.
, vol.13
, pp. 481-490
-
-
Chang, J.H.1
-
122
-
-
84881192927
-
reg-cell function
-
reg-cell function. Nature 499, 485-490 (2013).
-
(2013)
Nature
, vol.499
, pp. 485-490
-
-
Zeng, H.1
-
123
-
-
48249103057
-
+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
-
+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl Acad. Sci. USA 105, 10113-10118 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 10113-10118
-
-
Onishi, Y.1
Fehervari, Z.2
Yamaguchi, T.3
Sakaguchi, S.4
-
124
-
-
78449287872
-
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity
-
Au-Yeung, B. B. et al. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat. Immunol. 11, 1085-1092 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 1085-1092
-
-
Au-Yeung, B.B.1
-
125
-
-
84869872964
-
reg cell function
-
reg cell function. Nature 491, 554-559 (2012).
-
(2012)
Nature
, vol.491
, pp. 554-559
-
-
Ouyang, W.1
-
126
-
-
84922930171
-
FH cell responses
-
FH cell responses. Nat. Immunol. 16, 178-187 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 178-187
-
-
Shrestha, S.1
-
127
-
-
84922917657
-
reg cells maintains homeostasis and lineage stability
-
reg cells maintains homeostasis and lineage stability. Nat. Immunol. 16, 188-196 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 188-196
-
-
Huynh, A.1
-
129
-
-
84949546369
-
Immune homeostasis enforced by co-localized effector and regulatory T cells
-
Liu, Z. et al. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature 528, 225-230 (2015).
-
(2015)
Nature
, vol.528
, pp. 225-230
-
-
Liu, Z.1
-
131
-
-
79551521901
-
Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors
-
Hindley, J. P. et al. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Res. 71, 736-746 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 736-746
-
-
Hindley, J.P.1
-
132
-
-
84863899032
-
The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences
-
Sainz-Perez, A., Lim, A., Lemercier, B. & Leclerc, C. The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences. Cancer Res. 72, 3557-3569 (2012).
-
(2012)
Cancer Res.
, vol.72
, pp. 3557-3569
-
-
Sainz-Perez, A.1
Lim, A.2
Lemercier, B.3
Leclerc, C.4
-
133
-
-
84874745221
-
Aire-dependent thymic development of tumor-associated regulatory T cells
-
Malchow, S. et al. Aire-dependent thymic development of tumor-associated regulatory T cells. Science 339, 1219-1224 (2013).
-
(2013)
Science
, vol.339
, pp. 1219-1224
-
-
Malchow, S.1
-
134
-
-
84903188335
-
3K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
-
3K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510, 407-411 (2014).
-
(2014)
Nature
, vol.510
, pp. 407-411
-
-
Ali, K.1
-
135
-
-
34248214561
-
Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus
-
Erlebacher, A., Vencato, D., Price, K. A., Zhang, D. & Glimcher, L. H. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J. Clin. Invest. 117, 1399-1411 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1399-1411
-
-
Erlebacher, A.1
Vencato, D.2
Price, K.A.3
Zhang, D.4
Glimcher, L.H.5
-
136
-
-
84866991345
-
Pregnancy imprints regulatory memory that sustains anergy to fetal antigen
-
Rowe, J. H., Ertelt, J. M., Xin, L. & Way, S. S. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature 490, 102-106 (2012).
-
(2012)
Nature
, vol.490
, pp. 102-106
-
-
Rowe, J.H.1
Ertelt, J.M.2
Xin, L.3
Way, S.S.4
-
137
-
-
84863619688
-
Extrathymic generation of regulatory T cells in pacental mammals mitigates maternal-fetal conflict
-
Samstein, R. M., Josefowicz, S. Z., Arvey, A., Treuting, P. M. & Rudensky, A. Y. Extrathymic generation of regulatory T cells in pacental mammals mitigates maternal-fetal conflict. Cell 150, 29-38 (2012).
-
(2012)
Cell
, vol.150
, pp. 29-38
-
-
Samstein, R.M.1
Josefowicz, S.Z.2
Arvey, A.3
Treuting, P.M.4
Rudensky, A.Y.5
-
138
-
-
1542287265
-
Regulatory T cells mediate maternal tolerance to the fetus
-
Aluvihare, V. R., Kallikourdis, M. & Betz, A. G. Regulatory T cells mediate maternal tolerance to the fetus. Nat. Immunol. 5, 266-271 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 266-271
-
-
Aluvihare, V.R.1
Kallikourdis, M.2
Betz, A.G.3
-
139
-
-
30944445021
-
Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface
-
Zenclussen, A. C. et al. Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface. Eur. J. Immunol. 36, 82-94 (2006).
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 82-94
-
-
Zenclussen, A.C.1
-
140
-
-
57349108583
-
Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
-
Mold, J. E. et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 322, 1562-1565 (2008).
-
(2008)
Science
, vol.322
, pp. 1562-1565
-
-
Mold, J.E.1
-
141
-
-
84938309517
-
Cross-generational reproductive fitness enforced by microchimeric maternal cells
-
Kinder, J. M. et al. Cross-generational reproductive fitness enforced by microchimeric maternal cells. Cell 162, 505-515 (2015).
-
(2015)
Cell
, vol.162
, pp. 505-515
-
-
Kinder, J.M.1
-
142
-
-
80054020840
-
Peripheral education of the immune system by colonic commensal microbiota
-
Lathrop, S. K. et al. Peripheral education of the immune system by colonic commensal microbiota. Nature 478, 250-254 (2011).
-
(2011)
Nature
, vol.478
, pp. 250-254
-
-
Lathrop, S.K.1
-
143
-
-
84877742439
-
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
-
Cebula, A. et al. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature 497, 258-262 (2013).
-
(2013)
Nature
, vol.497
, pp. 258-262
-
-
Cebula, A.1
-
144
-
-
84881477044
-
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
-
Atarashi, K. et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 500, 232-236 (2013).
-
(2013)
Nature
, vol.500
, pp. 232-236
-
-
Atarashi, K.1
-
145
-
-
84866403123
-
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
-
Schlenner, S. M., Weigmann, B., Ruan, Q., Chen, Y. & von Boehmer, H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J. Exp. Med. 209, 1529-1535 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1529-1535
-
-
Schlenner, S.M.1
Weigmann, B.2
Ruan, Q.3
Chen, Y.4
Von Boehmer, H.5
-
146
-
-
84862777225
-
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
-
Josefowicz, S. Z. et al. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 482, 395-399 (2012).
-
(2012)
Nature
, vol.482
, pp. 395-399
-
-
Josefowicz, S.Z.1
-
147
-
-
38049177784
-
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
-
Zeiser, R. et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 111, 453-462 (2008).
-
(2008)
Blood
, vol.111
, pp. 453-462
-
-
Zeiser, R.1
-
148
-
-
84928591321
-
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
-
Klatzmann, D. & Abbas, A. K. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat. Rev. Immunol. 15,283-294 (2015).
-
(2015)
Nat. Rev. Immunol.
, vol.15
, pp. 283-294
-
-
Klatzmann, D.1
Abbas, A.K.2
-
149
-
-
84884271914
-
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
-
Simpson, T. R. et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J. Exp. Med. 210, 1695-1710 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 1695-1710
-
-
Simpson, T.R.1
-
150
-
-
84884229186
-
Activating Fcγ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
-
Bulliard, Y. et al. Activating Fcγ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J. Exp. Med. 210, 1685-1693 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 1685-1693
-
-
Bulliard, Y.1
-
151
-
-
84878936788
-
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
-
Selby, M. J. et al. Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol. Res. 1, 32-42 (2013).
-
(2013)
Cancer Immunol. Res.
, vol.1
, pp. 32-42
-
-
Selby, M.J.1
|