Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1

Nature

Volumn 426, Issue 6967, 2003, Pages 671-676

  Opferman, Joseph T ^a   Letai, Anthony ^a   Beard, Caroline ^a   Sorcinelli, Mia D ^a   Ong, Christy C ^a   Korsmeyer, Stanley J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; LIVING SYSTEMS STUDIES; PROTEINS;

CELLULAR HOMEOSTASIS;

IMMUNOLOGY;

BIM PROTEIN; CYTOKINE; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 7; PROTEIN MCL 1;

IMMUNE SYSTEM;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; GENE; GENE DELETION; GENE REARRANGEMENT; GENOTOXICITY; IMMUNE SYSTEM; LETHAL MUTANT; LETHALITY; LYMPHOCYTE; LYMPHOID CELL; MCL 1 GENE; MOUSE; NIDATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ALLELES; ANIMALS; ANTIGENS, CD19; APOPTOSIS; ATTACHMENT SITES, MICROBIOLOGICAL; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; GENE DELETION; INTEGRASES; MICE; NEOPLASM PROTEINS; ORGAN SPECIFICITY; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SPLEEN; STEM CELLS; T-LYMPHOCYTES; THYMUS GLAND; VIRAL PROTEINS;

ANIMALIA;

EID: 0348148880     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02067     Document Type: Article

References (30)

1. Marsden, V. S. & Strasser, A. Control point of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu. Rev. Immunol. 21, 71-105 (2003).
2. Rathmell, J. C. & Thompson, C. B. The central effectors of cell death in the immune system. Annu. Rev. Immunol. 17, 781-828 (1999).
3. Cao, X. et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity 2, 223-238 (1995).
4. Peschon, J. J. et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960 (1994).
5. von Freeden-Jeffry, U. et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181, 1519-1526 (1995).
6. Vella, A. T., Dow, S., Potter, T. A., Kappler, J. & Marrack, P. Cytokine-induced survival of activated T cells in vitro and in vivo. Proc. Natl Acad. Sci. USA 95, 3810-3815 (1998).
7. + T cells in vivo by IL-15. Immunity 8, 591-599 (1998).
8. Schluns, K. S., Kieper, W. C., Jameson, S. C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nature Immunol. 1, 426-432 (2000).
9. Yang, T., Buchan, H. L., Townsend, K. J. & Craig, R. W. MCL-1, a member of the BCL-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation. J. Cell. Physiol. 166, 523-536 (1996).
10. Zhou, P., Qian, L., Kozopas, K. M. & Craig, R. W. Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. Blood 89, 630-643 (1997).
11. Nijhawan, D. et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev. 17, 1475-1486 (2003).
12. Rinkenberger, J. L., Horning, S., Klocke, B., Roth, K. & Korsmeyer, S. J. Mcl-1 deficiency results in periimplantation embryonic lethality. Genes Dev. 14, 23-27 (2000).
13. Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730 (2001).
14. 1 sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8, 705-711 (2001).
15. Letai, A. et al. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2, 183-192 (2002).
16. Veis, D. J., Sorenson, C. M., Shutter, J. R. & Korsmeyer, S. J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75, 229-240 (1993).
17. Motoyama, N. et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267, 1506-1510 (1995).
18. Ma, A. et al. Bclx regulates the survival of double-positive thymocytes. Proc. Natl. Acad. Sci. USA 92, 4763-4767 (1995).
19. Lee, P. P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15, 763-774 (2001).
20. Rickert, R. C., Roes, J. & Rajewsky, K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25, 1317-1318 (1997).
21. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150, 4244-4252 (1993).
22. Corcoran, A. E., Riddell, A., Krooshoop, D. & Venkitaraman, A. R. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature 391, 904-907 (1998).
23. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. & Hayakawa, K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225 (1991).
24. Shinkai, Y. et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867 (1992).
25. Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
26. Bouillet, P. et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286, 1735-1738 (1999).
27. Ranger, A. M. et al. Bad-deficient mice develop diffuse large B cell lymphoma. Proc. Natl Acad. Sci. USA 100, 9324-9329 (2003).
28. Datta, S. R. et al. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3, 631-643 (2002).
29. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. & Weissman, I. L. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89, 1033-1041 (1997).
30. -/- mice. Cell 89, 1011-1019 (1997).