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Volumn 161, Issue 1, 1998, Pages 302-310

STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN; INTERLEUKIN 4; STAT6 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 0031859134     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (126)

References (67)
  • 1
    • 0030022218 scopus 로고    scopus 로고
    • Antibody class switching
    • Stavnezer, J. 1996. Antibody class switching. Adv. Immunol 61:79.
    • (1996) Adv. Immunol , vol.61 , pp. 79
    • Stavnezer, J.1
  • 3
    • 0023889066 scopus 로고
    • Mitogen-and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching
    • Lutzker, S., P. Rothman, R. Pollock, R. Coffman, and F. W. Alt. 1988. Mitogen-and IL-4-regulated expression of germ-line Ig γ2b transcripts: evidence for directed heavy chain class switching. Cell 53:177.
    • (1988) Cell , vol.53 , pp. 177
    • Lutzker, S.1    Rothman, P.2    Pollock, R.3    Coffman, R.4    Alt, F.W.5
  • 4
    • 0027273019 scopus 로고
    • A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b promoter and exon
    • Zhang, J., A. Bottaro, S. Li, V. Stewart, and F. W. Alt. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b promoter and exon. EMBO J. 12:3529.
    • (1993) EMBO J. , vol.12 , pp. 3529
    • Zhang, J.1    Bottaro, A.2    Li, S.3    Stewart, V.4    Alt, F.W.5
  • 5
    • 0027417869 scopus 로고
    • Shutdown of class switch recombination by deletion of a switch region control element
    • Jung, S., K. Rajewsky, and A. Radbruch. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259:984.
    • (1993) Science , vol.259 , pp. 984
    • Jung, S.1    Rajewsky, K.2    Radbruch, A.3
  • 6
    • 0027952630 scopus 로고
    • S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
    • Bottaro, A., R. Lansford, L. Xu, J. Zhang, P. Rothman, and F. W. Alt. 1994. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13:665.
    • (1994) EMBO J. , vol.13 , pp. 665
    • Bottaro, A.1    Lansford, R.2    Xu, L.3    Zhang, J.4    Rothman, P.5    Alt, F.W.6
  • 7
    • 0027372064 scopus 로고
    • Mechanism and regulation of immunoglobulin isotype switching
    • Coffman, R. L., D. A. Lebman, and P. Rothman. 1993. Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54:229.
    • (1993) Adv. Immunol. , vol.54 , pp. 229
    • Coffman, R.L.1    Lebman, D.A.2    Rothman, P.3
  • 8
    • 0024385049 scopus 로고
    • Rapid induction of transcription of unrearranged Sγ1 switch regions in activated murine B cells by interleukin 4
    • Esser, C., and A. Radbruch. 1989. Rapid induction of transcription of unrearranged Sγ1 switch regions in activated murine B cells by interleukin 4. EMBO J. 8:483.
    • (1989) EMBO J. , vol.8 , pp. 483
    • Esser, C.1    Radbruch, A.2
  • 9
    • 0344037977 scopus 로고
    • Synthesis of germ-line γ1 immunoglobulin heavy-chain transcripts in resting B cells: Induction by interleukin 4 and inhibition by interferon γ
    • Berton, M. T., J. W. Uhr, and E. S. Vitetta. 1989. Synthesis of germ-line γ1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon γ. Proc. Natl. Acad. Sci. USA 86:2829.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2829
    • Berton, M.T.1    Uhr, J.W.2    Vitetta, E.S.3
  • 10
    • 0024231914 scopus 로고
    • Mitogen plus interleukin 4 induction of C∈ transcripts in B lymphoid cells
    • Rothman, P., S. Lutzker, W. Cook, R. Coffman, and F. W. Alt. 1988. Mitogen plus interleukin 4 induction of C∈ transcripts in B lymphoid cells. J. Exp. Med. 168:2385.
    • (1988) J. Exp. Med. , vol.168 , pp. 2385
    • Rothman, P.1    Lutzker, S.2    Cook, W.3    Coffman, R.4    Alt, F.W.5
  • 11
    • 0345671747 scopus 로고
    • Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts
    • Radbruch, A., W. Muller, and K. Rajewsky. 1986. Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts. Proc. Natl. Acad. Sci. USA 83:3954.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 3954
    • Radbruch, A.1    Muller, W.2    Rajewsky, K.3
  • 12
    • 0024342940 scopus 로고
    • IL-4 induces the specific rearrangement of γ1 genes on the expressed and unexpressed chromosomes of lipopolysaccharide-activated normal murine B cells
    • Kepron, M. R., Y. W. Chen, J. W. Uhr, and E. S. Vitetta. 1989. IL-4 induces the specific rearrangement of γ1 genes on the expressed and unexpressed chromosomes of lipopolysaccharide-activated normal murine B cells. J. Immunol. 143:334.
    • (1989) J. Immunol. , vol.143 , pp. 334
    • Kepron, M.R.1    Chen, Y.W.2    Uhr, J.W.3    Vitetta, E.S.4
  • 13
    • 0028291593 scopus 로고
    • Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE
    • Purkerson, J. M., and P. C. Isakson. 1994. Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE. J. Exp. Med. 179:1877.
    • (1994) J. Exp. Med. , vol.179 , pp. 1877
    • Purkerson, J.M.1    Isakson, P.C.2
  • 14
    • 0022568935 scopus 로고
    • B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells
    • Coffman, R. L., J. Ohara, M. W. Bond, J. Carty, A. Zlotnik, and W. E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136:4538.
    • (1986) J. Immunol. , vol.136 , pp. 4538
    • Coffman, R.L.1    Ohara, J.2    Bond, M.W.3    Carty, J.4    Zlotnik, A.5    Paul, W.E.6
  • 17
    • 0026532658 scopus 로고
    • Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen
    • Shapira, S. K., D. Vercelli, H. H. Jabara, S. M. Fu, and R. S. Geha. 1992. Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen. J. Exp. Med. 175:289.
    • (1992) J. Exp. Med. , vol.175 , pp. 289
    • Shapira, S.K.1    Vercelli, D.2    Jabara, H.H.3    Fu, S.M.4    Geha, R.S.5
  • 18
    • 0028349260 scopus 로고
    • Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells
    • Jumper, M. D., J. B. Splawski, P. E. Lipsky, and K. Meek. 1994. Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells. J. Immunol. 152:438.
    • (1994) J. Immunol. , vol.152 , pp. 438
    • Jumper, M.D.1    Splawski, J.B.2    Lipsky, P.E.3    Meek, K.4
  • 19
    • 0028971990 scopus 로고
    • Induction of germ-line γ1 and ∈ Ig gene expression in murine B cells: IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals
    • Warren, W. D., and M. T. Berton. 1995. Induction of germ-line γ1 and ∈ Ig gene expression in murine B cells: IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals. J. Immunol. 155:5637.
    • (1995) J. Immunol. , vol.155 , pp. 5637
    • Warren, W.D.1    Berton, M.T.2
  • 21
    • 0027419799 scopus 로고
    • Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: Cooperative effects of cytokines
    • Maliszewski, C. R., K. Grabstein, W. C. Fanslow, R. Armitage, M. K. Spriggs, and T. A. Sato. 1993. Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: cooperative effects of cytokines. Eur. J. Immunol. 23:1044.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1044
    • Maliszewski, C.R.1    Grabstein, K.2    Fanslow, W.C.3    Armitage, R.4    Spriggs, M.K.5    Sato, T.A.6
  • 22
    • 0027331547 scopus 로고
    • Allergy-associated I∈ and Fc∈ receptor II (CD23) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element
    • Kohler, I., and E. P. Rieber. 1993. Allergy-associated I∈ and Fc∈ receptor II (CD23) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element. Eur. J. Immunol. 23:3066.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 3066
    • Kohler, I.1    Rieber, E.P.2
  • 23
    • 0027688778 scopus 로고
    • Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4
    • Kotanides, H., and N. C. Reich. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262:1265.
    • (1993) Science , vol.262 , pp. 1265
    • Kotanides, H.1    Reich, N.C.2
  • 24
  • 26
    • 0028244396 scopus 로고
    • Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    • Witthuhn, B. A., O. Silvennoinen, O. Miura, K. S. Lai, C. Cwik, E. T. Liu, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153.
    • (1994) Nature , vol.370 , pp. 153
    • Witthuhn, B.A.1    Silvennoinen, O.2    Miura, O.3    Lai, K.S.4    Cwik, C.5    Liu, E.T.6    Ihle, J.N.7
  • 28
    • 0029790559 scopus 로고    scopus 로고
    • Requirements for interleukin-4-induced gene expression and functional characterization of Stat6
    • Mikita, T., D. Campbell, P. Wu, K. Williamson, and U. Schindler. 1996. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 16:5811.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5811
    • Mikita, T.1    Campbell, D.2    Wu, P.3    Williamson, K.4    Schindler, U.5
  • 29
    • 0029795585 scopus 로고    scopus 로고
    • Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene
    • Kotanides, H., and N. C. Reich. 1996. Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J. Biol. Chem. 271:25555.
    • (1996) J. Biol. Chem. , vol.271 , pp. 25555
    • Kotanides, H.1    Reich, N.C.2
  • 30
    • 0031204428 scopus 로고    scopus 로고
    • Identification of a STAT6 domain required for IL-4-induced activation of transcription
    • Lu, B., M. Reichel, D. A. Fisher, J. F. Smith, and P. Rothman. 1997. Identification of a STAT6 domain required for IL-4-induced activation of transcription. J. Immunol. 159:1255.
    • (1997) J. Immunol. , vol.159 , pp. 1255
    • Lu, B.1    Reichel, M.2    Fisher, D.A.3    Smith, J.F.4    Rothman, P.5
  • 32
    • 0029006331 scopus 로고
    • IL-4 activates a latent DNA-binding factor that binds a shared IFN-γ and IL-4 response element present in the germline γ1 Ig promoter
    • Berton, M. T., and L. A. Linehan. 1995. IL-4 activates a latent DNA-binding factor that binds a shared IFN-γ and IL-4 response element present in the germline γ1 Ig promoter. J. Immunol. 154:4513.
    • (1995) J. Immunol. , vol.154 , pp. 4513
    • Berton, M.T.1    Linehan, L.A.2
  • 33
    • 0028917885 scopus 로고
    • Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline ∈ promoter: Regulation by NF-IL-4, a C/EBP family member and NF-kappaB/p50
    • Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline ∈ promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappaB/p50. J. Exp. Med. 181:181.
    • (1995) J. Exp. Med. , vol.181 , pp. 181
    • Delphin, S.1    Stavnezer, J.2
  • 34
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
    • (1996) Immunity , vol.4 , pp. 313
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 38
    • 0025974745 scopus 로고
    • Dextran-conjugated anti-Ig antibodies as a model for T cell-independent type 2 antigen-mediated stimulation of Ig secretion in vitro. I. Lymphokine dependence
    • Pecanha, L. M., C. M. Snapper, F. D. Finkelman, and J. J. Mond. 1991. Dextran-conjugated anti-Ig antibodies as a model for T cell-independent type 2 antigen-mediated stimulation of Ig secretion in vitro. I. Lymphokine dependence. J. Immunol. 146:833.
    • (1991) J. Immunol. , vol.146 , pp. 833
    • Pecanha, L.M.1    Snapper, C.M.2    Finkelman, F.D.3    Mond, J.J.4
  • 40
    • 0018775823 scopus 로고
    • Properties and applications of monoclonal antibodies directed against determinants of they Thy-1 locus
    • Marshak-Rothstein, A., P. Fink, T. Gridley, D. H. Raulet, M. J. Bevan, and M. L. Gefter. 1979. Properties and applications of monoclonal antibodies directed against determinants of they Thy-1 locus. J. Immunol. 122:2491.
    • (1979) J. Immunol. , vol.122 , pp. 2491
    • Marshak-Rothstein, A.1    Fink, P.2    Gridley, T.3    Raulet, D.H.4    Bevan, M.J.5    Gefter, M.L.6
  • 41
    • 0022227152 scopus 로고
    • Small and large B cells respond differently to T cell-derived B cell growth and differentiation factors
    • Layton, J. E., P. H. Krammer, T. Hamaoka, J. W. Uhr, and E. S. Vitetta. 1985. Small and large B cells respond differently to T cell-derived B cell growth and differentiation factors. J. Mol. Cell. Immunol. 2:155.
    • (1985) J. Mol. Cell. Immunol. , vol.2 , pp. 155
    • Layton, J.E.1    Krammer, P.H.2    Hamaoka, T.3    Uhr, J.W.4    Vitetta, E.S.5
  • 42
    • 0018291288 scopus 로고
    • Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors
    • Unkeless, J. C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580.
    • (1979) J. Exp. Med. , vol.150 , pp. 580
    • Unkeless, J.C.1
  • 43
    • 0025159276 scopus 로고
    • Structure and expression of murine germ-line immunoglobulin ∈ heavy chain transcripts induced by interleukin 4
    • Gerondakis, S. 1990. Structure and expression of murine germ-line immunoglobulin ∈ heavy chain transcripts induced by interleukin 4. Proc. Natl Acad. Sci. USA 87:1581.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 1581
    • Gerondakis, S.1
  • 44
    • 0020339031 scopus 로고
    • The nucleotide sequence of the mouse immunoglobulin ∈ gene: Comparison with the human ∈ gene sequence
    • Ishida, N., S. Ueda, H. Hayashida, T. Miyata, and T. Honjo. 1982. The nucleotide sequence of the mouse immunoglobulin ∈ gene: comparison with the human ∈ gene sequence. EMBO J. 1:1117.
    • (1982) EMBO J. , vol.1 , pp. 1117
    • Ishida, N.1    Ueda, S.2    Hayashida, H.3    Miyata, T.4    Honjo, T.5
  • 45
    • 0026523290 scopus 로고
    • IL-4-induced expression of germline γ1 transcripts in B cells following cognate interactions with T helper cells
    • Berton, M. T., and E. S. Vitetta. 1992. IL-4-induced expression of germline γ1 transcripts in B cells following cognate interactions with T helper cells. Int. Immunol. 4:387.
    • (1992) Int. Immunol. , vol.4 , pp. 387
    • Berton, M.T.1    Vitetta, E.S.2
  • 46
    • 0022634236 scopus 로고
    • DNA sequence of the murine γ1 switch segment reveals novel structural elements
    • Mowatt, M. R., and W. A. Dunnick. 1986. DNA sequence of the murine γ1 switch segment reveals novel structural elements. J. Immunol. 136:2674.
    • (1986) J. Immunol. , vol.136 , pp. 2674
    • Mowatt, M.R.1    Dunnick, W.A.2
  • 49
    • 0002470839 scopus 로고
    • Preparation of nuclear and cytoplasmic extracts from mammalian cells
    • F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, eds. J. W. Wiley and Sons, New York
    • Abmayr, S. M., and J. L. Workman. 1994. Preparation of nuclear and cytoplasmic extracts from mammalian cells. In Current Protocols in Molecular Biology. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, eds. J. W. Wiley and Sons, New York, p. 12.1.1.
    • (1994) Current Protocols in Molecular Biology , pp. 1211
    • Abmayr, S.M.1    Workman, J.L.2
  • 50
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
    • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72:248.
    • (1976) Anal. Biochem. , vol.72 , pp. 248
    • Bradford, M.M.1
  • 51
    • 0027169028 scopus 로고
    • DNA rearrangement can account for in vitro switching to IgG1
    • Chu, C. C., E. E. Max, and W. E. Paul. 1993. DNA rearrangement can account for in vitro switching to IgG1. J. Exp. Med. 178:1381.
    • (1993) J. Exp. Med. , vol.178 , pp. 1381
    • Chu, C.C.1    Max, E.E.2    Paul, W.E.3
  • 52
    • 0026026410 scopus 로고
    • Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen
    • Rousset, F., E. Garcia, and J. Banchereau. 1991. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J. Exp. Med. 173:705.
    • (1991) J. Exp. Med. , vol.173 , pp. 705
    • Rousset, F.1    Garcia, E.2    Banchereau, J.3
  • 53
    • 0026479997 scopus 로고
    • The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: Expression of a soluble form of gp39 with B cell co-stimulatory activity
    • Hollenbaugh, D., L. S. Grosmaire, C. D. Kullas, N. J. Chalupny, S. Braesch-Andersen, R. J. Noelle, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 11:4313.
    • (1992) EMBO J. , vol.11 , pp. 4313
    • Hollenbaugh, D.1    Grosmaire, L.S.2    Kullas, C.D.3    Chalupny, N.J.4    Braesch-Andersen, S.5    Noelle, R.J.6    Stamenkovic, I.7    Ledbetter, J.A.8    Aruffo, A.9
  • 55
    • 0028136532 scopus 로고
    • Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies
    • Hasbold, J., C. Johnson-Leger, C. J. Atkins, E. A. Clark, and G. G. Klaus. 1994. Properties of mouse CD40: cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies. Eur. J. Immunol. 24:1835.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1835
    • Hasbold, J.1    Johnson-Leger, C.2    Atkins, C.J.3    Clark, E.A.4    Klaus, G.G.5
  • 56
    • 0028937707 scopus 로고
    • Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity
    • Seidel, H. M., L. H. Milocco, P. Lamb, J. E. Darnell, Jr., and R. B. Stein. 1995. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92:3041.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3041
    • Seidel, H.M.1    Milocco, L.H.2    Lamb, P.3    Darnell Jr., J.E.4    Stein, R.B.5
  • 57
    • 0029001660 scopus 로고
    • Components of a Stat recognition code: Evidence for two layers of molecular selectivity
    • Schindler, U., P. Wi, M. Rothe, M. Brasseur, and S. L. McKnight. 1995. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:689.
    • (1995) Immunity , vol.2 , pp. 689
    • Schindler, U.1    Wi, P.2    Rothe, M.3    Brasseur, M.4    McKnight, S.L.5
  • 58
    • 0028968667 scopus 로고
    • Switch transcripts in immunoglobulin class switching
    • Lorenz, M., S. Jung, and A. Radbruch. 1995. Switch transcripts in immunoglobulin class switching. Science 267:1825.
    • (1995) Science , vol.267 , pp. 1825
    • Lorenz, M.1    Jung, S.2    Radbruch, A.3
  • 59
    • 0028022805 scopus 로고
    • Activation of the Ig germ-line γ1 promoter: Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site
    • Lundgren, M., C. Larsson, A. Femino, M. Xu, J. Stavnezer, and E. Severinson. 1994. Activation of the Ig germ-line γ1 promoter: involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. J. Immunol. 153:2983.
    • (1994) J. Immunol. , vol.153 , pp. 2983
    • Lundgren, M.1    Larsson, C.2    Femino, A.3    Xu, M.4    Stavnezer, J.5    Severinson, E.6
  • 60
    • 0027441928 scopus 로고
    • Interleukin 5 induces Sμ-Sγ1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: A three component model for Ig class switching
    • Mandler, R., C. C. Chu, W. E. Paul, E. E. Max, and C. M. Snapper. 1993. Interleukin 5 induces Sμ-Sγ1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching. J. Exp. Med. 178:1577.
    • (1993) J. Exp. Med. , vol.178 , pp. 1577
    • Mandler, R.1    Chu, C.C.2    Paul, W.E.3    Max, E.E.4    Snapper, C.M.5
  • 62
    • 0027465755 scopus 로고
    • Towards a comprehensive view of immunoglobulin class switching
    • Snapper, C. M., and J. J. Mond. 1993. Towards a comprehensive view of immunoglobulin class switching. Immunol. Today 14:15.
    • (1993) Immunol. Today , vol.14 , pp. 15
    • Snapper, C.M.1    Mond, J.J.2
  • 63
    • 0025942519 scopus 로고
    • Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line ∈ transcripts
    • Rothman, P., S. C. Li, B. Gorham, L. Glimcher, F. Alt, and M. Boothby. 1991. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line ∈ transcripts. Mol. Cell. Biol. 11:5551.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 5551
    • Rothman, P.1    Li, S.C.2    Gorham, B.3    Glimcher, L.4    Alt, F.5    Boothby, M.6
  • 64
    • 0027930810 scopus 로고
    • The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice
    • von der Weid, T., M. Kopf, G. Kohler, and J. Langhorne. 1994. The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur. J. Immunol. 24:2285.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2285
    • Von der Weid, T.1    Kopf, M.2    Kohler, G.3    Langhorne, J.4
  • 65
    • 0030023112 scopus 로고    scopus 로고
    • Susceptibility to Leishmania major infection in interleukin-4-deficient mice
    • Noben-Trauth, N., P. Kropf, and I. Muller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987.
    • (1996) Science , vol.271 , pp. 987
    • Noben-Trauth, N.1    Kropf, P.2    Muller, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.