메뉴 건너뛰기




Volumn 16, Issue 10, 2016, Pages 612-625

T follicular helper cells in space-time

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELL CONTACT; CELL DIFFERENTIATION; CELL MATURATION; HELPER CELL; HUMAN; HUMORAL IMMUNITY; MEMORY T LYMPHOCYTE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPETITION PRIMING; REVIEW; T FOLLICULAR HELPER CELL; TRANSCRIPTION REGULATION; ANIMAL; ANTIGEN MEDIATED CLONAL SELECTION; CELL COMMUNICATION; CYTOLOGY; GENETICS; GERMINAL CENTER; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL SYNAPSE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

EID: 84984848116     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.94     Document Type: Review
Times cited : (221)

References (175)
  • 1
    • 84875551472 scopus 로고    scopus 로고
    • Broadly neutralizing antiviral antibodies
    • Corti, D. & Lanzavecchia, A. Broadly neutralizing antiviral antibodies. Annu. Rev. Immunol. 31, 705-742 (2013).
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 705-742
    • Corti, D.1    Lanzavecchia, A.2
  • 2
    • 35848969753 scopus 로고    scopus 로고
    • Duration of humoral immunity to common viral and vaccine antigens
    • Amanna, I. J., Carlson, N. E. & Slifka, M. K. Duration of humoral immunity to common viral and vaccine antigens. N. Engl. J. Med. 357, 1903-1915 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1903-1915
    • Amanna, I.J.1    Carlson, N.E.2    Slifka, M.K.3
  • 3
    • 0016274718 scopus 로고
    • Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice
    • Jacobson, E. B., Caporale, L. H. & Thorbecke, G. J. Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice. Cell. Immunol. 13, 416-430 (1974).
    • (1974) Cell. Immunol. , vol.13 , pp. 416-430
    • Jacobson, E.B.1    Caporale, L.H.2    Thorbecke, G.J.3
  • 4
    • 1842631032 scopus 로고    scopus 로고
    • T-Cell-B-cell cooperation
    • Mitchison, N. A. T-Cell-B-cell cooperation. Nat. Rev. Immunol. 4, 308-312 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 308-312
    • Mitchison, N.A.1
  • 5
    • 0028283841 scopus 로고
    • Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
    • Forster, R., Emrich, T., Kremmer, E. & Lipp, M. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood 84, 830-840 (1994).
    • (1994) Blood , vol.84 , pp. 830-840
    • Forster, R.1    Emrich, T.2    Kremmer, E.3    Lipp, M.4
  • 6
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • Forster, R. et al. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87, 1037-1047 (1996).
    • (1996) Cell , vol.87 , pp. 1037-1047
    • Forster, R.1
  • 7
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld, D. et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192, 1545-1552 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1545-1552
    • Breitfeld, D.1
  • 8
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli, P. et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192, 1553-1562 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1553-1562
    • Schaerli, P.1
  • 9
    • 0035554935 scopus 로고    scopus 로고
    • Separable effector T cell populations specialized for B cell help or tissue inflammation
    • Campbell, D. J., Kim, C. H. & Butcher, E. C. Separable effector T cell populations specialized for B cell help or tissue inflammation. Nat. Immunol. 2, 876-881 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 876-881
    • Campbell, D.J.1    Kim, C.H.2    Butcher, E.C.3
  • 10
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova, T. et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 173, 68-78 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 68-78
    • Chtanova, T.1
  • 11
    • 4644325602 scopus 로고    scopus 로고
    • Unique gene expression program of human germinal center T helper cells
    • Kim, C. H. et al. Unique gene expression program of human germinal center T helper cells. Blood 104, 1952-1960 (2004).
    • (2004) Blood , vol.104 , pp. 1952-1960
    • Kim, C.H.1
  • 12
    • 38049144850 scopus 로고    scopus 로고
    • high germinal center-associated subpopulation
    • high germinal center-associated subpopulation. J. Immunol. 179, 5099-5108 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 5099-5108
    • Haynes, N.M.1
  • 13
    • 23444434705 scopus 로고    scopus 로고
    • +follicular B helper T cell maintenance in vivo
    • +follicular B helper T cell maintenance in vivo. J. Immunol. 175, 2340-2348 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 2340-2348
    • Akiba, H.1
  • 14
    • 33746877544 scopus 로고    scopus 로고
    • Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
    • Dorfman, D. M., Brown, J. A., Shahsafaei, A. & Freeman, G. J. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am. J. Surg. Pathol. 30, 802-810 (2006).
    • (2006) Am. J. Surg. Pathol. , vol.30 , pp. 802-810
    • Dorfman, D.M.1    Brown, J.A.2    Shahsafaei, A.3    Freeman, G.J.4
  • 15
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva, R. I. et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138-149 (2008).
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1
  • 16
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva, R. I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005 (2009).
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 17
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston, R. J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006-1010 (2009).
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 18
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457-468 (2009).
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 20
    • 0037408497 scopus 로고    scopus 로고
    • IL-6 production by pulmonary dendritic cells impedes Th1 immune responses
    • Dodge, I. L., Carr, M. W., Cernadas, M. & Brenner, M. B. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J. Immunol. 170, 4457-4464 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 4457-4464
    • Dodge, I.L.1    Carr, M.W.2    Cernadas, M.3    Brenner, M.B.4
  • 21
    • 45149123617 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Exp. Med. 205, 1369-1379 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1369-1379
    • Suto, A.1
  • 22
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang, A. et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29, 127-137 (2008).
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1
  • 23
    • 63849275584 scopus 로고    scopus 로고
    • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    • Eddahri, F. et al. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113, 2426-2433 (2009).
    • (2009) Blood , vol.113 , pp. 2426-2433
    • Eddahri, F.1
  • 24
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells toregulate Bcl-6 expression and germinal center responses
    • Linterman, M. A. et al. IL-21 acts directly on B cells toregulate Bcl-6 expression and germinal center responses. J. Exp. Med. 207, 353-363 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 353-363
    • Linterman, M.A.1
  • 25
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos, D. et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J. Exp. Med. 207, 365-378 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 365-378
    • Zotos, D.1
  • 26
    • 79952637807 scopus 로고    scopus 로고
    • IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation
    • Eto, D. et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS ONE 6, e17739 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e17739
    • Eto, D.1
  • 27
    • 77955924180 scopus 로고    scopus 로고
    • Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling
    • Deenick, E. K. et al. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33, 241-253 (2010).
    • (2010) Immunity , vol.33 , pp. 241-253
    • Deenick, E.K.1
  • 28
    • 80051618656 scopus 로고    scopus 로고
    • Cutting edge: Dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation
    • Goenka, R. et al. Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation. J. Immunol. 187, 1091-1095 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 1091-1095
    • Goenka, R.1
  • 29
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi, Y. S. et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34, 1-15 (2011).
    • (2011) Immunity , vol.34 , pp. 1-15
    • Choi, Y.S.1
  • 30
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet, A. T. et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10, 167-175 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 167-175
    • Bauquet, A.T.1
  • 31
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence, A. et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26, 371-381 (2007).
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1
  • 32
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato, A. et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36, 847-856 (2012).
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1
  • 34
    • 84859487740 scopus 로고    scopus 로고
    • STAT5 negatively regulates T follicular helper (Tfh) cell generation and function
    • Nurieva, R. I. et al. STAT5 negatively regulates T follicular helper (Tfh) cell generation and function. J. Biol. Chem. 287, 11234-11239 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 11234-11239
    • Nurieva, R.I.1
  • 36
    • 84873640954 scopus 로고    scopus 로고
    • Transcriptional regulation of follicular T-helper (Tfh) cells
    • Liu, X., Nurieva, R. I. & Dong, C. Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol. Rev. 252, 139-145 (2013).
    • (2013) Immunol. Rev. , vol.252 , pp. 139-145
    • Liu, X.1    Nurieva, R.I.2    Dong, C.3
  • 37
    • 79956081339 scopus 로고    scopus 로고
    • The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
    • Ise, W. et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat. Immunol. 12, 536-543 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 536-543
    • Ise, W.1
  • 38
    • 84861872906 scopus 로고    scopus 로고
    • Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
    • Bollig, N. et al. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc. Natl Acad. Sci. USA 109, 8664-8669 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 8664-8669
    • Bollig, N.1
  • 39
    • 84875417243 scopus 로고    scopus 로고
    • Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation
    • Choi, Y. S., Eto, D., Yang, J. A., Lao, C. & Crotty, S. Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation. J. Immunol. 190, 3049-3053 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 3049-3053
    • Choi, Y.S.1    Eto, D.2    Yang, J.A.3    Lao, C.4    Crotty, S.5
  • 40
    • 84896372779 scopus 로고    scopus 로고
    • Transcription factor STAT3 and type i interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells
    • Ray, J. P. et al. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity 40, 367-377 (2014).
    • (2014) Immunity , vol.40 , pp. 367-377
    • Ray, J.P.1
  • 41
    • 84859711557 scopus 로고    scopus 로고
    • Functional STAT3 deficiency compromises the generation of human T follicular helper cells
    • Ma, C. S. et al. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood 11 9, 3997-4008 (2012).
    • (2012) Blood , vol.119 , pp. 3997-4008
    • Ma, C.S.1
  • 42
    • 84877332319 scopus 로고    scopus 로고
    • IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans
    • Schmitt, N. et al. IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans. Blood 121, 3375-3385 (2013).
    • (2013) Blood , vol.121 , pp. 3375-3385
    • Schmitt, N.1
  • 43
    • 84939603374 scopus 로고    scopus 로고
    • The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection
    • Xu, L. et al. The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection. Nat. Immunol. 16, 991-999 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 991-999
    • Xu, L.1
  • 44
    • 84939617686 scopus 로고    scopus 로고
    • FH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
    • FH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat. Immunol. 16, 980-990 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 980-990
    • Choi, Y.S.1
  • 45
    • 84942825205 scopus 로고    scopus 로고
    • TCF1 is required for the T follicular helper cell response to viral infection
    • Wu, T. et al. TCF1 is required for the T follicular helper cell response to viral infection. Cell Rep. 12, 2099-2110 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 2099-2110
    • Wu, T.1
  • 46
    • 84902653708 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells
    • Xiao, N. et al. The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Nat. Immunol. 15, 657-666 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 657-666
    • Xiao, N.1
  • 47
    • 84923044855 scopus 로고    scopus 로고
    • ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation
    • Stone, E. L. et al. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity 42, 239-251 (2015).
    • (2015) Immunity , vol.42 , pp. 239-251
    • Stone, E.L.1
  • 48
    • 84902659927 scopus 로고    scopus 로고
    • The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells
    • Wang, H. et al. The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nat. Immunol. 15, 667-675 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 667-675
    • Wang, H.1
  • 49
    • 84897954312 scopus 로고    scopus 로고
    • Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development
    • Liu, X. et al. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature 507, 513-518 (2014).
    • (2014) Nature , vol.507 , pp. 513-518
    • Liu, X.1
  • 50
    • 84922695639 scopus 로고    scopus 로고
    • ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2
    • Weber, J. P. et al. ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2. J. Exp. Med. 212, 217-233 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 217-233
    • Weber, J.P.1
  • 51
    • 84922965713 scopus 로고    scopus 로고
    • + T follicular helper cell differentiation
    • + T follicular helper cell differentiation. Immunity 42, 252-264 (2015).
    • (2015) Immunity , vol.42 , pp. 252-264
    • Lee, J.Y.1
  • 52
    • 84928253323 scopus 로고    scopus 로고
    • BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms
    • Hatzi, K. et al. BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms. J. Exp. Med. 212, 539-553 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 539-553
    • Hatzi, K.1
  • 53
    • 82055177182 scopus 로고    scopus 로고
    • How T cells earn the follicular rite of passage
    • Vinuesa, C. G. & Cyster, J. G. How T cells earn the follicular rite of passage. Immunity 35, 671-680 (2011).
    • (2011) Immunity , vol.35 , pp. 671-680
    • Vinuesa, C.G.1    Cyster, J.G.2
  • 54
    • 33846400415 scopus 로고    scopus 로고
    • The germinal center response is impaired in the absence of T cell-expressed CXCR5
    • Arnold, C. N., Campbell, D. J., Lipp, M. & Butcher, E. C. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur. J. Immunol. 37, 100-109 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , pp. 100-109
    • Arnold, C.N.1    Campbell, D.J.2    Lipp, M.3    Butcher, E.C.4
  • 55
    • 84959088532 scopus 로고    scopus 로고
    • Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper cell differentiation
    • Liu, X. et al. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper cell differentiation. Cell Rep. 14, 1735-1747 (2016).
    • (2016) Cell Rep. , vol.14 , pp. 1735-1747
    • Liu, X.1
  • 56
    • 0345505646 scopus 로고    scopus 로고
    • Inhibition of Th2 differentiation and GATA-3 expression by BCL-6
    • Kusam, S., Toney, L. M., Sato, H. & Dent, A. L. Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J. Immunol. 170, 2435-2441 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 2435-2441
    • Kusam, S.1    Toney, L.M.2    Sato, H.3    Dent, A.L.4
  • 57
    • 77952780554 scopus 로고    scopus 로고
    • Transcriptional repressor BCL6 controls Th17 responses by controlling gene expression in both T cells and macrophages
    • Mondal, A., Sawant, D. & Dent, A. L. Transcriptional repressor BCL6 controls Th17 responses by controlling gene expression in both T cells and macrophages. J. Immunol. 184, 4123-4132 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 4123-4132
    • Mondal, A.1    Sawant, D.2    Dent, A.L.3
  • 58
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt, R. L., Liang, H. E. & Locksley, R. M. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 10, 385-393 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 59
    • 65549134481 scopus 로고    scopus 로고
    • T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    • Zaretsky, A. G. et al. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J. Exp. Med. 206, 991-999 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 991-999
    • Zaretsky, A.G.1
  • 60
    • 77955280012 scopus 로고    scopus 로고
    • Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
    • Yusuf, I. et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J. Immunol. 185, 190-202 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 190-202
    • Yusuf, I.1
  • 61
    • 84875473675 scopus 로고    scopus 로고
    • Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses
    • Hirota, K. et al. Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat. Immunol. 14, 372-379 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 372-379
    • Hirota, K.1
  • 62
    • 84958121940 scopus 로고    scopus 로고
    • T follicular helper cell plasticity shapes pathogenic T helper 2 cell-mediated immunity to inhaled house dust mite
    • Ballesteros-Tato, A. et al. T follicular helper cell plasticity shapes pathogenic T helper 2 cell-mediated immunity to inhaled house dust mite. Immunity 44, 259-273 (2016).
    • (2016) Immunity , vol.44 , pp. 259-273
    • Ballesteros-Tato, A.1
  • 63
    • 78751690647 scopus 로고    scopus 로고
    • + T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • + T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 34, 108-121 (2011).
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1
  • 64
    • 84869213212 scopus 로고    scopus 로고
    • Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers
    • Lee, S. K. et al. Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. Immunity 37, 880-892 (2012).
    • (2012) Immunity , vol.37 , pp. 880-892
    • Lee, S.K.1
  • 65
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki, K. et al. A critical role for IL-21 in regulating immunoglobulin production. Science 298, 1630-1634 (2002).
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1
  • 66
    • 77956273246 scopus 로고    scopus 로고
    • Proinflammatory T helper type 17 cells are effective B-cell helpers
    • Mitsdoerffer, M. et al. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc. Natl Acad. Sci. USA 107, 14292-14297 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 14292-14297
    • Mitsdoerffer, M.1
  • 67
    • 84911132031 scopus 로고    scopus 로고
    • Bcl-6 directly represses the gene program of the glycolysis pathway
    • Oestreich, K. J. et al. Bcl-6 directly represses the gene program of the glycolysis pathway. Nat. Immunol. 15, 957-964 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 957-964
    • Oestreich, K.J.1
  • 68
    • 84866562625 scopus 로고    scopus 로고
    • Metabolic checkpoints in activated T cells
    • Wang, R. & Green, D. R. Metabolic checkpoints in activated T cells. Nat. Immunol. 13, 907-915 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 907-915
    • Wang, R.1    Green, D.R.2
  • 69
    • 84944681622 scopus 로고    scopus 로고
    • The Interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells
    • Ray, J. P. et al. The Interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells. Immunity 43, 690-702 (2015).
    • (2015) Immunity , vol.43 , pp. 690-702
    • Ray, J.P.1
  • 70
    • 75649136214 scopus 로고    scopus 로고
    • Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
    • Crotty, S., Johnston, R. J. & Schoenberger, S. P. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat. Immunol. 11, 114-120 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 114-120
    • Crotty, S.1    Johnston, R.J.2    Schoenberger, S.P.3
  • 71
    • 80755172184 scopus 로고    scopus 로고
    • Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    • Pepper, M., Pagan, A. J., Igyarto, B. Z., Taylor, J. J. & Jenkins, M. K. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35, 583-595 (2011).
    • (2011) Immunity , vol.35 , pp. 583-595
    • Pepper, M.1    Pagan, A.J.2    Igyarto, B.Z.3    Taylor, J.J.4    Jenkins, M.K.5
  • 73
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • Zhu, J., Yamane, H. & Paul, W. E. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 28, 445-489 (2010).
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 74
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea, J. J. & Paul, W. E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327, 1098-1102 (2010).
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 75
    • 84908148200 scopus 로고    scopus 로고
    • T follicular helper cell differentiation, function, and roles in disease
    • Crotty, S. T follicular helper cell differentiation, function, and roles in disease. Immunity 41, 529-542 (2014).
    • (2014) Immunity , vol.41 , pp. 529-542
    • Crotty, S.1
  • 76
    • 80755136623 scopus 로고    scopus 로고
    • Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells
    • Lu, K. T. et al. Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity 35, 622-632 (2011).
    • (2011) Immunity , vol.35 , pp. 622-632
    • Lu, K.T.1
  • 78
    • 0030900762 scopus 로고    scopus 로고
    • The changing preference of T and B cells for partners as T-dependent antibody responses develop
    • MacLennan, I. C. et al. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol. Rev. 156, 53-66 (1997).
    • (1997) Immunol. Rev. , vol.156 , pp. 53-66
    • MacLennan, I.C.1
  • 81
    • 0035804254 scopus 로고    scopus 로고
    • ICOS co-stimulatory receptor is essential for T-cell activation and function
    • Dong, C. et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409, 97-101 (2001).
    • (2001) Nature , vol.409 , pp. 97-101
    • Dong, C.1
  • 82
    • 0035804268 scopus 로고    scopus 로고
    • ICOS is critical for CD40-mediated antibody class switching
    • McAdam, A. J. et al. ICOS is critical for CD40-mediated antibody class switching. Nature 409, 102-105 (2001).
    • (2001) Nature , vol.409 , pp. 102-105
    • McAdam, A.J.1
  • 83
    • 0035804269 scopus 로고    scopus 로고
    • ICOS is essential for effective T-helper-cell responses
    • Tafuri, A. et al. ICOS is essential for effective T-helper-cell responses. Nature 409, 105-109 (2001).
    • (2001) Nature , vol.409 , pp. 105-109
    • Tafuri, A.1
  • 84
    • 0037448564 scopus 로고    scopus 로고
    • SAP is required for generating long-term humoral immunity
    • Crotty, S., Kersh, E. N., Cannons, J., Schwartzberg, P. L. & Ahmed, R. SAP is required for generating long-term humoral immunity. Nature 421, 282-287 (2003).
    • (2003) Nature , vol.421 , pp. 282-287
    • Crotty, S.1    Kersh, E.N.2    Cannons, J.3    Schwartzberg, P.L.4    Ahmed, R.5
  • 85
    • 0032479526 scopus 로고    scopus 로고
    • Visualization of specific B and T lymphocyte interactions in the lymph node
    • Garside, P. et al. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281, 96-99 (1998).
    • (1998) Science , vol.281 , pp. 96-99
    • Garside, P.1
  • 86
    • 4744355547 scopus 로고    scopus 로고
    • Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction
    • Cunningham, A. F., Serre, K., Mohr, E., Khan, M. & Toellner, K. M. Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction. Immunology 113, 187-193 (2004).
    • (2004) Immunology , vol.113 , pp. 187-193
    • Cunningham, A.F.1    Serre, K.2    Mohr, E.3    Khan, M.4    Toellner, K.M.5
  • 87
    • 33746069706 scopus 로고    scopus 로고
    • Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
    • Lesley, R., Kelly, L. M., Xu, Y. & Cyster, J. G. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc. Natl Acad. Sci. USA 103, 10717-10722 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 10717-10722
    • Lesley, R.1    Kelly, L.M.2    Xu, Y.3    Cyster, J.G.4
  • 88
    • 0034665088 scopus 로고    scopus 로고
    • + T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo
    • + T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo. J. Immunol. 165, 3136-3144 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 3136-3144
    • Smith, K.M.1
  • 89
    • 21844450539 scopus 로고    scopus 로고
    • Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    • Okada, T. et al. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 3, e150 (2005).
    • (2005) PLoS Biol. , vol.3 , pp. e150
    • Okada, T.1
  • 90
    • 70349249529 scopus 로고    scopus 로고
    • Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts
    • Chan, T. D. et al. Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts. J. Immunol. 183, 3139-3149 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 3139-3149
    • Chan, T.D.1
  • 91
    • 79958255209 scopus 로고    scopus 로고
    • A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center
    • Schwickert, T. A. et al. A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J. Exp. Med. 208, 1243-1252 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1243-1252
    • Schwickert, T.A.1
  • 92
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T- B cell interactions underlie germinal centre formation
    • Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L. & Germain, R. N. SAP-controlled T- B cell interactions underlie germinal centre formation. Nature 455, 764-769 (2008).
    • (2008) Nature , vol.455 , pp. 764-769
    • Qi, H.1    Cannons, J.L.2    Klauschen, F.3    Schwartzberg, P.L.4    Germain, R.N.5
  • 93
    • 84907495013 scopus 로고    scopus 로고
    • SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions
    • Chu, C. et al. SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions. J. Immunol. 193, 3860-3871 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 3860-3871
    • Chu, C.1
  • 94
    • 58849137120 scopus 로고    scopus 로고
    • A novel ICOS-independent, but CD28-and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine
    • Chen, Q. et al. A novel ICOS-independent, but CD28-and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine. J. Immunol. 181, 8258-8266 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8258-8266
    • Chen, Q.1
  • 95
    • 79960342424 scopus 로고    scopus 로고
    • B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
    • Lee, S. K. et al. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J. Exp. Med. 208, 1377-1388 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1377-1388
    • Lee, S.K.1
  • 96
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen, C. D., Okada, T., Tang, H. L. & Cyster, J. G. Imaging of germinal center selection events during affinity maturation. Science 315, 528-531 (2007).
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 97
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot, S. M. et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 34, 947-960 (2011).
    • (2011) Immunity , vol.34 , pp. 947-960
    • Kerfoot, S.M.1
  • 98
    • 84907272327 scopus 로고    scopus 로고
    • Dynamic signaling by T follicular helper cells during germinal center B cell selection
    • Shulman, Z. et al. Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science 345, 1058-1062 (2014).
    • (2014) Science , vol.345 , pp. 1058-1062
    • Shulman, Z.1
  • 99
    • 84923778281 scopus 로고    scopus 로고
    • T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
    • Liu, D. et al. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature 517, 214-218 (2015).
    • (2015) Nature , vol.517 , pp. 214-218
    • Liu, D.1
  • 100
    • 78149477766 scopus 로고    scopus 로고
    • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    • Victora, G. D. et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143, 592-605 (2010).
    • (2010) Cell , vol.143 , pp. 592-605
    • Victora, G.D.1
  • 101
    • 84883801440 scopus 로고    scopus 로고
    • Diversity among memory B cells: Origin, consequences, and utility
    • Tarlinton, D. & Good-Jacobson, K. Diversity among memory B cells: origin, consequences, and utility. Science 341, 1205-1211 (2013).
    • (2013) Science , vol.341 , pp. 1205-1211
    • Tarlinton, D.1    Good-Jacobson, K.2
  • 102
    • 0028939698 scopus 로고
    • + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex
    • + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181, 1293-1301 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 1293-1301
    • Casamayor-Palleja, M.1    Khan, M.2    MacLennan, I.C.3
  • 103
    • 84901644301 scopus 로고    scopus 로고
    • Clonal selection in the germinal centre by regulated proliferation and hypermutation
    • Gitlin, A. D., Shulman, Z. & Nussenzweig, M. C. Clonal selection in the germinal centre by regulated proliferation and hypermutation. Nature 509, 637-640 (2014).
    • (2014) Nature , vol.509 , pp. 637-640
    • Gitlin, A.D.1    Shulman, Z.2    Nussenzweig, M.C.3
  • 104
    • 0038675204 scopus 로고    scopus 로고
    • Extrafollicular antibody responses
    • MacLennan, I. C. et al. Extrafollicular antibody responses. Immunol. Rev. 194, 8-18 (2003).
    • (2003) Immunol. Rev. , vol.194 , pp. 8-18
    • MacLennan, I.C.1
  • 105
    • 47249097068 scopus 로고    scopus 로고
    • The role of IL-21 in regulating B-cell function in health and disease
    • Ettinger, R., Kuchen, S. & Lipsky, P. E. The role of IL-21 in regulating B-cell function in health and disease. Immunol. Rev. 223, 60-86 (2008).
    • (2008) Immunol. Rev. , vol.223 , pp. 60-86
    • Ettinger, R.1    Kuchen, S.2    Lipsky, P.E.3
  • 106
    • 84866320759 scopus 로고    scopus 로고
    • Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas
    • Victora, G. D. et al. Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood 120, 2240-2248 (2012).
    • (2012) Blood , vol.120 , pp. 2240-2248
    • Victora, G.D.1
  • 107
    • 84859897308 scopus 로고    scopus 로고
    • The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
    • Luthje, K. et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat. Immunol. 13, 491-498 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 491-498
    • Luthje, K.1
  • 108
    • 84928211881 scopus 로고    scopus 로고
    • T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses
    • Suan, D. et al. T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses. Immunity 42, 704-718 (2015).
    • (2015) Immunity , vol.42 , pp. 704-718
    • Suan, D.1
  • 109
    • 77956944349 scopus 로고    scopus 로고
    • Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel
    • Chen, G. et al. Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. J. Immunol. 185, 2350-2359 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 2350-2359
    • Chen, G.1
  • 110
    • 0032550353 scopus 로고    scopus 로고
    • T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching
    • Toellner, K. M. et al. T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J. Exp. Med. 187, 1193-1204 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 1193-1204
    • Toellner, K.M.1
  • 111
    • 33344458030 scopus 로고    scopus 로고
    • T cells use two directionally distinct pathways for cytokine secretion
    • Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S. & Davis, M. M. T cells use two directionally distinct pathways for cytokine secretion. Nat. Immunol. 7, 247-255 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 247-255
    • Huse, M.1    Lillemeier, B.F.2    Kuhns, M.S.3    Chen, D.S.4    Davis, M.M.5
  • 112
    • 0025978984 scopus 로고
    • Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells
    • Kupfer, A., Mosmann, T. R. & Kupfer, H. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc. Natl Acad. Sci. USA 88, 775-779 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 775-779
    • Kupfer, A.1    Mosmann, T.R.2    Kupfer, H.3
  • 113
    • 4944266186 scopus 로고    scopus 로고
    • A role for the immunological synapse in lineage commitment of CD4 lymphocytes
    • Maldonado, R. A., Irvine, D. J., Schreiber, R. & Glimcher, L. H. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431, 527-532 (2004).
    • (2004) Nature , vol.431 , pp. 527-532
    • Maldonado, R.A.1    Irvine, D.J.2    Schreiber, R.3    Glimcher, L.H.4
  • 114
    • 79952201000 scopus 로고    scopus 로고
    • Understanding the structure and function of the immunological synapse
    • Dustin, M. L., Chakraborty, A. K. & Shaw, A. S. Understanding the structure and function of the immunological synapse. Cold Spring Harb Perspect Biol 2, a002311 (2010).
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , pp. a002311
    • Dustin, M.L.1    Chakraborty, A.K.2    Shaw, A.S.3
  • 115
    • 13844296663 scopus 로고    scopus 로고
    • Immunological synapses are versatile structures enabling selective T cell polarization
    • Depoil, D. et al. Immunological synapses are versatile structures enabling selective T cell polarization. Immunity 22, 185-194 (2005).
    • (2005) Immunity , vol.22 , pp. 185-194
    • Depoil, D.1
  • 116
    • 84891808033 scopus 로고    scopus 로고
    • Follicular T-helper cells: Controlled localization and cellular interactions
    • Qi, H. et al. Follicular T-helper cells: controlled localization and cellular interactions. Immunol. Cell Biol. 92, 28-33 (2014).
    • (2014) Immunol. Cell Biol. , vol.92 , pp. 28-33
    • Qi, H.1
  • 117
    • 0015631780 scopus 로고
    • Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates
    • Katz, D. H., Hamaoka, T. & Benacerraf, B. Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates. J. Exp. Med. 137, 1405-1418 (1973).
    • (1973) J. Exp. Med. , vol.137 , pp. 1405-1418
    • Katz, D.H.1    Hamaoka, T.2    Benacerraf, B.3
  • 118
    • 0011909429 scopus 로고
    • Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions
    • Katz, D. H., Hamaoka, T., Dorf, M. E. & Benacerraf, B. Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions. Proc. Natl Acad. Sci. USA 70, 2624-2628 (1973).
    • (1973) Proc. Natl Acad. Sci. USA , vol.70 , pp. 2624-2628
    • Katz, D.H.1    Hamaoka, T.2    Dorf, M.E.3    Benacerraf, B.4
  • 119
    • 0018746961 scopus 로고
    • Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells
    • Singer, A., Hathcock, K. S. & Hodes, R. J. Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells. J. Exp. Med. 149, 1208-1226 (1979).
    • (1979) J. Exp. Med. , vol.149 , pp. 1208-1226
    • Singer, A.1    Hathcock, K.S.2    Hodes, R.J.3
  • 120
    • 0018857773 scopus 로고
    • Cellular and genetic control of antibody responses. VIII. MHC restricted recognition of accessory cells, not B cells, by parent-specific subpopulations of normal F1 T helper cells
    • Singer, A., Hathcock, K. S. & Hodes, R. J. Cellular and genetic control of antibody responses. VIII. MHC restricted recognition of accessory cells, not B cells, by parent-specific subpopulations of normal F1 T helper cells. J. Immunol. 124, 1079-1085 (1980).
    • (1980) J. Immunol. , vol.124 , pp. 1079-1085
    • Singer, A.1    Hathcock, K.S.2    Hodes, R.J.3
  • 121
    • 84894082425 scopus 로고    scopus 로고
    • Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues
    • Honda, T. et al. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity 40, 235-247 (2014).
    • (2014) Immunity , vol.40 , pp. 235-247
    • Honda, T.1
  • 122
    • 0042847271 scopus 로고    scopus 로고
    • Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling
    • Faroudi, M., Zaru, R., Paulet, P., Muller, S. & Valitutti, S. Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling. J. Immunol. 171, 1128-1132 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 1128-1132
    • Faroudi, M.1    Zaru, R.2    Paulet, P.3    Muller, S.4    Valitutti, S.5
  • 123
    • 79955738613 scopus 로고    scopus 로고
    • A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation
    • Clark, C. E., Hasan, M. & Bousso, P. A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation. PLoS ONE 6, e18916 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e18916
    • Clark, C.E.1    Hasan, M.2    Bousso, P.3
  • 124
    • 84874273811 scopus 로고    scopus 로고
    • The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells
    • Marangoni, F. et al. The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity 38, 237-249 (2013).
    • (2013) Immunity , vol.38 , pp. 237-249
    • Marangoni, F.1
  • 125
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber, D. L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687 (2006).
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 126
    • 84866559149 scopus 로고    scopus 로고
    • Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1
    • Xiao, G., Deng, A., Liu, H., Ge, G. & Liu, X. Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1. Proc. Natl Acad. Sci. USA 109, 15419-15424 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 15419-15424
    • Xiao, G.1    Deng, A.2    Liu, H.3    Ge, G.4    Liu, X.5
  • 127
    • 84945446955 scopus 로고    scopus 로고
    • Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells
    • Chen, X., Ma, W., Zhang, T., Wu, L. & Qi, H. Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells. Protein Cell 6, 825-832 (2015).
    • (2015) Protein Cell , vol.6 , pp. 825-832
    • Chen, X.1    Ma, W.2    Zhang, T.3    Wu, L.4    Qi, H.5
  • 128
    • 84875549975 scopus 로고    scopus 로고
    • Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
    • Baumjohann, D. et al. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity 38, 596-605 (2013).
    • (2013) Immunity , vol.38 , pp. 596-605
    • Baumjohann, D.1
  • 129
    • 84862988085 scopus 로고    scopus 로고
    • The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development
    • Kageyama, R. et al. The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity 36, 986-1002 (2012).
    • (2012) Immunity , vol.36 , pp. 986-1002
    • Kageyama, R.1
  • 130
    • 84965000305 scopus 로고    scopus 로고
    • A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center T cells via the kinase TBK1
    • Pedros, C. et al. A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center T cells via the kinase TBK1. Nat. Immunol, http://dx.doi.org/10.1038/ni.3463 (2016).
    • (2016) Nat. Immunol
    • Pedros, C.1
  • 131
    • 84859709856 scopus 로고    scopus 로고
    • From SAP-less T cells to helpless B cells and back: Dynamic T- B cell interactions underlie germinal center development and function
    • Qi, H. From SAP-less T cells to helpless B cells and back: dynamic T- B cell interactions underlie germinal center development and function. Immunol. Rev. 247, 24-35 (2012).
    • (2012) Immunol. Rev. , vol.247 , pp. 24-35
    • Qi, H.1
  • 132
    • 84876793426 scopus 로고    scopus 로고
    • Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility
    • Xu, H. et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496, 523-527 (2013).
    • (2013) Nature , vol.496 , pp. 523-527
    • Xu, H.1
  • 133
    • 41849128523 scopus 로고    scopus 로고
    • The FoxO code
    • Calnan, D. R. & Brunet, A. The FoxO code. Oncogene 27, 2276-2288 (2008).
    • (2008) Oncogene , vol.27 , pp. 2276-2288
    • Calnan, D.R.1    Brunet, A.2
  • 134
    • 58449102260 scopus 로고    scopus 로고
    • Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    • Kerdiles, Y. M. et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat. Immunol. 10, 176-184 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 176-184
    • Kerdiles, Y.M.1
  • 135
    • 84920956940 scopus 로고    scopus 로고
    • A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells
    • Leavenworth, J. W., Verbinnen, B., Yin, J., Huang, H. & Cantor, H. A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat. Immunol. 16, 96-106 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 96-106
    • Leavenworth, J.W.1    Verbinnen, B.2    Yin, J.3    Huang, H.4    Cantor, H.5
  • 136
    • 73949090666 scopus 로고    scopus 로고
    • Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
    • Gigoux, M. et al. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc. Natl Acad. Sci. USA 106, 20371-20376 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 20371-20376
    • Gigoux, M.1
  • 137
    • 84880767787 scopus 로고    scopus 로고
    • FH differentiation
    • FH differentiation. Nat. Immunol. 14, 849-857 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 849-857
    • Kang, S.G.1
  • 138
    • 84880778954 scopus 로고    scopus 로고
    • FH cell differentiation and represses subset-inappropriate gene expression
    • FH cell differentiation and represses subset-inappropriate gene expression. Nat. Immunol. 14, 840-848 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 840-848
    • Baumjohann, D.1
  • 139
    • 39749163245 scopus 로고    scopus 로고
    • Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    • Xiao, C. et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat. Immunol. 9, 405-414 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 405-414
    • Xiao, C.1
  • 140
    • 84876781274 scopus 로고    scopus 로고
    • Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation
    • Vogel, K. U. et al. Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 38, 655-668 (2013).
    • (2013) Immunity , vol.38 , pp. 655-668
    • Vogel, K.U.1
  • 141
    • 84876775237 scopus 로고    scopus 로고
    • Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation
    • Pratama, A. et al. Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Immunity 38, 669-680 (2013).
    • (2013) Immunity , vol.38 , pp. 669-680
    • Pratama, A.1
  • 142
    • 84923365460 scopus 로고    scopus 로고
    • MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres
    • Pratama, A. et al. MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres. Nat. Commun. 6, 6436 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6436
    • Pratama, A.1
  • 143
    • 33749382321 scopus 로고    scopus 로고
    • Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells
    • Tan, A. H., Wong, S. C. & Lam, K. P. Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells. J. Biol. Chem. 281, 28666-28678 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 28666-28678
    • Tan, A.H.1    Wong, S.C.2    Lam, K.P.3
  • 144
    • 84930211068 scopus 로고    scopus 로고
    • Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue
    • Qi, H., Kastenmuller, W. & Germain, R. N. Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue. Ann. Rev. Cell Dev. Biol. 30, 141-167 (2014).
    • (2014) Ann. Rev. Cell Dev. Biol. , vol.30 , pp. 141-167
    • Qi, H.1    Kastenmuller, W.2    Germain, R.N.3
  • 145
    • 84877710866 scopus 로고    scopus 로고
    • + T cells from a diverse repertoire produce different effector cell types during infection
    • + T cells from a diverse repertoire produce different effector cell types during infection. Cell 153, 785-796 (2013).
    • (2013) Cell , vol.153 , pp. 785-796
    • Tubo, N.J.1
  • 146
    • 0028892141 scopus 로고
    • The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene
    • Fukuda, T. et al. The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. Oncogene 11, 1657-1663 (1995).
    • (1995) Oncogene , vol.11 , pp. 1657-1663
    • Fukuda, T.1
  • 147
    • 80052649061 scopus 로고    scopus 로고
    • Cutting edge: Distinct waves of BCL6 expression during T follicular helper cell development
    • Baumjohann, D., Okada, T. & Ansel, K. M. Cutting edge: distinct waves of BCL6 expression during T follicular helper cell development. J. Immunol. 187, 2089-2092 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 2089-2092
    • Baumjohann, D.1    Okada, T.2    Ansel, K.M.3
  • 148
    • 0347717903 scopus 로고    scopus 로고
    • T-Cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel, T. R., Henrickson, S. E. & Von Andrian, U. H. T-Cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154-159 (2004).
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 150
    • 0037036114 scopus 로고    scopus 로고
    • Dynamic imaging of T cell-dendritic cell interactions in lymph nodes
    • Stoll, S., Delon, J., Brotz, T. M. & Germain, R. N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873-1876 (2002).
    • (2002) Science , vol.296 , pp. 1873-1876
    • Stoll, S.1    Delon, J.2    Brotz, T.M.3    Germain, R.N.4
  • 151
    • 81055157812 scopus 로고    scopus 로고
    • Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
    • Harker, J. A., Lewis, G. M., Mack, L. & Zuniga, E. I. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 334, 825-829 (2011).
    • (2011) Science , vol.334 , pp. 825-829
    • Harker, J.A.1    Lewis, G.M.2    Mack, L.3    Zuniga, E.I.4
  • 152
    • 84896510761 scopus 로고    scopus 로고
    • FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability
    • Leon, B., Bradley, J. E., Lund, F. E., Randall, T. D. & Ballesteros-Tato, A. FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability. Nat. Commun. 5, 3495 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3495
    • Leon, B.1    Bradley, J.E.2    Lund, F.E.3    Randall, T.D.4    Ballesteros-Tato, A.5
  • 153
    • 84990310424 scopus 로고    scopus 로고
    • The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa
    • Marshall, H. D. et al. The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. Elife 4, e04851 (2015).
    • (2015) Elife , vol.4 , pp. e04851
    • Marshall, H.D.1
  • 154
    • 24744448228 scopus 로고    scopus 로고
    • Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
    • Hardtke, S., Ohl, L. & Forster, R. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106, 1924-1931 (2005).
    • (2005) Blood , vol.106 , pp. 1924-1931
    • Hardtke, S.1    Ohl, L.2    Forster, R.3
  • 155
    • 84971254846 scopus 로고    scopus 로고
    • EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
    • Li, J., Lu, E., Yi, T. & Cyster, J. G. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature 533, 110-114 (2016).
    • (2016) Nature , vol.533 , pp. 110-114
    • Li, J.1    Lu, E.2    Yi, T.3    Cyster, J.G.4
  • 156
    • 0142219442 scopus 로고    scopus 로고
    • Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
    • Shapiro-Shelef, M. et al. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19, 607-620 (2003).
    • (2003) Immunity , vol.19 , pp. 607-620
    • Shapiro-Shelef, M.1
  • 157
    • 42649120075 scopus 로고    scopus 로고
    • Regulation and functions of Blimp-1 in T and B lymphocytes
    • Martins, G. & Calame, K. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu. Rev. Immunol. 26, 133-169 (2008).
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 133-169
    • Martins, G.1    Calame, K.2
  • 158
    • 84903751744 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers
    • Moriyama, S. et al. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J. Exp. Med. 211, 1297-1305 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1297-1305
    • Moriyama, S.1
  • 159
    • 84881252552 scopus 로고    scopus 로고
    • T follicular helper cell dynamics in germinal centers
    • Shulman, Z. et al. T follicular helper cell dynamics in germinal centers. Science 341, 673-677 (2013).
    • (2013) Science , vol.341 , pp. 673-677
    • Shulman, Z.1
  • 160
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano, M. et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34, 961-972 (2011).
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1
  • 161
    • 84885741984 scopus 로고    scopus 로고
    • + T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
    • + T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity 39, 770-781 (2013).
    • (2013) Immunity , vol.39 , pp. 770-781
    • He, J.1
  • 162
    • 84885743368 scopus 로고    scopus 로고
    • + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    • + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity 39, 758-769 (2013).
    • (2013) Immunity , vol.39 , pp. 758-769
    • Locci, M.1
  • 163
    • 84875129611 scopus 로고    scopus 로고
    • Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination
    • Bentebibel, S. E. et al. Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Sci. Transl Med. 5, 176ra132 (2013).
    • (2013) Sci. Transl Med. , vol.5 , pp. 176ra132
    • Bentebibel, S.E.1
  • 164
    • 84864742274 scopus 로고    scopus 로고
    • T-Follicular helper cells survive as long-term memory cells
    • Weber, J. P., Fuhrmann, F. & Hutloff, A. T-Follicular helper cells survive as long-term memory cells. Eur. J. Immunol. 42, 1981-1988 (2012).
    • (2012) Eur. J. Immunol , vol.42 , pp. 1981-1988
    • Weber, J.P.1    Fuhrmann, F.2    Hutloff, A.3
  • 165
    • 34250765587 scopus 로고    scopus 로고
    • Lymphoid reservoirs of antigen-specific memory T helper cells
    • Fazilleau, N. et al. Lymphoid reservoirs of antigen-specific memory T helper cells. Nat. Immunol. 8, 753-761 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 753-761
    • Fazilleau, N.1
  • 166
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    • Fazilleau, N., McHeyzer-Williams, L. J., Rosen, H. & McHeyzer-Williams, M. G. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat. Immunol. 10, 375-384 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 167
    • 84870285173 scopus 로고    scopus 로고
    • Bcl6 expression specifies the T follicular helper cell program in vivo
    • Liu, X. et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J. Exp. Med. 209, 1841-1852 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1841-1852
    • Liu, X.1
  • 168
    • 84875444198 scopus 로고    scopus 로고
    • Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory
    • Choi, Y. S. et al. Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J. Immunol. 190, 4014-4026 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 4014-4026
    • Choi, Y.S.1
  • 169
    • 84876780521 scopus 로고    scopus 로고
    • + T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection
    • + T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity 38, 805-817 (2013).
    • (2013) Immunity , vol.38 , pp. 805-817
    • Hale, J.S.1
  • 170
    • 70450265288 scopus 로고    scopus 로고
    • FH) cell lineage is induced by IL-12
    • FH) cell lineage is induced by IL-12. Immunol. Cell Biol. 87, 590-600 (2009).
    • (2009) Immunol. Cell Biol. , vol.87 , pp. 590-600
    • Ma, C.S.1
  • 171
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: Function, generation, and maintenance
    • Sallusto, F., Geginat, J. & Lanzavecchia, A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22, 745-763 (2004).
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 173
    • 84255178198 scopus 로고    scopus 로고
    • Early Th1 cell differentiation is marked by a Tfh cell-like transition
    • Nakayamada, S. et al. Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 35, 919-931 (2011).
    • (2011) Immunity , vol.35 , pp. 919-931
    • Nakayamada, S.1
  • 174
    • 58849092225 scopus 로고    scopus 로고
    • Epigenetic control of T-helper-cell differentiation
    • Wilson, C. B., Rowell, E. & Sekimata, M. Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol. 9, 91-105 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 91-105
    • Wilson, C.B.1    Rowell, E.2    Sekimata, M.3
  • 175
    • 84859401055 scopus 로고    scopus 로고
    • Transcriptional and epigenetic control of T helper cell specification: Molecular mechanisms underlying commitment and plasticity
    • Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K. & O'Shea, J. J. Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30, 707-731 (2012).
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 707-731
    • Kanno, Y.1    Vahedi, G.2    Hirahara, K.3    Singleton, K.4    O'Shea, J.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.