Restoring function in exhausted CD8 T cells during chronic viral infection

Nature

Volumn 439, Issue 7077, 2006, Pages 682-687

  Barber, Daniel L ^a   Wherry, E John ^b   Masopust, David ^a   Zhu, Baogong ^c   Allison, James P ^d   Sharpe, Arlene H ^e   Freeman, Gordon J ^c   Ahmed, Rafi ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WISTAR INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; GENES; MEDICAL PROBLEMS; MOLECULAR STRUCTURE; PROTEINS; VIRUSES;

CD8 T CELLS; CHRONIC VIRAL INFECTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS (LCMV); T-CELL DYSFUNCTION;

CELLS;

CD8 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PROGRAMMED DEATH 1 PROTEIN; PROGRAMMED DEATH LIGAND 1 ANTIBODY; PROTEIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

MEDICINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; VIRUS INFECTION; VIRUS LOAD;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHRONIC DISEASE; GENE EXPRESSION REGULATION; IMMUNE TOLERANCE; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMBRANE GLYCOPROTEINS; MICE; PEPTIDES; SUBSTRATE SPECIFICITY; VIRUS DISEASES;

ANIMALIA; LYMPHOCYTIC CHORIOMENINGITIS VIRUS;

EID: 32544459770     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature04444     Document Type: Article

References (30)

1. Klenerman, P. & Hill, A. T cells and viral persistence: lessons from diverse infections. Nature Immunol. 6, 873-879 (2005).
2. Wherry, E. J., Barber, D. L., Kaech, S. M., Blattman, J. N. & Ahmed, R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad. Sci. USA 101, 16004-16009 (2004).
3. Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R. & Ahmed, R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77, 4911-4927 (2003).
4. Zajac, A. J. et al. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med 188, 2205-2213 (1998).
5. Gallimore, A. et al. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 187, 1383-1393 (1998).
6. Pantaleo, G. & Koup, R. A. Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nature Med. 10, 806-810 (2004).
7. Letvin, N. L. & Walker, B. D. Immunopathogenesis and immunotherapy in AIDS virus infections. Nature Med. 9, 861-866 (2003).
8. Rehermann, B. & Nascimbeni, M. Immunology of hepatitis B virus and hepatitis C virus infection. Nature Rev. Immunol. 5, 215-229 (2005).
9. Matloubian, M., Kolhekar, S. R., Somasundaram, T. & Ahmed, R. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 67, 7340-7349 (1993).
10. Ishida, Y., Agata, Y., Shibahara, K. & Honjo, T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11, 3887-3895 (1992).
11. Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999).
12. Sharpe, A. H. & Freeman, G. J. The B7-CD28 superfamily. Nature Rev. Immunol. 2, 116-126 (2002).
13. Chen, L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nature Rev. Immunol. 4, 336-347 (2004).
14. Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027-1034 (2000).
15. Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Med. 5, 1365-1369 (1999).
16. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68, 8056-8063 (1994).
17. + T-cell response. Nature Rev. Immunol. 4, 595-602 (2004).
18. Shin, T. et al. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J. Exp. Med. 201, 1531-1541 (2005).
19. Oflazoglu, E. et al. Paradoxical role of programmed death-1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo. Eur. J. Immunol. 34, 3326-3336 (2004).
20. Egen, J. G., Kuhns, M. S. & Allison, J. P. CTLA-4: new insights into its biological function and use in tumour immunotherapy. Nature Immunol. 3, 611-618 (2002).
21. + T cell tolerance through PD-1 and CTLA-4. Nature Immunol. 6, 280-286 (2005).
22. + T cell function during in vivo memory or tolerance induction. Immunity 8, 581-590 (1998).
23. + T cells. J. Exp. Med. 198, 1107-1117 (2003).
24. Iwai, Y., Terawaki, S., Ikegawa, M., Okazaki, T. & Honjo, T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 198, 39-50 (2003).
25. + T cell effector functions after antigen recognition in the liver. Immunity 23, 53-63 (2005).
26. Dudley, M. E. & Rosenberg, S. A. Adoptive-cell-transfer therapy for the treatment of patients with cancer. Nature Rev. Cancer 3, 666-675 (2003).
27. Autran, B., Carcelain, G., Combadiere, B. & Debre, P. Therapeutic vaccines for chronic infections. Science 305, 205-208 (2004).
28. Wherry, E. J., Blattman, J. N. & Ahmed, R. Low CD8 T-cell proliferate potential and high viral load limit the effectiveness of therapeutic vaccination. J. Virol. 79, 8960-8968 (2005).
29. + T cell activation and cytolysis. Eur. J. Immunol. 33, 3117-3126 (2003).
30. Kaech, S. M., Hemby, S., Kersh, E. & Ahmed, R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111, 837-851 (2002).