The interleukin 7 receptor is required for T cell receptor γ locus accessibility to the V(D)J recombinase

Journal of Experimental Medicine

Volumn 191, Issue 6, 2000, Pages 1045-1050

  Schlissel, Mark S ^a   Durum, Scott D ^b   Muegge, Kathrin ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chromatin; Immunology; Interleukins; Recombination; T lymphocytes

Indexed keywords

IMMUNOGLOBULIN J CHAIN; INTERLEUKIN 7 RECEPTOR; RECOMBINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CHROMATIN; DNA CLEAVAGE; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC RECOMBINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; DNA NUCLEOTIDYLTRANSFERASES; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; HOMEODOMAIN PROTEINS; HYDROLYSIS; INTEGRASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIGENE FAMILY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN-7; RECOMBINASES; RECOMBINATION, GENETIC; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 0034689009     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.6.1045     Document Type: Article

References (32)

1. IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions
2. Cell-fate decisions in early T cell development: Regulation by cytokine receptors and the pre-TCR
3. Interleukin-7: Physiological roles and mechanisms of action
4. + severe combined immunodeficiency
5. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immnnodeficiency in humans
6. Mutations of Jak-3 gene in patients with autosomal severe combined immunodeficiency (SCID)
7. The trophic action of IL-7 on pro-T cells: Inhibition of apoptosis of pro-Tl, T2 and T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways
8. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
9. - mice
10. The V-J recombination oft cell receptor γ genes is blocked in interleukin-7 receptor-deficient mice
11. Defective T-cell receptor γ gene rearrangement in interleukin 7 receptor knockout mice
12. Interlenkin 7 receptor control of T cell receptor gamma gene rearrangement: Role of receptor-associated chains and locus accessibility
13. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
14. Lymphoid development and function in IL-7R deficient mice
15. Double-straud signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, R. AG-dependent, and cell cycle regulated
16. Euhancer control of V(D)J recombination at the TCRbeta locus: Differential effects on DNA cleavage and joining
17. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
18. Developmental regulation of V(D)J recombination at the TCR alpha/delta locus
19. Accessibility and the developmental regulation of V(D)J recombination
20. VDJ recombination: A transposase goes to work
21. Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): Implications for TCR alpha locus accessibility
22. Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
23. Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain
24. Identification of a T-cell-specific transcriptional enhancer located 3' of Cγl in the routine T-cell receptor γ locus
25. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development
26. T cell receptor (TCR)-β gene recombination: Dissociation from cell cycle regulation and developmental progression during T cell ontogeny
27. CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intzathymic precursor cells
28. Induction of germline transcription in the TCRγ locus by Stat5: Implications for the accessibility control by the IL-7 receptor
29. Activation of immunoglobulin kappa gene rearrangement correlates with induction of kappa gene transcription
30. Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase
31. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1
32. Genomic organization of the T cell receptor genes in the mouse