메뉴 건너뛰기




Volumn 44, Issue 3, 2016, Pages 450-462

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

FIBROSIS; MACROPHAGE; MACROPHAGE ACTIVATION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TISSUE INJURY; TISSUE REGENERATION; TISSUE REPAIR; WOUND HEALING; ANIMAL; CELL COMMUNICATION; CELL DIFFERENTIATION; HUMAN; PATHOLOGY; PHYSIOLOGY; REGENERATION;

EID: 84960437624     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.02.015     Document Type: Review
Times cited : (2676)

References (129)
  • 4
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • Baeck C., Wehr A., Karlmark K.R., Heymann F., Vucur M., Gassler N., Huss S., Klussmann S., Eulberg D., Luedde T., et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 2012, 61:416-426.
    • (2012) Gut , vol.61 , pp. 416-426
    • Baeck, C.1    Wehr, A.2    Karlmark, K.R.3    Heymann, F.4    Vucur, M.5    Gassler, N.6    Huss, S.7    Klussmann, S.8    Eulberg, D.9    Luedde, T.10
  • 5
    • 84896707511 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice
    • Baeck C., Wei X., Bartneck M., Fech V., Heymann F., Gassler N., Hittatiya K., Eulberg D., Luedde T., Trautwein C., Tacke F. Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice. Hepatology 2014, 59:1060-1072.
    • (2014) Hepatology , vol.59 , pp. 1060-1072
    • Baeck, C.1    Wei, X.2    Bartneck, M.3    Fech, V.4    Heymann, F.5    Gassler, N.6    Hittatiya, K.7    Eulberg, D.8    Luedde, T.9    Trautwein, C.10    Tacke, F.11
  • 7
    • 0027104066 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors
    • Berse B., Brown L.F., Van de Water L., Dvorak H.F., Senger D.R. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell 1992, 3:211-220.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 211-220
    • Berse, B.1    Brown, L.F.2    Van de Water, L.3    Dvorak, H.F.4    Senger, D.R.5
  • 8
    • 84921284050 scopus 로고    scopus 로고
    • Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection
    • Blériot C., Dupuis T., Jouvion G., Eberl G., Disson O., Lecuit M. Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection. Immunity 2015, 42:145-158.
    • (2015) Immunity , vol.42 , pp. 145-158
    • Blériot, C.1    Dupuis, T.2    Jouvion, G.3    Eberl, G.4    Disson, O.5    Lecuit, M.6
  • 19
    • 84859060783 scopus 로고    scopus 로고
    • Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts
    • Chen G., Chen H., Wang C., Peng Y., Sun L., Liu H., Liu F. Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts. PLoS ONE 2012, 7:e33626.
    • (2012) PLoS ONE , vol.7 , pp. e33626
    • Chen, G.1    Chen, H.2    Wang, C.3    Peng, Y.4    Sun, L.5    Liu, H.6    Liu, F.7
  • 22
    • 84896808531 scopus 로고    scopus 로고
    • Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages
    • Cho D.I., Kim M.R., Jeong H.Y., Jeong H.C., Jeong M.H., Yoon S.H., Kim Y.S., Ahn Y. Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages. Exp. Mol. Med. 2014, 46:e70.
    • (2014) Exp. Mol. Med. , vol.46 , pp. e70
    • Cho, D.I.1    Kim, M.R.2    Jeong, H.Y.3    Jeong, H.C.4    Jeong, M.H.5    Yoon, S.H.6    Kim, Y.S.7    Ahn, Y.8
  • 23
    • 65549108648 scopus 로고    scopus 로고
    • Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis
    • Chujo S., Shirasaki F., Kondo-Miyazaki M., Ikawa Y., Takehara K. Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis. J. Cell. Physiol. 2009, 220:189-195.
    • (2009) J. Cell. Physiol. , vol.220 , pp. 189-195
    • Chujo, S.1    Shirasaki, F.2    Kondo-Miyazaki, M.3    Ikawa, Y.4    Takehara, K.5
  • 26
  • 29
    • 84866551217 scopus 로고    scopus 로고
    • IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration
    • Deng B., Wehling-Henricks M., Villalta S.A., Wang Y., Tidball J.G. IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration. J. Immunol. 2012, 189:3669-3680.
    • (2012) J. Immunol. , vol.189 , pp. 3669-3680
    • Deng, B.1    Wehling-Henricks, M.2    Villalta, S.A.3    Wang, Y.4    Tidball, J.G.5
  • 34
    • 84904401883 scopus 로고    scopus 로고
    • Origin and functions of tissue macrophages
    • Epelman S., Lavine K.J., Randolph G.J. Origin and functions of tissue macrophages. Immunity 2014, 41:21-35.
    • (2014) Immunity , vol.41 , pp. 21-35
    • Epelman, S.1    Lavine, K.J.2    Randolph, G.J.3
  • 35
    • 84896689625 scopus 로고    scopus 로고
    • High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury
    • Evans T.A., Barkauskas D.S., Myers J.T., Hare E.G., You J.Q., Ransohoff R.M., Huang A.Y., Silver J. High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Exp. Neurol. 2014, 254:109-120.
    • (2014) Exp. Neurol. , vol.254 , pp. 109-120
    • Evans, T.A.1    Barkauskas, D.S.2    Myers, J.T.3    Hare, E.G.4    You, J.Q.5    Ransohoff, R.M.6    Huang, A.Y.7    Silver, J.8
  • 37
    • 80054899779 scopus 로고    scopus 로고
    • Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    • Galli S.J., Borregaard N., Wynn T.A. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat. Immunol. 2011, 12:1035-1044.
    • (2011) Nat. Immunol. , vol.12 , pp. 1035-1044
    • Galli, S.J.1    Borregaard, N.2    Wynn, T.A.3
  • 39
    • 84878699191 scopus 로고    scopus 로고
    • Macrophages are required for adult salamander limb regeneration
    • Godwin J.W., Pinto A.R., Rosenthal N.A. Macrophages are required for adult salamander limb regeneration. Proc. Natl. Acad. Sci. USA 2013, 110:9415-9420.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 9415-9420
    • Godwin, J.W.1    Pinto, A.R.2    Rosenthal, N.A.3
  • 41
    • 84963490949 scopus 로고    scopus 로고
    • The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor
    • Gomez Perdiguero E., Klapproth K., Schulz C., Busch K., de Bruijn M., Rodewald H.R., Geissmann F. The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor. Immunity 2015, 43:1023-1024.
    • (2015) Immunity , vol.43 , pp. 1023-1024
    • Gomez Perdiguero, E.1    Klapproth, K.2    Schulz, C.3    Busch, K.4    de Bruijn, M.5    Rodewald, H.R.6    Geissmann, F.7
  • 43
    • 84872142459 scopus 로고    scopus 로고
    • JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
    • Han M.S., Jung D.Y., Morel C., Lakhani S.A., Kim J.K., Flavell R.A., Davis R.J. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 2013, 339:218-222.
    • (2013) Science , vol.339 , pp. 218-222
    • Han, M.S.1    Jung, D.Y.2    Morel, C.3    Lakhani, S.A.4    Kim, J.K.5    Flavell, R.A.6    Davis, R.J.7
  • 47
    • 0034492958 scopus 로고    scopus 로고
    • NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease
    • Hesse M., Cheever A.W., Jankovic D., Wynn T.A. NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease. Am. J. Pathol. 2000, 157:945-955.
    • (2000) Am. J. Pathol. , vol.157 , pp. 945-955
    • Hesse, M.1    Cheever, A.W.2    Jankovic, D.3    Wynn, T.A.4
  • 48
  • 50
    • 84857618521 scopus 로고    scopus 로고
    • Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    • Hume D.A., MacDonald K.P. Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood 2012, 119:1810-1820.
    • (2012) Blood , vol.119 , pp. 1810-1820
    • Hume, D.A.1    MacDonald, K.P.2
  • 55
    • 0024730940 scopus 로고
    • Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation
    • Khalil N., Bereznay O., Sporn M., Greenberg A.H. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 1989, 170:727-737.
    • (1989) J. Exp. Med. , vol.170 , pp. 727-737
    • Khalil, N.1    Bereznay, O.2    Sporn, M.3    Greenberg, A.H.4
  • 56
    • 34547438704 scopus 로고    scopus 로고
    • Pro-resolution properties of macrophages in renal injury
    • Kluth D.C. Pro-resolution properties of macrophages in renal injury. Kidney Int. 2007, 72:234-236.
    • (2007) Kidney Int. , vol.72 , pp. 234-236
    • Kluth, D.C.1
  • 61
    • 84908028367 scopus 로고    scopus 로고
    • TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord
    • Kroner A., Greenhalgh A.D., Zarruk J.G., Passos Dos Santos R., Gaestel M., David S. TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 2014, 83:1098-1116.
    • (2014) Neuron , vol.83 , pp. 1098-1116
    • Kroner, A.1    Greenhalgh, A.D.2    Zarruk, J.G.3    Passos Dos Santos, R.4    Gaestel, M.5    David, S.6
  • 62
    • 0036721716 scopus 로고    scopus 로고
    • Shaping gene expression in activated and resting primary macrophages by IL-10
    • Lang R., Patel D., Morris J.J., Rutschman R.L., Murray P.J. Shaping gene expression in activated and resting primary macrophages by IL-10. J. Immunol. 2002, 169:2253-2263.
    • (2002) J. Immunol. , vol.169 , pp. 2253-2263
    • Lang, R.1    Patel, D.2    Morris, J.J.3    Rutschman, R.L.4    Murray, P.J.5
  • 64
    • 84877064608 scopus 로고    scopus 로고
    • Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair
    • Lech M., Anders H.J. Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair. Biochim. Biophys. Acta 2013, 1832:989-997.
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 989-997
    • Lech, M.1    Anders, H.J.2
  • 66
    • 78651473243 scopus 로고    scopus 로고
    • Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages
    • London A., Itskovich E., Benhar I., Kalchenko V., Mack M., Jung S., Schwartz M. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J. Exp. Med. 2011, 208:23-39.
    • (2011) J. Exp. Med. , vol.208 , pp. 23-39
    • London, A.1    Itskovich, E.2    Benhar, I.3    Kalchenko, V.4    Mack, M.5    Jung, S.6    Schwartz, M.7
  • 68
    • 78149462163 scopus 로고    scopus 로고
    • An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
    • MacDonald K.P., Palmer J.S., Cronau S., Seppanen E., Olver S., Raffelt N.C., Kuns R., Pettit A.R., Clouston A., Wainwright B., et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood 2010, 116:3955-3963.
    • (2010) Blood , vol.116 , pp. 3955-3963
    • MacDonald, K.P.1    Palmer, J.S.2    Cronau, S.3    Seppanen, E.4    Olver, S.5    Raffelt, N.C.6    Kuns, R.7    Pettit, A.R.8    Clouston, A.9    Wainwright, B.10
  • 72
    • 18544378668 scopus 로고    scopus 로고
    • Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo
    • Mitchell S., Thomas G., Harvey K., Cottell D., Reville K., Berlasconi G., Petasis N.A., Erwig L., Rees A.J., Savill J., et al. Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. J. Am. Soc. Nephrol. 2002, 13:2497-2507.
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 2497-2507
    • Mitchell, S.1    Thomas, G.2    Harvey, K.3    Cottell, D.4    Reville, K.5    Berlasconi, G.6    Petasis, N.A.7    Erwig, L.8    Rees, A.J.9    Savill, J.10
  • 74
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008, 8:958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 76
    • 84940447241 scopus 로고    scopus 로고
    • Macrophages decide between regeneration and fibrosis in muscle
    • Muñoz-Cánoves P., Serrano A.L. Macrophages decide between regeneration and fibrosis in muscle. Trends Endocrinol. Metab. 2015, 26:449-450.
    • (2015) Trends Endocrinol. Metab. , vol.26 , pp. 449-450
    • Muñoz-Cánoves, P.1    Serrano, A.L.2
  • 77
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 2011, 11:723-737.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 82
    • 84892380278 scopus 로고    scopus 로고
    • Macrophage activation and skeletal muscle healing following traumatic injury
    • Novak M.L., Weinheimer-Haus E.M., Koh T.J. Macrophage activation and skeletal muscle healing following traumatic injury. J. Pathol. 2014, 232:344-355.
    • (2014) J. Pathol. , vol.232 , pp. 344-355
    • Novak, M.L.1    Weinheimer-Haus, E.M.2    Koh, T.J.3
  • 83
    • 84926523845 scopus 로고    scopus 로고
    • Macrophages and cancer: from mechanisms to therapeutic implications
    • Ostuni R., Kratochvill F., Murray P.J., Natoli G. Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol. 2015, 36:229-239.
    • (2015) Trends Immunol. , vol.36 , pp. 229-239
    • Ostuni, R.1    Kratochvill, F.2    Murray, P.J.3    Natoli, G.4
  • 88
    • 78651247933 scopus 로고    scopus 로고
    • MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway
    • Ponomarev E.D., Veremeyko T., Barteneva N., Krichevsky A.M., Weiner H.L. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat. Med. 2011, 17:64-70.
    • (2011) Nat. Med. , vol.17 , pp. 64-70
    • Ponomarev, E.D.1    Veremeyko, T.2    Barteneva, N.3    Krichevsky, A.M.4    Weiner, H.L.5
  • 89
  • 91
    • 84929309326 scopus 로고    scopus 로고
    • Resolution of liver fibrosis: basic mechanisms and clinical relevance
    • Ramachandran P., Iredale J.P., Fallowfield J.A. Resolution of liver fibrosis: basic mechanisms and clinical relevance. Semin. Liver Dis. 2015, 35:119-131.
    • (2015) Semin. Liver Dis. , vol.35 , pp. 119-131
    • Ramachandran, P.1    Iredale, J.P.2    Fallowfield, J.A.3
  • 92
    • 0023795580 scopus 로고
    • Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping
    • Rappolee D.A., Mark D., Banda M.J., Werb Z. Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Science 1988, 241:708-712.
    • (1988) Science , vol.241 , pp. 708-712
    • Rappolee, D.A.1    Mark, D.2    Banda, M.J.3    Werb, Z.4
  • 94
    • 77950525439 scopus 로고    scopus 로고
    • Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    • Said E.A., Dupuy F.P., Trautmann L., Zhang Y., Shi Y., El-Far M., Hill B.J., Noto A., Ancuta P., Peretz Y., et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat. Med. 2010, 16:452-459.
    • (2010) Nat. Med. , vol.16 , pp. 452-459
    • Said, E.A.1    Dupuy, F.P.2    Trautmann, L.3    Zhang, Y.4    Shi, Y.5    El-Far, M.6    Hill, B.J.7    Noto, A.8    Ancuta, P.9    Peretz, Y.10
  • 95
    • 0141989767 scopus 로고    scopus 로고
    • Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair
    • Sandler N.G., Mentink-Kane M.M., Cheever A.W., Wynn T.A. Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. J. Immunol. 2003, 171:3655-3667.
    • (2003) J. Immunol. , vol.171 , pp. 3655-3667
    • Sandler, N.G.1    Mentink-Kane, M.M.2    Cheever, A.W.3    Wynn, T.A.4
  • 96
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M., O'Garra A. The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 2010, 10:170-181.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 99
    • 0022404365 scopus 로고
    • A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
    • Shimokado K., Raines E.W., Madtes D.K., Barrett T.B., Benditt E.P., Ross R. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 1985, 43:277-286.
    • (1985) Cell , vol.43 , pp. 277-286
    • Shimokado, K.1    Raines, E.W.2    Madtes, D.K.3    Barrett, T.B.4    Benditt, E.P.5    Ross, R.6
  • 101
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • Sica A., Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 2012, 122:787-795.
    • (2012) J. Clin. Invest. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 104
    • 84943279279 scopus 로고    scopus 로고
    • MiR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program
    • Su S., Zhao Q., He C., Huang D., Liu J., Chen F., Chen J., Liao J.Y., Cui X., Zeng Y., et al. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat. Commun. 2015, 6:8523.
    • (2015) Nat. Commun. , vol.6 , pp. 8523
    • Su, S.1    Zhao, Q.2    He, C.3    Huang, D.4    Liu, J.5    Chen, F.6    Chen, J.7    Liao, J.Y.8    Cui, X.9    Zeng, Y.10
  • 111
    • 84937719061 scopus 로고    scopus 로고
    • Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
    • Warnatsch A., Ioannou M., Wang Q., Papayannopoulos V. Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science 2015, 349:316-320.
    • (2015) Science , vol.349 , pp. 316-320
    • Warnatsch, A.1    Ioannou, M.2    Wang, Q.3    Papayannopoulos, V.4
  • 112
    • 84910020145 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • Wehr A., Baeck C., Ulmer F., Gassler N., Hittatiya K., Luedde T., Neumann U.P., Trautwein C., Tacke F. Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. PLoS ONE 2014, 9:e112327.
    • (2014) PLoS ONE , vol.9 , pp. e112327
    • Wehr, A.1    Baeck, C.2    Ulmer, F.3    Gassler, N.4    Hittatiya, K.5    Luedde, T.6    Neumann, U.P.7    Trautwein, C.8    Tacke, F.9
  • 115
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the T(H)1/T(H)2 paradigm
    • Wynn T.A. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Immunol. 2004, 4:583-594.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 583-594
    • Wynn, T.A.1
  • 116
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • Wynn T.A. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 2007, 117:524-529.
    • (2007) J. Clin. Invest. , vol.117 , pp. 524-529
    • Wynn, T.A.1
  • 117
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn T.A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 2008, 214:199-210.
    • (2008) J. Pathol. , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 118
    • 77954961992 scopus 로고    scopus 로고
    • Macrophages: master regulators of inflammation and fibrosis
    • Wynn T.A., Barron L. Macrophages: master regulators of inflammation and fibrosis. Semin. Liver Dis. 2010, 30:245-257.
    • (2010) Semin. Liver Dis. , vol.30 , pp. 245-257
    • Wynn, T.A.1    Barron, L.2
  • 119
    • 84863702343 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    • Wynn T.A., Ramalingam T.R. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat. Med. 2012, 18:1028-1040.
    • (2012) Nat. Med. , vol.18 , pp. 1028-1040
    • Wynn, T.A.1    Ramalingam, T.R.2
  • 120
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn T.A., Chawla A., Pollard J.W. Macrophage biology in development, homeostasis and disease. Nature 2013, 496:445-455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 122
    • 84862591151 scopus 로고    scopus 로고
    • Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
    • Xu H., Zhu J., Smith S., Foldi J., Zhao B., Chung A.Y., Outtz H., Kitajewski J., Shi C., Weber S., et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat. Immunol. 2012, 13:642-650.
    • (2012) Nat. Immunol. , vol.13 , pp. 642-650
    • Xu, H.1    Zhu, J.2    Smith, S.3    Foldi, J.4    Zhao, B.5    Chung, A.Y.6    Outtz, H.7    Kitajewski, J.8    Shi, C.9    Weber, S.10
  • 123
    • 84926308649 scopus 로고    scopus 로고
    • NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
    • Xu J., Chi F., Guo T., Punj V., Lee W.N., French S.W., Tsukamoto H. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J. Clin. Invest. 2015, 125:1579-1590.
    • (2015) J. Clin. Invest. , vol.125 , pp. 1579-1590
    • Xu, J.1    Chi, F.2    Guo, T.3    Punj, V.4    Lee, W.N.5    French, S.W.6    Tsukamoto, H.7
  • 124
    • 84937714668 scopus 로고    scopus 로고
    • Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation
    • Yuk J.M., Kim T.S., Kim S.Y., Lee H.M., Han J., Dufour C.R., Kim J.K., Jin H.S., Yang C.S., Park K.S., et al. Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity 2015, 43:80-91.
    • (2015) Immunity , vol.43 , pp. 80-91
    • Yuk, J.M.1    Kim, T.S.2    Kim, S.Y.3    Lee, H.M.4    Han, J.5    Dufour, C.R.6    Kim, J.K.7    Jin, H.S.8    Yang, C.S.9    Park, K.S.10
  • 125
    • 84930682376 scopus 로고    scopus 로고
    • Recurrent turnover of senescent cells during regeneration of a complex structure
    • Published online May 5, 2015
    • Yun M.H., Davaapil H., Brockes J.P. Recurrent turnover of senescent cells during regeneration of a complex structure. eLife 2015, 4. Published online May 5, 2015. 10.7554/eLife.05505.
    • (2015) eLife , vol.4
    • Yun, M.H.1    Davaapil, H.2    Brockes, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.