Cutting edge: The common γ-chain is an indispensable subunit of the IL-21 receptor complex

Journal of Immunology

Volumn 167, Issue 1, 2001, Pages 1-5

  Asao, H ^a   Okuyama, C ^a   Kumaki, S ^a   Ishii, N ^a   Tsuchiya, S ^a   Foster, D ^a   Sugamura, K ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN RECEPTOR; JANUS KINASE; RECEPTOR SUBUNIT; STAT1 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0035400054     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.1.1     Document Type: Article

References (29)

1. Cytokine receptors and signal transduction
2. Gp130 and the interleukin-6 family of cytokines
3. Cloning of the γ chain of the human IL-2 receptor
4. Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: Involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways
5. The common γ-chain for multiple cytokine receptors
6. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans
7. The interleukin-2 receptor γ chain: Its role in the multiple cytokine receptor complexes and T cell development in XSCID
8. Impairment of ligand binding and growth signaling of mutant IL-2 receptor γ-chains in patients with X-linked severe combined immunodeficiency
9. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain
10. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
11. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain
12. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
13. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
14. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain
15. Immune responses in interleukin-2-deficient mice
16. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor
17. Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL15RA and IL2RA genes
18. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
19. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain
20. Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling
21. Interleukin 2-induced activation of Jak3: Possible involvement in signal transduction for c-myc induction and cell proliferation
22. Functional role of interleukin-4 (IL-4) and IL-7 in the development of X-linked severe combined immunodeficiency
23. Expression of the IL-2 receptor γ chain on various populations in human peripheral blood
24. Interferon-γ has dual potentials in inhibiting or promoting cell proliferation
25. c chain of the IL-2 receptor
26. c chains with Jak1 and Jak3: Implications for XSCID and XCID
27. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
28. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
29. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins