Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

ACS Chemical Biology

Volumn 11, Issue 12, 2016, Pages 3442-3451

  Telliez, Jean Baptiste ^a   Dowty, Martin E ^a   Wang, Lu ^a   Jussif, Jason ^a   Lin, Tsung ^a   Li, Li ^a   Moy, Erick ^a   Balbo, Paul ^a   Li, Wei ^a   Zhao, Yajuan ^a   Crouse, Kimberly ^a   Dickinson, Caitlyn ^a   Symanowicz, Peter ^a   Hegen, Martin ^a   Banker, Mary Ellen ^a   Vincent, Fabien ^a   Unwalla, Ray ^a   Liang, Sidney ^a   Gilbert, Adam M ^a   Brown, Matthew F ^a   Hayward, Matthew ^a   Montgomery, Justin ^a   Yang, Xin ^a   Bauman, Jonathan ^a   Trujillo, John I ^a   Casimiro Garcia, Agustin ^a   Vajdos, Felix F ^a   Leung, Louis ^a   Geoghegan, Kieran F ^a   Quazi, Amira ^a   Xuan, Dejun ^a   Jones, Lyn ^a   Hett, Erik ^a   Wright, Katherine ^a   Clark, James D ^a   Thorarensen, Atli ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD23 ANTIGEN; CD34 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; JANUS KINASE 1; JANUS KINASE 3; JANUS KINASE 3 INHIBITOR; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 4; PF 06651600; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; PF-06651600; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ADJUVANT ARTHRITIS; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG BLOOD LEVEL; ENZYME INHIBITION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; CYTOLOGY; DISEASE MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOLOGY; METABOLISM; MOLECULAR MODEL; MOUSE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INTERLEUKIN-10; INTERLEUKIN-1BETA; JANUS KINASE 1; JANUS KINASE 3; MACROPHAGES; MICE; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PYRIMIDINES; PYRROLES; RATS; TH1 CELLS; TH17 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85006377210     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.6b00677     Document Type: Article

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