Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Nature

Volumn 542, Issue 7639, 2017, Pages 110-114

  Rao, Deepak A ^a   Gurish, Michael F ^a   Marshall, Jennifer L ^b   Slowikowski, Kamil ^a,c,d   Fonseka, Chamith Y ^a,c   Liu, Yanyan ^a   Donlin, Laura T ^e   Henderson, Lauren A ^f   Wei, Kevin ^a   Mizoguchi, Fumitaka ^a   Teslovich, Nikola C ^a,c   Weinblatt, Michael E ^a   Massarotti, Elena M ^a   Coblyn, Jonathan S ^a   Helfgott, Simon M ^a   Lee, Yvonne C ^a   Todd, Derrick J ^a   Bykerk, Vivian P ^e,g   Goodman, Susan M ^e,g   Pernis, Alessandra B ^e,g   Ivashkiv, Lionel B ^e   Karlson, Elizabeth W ^a   Nigrovic, Peter A ^a,f   Filer, Andrew ^b   Buckley, Christopher D ^b   Lederer, James A ^a   Raychaudhuri, Soumya ^a,c,d,h,i   Brenner, Michael B ^a   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c HARVARD UNIVERSITY   (United States)

^d LABORATORY FOR MOLECULAR MEDICINE   (United States)

^e HOSPITAL FOR SPECIAL SURGERY   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

ⁱ UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; CYTOKINE; ICOS PROTEIN; INTERLEUKIN 21; METHOTREXATE; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BCL 6; RITUXIMAB; SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE; SLAMF5 PROTEIN; TOCILIZUMAB; TOFACITINIB; TRANSCRIPTION FACTOR MAF; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG; BCL6 PROTEIN, HUMAN; CD84 PROTEIN, HUMAN; CHEMOKINE RECEPTOR; CXCL13 PROTEIN, HUMAN; CXCR5 PROTEIN, HUMAN; ICOS PROTEIN, HUMAN; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN DERIVATIVE; MACROPHAGE ACTIVATING FACTOR; PDCD1 PROTEIN, HUMAN; PRDM1 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ANTIBODY; CELLS AND CELL COMPONENTS; GENE EXPRESSION; IMMUNE SYSTEM; PATHOLOGY; PLASMA; SECRETION;

ADULT; AGED; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BIOLOGICAL THERAPY; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOMETRY; FEMALE; FLOW CYTOMETRY; HELPER CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; JOINT; LYMPHOCYTE SUBPOPULATION; MALE; MASS CYTOMETRY; MIDDLE AGED; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE ACTIVATION; TRANSCRIPTOMICS; VERY ELDERLY; BLOOD; CELL MOTION; DEFICIENCY; GENE EXPRESSION PROFILING; IMMUNOLOGY; METABOLISM; PATHOLOGY; SECRETION (PROCESS); SYNOVIAL FLUID;

ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CHEMOKINE CXCL13; GENE EXPRESSION PROFILING; HUMANS; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; INTERLEUKINS; MACROPHAGE-ACTIVATING FACTORS; PROGRAMMED CELL DEATH 1 RECEPTOR; PROTO-ONCOGENE PROTEINS C-BCL-6; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR5; REPRESSOR PROTEINS; SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE FAMILY; SYNOVIAL FLUID; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 85011994125     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature20810     Document Type: Article

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