-
1
-
-
0022617990
-
Type I diabetes mellitus. A chronic autoimmune disease
-
Eisenbarth, G. S. Type I diabetes mellitus. A chronic autoimmune disease. N. Engl. J. Med. 314, 1360-1368 (1986). (Pubitemid 16122469)
-
(1986)
New England Journal of Medicine
, vol.314
, Issue.21
, pp. 1360-1368
-
-
Eisenbarth, G.S.1
-
2
-
-
0016261369
-
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
-
Bottazzo, G. F., Florin-Christensen, A. & Doniach, D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2, 1279-1283 (1974).
-
(1974)
Lancet
, vol.2
, pp. 1279-1283
-
-
Bottazzo, G.F.1
Florin-Christensen, A.2
Doniach, D.3
-
3
-
-
0021873134
-
Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases
-
Sibley, R. K., Sutherland, D. E., Goetz, F. & Michael, A. F. Recurrent diabetes mellitus in the pancreas iso-and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab. Invest. 53, 132-144 (1985). (Pubitemid 15049005)
-
(1985)
Laboratory Investigation
, vol.53
, Issue.2
, pp. 132-144
-
-
Sibley, R.K.1
Sutherland, D.E.R.2
Goetz, F.3
Michael, A.F.4
-
4
-
-
0022348847
-
Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus
-
Eisenbarth, G. S. et al. Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus. Diabetes Res. 2, 271-276 (1985). (Pubitemid 16213226)
-
(1985)
Diabetes Research
, vol.2
, Issue.6
, pp. 271-276
-
-
Eisenbarth, G.S.1
Srikanta, S.2
Jackson, R.3
-
5
-
-
0021359025
-
Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset
-
Stiller, C. R. et al. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 223, 1362-1367 (1984). (Pubitemid 14161003)
-
(1984)
Science
, vol.223
, Issue.4643
, pp. 1362-1367
-
-
Stiller, C.R.1
Dupre, J.2
Gent, M.3
-
6
-
-
0017646011
-
B cell function and blood glucose control in insulin dependent diabetes within the first month of insulin treatment
-
Faber, O. K. & Binder, C. Bcell function and blood glucose control in insulin dependent diabetics within the first month of insulin treatment. Diabetologia 13, 263-268 (1977). (Pubitemid 8109393)
-
(1977)
Diabetologia
, vol.13
, Issue.3
, pp. 263-268
-
-
Faber, O.K.1
Binder, C.2
-
7
-
-
9144268894
-
C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function: Report of an ADA Workshop, 21-22 October 2001
-
DOI 10.2337/diabetes.53.1.250
-
Palmer, J. P., et al. Cpeptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve β-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 53, 250-264 (2004). (Pubitemid 38044724)
-
(2004)
Diabetes
, vol.53
, Issue.1
, pp. 250-264
-
-
Palmer, J.P.1
Fleming, G.A.2
Greenbaum, C.J.3
Herold, K.C.4
Jansa, L.D.5
Kolb, H.6
Lachin, J.M.7
Polonsky, K.S.8
Pozzilli, P.9
Skyler, J.S.10
Steffes, M.W.11
-
8
-
-
0041666293
-
β-cell function and the development of diabetes-related complications in the diabetes control and complications trial
-
DOI 10.2337/diacare.26.3.832
-
Steffes, M. W. Sibley, S., Jackson, M. & Thomas, W. β-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 26, 832-836 (2003). (Pubitemid 36929351)
-
(2003)
Diabetes Care
, vol.26
, Issue.3
, pp. 832-836
-
-
Steffes, M.W.1
Sibley, S.2
Jackson, M.3
Thomas, W.4
-
9
-
-
79958043752
-
Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children
-
Ziegler, A. G. et al. Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. J. Autoimmun. 37, 3-7 (2011).
-
(2011)
J. Autoimmun
, vol.37
, pp. 3-7
-
-
Ziegler, A.G.1
-
10
-
-
18844374468
-
A worm's eye view of the immune system: Consequences for evolution of human autoimmune disease
-
DOI 10.1038/nri1601
-
Dunne, D. W. & Cooke, A. A worm's eye view of the immune system: consequences for evolution of human autoimmune disease. Nature Rev. Immunol. 5, 420-426 (2005). (Pubitemid 40685991)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.5
, pp. 420-426
-
-
Dunne, D.W.1
Cooke, A.2
-
11
-
-
0028007192
-
Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes
-
Atkinson, M. A. et al. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94, 2125-2129 (1994). (Pubitemid 24348254)
-
(1994)
Journal of Clinical Investigation
, vol.94
, Issue.5
, pp. 2125-2129
-
-
Atkinson, M.A.1
Bowman, M.A.2
Campbell, L.3
Darrow, B.L.4
Kaufman, D.L.5
Maclaren, N.K.6
-
12
-
-
0024417450
-
Hay fever, hygiene, and household size
-
Strachan, D. P. Hay fever, hygiene, and household size. BMJ 299, 1259-1260 (1989). (Pubitemid 19280051)
-
(1989)
British Medical Journal
, vol.299
, Issue.6710
, pp. 1259-1260
-
-
Strachan, D.P.1
-
13
-
-
84866166082
-
The hygiene hypo thesis: An explanation for the increased frequency of insulin-dependent diabetes
-
Bach, J. F. & Chatenoud, L. The hygiene hypothesis: an explanation for the increased frequency of insulin-dependent diabetes. Cold Spring Harb. Perspect. Med. 2, a007799 (2012).
-
(2012)
Cold Spring Harb. Perspect. Med
, vol.2
-
-
Bach, J.F.1
Chatenoud, L.2
-
14
-
-
2942514674
-
Infection and autoimmunity: Are we winning the war, only to lose the peace?
-
DOI 10.1016/j.pt.2004.04.010, PII S1471492204001059
-
Cooke, A., Zaccone, P., Raine, T., Phillips, J. M. & Dunne, D. W. Infection and autoimmunity: are we winning the war, only to lose the peace? Trends Parasitol. 20, 316-321 (2004). (Pubitemid 38749074)
-
(2004)
Trends in Parasitology
, vol.20
, Issue.7
, pp. 316-321
-
-
Cooke, A.1
Zaccone, P.2
Raine, T.3
Phillips, J.M.4
Dunne, D.W.5
-
15
-
-
3042549457
-
The impact of infection on the incidence of autoimmune disease
-
DOI 10.2174/1568026043451258
-
David, T., Thomas, C., Zaccone, P., Dunne, D. W. & Cooke, A. The impact of infection on the incidence of autoimmune disease. Curr. Top. Med. Chem. 4, 521-529 (2004). (Pubitemid 38832735)
-
(2004)
Current Topics in Medicinal Chemistry
, vol.4
, Issue.5
, pp. 521-529
-
-
Thomas, T.D.C.1
Zaccone, P.2
Dunne, D.W.3
Cooke, A.4
-
16
-
-
34247627376
-
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
-
DOI 10.1073/pnas.0700442104
-
Dotta, F. et al. Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc. Natl Acad. Sci. USA 104, 5115-5120 (2007). (Pubitemid 47186185)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.12
, pp. 5115-5120
-
-
Dotta, F.1
Censini, S.2
Van Halteren, A.G.S.3
Marselli, L.4
Masini, M.5
Dionisi, S.6
Mosca, F.7
Boggi, U.8
Muda, A.O.9
Del Prato, S.10
Elliott, J.F.11
Covacci, A.12
Rappuoli, R.13
Roep, B.O.14
Marchetti, P.15
-
17
-
-
0018799757
-
Virus-induced diabetes mellitus. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis
-
Yoon, J. W., Austin, M., Onodera, T. & Notkins, A. L. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N. Engl. J. Med. 300, 1173-1179 (1979). (Pubitemid 9191515)
-
(1979)
New England Journal of Medicine
, vol.300
, Issue.21
, pp. 1173-1179
-
-
Yoon, J.W.1
Austin, M.2
Onodera, T.3
Notkins, A.L.4
-
18
-
-
67349214073
-
A case of fulminant type 1 diabetes with coxsackie B4 virus infection diagnosed by elevated serum levels of neutralizing antibody
-
Akatsuka, H. et al. A case of fulminant type 1 diabetes with coxsackie B4 virus infection diagnosed by elevated serum levels of neutralizing antibody. Diabetes Res. Clin. Pract. 84, e50-e52 (2009).
-
(2009)
Diabetes Res. Clin. Pract
, vol.84
-
-
Akatsuka, H.1
-
19
-
-
34447617193
-
Induction of the chemokine interferon-γ-inducible protein10 in human pancreatic islets during enterovirus infection
-
Berg, A. K., Korsgren, O. & Frisk, G. Induction of the chemokine interferon-γ-inducible protein10 in human pancreatic islets during enterovirus infection. Diabetologia 49, 2697-2703 (2006).
-
(2006)
Diabetologia
, vol.49
, pp. 2697-2703
-
-
Berg, A.K.1
Korsgren, O.2
Frisk, G.3
-
20
-
-
0346366978
-
Among CXCR3 Chemokines, IFN-γ-Inducible Protein of 10 kDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-γ (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease
-
Christen, U., McGavern, D. B., Luster, A. D., von Herrath, M. G. & Oldstone, M. B. Among CXCR3 chemokines, IFN-γ-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-γ (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J. Immunol. 171, 6838-6845 (2003). (Pubitemid 37532119)
-
(2003)
Journal of Immunology
, vol.171
, Issue.12
, pp. 6838-6845
-
-
Christen, U.1
McGavern, D.B.2
Luster, A.D.3
Von Herrath, M.G.4
Oldstone, M.B.A.5
-
21
-
-
77951824938
-
Phagocytosis of enterovirus-infected pancreatic β-cells triggers innate immune responses in human dendritic cells
-
Schulte, B. M. et al. Phagocytosis of enterovirus-infected pancreatic β-cells triggers innate immune responses in human dendritic cells. Diabetes 59, 1182-1191 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 1182-1191
-
-
Schulte, B.M.1
-
22
-
-
84862637797
-
Gut immune maturation depends on colonization with a host-specific microbiota
-
Chung, H. et al. Gut immune maturation depends on colonization with a host-specific microbiota. Cell 149, 1578-1593 (2012).
-
(2012)
Cell
, vol.149
, pp. 1578-1593
-
-
Chung, H.1
-
23
-
-
83655165390
-
The influence of the microbiota on type1 diabetes: On the threshold of a leap forward in our understanding
-
Mathis, D. & Benoist, C. The influence of the microbiota on type1 diabetes: on the threshold of a leap forward in our understanding. Immunol. Rev. 245, 239-249 (2012).
-
(2012)
Immunol. Rev
, vol.245
, pp. 239-249
-
-
Mathis, D.1
Benoist, C.2
-
24
-
-
77954738601
-
Inducible Foxp3+ regulatory Tcell development by a commensal bacterium of the intestinal microbiota
-
Round, J. L. & Mazmanian, S. K. Inducible Foxp3+ regulatory Tcell development by a commensal bacterium of the intestinal microbiota. Proc. Natl Acad. Sci. USA 107, 12204-12209 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 12204-12209
-
-
Round, J.L.1
Mazmanian, S.K.2
-
25
-
-
78650616947
-
Toward defining the autoimmune microbiome for type 1 diabetes
-
Giongo, A. et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J. 5, 82-91 (2011).
-
(2011)
ISME J
, vol.5
, pp. 82-91
-
-
Giongo, A.1
-
26
-
-
78049265809
-
In vitro immunomodulatory activity of Lactobacillus fermentum CECT5716 and Lactobacillus salivarius CECT5713: Two probiotic strains isolated from human breast milk
-
Perez-Cano, F. J., Dong, H. & Yaqoob, P. In vitro immunomodulatory activity of Lactobacillus fermentum CECT5716 and Lactobacillus salivarius CECT5713: two probiotic strains isolated from human breast milk. Immunobiology 215, 996-1004 (2010).
-
(2010)
Immunobiology
, vol.215
, pp. 996-1004
-
-
Perez-Cano, F.J.1
Dong, H.2
Yaqoob, P.3
-
27
-
-
79952748674
-
Proinflammatory Tcell responses to gut microbiota promote experimental autoimmune encephalomyelitis
-
Lee, Y. K., Menezes, J. S., Umesaki, Y. & Mazmanian, S. K. Proinflammatory Tcell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4615-4622 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, Issue.SUPPL. 1
, pp. 4615-4622
-
-
Lee, Y.K.1
Menezes, J.S.2
Umesaki, Y.3
Mazmanian, S.K.4
-
28
-
-
53349173070
-
Specific microbiota direct the differentiation of IL17producing T-helper cells in the mucosa of the small intestine
-
Ivanov, I. I. et al. Specific microbiota direct the differentiation of IL17producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4, 337-349 (2008).
-
(2008)
Cell Host Microbe
, vol.4
, pp. 337-349
-
-
Ivanov, I.I.1
-
29
-
-
79956315886
-
Intestinal bacterial colonization induces mutualistic regulatory T cell responses
-
Geuking, M. B. et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 34, 794-806 (2011).
-
(2011)
Immunity
, vol.34
, pp. 794-806
-
-
Geuking, M.B.1
-
30
-
-
79960983258
-
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
-
Kriegel, M. A. et al. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc. Natl Acad. Sci. USA 108, 11548-11553 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 11548-11553
-
-
Kriegel, M.A.1
-
31
-
-
54549122338
-
Innate immunity and intestinal microbiota in the development of type 1 diabetes
-
Wen, L. et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 455, 1109-1113 (2008).
-
(2008)
Nature
, vol.455
, pp. 1109-1113
-
-
Wen, L.1
-
33
-
-
0141593569
-
Early Infant Feeding and Risk of Developing Type 1 Diabetes-Associated Autoantibodies
-
DOI 10.1001/jama.290.13.1721
-
Ziegler, A. G., Schmid, S., Huber, D., Hummel, M. & Bonifacio, E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290, 1721-1728 (2003). (Pubitemid 37430622)
-
(2003)
Journal of the American Medical Association
, vol.290
, Issue.13
, pp. 1721-1728
-
-
Ziegler, A.-G.1
Schmid, S.2
Huber, D.3
Hummel, M.4
Bonifacio, E.5
-
34
-
-
0141816761
-
Timing of Initial Cereal Exposure in Infancy and Risk of Islet Autoimmunity
-
DOI 10.1001/jama.290.13.1713
-
Norris, J. M. et al. Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 290, 1713-1720 (2003). (Pubitemid 37430621)
-
(2003)
Journal of the American Medical Association
, vol.290
, Issue.13
, pp. 1713-1720
-
-
Norris, J.M.1
Barriga, K.2
Klingensmith, G.3
Hoffman, M.4
Eisenbarth, G.S.5
Erlich, H.A.6
Rewers, M.7
-
35
-
-
20044370128
-
Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: A pilot study
-
DOI 10.1007/s00125-005-1733-3
-
Akerblom, H. K. et al. Dietary manipulation of β cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study. Diabetologia 48, 829-837 (2005). (Pubitemid 40767974)
-
(2005)
Diabetologia
, vol.48
, Issue.5
, pp. 829-837
-
-
Akerblom, H.K.1
Virtanen, S.M.2
Ilonen, J.3
Savilahti, E.4
Vaarala, O.5
Reunanen, A.6
Teramo, K.7
Hamalainen, A.-M.8
Paronen, J.9
Riikjarv, M.-A.10
Ormisson, A.11
Ludvigsson, J.12
-
36
-
-
78149475225
-
Dietary intervention in infancy and later signs of β-cell autoimmunity
-
Knip, M. et al. Dietary intervention in infancy and later signs of β-cell autoimmunity. N. Engl. J. Med. 363, 1900-1908 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 1900-1908
-
-
Knip, M.1
-
37
-
-
4644225746
-
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse
-
DOI 10.2337/diabetes.53.10.2581
-
Wong, F. S. et al. Investigation of the role of Bcells in type 1 diabetes in the NOD mouse. Diabetes 53, 2581-2587 (2004). (Pubitemid 39299265)
-
(2004)
Diabetes
, vol.53
, Issue.10
, pp. 2581-2587
-
-
Wong, F.S.1
Wen, L.2
Tang, M.3
Ramanathan, M.4
Visintin, I.5
Daugherty, J.6
Hannum, L.G.7
Janeway Jr., C.A.8
Shlomchik, M.J.9
-
38
-
-
58149359257
-
Targeting CD22 reprograms Bcells and reverses autoimmune diabetes
-
Fiorina, P. et al. Targeting CD22 reprograms Bcells and reverses autoimmune diabetes. Diabetes 57, 3013-3024 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 3013-3024
-
-
Fiorina, P.1
-
39
-
-
36849027817
-
Treatment with CD20specific antibody prevents and reverses autoimmune diabetes in mice
-
Hu, C. Y. et al. Treatment with CD20specific antibody prevents and reverses autoimmune diabetes in mice. J. Clin. Invest. 117, 3857-3867 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 3857-3867
-
-
Hu, C.Y.1
-
40
-
-
36749011882
-
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
-
DOI 10.1073/pnas.0705894104
-
Wenzlau, J. M. et al. The cation efflux transporter ZNT8 (SLC30A8) is a major autoantigen in human type 1 diabetes. Proc. Natl Acad. Sci. USA 104, 17040-17045 (2007). (Pubitemid 350210987)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.43
, pp. 17040-17045
-
-
Wenzlau, J.M.1
Juhl, K.2
Yu, L.3
Moua, O.4
Sarkar, S.A.5
Gottlieb, P.6
Rewers, M.7
Eisenbarth, G.S.8
Jensen, J.9
Davidson, H.W.10
Hutton, J.C.11
-
41
-
-
33845316086
-
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
-
DOI 10.1172/JCI29602
-
Krishnamurthy, B. et al. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J. Clin. Invest. 116, 3258-3265 (2006). (Pubitemid 44878640)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.12
, pp. 3258-3265
-
-
Krishnamurthy, B.1
Dudek, N.L.2
McKenzie, M.D.3
Purcell, A.W.4
Brooks, A.G.5
Gellert, S.6
Colman, P.G.7
Harrison, L.C.8
Lew, A.M.9
Thomas, H.E.10
Kay, T.W.H.11
-
42
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
DOI 10.1038/nature03523
-
Nakayama, M. et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435, 220-223 (2005). (Pubitemid 40685949)
-
(2005)
Nature
, vol.435
, Issue.7039
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Moriyama, H.3
Babaya, N.4
Liu, E.5
Miao, D.6
Yu, L.7
Wegmann, D.R.8
Hutton, J.C.9
Elliott, J.F.10
Eisenbarth, G.S.11
-
43
-
-
0035451681
-
Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice
-
Bot, A. et al. Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. J. Immunol. 167, 2950-2955 (2001). (Pubitemid 32768931)
-
(2001)
Journal of Immunology
, vol.167
, Issue.5
, pp. 2950-2955
-
-
Bot, A.1
Smith, D.2
Bot, S.3
Hughes, A.4
Wolfe, T.5
Wang, L.6
Woods, C.7
Von Herrath, M.8
-
44
-
-
36448978896
-
Type 1 diabetes as a relapsing-remitting disease?
-
DOI 10.1038/nri2192, PII NRI2192
-
von Herrath, M., Sanda, S. & Herold, K. Type 1 diabetes as a relapsing-remitting disease? Nature Rev. Immunol. 7, 988-994 (2007). (Pubitemid 350166057)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.12
, pp. 988-994
-
-
Von Herrath, M.1
Sanda, S.2
Herold, K.3
-
45
-
-
0034652317
-
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
-
DOI 10.1073/pnas.040556697
-
Yu, L. et al. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc. Natl Acad. Sci. USA 97, 1701-1706 (2000). (Pubitemid 30118506)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1701-1706
-
-
Yu, L.1
Robles, D.T.2
Abiru, N.3
Kaur, P.4
Rewers, M.5
Kelemen, K.6
Eisenbarth, G.S.7
-
46
-
-
55849116389
-
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
-
Skowera, A. et al. CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J. Clin. Invest. 118, 3390-3402 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 3390-3402
-
-
Skowera, A.1
-
47
-
-
5444222000
-
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
-
DOI 10.1038/ni1120
-
Jaeckel, E., Lipes, M. A. & von Boehmer, H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nature Immunol. 5, 1028-1035 (2004). (Pubitemid 41057722)
-
(2004)
Nature Immunology
, vol.5
, Issue.10
, pp. 1028-1035
-
-
Jaeckel, E.1
Lipes, M.A.2
Von Boehmer, H.3
-
48
-
-
85047689216
-
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
-
DOI 10.1172/JCI200316584
-
Thebault-Baumont, K. et al. Acceleration of type 1 diabetes mellitus in proinsulin 2deficient NOD mice. J. Clin. Invest. 111, 851-857 (2003). (Pubitemid 37074960)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.6
, pp. 851-857
-
-
Thebault-Baumont, K.1
Dubois-Laforgue, D.2
Krief, P.3
Briand, J.-P.4
Halbout, P.5
Vallon-Geoffroy, K.6
Morin, J.7
Laloux, V.8
Lehuen, A.9
Carel, J.-C.10
Jami, J.11
Muller, S.12
Boitard, C.13
-
49
-
-
2442567829
-
Back to central tolerance
-
DOI 10.1016/S1074-7613(04)00111-6, PII S1074761304001116
-
Mathis, D. & Benoist, C. Back to central tolerance. Immunity 20, 509-516 (2004). (Pubitemid 38638121)
-
(2004)
Immunity
, vol.20
, Issue.5
, pp. 509-516
-
-
Mathis, D.1
Benoist, C.2
-
50
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
DOI 10.1016/j.immuni.2005.07.005, PII S1074761305002372
-
Anderson, M. S. et al. The cellular mechanism of AIRE control of T cell tolerance. Immunity 23, 227-239 (2005). (Pubitemid 41169291)
-
(2005)
Immunity
, vol.23
, Issue.2
, pp. 227-239
-
-
Anderson, M.S.1
Venanzi, E.S.2
Chen, Z.3
Berzins, S.P.4
Benoist, C.5
Mathis, D.6
-
51
-
-
0041335584
-
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse
-
DOI 10.1073/pnas.1834450100
-
Moriyama, H. et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc. Natl Acad. Sci. USA 100, 10376-10381 (2003). (Pubitemid 37071886)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.18
, pp. 10376-10381
-
-
Moriyama, H.1
Abiru, N.2
Paronen, J.3
Sikora, K.4
Liu, E.5
Miao, D.6
Devendra, D.7
Beilke, J.8
Gianani, R.9
Gill, R.G.10
Elsenbarth, G.S.11
-
52
-
-
0036315824
-
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
-
Chentoufi, A. A. & Polychronakos, C. Insulin expression levels in the thymus modulate insulin-specific autoreactive Tcell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51, 1383-1390 (2002). (Pubitemid 34826603)
-
(2002)
Diabetes
, vol.51
, Issue.5
, pp. 1383-1390
-
-
Chentoufi, A.A.1
Polychronakos, C.2
-
53
-
-
77949872804
-
Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes
-
Mohan, J. F. et al. Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes. Nature Immunol. 11, 350-354 (2010).
-
(2010)
Nature Immunol
, vol.11
, pp. 350-354
-
-
Mohan, J.F.1
-
54
-
-
84855476371
-
Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion
-
Mohan, J. F., Petzold, S. J. & Unanue, E. R. Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion. J. Exp. Med. 208, 2375-2383 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 2375-2383
-
-
Mohan, J.F.1
Petzold, S.J.2
Unanue, E.R.3
-
55
-
-
77951905379
-
Molecular targeting of islet autoantigens
-
Stadinski, B., Kappler, J. & Eisenbarth, G. S. Molecular targeting of islet autoantigens. Immunity 32, 446-456 (2010).
-
(2010)
Immunity
, vol.32
, pp. 446-456
-
-
Stadinski, B.1
Kappler, J.2
Eisenbarth, G.S.3
-
56
-
-
80053628904
-
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
-
Crawford, F. et al. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc. Natl Acad. Sci. USA 108, 16729-16734 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 16729-16734
-
-
Crawford, F.1
-
57
-
-
77954643719
-
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
-
Stadinski, B. D. et al. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc. Natl Acad. Sci. USA 107, 10978-10983 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 10978-10983
-
-
Stadinski, B.D.1
-
58
-
-
80052376347
-
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
-
Menard, L. et al. The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J. Clin. Invest. 121, 3635-3644 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 3635-3644
-
-
Menard, L.1
-
59
-
-
64749116743
-
Genetics of type 1A diabetes
-
Concannon, P., Rich, S. S. & Nepom, G. T. Genetics of type 1A diabetes. N. Engl. J. Med. 360, 1646-1654 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1646-1654
-
-
Concannon, P.1
Rich, S.S.2
Nepom, G.T.3
-
60
-
-
0027468997
-
a donors
-
Christianson, S. W., Shultz, L. D. & Leiter, E. H. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ Tcells from diabetic versus prediabetic NOD.NON-Thy1a donors. Diabetes 42, 44-55 (1993). (Pubitemid 23013794)
-
(1993)
Diabetes
, vol.42
, Issue.1
, pp. 44-55
-
-
Christianson, S.W.1
Shultz, L.D.2
Leiter, E.H.3
-
61
-
-
0023905731
-
+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice
-
Miller, B. J., Appel, M. C., O'Neil, J. J. & Wicker, L. S. Both the Lyt2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140, 52-58 (1988). (Pubitemid 18050680)
-
(1988)
Journal of Immunology
, vol.140
, Issue.1
, pp. 52-58
-
-
Miller, B.J.1
Appel, M.C.2
O'Neil, J.J.3
Wicker, L.S.4
-
62
-
-
0029978038
-
Checkpoints in the progression of autoimmune disease: Lessons from diabetes models
-
DOI 10.1073/pnas.93.6.2260
-
Andre, I. et al. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc. Natl Acad. Sci. USA 93, 2260-2263 (1996). (Pubitemid 26104338)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.6
, pp. 2260-2263
-
-
Andre, I.1
Gonzalez, A.2
Wang, B.3
Katz, J.4
Benoist, C.5
Mathis, D.6
-
63
-
-
0027378612
-
Following a diabetogenic T cell from genesis through pathogenesis
-
DOI 10.1016/0092-8674(93)90730-E
-
Katz, J. D., Wang, B., Haskins, K., Benoist, C. & Mathis, D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74, 1089-1100 (1993). (Pubitemid 23289465)
-
(1993)
Cell
, vol.74
, Issue.6
, pp. 1089-1100
-
-
Katz, J.D.1
Wang, B.2
Haskins, K.3
Benoist, C.4
Mathis, D.5
-
64
-
-
0030588572
-
+ T Cells Expressing Identical Endogenous TCR-α Chains
-
Verdaguer, J. et al. Acceleration of spontaneous diabetes in TCR-β-transgenic nonobese diabetic mice by β-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-α chains. J. Immunol. 157, 4726-4735 (1996). (Pubitemid 126449398)
-
(1996)
Journal of Immunology
, vol.157
, Issue.10
, pp. 4726-4735
-
-
Verdaguer, J.1
Yoon, J.-W.2
Anderson, B.3
Averill, N.4
Utsugi, T.5
Park, B.-J.6
Santamaria, P.7
-
65
-
-
70349745490
-
T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
-
Lennon, G. P. et al. T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 31, 643-653 (2009).
-
(2009)
Immunity
, vol.31
, pp. 643-653
-
-
Lennon, G.P.1
-
66
-
-
8844233573
-
Limited clonality in autoimmunity: Drivers and regulators
-
DOI 10.1016/j.autrev.2004.07.008, PII S1568997204001156
-
van den Elzen, P. et al. Limited clonality in autoimmunity: drivers and regulators. Autoimmun. Rev. 3, 524-529 (2004). (Pubitemid 39531245)
-
(2004)
Autoimmunity Reviews
, vol.3
, Issue.7-8 SPEC. ISSUE
, pp. 524-529
-
-
Van Den Elzen, P.1
Menezes, J.S.2
Ametani, A.3
Maverakis, E.4
Madakamutil, L.5
Tang, X.-L.6
Kumar, V.7
Sercarz, E.E.8
-
67
-
-
0037047063
-
Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice
-
DOI 10.1073/pnas.142284899
-
Baker, F. J., Lee, M., Chien, Y. H. & Davis, M. M. Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice. Proc. Natl Acad. Sci. USA 99, 9374-9379 (2002). (Pubitemid 34764621)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.14
, pp. 9374-9379
-
-
Baker, F.J.1
Lee, M.2
Chien, Y.-H.3
Davis, M.M.4
-
68
-
-
79953189382
-
TCR bias of in vivo expanded T cells in pancreatic islets and spleen at the onset in human type 1 diabetes
-
Codina-Busqueta, E. et al. TCR bias of in vivo expanded T cells in pancreatic islets and spleen at the onset in human type 1 diabetes. J. Immunol. 186, 3787-3797 (2011).
-
(2011)
J. Immunol
, vol.186
, pp. 3787-3797
-
-
Codina-Busqueta, E.1
-
69
-
-
84859519651
-
Germline TRAV5D4 Tcell receptor sequence targets a primary insulin peptide of NOD mice
-
Nakayama, M. et al. Germline TRAV5D4 Tcell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes 61, 857-865 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 857-865
-
-
Nakayama, M.1
-
70
-
-
4344622052
-
Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: Generation by retroviral-mediated stem cell gene transfer
-
Arnold, P. Y., Burton, A. R. & Vignali, D. A. Diabetes incidence is unaltered in glutamate decarboxylase 65specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer. J. Immunol. 173, 3103-3111 (2004). (Pubitemid 39142016)
-
(2004)
Journal of Immunology
, vol.173
, Issue.5
, pp. 3103-3111
-
-
Arnold, P.Y.1
Burton, A.R.2
Vignali, D.A.A.3
-
71
-
-
34250642773
-
Generation of Tcell receptor retrogenic mice
-
Holst, J. et al. Generation of Tcell receptor retrogenic mice. Nature Protoc. 1, 406-417 (2006).
-
(2006)
Nature Protoc
, vol.1
, pp. 406-417
-
-
Holst, J.1
-
72
-
-
33646356743
-
Rapid analysis of Tcell selection in vivo using T cell-receptor retrogenic mice
-
Holst, J., Vignali, K. M., Burton, A. R. & Vignali, D. A. Rapid analysis of Tcell selection in vivo using T cell-receptor retrogenic mice. Nature Methods 3, 191-197 (2006).
-
(2006)
Nature Methods
, vol.3
, pp. 191-197
-
-
Holst, J.1
Vignali, K.M.2
Burton, A.R.3
Vignali, D.A.4
-
73
-
-
84861733007
-
Tcell receptor retrogenic mice: A rapid, flexible alternative to Tcell receptor transgenic mice
-
Bettini, M. L., Bettini, M. & Vignali, D. A. Tcell receptor retrogenic mice: a rapid, flexible alternative to Tcell receptor transgenic mice. Immunology 136, 265-272 (2012).
-
(2012)
Immunology
, vol.136
, pp. 265-272
-
-
Bettini, M.L.1
Bettini, M.2
Vignali, D.A.3
-
74
-
-
84867041203
-
Network for Pancreatic Organ Donors with Diabetes (nPOD): Developing a tissue biobank for type 1 diabetes
-
Campbell-Thompson, M. et al. Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes. Diabetes Metab. Res. Rev. 28, 608-617 (2012).
-
(2012)
Diabetes Metab. Res. Rev
, vol.28
, pp. 608-617
-
-
Campbell-Thompson, M.1
-
75
-
-
84856825977
-
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
-
Coppieters, K. T. et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J. Exp. Med. 209, 51-60 (2012).
-
(2012)
J. Exp. Med
, vol.209
, pp. 51-60
-
-
Coppieters, K.T.1
-
76
-
-
44349122496
-
Prevention of type 1 diabetes: The time has come
-
DOI 10.1038/ncpendmet0832, PII NCPENDMET0832
-
Sherr, J., Sosenko, J., Skyler, J. S. & Herold, K. C. Prevention of type 1 diabetes: the time has come. Nature Clin. Pract. Endocrinol. Metab. 4, 334-343 (2008). (Pubitemid 351733474)
-
(2008)
Nature Clinical Practice Endocrinology and Metabolism
, vol.4
, Issue.6
, pp. 334-343
-
-
Sherr, J.1
Sosenko, J.2
Skyler, J.S.3
Herold, K.C.4
-
77
-
-
72249122333
-
Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1
-
Orban, T. et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 32, 2269-2274 (2009).
-
(2009)
Diabetes Care
, vol.32
, pp. 2269-2274
-
-
Orban, T.1
-
78
-
-
0037244718
-
Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes
-
DOI 10.1210/jc.2002-020760
-
Krischer, J. P. et al. Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J. Clin. Endocrinol. Metab. 88, 103-108 (2003). (Pubitemid 36115150)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.1
, pp. 103-108
-
-
Krischer, J.P.1
Cuthbertson, D.D.2
Yu, L.3
Orban, T.4
Maclaren, N.5
Jackson, R.6
Winter, W.E.7
Schatz, D.A.8
Palmer, J.P.9
Eisenbarth, G.S.10
-
79
-
-
0031945499
-
How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
-
DOI 10.1146/annurev.immunol.16.1.619
-
Waldmann, H. & Cobbold, S. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Annu. Rev. Immunol. 16, 619-644 (1998). (Pubitemid 28183379)
-
(1998)
Annual Review of Immunology
, vol.16
, pp. 619-644
-
-
Waldmann, H.1
Cobbold, S.2
-
80
-
-
79953220761
-
Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
-
Fourlanos, S. et al. Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes 60, 1237-1245 (2011).
-
(2011)
Diabetes
, vol.60
, pp. 1237-1245
-
-
Fourlanos, S.1
-
81
-
-
17444437590
-
Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial
-
Chaillous, L. et al. Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Lancet 356, 545-549 (2000). (Pubitemid 30611859)
-
(2000)
Lancet
, vol.356
, Issue.9229
, pp. 545-549
-
-
Chaillous, L.1
Lefevre, H.2
Thivolet, C.3
Boitard, C.4
Lahlou, N.5
Atlan-Gepner, C.6
Bouhanick, B.7
Mogenet, A.8
Nicolino, M.9
Carel, J.-C.10
Lecomte, P.11
Marechaud, R.12
Bougneres, P.13
Charbonnel, B.14
Sai, P.15
-
82
-
-
0037198427
-
Effects of insulin in relatives of patients with type 1 diabetes mellitus
-
Diabetes Prevention Trial-Type 1 Diabetes Study Group
-
Diabetes Prevention Trial-Type 1 Diabetes Study Group. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N. Engl. J. Med. 346, 1685-1691 (2002).
-
(2002)
N. Engl. J. Med
, vol.346
, pp. 1685-1691
-
-
-
83
-
-
18144391496
-
Effects of oral insulin in relatives of patients with type 1 diabetes: The diabetes prevention trial-type 1
-
DOI 10.2337/diacare.28.5.1068
-
Skyler, J. S. et al. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1. Diabetes Care 28, 1068-1076 (2005). (Pubitemid 40616615)
-
(2005)
Diabetes Care
, vol.28
, Issue.5
, pp. 1068-1076
-
-
Skyler, J.S.1
-
84
-
-
55249110198
-
GAD treatment and insulin secretion in recent-onset type 1 diabetes
-
Ludvigsson, J. et al. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 359, 1909-1920 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1909-1920
-
-
Ludvigsson, J.1
-
85
-
-
84856564903
-
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
-
Ludvigsson, J. et al. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N. Engl. J. Med. 366, 433-442 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 433-442
-
-
Ludvigsson, J.1
-
86
-
-
79960743608
-
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial
-
Wherrett, D. K. et al. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet 378, 319-327 (2011).
-
(2011)
Lancet
, vol.378
, pp. 319-327
-
-
Wherrett, D.K.1
-
87
-
-
77950636402
-
Failure to preserve β-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new-onset type 1 diabetes
-
Gottlieb, P. A. et al. Failure to preserve β-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new-onset type 1 diabetes. Diabetes Care 33, 826-832 (2010).
-
(2010)
Diabetes Care
, vol.33
, pp. 826-832
-
-
Gottlieb, P.A.1
-
88
-
-
70449480577
-
Rituximab Blymphocyte depletion, and preservation of β-cell function
-
Pescovitz, M. D. et al. Rituximab, Blymphocyte depletion, and preservation of β-cell function. N. Engl. J. Med. 361, 2143-2152 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 2143-2152
-
-
Pescovitz, M.D.1
-
89
-
-
80051940031
-
Increased T cell proliferative responses to islet antigens identify clinical responders to antiCD20 monoclonal antibody (rituximab) therapy in type 1 diabetes
-
Herold, K. C. et al. Increased T cell proliferative responses to islet antigens identify clinical responders to antiCD20 monoclonal antibody (rituximab) therapy in type 1 diabetes. J. Immunol. 187, 1998-2005 (2011).
-
(2011)
J. Immunol
, vol.187
, pp. 1998-2005
-
-
Herold, K.C.1
-
90
-
-
80053434203
-
Rituximab selectively suppresses specific islet antibodies
-
Yu, L. et al. Rituximab selectively suppresses specific islet antibodies. Diabetes 60, 2560-2565 (2011).
-
(2011)
Diabetes
, vol.60
, pp. 2560-2565
-
-
Yu, L.1
-
91
-
-
0028900297
-
Differential effects of antiB71 and antiB72 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
-
Lenschow, D. J. et al. Differential effects of antiB71 and antiB72 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181, 1145-1155 (1995).
-
(1995)
J. Exp. Med
, vol.181
, pp. 1145-1155
-
-
Lenschow, D.J.1
-
92
-
-
16044371193
-
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
-
DOI 10.1016/S1074-7613(00)80323-4
-
Lenschow, D. J. et al. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 5, 285-293 (1996). (Pubitemid 26341371)
-
(1996)
Immunity
, vol.5
, Issue.3
, pp. 285-293
-
-
Lenschow, D.J.1
Herold, K.C.2
Rhee, L.3
Patel, B.4
Koons, A.5
Qin, H.-Y.6
Fuchs, E.7
Singh, B.8
Thompson, C.B.9
Bluestone, J.A.10
-
93
-
-
79960912796
-
Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: A randomised, double-blind, placebo-controlled trial
-
Orban, T. et al. Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 378, 412-419 (2011).
-
(2011)
Lancet
, vol.378
, pp. 412-419
-
-
Orban, T.1
-
94
-
-
0027361654
-
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients
-
Itoh, N. et al. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J. Clin. Invest. 92, 2313-2322 (1993). (Pubitemid 23333537)
-
(1993)
Journal of Clinical Investigation
, vol.92
, Issue.5
, pp. 2313-2322
-
-
Itoh, N.1
Hanafusa, T.2
Miyazaki, A.3
Miyagawa, J.-I.4
Yamagata, K.5
Yamamoto, K.6
Waguri, M.7
Imagawa, A.8
Tamura, S.9
Inada, M.10
Kawata, S.11
Tarui, S.12
Kono, N.13
Matsuzawa, Y.14
-
95
-
-
2942546678
-
NKG2D blockade prevents autoimmune diabetes in NOD mice
-
DOI 10.1016/j.immuni.2004.05.008, PII S1074761304001402
-
Ogasawara, K. et al. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20, 757-767 (2004). (Pubitemid 38757445)
-
(2004)
Immunity
, vol.20
, Issue.6
, pp. 757-767
-
-
Ogasawara, K.1
Hamerman, J.A.2
Ehrlich, L.R.3
Bour-Jordan, H.4
Santamaria, P.5
Bluestone, J.A.6
Lanier, L.L.7
-
96
-
-
84865811698
-
NK cells are not required for spontaneous autoimmune diabetes in NOD mice
-
Beilke, J. N. et al. NK cells are not required for spontaneous autoimmune diabetes in NOD mice. PLoS ONE 7, e36011 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Beilke, J.N.1
-
97
-
-
0030049651
-
Interleukin-1 effect on glycemia in the non-obese diabetic mouse at the pre-diabetic stage
-
Amrani, A. et al. Interleukin1 effect on glycemia in the non-obese diabetic mouse at the pre-diabetic stage. J. Endocrinol. 148, 139-148 (1996). (Pubitemid 26017042)
-
(1996)
Journal of Endocrinology
, vol.148
, Issue.1
, pp. 139-148
-
-
Amrani, A.1
Jafarian-Tehrani, M.2
Mormede, P.3
Durant, S.4
Pleau, J.-M.5
Haour, F.6
Dardenne, M.7
Homo-Delarche, F.8
-
98
-
-
0025095283
-
Cytotoxic effects of cytokines on islet β-cells: Evidence for involvement of eicosanoids
-
Rabinovitch, A., Baquerizo, H. & Sumoski, W. Cytotoxic effects of cytokines on islet β-cells: evidence for involvement of eicosanoids. Endocrinology 126, 67-71 (1990). (Pubitemid 20037126)
-
(1990)
Endocrinology
, vol.126
, Issue.1
, pp. 67-71
-
-
Rabinovitch, A.1
Baquerizo, H.2
Sumoski, W.3
-
99
-
-
0347360367
-
IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse
-
DOI 10.2337/diabetes.53.1.113
-
Thomas, H. E. et al. IL1 receptor deficiency slows progression to diabetes in the NOD mouse. Diabetes 53, 113-121 (2004). (Pubitemid 38044705)
-
(2004)
Diabetes
, vol.53
, Issue.1
, pp. 113-121
-
-
Thomas, H.E.1
Irawaty, W.2
Darwiche, R.3
Brodnicki, T.C.4
Santamaria, P.5
Allison, J.6
Kay, T.W.H.7
-
100
-
-
0030995686
-
Treatment with neutralizing antibodies specific for IL-1β prevents cyclophosphamide-induced diabetes in nonobese diabetic mice
-
Cailleau, C., Diu-Hercend, A., Ruuth, E., Westwood, R. & Carnaud, C. Treatment with neutralizing antibodies specific for IL1β prevents cyclophosphamide-induced diabetes in nonobese diabetic mice. Diabetes 46, 937-940 (1997). (Pubitemid 27220991)
-
(1997)
Diabetes
, vol.46
, Issue.6
, pp. 937-940
-
-
Cailleau, C.1
Diu-Hercend, A.2
Ruuth, E.3
Westwood, R.4
Carnaud, C.5
-
101
-
-
0025951776
-
Insulitis in type 1 (insulin-dependent) diabetes mellitus in man-macrophages, lymphocytes, and interferon-γ containing cells
-
Foulis, A. K., McGill, M. & Farquharson, M. A. Insulitis in type 1 (insulin-dependent) diabetes mellitus in man-macrophages, lymphocytes, and interferon-γ containing cells. J. Pathol. 165, 97-103 (1991).
-
(1991)
J. Pathol
, vol.165
, pp. 97-103
-
-
Foulis, A.K.1
McGill, M.2
Farquharson, M.A.3
-
102
-
-
55849136929
-
Curative and β cell regenerative effects of α1antitrypsin treatment in autoimmune diabetic NOD mice
-
Koulmanda, M. et al. Curative and β cell regenerative effects of α1antitrypsin treatment in autoimmune diabetic NOD mice. Proc. Natl Acad. Sci. USA 105, 16242-16247 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 16242-16247
-
-
Koulmanda, M.1
-
103
-
-
84861815123
-
Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes
-
Schilling, E. et al. Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes. Innate Immun. 18, 518-530 (2012).
-
(2012)
Innate Immun
, vol.18
, pp. 518-530
-
-
Schilling, E.1
-
104
-
-
1642277657
-
European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes
-
Gale, E. A., Bingley, P. J., Emmett, C. L. & Collier, T. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 363, 925-931 (2004).
-
(2004)
Lancet
, vol.363
, pp. 925-931
-
-
Gale, E.A.1
Bingley, P.J.2
Emmett, C.L.3
Collier, T.4
-
105
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
DOI 10.1056/NEJMoa065213
-
Larsen, C. M. et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356, 1517-1526 (2007). (Pubitemid 46588416)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.15
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Volund, A.4
Ehses, J.A.5
Seifert, B.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
106
-
-
77954311838
-
Short-term IL1β blockade reduces monocyte CD11b integrin expression in an IL8 dependent fashion in patients with type 1 diabetes
-
Sanda, S. et al. Short-term IL1β blockade reduces monocyte CD11b integrin expression in an IL8 dependent fashion in patients with type 1 diabetes. Clin. Immunol. 136, 170-173 (2010).
-
(2010)
Clin. Immunol
, vol.136
, pp. 170-173
-
-
Sanda, S.1
-
107
-
-
33745817772
-
+ regulatory T cell function via innate TLR2 signaling
-
DOI 10.1172/JCI28423
-
Zanin-Zhorov, A. et al. Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J. Clin. Invest. 116, 2022-2032 (2006). (Pubitemid 44033326)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 2022-2032
-
-
Zanin-Zhorov, A.1
Cahalon, L.2
Tal, G.3
Margalit, R.4
Lider, O.5
Cohen, I.R.6
-
108
-
-
0035944844
-
β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
-
DOI 10.1016/S0140-6736(01)06801-5
-
Raz, I. et al. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358, 1749-1753 (2001). (Pubitemid 33152998)
-
(2001)
Lancet
, vol.358
, Issue.9295
, pp. 1749-1753
-
-
Raz, I.1
Elias, D.2
Avron, A.3
Tamir, M.4
Metzger, M.5
Cohen, I.R.6
-
109
-
-
33745817085
-
+ T reg cells
-
DOI 10.1084/jem.20060772
-
Liu, W. et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203, 1701-1711 (2006). (Pubitemid 44036276)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1701-1711
-
-
Liu, W.1
Putnam, A.L.2
Xu-yu, Z.3
Szot, G.L.4
Lee, M.R.5
Zhu, S.6
Gottlieb, P.A.7
Kapranov, P.8
Gingeras, T.R.9
De St. Groth, B.F.10
Clayberger, C.11
Soper, D.M.12
Ziegler, S.F.13
Bluestone, J.A.14
-
110
-
-
47249124078
-
Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities
-
DOI 10.1111/j.1600-065X.2008.00637.x
-
Brusko, T. M., Putnam, A. L. & Bluestone, J. A. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol. Rev. 223, 371-390 (2008). (Pubitemid 351986182)
-
(2008)
Immunological Reviews
, vol.223
, Issue.1
, pp. 371-390
-
-
Brusko, T.M.1
Putnam, A.L.2
Bluestone, J.A.3
-
111
-
-
69049107358
-
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
-
Zhou, X. et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nature Immunol. 10, 1000-1007 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 1000-1007
-
-
Zhou, X.1
-
112
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
Zheng, Y. et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808-812 (2010).
-
(2010)
Nature
, vol.463
, pp. 808-812
-
-
Zheng, Y.1
-
113
-
-
0035059417
-
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
-
DOI 10.1146/annurev.immunol.19.1.225
-
Salomon, B. & Bluestone, J. A. Complexities of CD28/B7: CTLA4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19, 225-252 (2001). (Pubitemid 32368035)
-
(2001)
Annual Review of Immunology
, vol.19
, pp. 225-252
-
-
Salomon, B.1
Bluestone, J.A.2
-
114
-
-
0033682056
-
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
-
Salomon, B. et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
-
115
-
-
79959716366
-
NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with antiCD3 antibody
-
Ablamunits, V., Henegariu, O., Preston-Hurlburt, P. & Herold, K. C. NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with antiCD3 antibody. Eur. J. Immunol. 41, 1832-1842 (2011).
-
(2011)
Eur. J. Immunol
, vol.41
, pp. 1832-1842
-
-
Ablamunits, V.1
Henegariu, O.2
Preston-Hurlburt, P.3
Herold, K.C.4
-
116
-
-
0141703239
-
+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes
-
DOI 10.1073/pnas.1834400100
-
Green, E. A., Gorelik, L., McGregor, C. M., Tran, E. H. & Flavell, R. A. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc. Natl Acad. Sci. USA 100, 10878-10883 (2003). (Pubitemid 37140121)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.19
, pp. 10878-10883
-
-
Green, E.A.1
Gorelik, L.2
McGregor, C.M.3
Tran, E.H.4
Flavell, R.A.5
-
117
-
-
34547204632
-
Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
-
DOI 10.1073/pnas.0701171104
-
You, S. et al. Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of antiCD3 antibody treatment. Proc. Natl Acad. Sci. USA 104, 6335-6340 (2007). (Pubitemid 47186095)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.15
, pp. 6335-6340
-
-
You, S.1
Leforban, B.2
Garcia, C.3
Bach, J.-F.4
Bluestone, J.A.5
Chatenoud, L.6
-
118
-
-
0035806323
-
Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
-
Levings, M. K., Sangregorio, R. & Roncarolo, M. G. Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193, 1295-1302 (2001).
-
(2001)
J. Exp. Med
, vol.193
, pp. 1295-1302
-
-
Levings, M.K.1
Sangregorio, R.2
Roncarolo, M.G.3
-
119
-
-
0037131969
-
+ T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells
-
DOI 10.1084/jem.20021139
-
Levings, M. K. et al. Human CD25+CD4+ T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196, 1335-1346 (2002). (Pubitemid 35375552)
-
(2002)
Journal of Experimental Medicine
, vol.196
, Issue.10
, pp. 1335-1346
-
-
Levings, M.K.1
Sangregorio, R.2
Sartirana, C.3
Moschin, A.L.4
Battaglia, M.5
Orban, P.C.6
Roncarolo, M.-G.7
-
120
-
-
0035181582
-
Type 1 T regulatory cells
-
DOI 10.1034/j.1600-065X.2001.1820105.x
-
Roncarolo, M. G., Bacchetta, R., Bordignon, C., Narula, S. & Levings, M. K. Type 1 T regulatory cells. Immunol. Rev. 182, 68-79 (2001). (Pubitemid 33070208)
-
(2001)
Immunological Reviews
, vol.182
, pp. 68-79
-
-
Roncarolo, M.G.1
Bacchetta, R.2
Bordignon, C.3
Narula, S.4
Levings, M.K.5
-
121
-
-
84871642405
-
Context and location dependence of adaptive Foxp3+regulatory T cell formation during immunopathological conditions
-
Heiber, J. F. & Geiger, T. L. Context and location dependence of adaptive Foxp3+regulatory T cell formation during immunopathological conditions. Cell. Immunol. 279, 60-65 (2012).
-
(2012)
Cell. Immunol
, vol.279
, pp. 60-65
-
-
Heiber, J.F.1
Geiger, T.L.2
-
122
-
-
80053550261
-
Cutting edge: Accelerated autoimmune diabetes in the absence of LAG3
-
Bettini, M. et al. Cutting edge: accelerated autoimmune diabetes in the absence of LAG3. J. Immunol. 187, 3493-3498 (2011).
-
(2011)
J. Immunol
, vol.187
, pp. 3493-3498
-
-
Bettini, M.1
-
123
-
-
0028867420
-
Loss of CTLA4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA4
-
Tivol, E. A. et al. Loss of CTLA4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA4. Immunity 3, 541-547 (1995).
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
-
124
-
-
9244261022
-
+ regulatory T cell function
-
DOI 10.1002/eji.200425143
-
Tang, Q. et al. Distinct roles of CTLA4 and TGF-β in CD4+CD25+ regulatory T cell function. Eur. J. Immunol. 34, 2996-3005 (2004). (Pubitemid 39549379)
-
(2004)
European Journal of Immunology
, vol.34
, Issue.11
, pp. 2996-3005
-
-
Tang, Q.1
Boden, E.K.2
Henriksen, K.J.3
Bour-Jordan, H.4
Bi, M.5
Bluestone, J.A.6
-
125
-
-
33644784891
-
Transforming growth factor-β and natural killer Tcells are involved in the protective effect of a bacterial extract on type 1 diabetes
-
Alyanakian, M. A. et al. Transforming growth factor-β and natural killer Tcells are involved in the protective effect of a bacterial extract on type 1 diabetes. Diabetes 55, 179-185 (2006).
-
(2006)
Diabetes
, vol.55
, pp. 179-185
-
-
Alyanakian, M.A.1
-
126
-
-
5044220930
-
IDO expression by dendritic cells: Tolerance and tryptophan catabolism
-
DOI 10.1038/nri1457
-
Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nature Rev. Immunol. 4, 762-774 (2004). (Pubitemid 39336293)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.10
, pp. 762-774
-
-
Mellor, A.L.1
Munn, D.H.2
-
127
-
-
78449296907
-
IL35mediated induction of a potent regulatory T cell population
-
Collison, L. W. et al. IL35mediated induction of a potent regulatory T cell population. Nature Immunol. 11, 1093-1101 (2010).
-
(2010)
Nature Immunol
, vol.11
, pp. 1093-1101
-
-
Collison, L.W.1
-
128
-
-
58949100205
-
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin2 receptor production
-
Maier, L. M. et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin2 receptor production. PLoS Genet. 5, e1000322 (2009).
-
(2009)
PLoS Genet
, vol.5
-
-
Maier, L.M.1
-
129
-
-
0037648405
-
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
-
DOI 10.1038/nature01621
-
Ueda, H. et al. Association of the Tcell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423, 506-511 (2003). (Pubitemid 36648570)
-
(2003)
Nature
, vol.423
, Issue.6939
, pp. 506-511
-
-
Ueda, H.1
Howson, J.M.M.2
Esposito, L.3
Heward, J.4
Snook, H.5
Chamberlain, G.6
Rainbow, D.B.7
Hunter, K.M.D.8
Smith, A.N.9
Di Genova, G.10
Herr, M.H.11
Dahlman, I.12
Payne, F.13
Smyth, D.14
Lowe, C.15
Twells, R.C.J.16
Howlett, S.17
Healy, B.18
Nutland, S.19
Rance, H.E.20
Everett, V.21
Smink, L.J.22
Lam, A.C.23
Cordell, H.J.24
Walker, N.M.25
Bordin, C.26
Hulme, J.27
Motzo, C.28
Cucca, F.29
Hess, J.F.30
Metzker, M.L.31
Rogers, J.32
Gregory, S.33
Allahabadia, A.34
Nithiyananthan, R.35
Tuomilehto-Wolf, E.36
Tuomilehto, J.37
Bingley, P.38
Gillespie, K.M.39
Undlien, D.E.40
Ronningen, K.S.41
Guja, C.42
Ionescu-Tirgoviste, C.43
Savage, D.A.44
Maxwell, A.P.45
Carson, D.J.46
Patterson, C.C.47
Franklyn, J.A.48
Clayton, D.G.49
Peterson, L.B.50
Wicker, L.S.51
Todd, J.A.52
Gough, S.C.L.53
more..
-
130
-
-
77449143100
-
Defects in IL2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory Tcells of type 1 diabetic subjects
-
Long, S. A. et al. Defects in IL2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory Tcells of type 1 diabetic subjects. Diabetes 59, 407-415 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 407-415
-
-
Long, S.A.1
-
131
-
-
77956257716
-
IL2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
-
Grinberg-Bleyer, Y. et al. IL2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J. Exp. Med. 207, 1871-1878 (2010).
-
(2010)
J. Exp. Med
, vol.207
, pp. 1871-1878
-
-
Grinberg-Bleyer, Y.1
-
132
-
-
79955028001
-
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
-
McClymont, S. A. et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J. Immunol. 186, 3918-3926 (2011).
-
(2011)
J. Immunol
, vol.186
, pp. 3918-3926
-
-
McClymont, S.A.1
-
133
-
-
0036314243
-
Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
-
Rabinovitch, A., Suarez-Pinzon, W. L., Shapiro, A. M., Rajotte, R. V. & Power, R. Combination therapy with sirolimus and interleukin2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes 51, 638-645 (2002). (Pubitemid 34760170)
-
(2002)
Diabetes
, vol.51
, Issue.3
, pp. 638-645
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
James Shapiro, A.M.3
Rajotte, R.V.4
Power, R.5
-
134
-
-
40749153195
-
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation
-
Simon, G. et al. Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation. Diabetes 57, 405-414 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 405-414
-
-
Simon, G.1
-
135
-
-
0141796312
-
TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
-
DOI 10.1038/nm924
-
Belghith, M. et al. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nature Med. 9, 1202-1208 (2003). (Pubitemid 37173706)
-
(2003)
Nature Medicine
, vol.9
, Issue.9
, pp. 1202-1208
-
-
Belghith, M.1
Bluestone, J.A.2
Barriot, S.3
Megret, J.4
Bach, J.-F.5
Chatenoud, L.6
-
136
-
-
79960919901
-
Control of TH17 cells occurs in the small intestine
-
Esplugues, E. et al. Control of TH17 cells occurs in the small intestine. Nature 475, 514-518 (2011).
-
(2011)
Nature
, vol.475
, pp. 514-518
-
-
Esplugues, E.1
-
137
-
-
84856274206
-
Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients
-
Waldron-Lynch, F. et al. Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Sci. Transl. Med. 4, 118ra112 (2012).
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Waldron-Lynch, F.1
-
138
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3γ1(ala-ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
DOI 10.2337/diabetes.54.6.1763
-
Herold, K. C. et al. A single course of antiCD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in Cpeptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54, 1763-1769 (2005). (Pubitemid 40770766)
-
(2005)
Diabetes
, vol.54
, Issue.6
, pp. 1763-1769
-
-
Herold, K.C.1
Gitelman, S.E.2
Masharani, U.3
Hagopian, W.4
Bisikirska, B.5
Donaldson, D.6
Rother, K.7
Diamond, B.8
Harlan, D.M.9
Bluestone, J.A.10
-
139
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
DOI 10.1056/NEJMoa012864
-
Herold, K. C. et al. AntiCD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346, 1692-1698 (2002). (Pubitemid 34547482)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.22
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
-
140
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
DOI 10.1056/NEJMoa043980
-
Keymeulen, B. et al. Insulin needs after CD3antibody therapy in new-onset type 1 diabetes. N. Engl. J. Med. 352, 2598-2608 (2005). (Pubitemid 41007846)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.25
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
Mathieu, C.4
Kaufman, L.5
Hale, G.6
Gorus, F.7
Goldman, M.8
Walter, M.9
Candon, S.10
Schandene, L.11
Crenier, L.12
De Block, C.13
Seigneurin, J.-M.14
De Pauw, P.15
Pierard, D.16
Weets, I.17
Rebello, P.18
Bird, P.19
Berrie, E.20
Frewin, M.21
Waldmann, H.22
Bach, J.-F.23
Pipeleers, D.24
Chatenoud, L.25
more..
-
141
-
-
77949266510
-
Four-year metabolic outcome of a randomised controlled CD3antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual β cell mass
-
Keymeulen, B. et al. Four-year metabolic outcome of a randomised controlled CD3antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual β cell mass. Diabetologia 53, 614-623 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 614-623
-
-
Keymeulen, B.1
-
142
-
-
26444515022
-
+ Tregs
-
DOI 10.1172/JCI23961
-
Bisikirska, B., Colgan, J., Luban, J., Bluestone, J. A. & Herold, K. C. TCR stimulation with modified antiCD3 mAb expands CD8 T cell population and induces CD8CD25 TRegs. J. Clin. Invest. 115, 2904-2913 (2005). (Pubitemid 41434418)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2904-2913
-
-
Bisikirska, B.1
Colgan, J.2
Luban, J.3
Bluestone, J.A.4
Herold, K.C.5
-
143
-
-
0037314237
-
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)
-
DOI 10.1172/JCI200316090
-
Herold, K. C. et al. Activation of human T cells by FcR nonbinding antiCD3 mAb, hOKT3γ1(Ala-Ala). J. Clin. Invest. 111, 409-418 (2003). (Pubitemid 36182218)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.3
, pp. 409-418
-
-
Herold, K.C.1
Burton, J.B.2
Francois, F.3
Poumian-Ruiz, E.4
Glandt, M.5
Bluestone, J.A.6
-
144
-
-
80051471700
-
Teplizumab for treatment of type 1 diabetes (Protege study): 1year results from a randomised, placebo-controlled trial
-
Sherry, N. et al. Teplizumab for treatment of type 1 diabetes (Protege study): 1year results from a randomised, placebo-controlled trial. Lancet 378, 487-497 (2011).
-
(2011)
Lancet
, vol.378
, pp. 487-497
-
-
Sherry, N.1
-
145
-
-
84876095279
-
Teplizumab treatment may improve Cpeptide responses in participants with type 1 diabetes after the new-onset period: A randomised controlled trial
-
Herold, K. C. et al. Teplizumab treatment may improve Cpeptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia 56, 391-400 (2012).
-
(2012)
Diabetologia
, vol.56
, pp. 391-400
-
-
Herold, K.C.1
-
146
-
-
84865478468
-
Rapamycin/IL2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
-
Long, S. A. et al. Rapamycin/IL2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes 61, 2340-2348 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 2340-2348
-
-
Long, S.A.1
-
147
-
-
0027479685
-
Infectious transplantation tolerance
-
Qin, S. et al. "Infectious" transplantation tolerance. Science 259, 974-977 (1993).
-
(1993)
Science
, vol.259
, pp. 974-977
-
-
Qin, S.1
-
148
-
-
84555188737
-
Synergistic reversal of type 1 diabetes in NOD mice with antiCD3 and interleukin1 blockade: Evidence of improved immune regulation
-
Ablamunits, V. et al. Synergistic reversal of type 1 diabetes in NOD mice with antiCD3 and interleukin1 blockade: evidence of improved immune regulation. Diabetes 61, 145-154 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 145-154
-
-
Ablamunits, V.1
-
149
-
-
0028973284
-
Interleukin-1beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: Evidence for the involvement of nuclear factor kappaB in the signaling mechanism
-
DOI 10.1210/en.136.11.4790
-
Kwon, G., Corbett, J. A., Rodi, C. P., Sullivan, P. & McDaniel, M. L. Interleukin1 β-induced nitric oxide synthase expression by rat pancreatic β-cells: evidence for the involvement of nuclear factor κ B in the signaling mechanism. Endocrinology 136, 4790-4795 (1995). (Pubitemid 3002171)
-
(1995)
Endocrinology
, vol.136
, Issue.11
, pp. 4790-4795
-
-
Kwon Guim1
Corbett, J.A.2
Rodi, C.P.3
Sullivan, P.4
McDaniel, M.L.5
-
150
-
-
70349884094
-
Interferon regulatory factor1 is a key transcription factor in murine β cells under immune attack
-
Gysemans, C. et al. Interferon regulatory factor1 is a key transcription factor in murine β cells under immune attack. Diabetologia 52, 2374-2384 (2009).
-
(2009)
Diabetologia
, vol.52
, pp. 2374-2384
-
-
Gysemans, C.1
-
151
-
-
58149348476
-
β-cell Mass and Type 1 Diabetes: Going Going Gone?
-
Akirav, E., Kushner, J. A. & Herold, K. C. β-cell mass and type 1 diabetes: going, going, gone? Diabetes 57, 2883-2888 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 2883-2888
-
-
Akirav, E.1
Kushner, J.A.2
Herold, K.C.3
-
152
-
-
33845523340
-
Effects of autoimmunity and immune therapy on β-cell turnover in type 1 diabetes
-
DOI 10.2337/db05-1034
-
Sherry, N. A. et al. Effects of autoimmunity and immune therapy on β-cell turnover in type 1 diabetes. Diabetes 55, 3238-3245 (2006). (Pubitemid 44923579)
-
(2006)
Diabetes
, vol.55
, Issue.12
, pp. 3238-3245
-
-
Sherry, N.A.1
Kushner, J.A.2
Glandt, M.3
Kitamura, T.4
Brillantes, A.-M.B.5
Herold, K.C.6
-
153
-
-
82755197361
-
Detection of β cell death in diabetes using differentially methylated circulating DNA
-
Akirav, E. M. et al. Detection of β cell death in diabetes using differentially methylated circulating DNA. Proc. Natl Acad. Sci. USA 108, 19018-19023 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 19018-19023
-
-
Akirav, E.M.1
-
154
-
-
84866389264
-
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure
-
Talchai, C., Xuan, S., Lin, H. V., Sussel, L. & Accili, D. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 150, 1223-1234 (2012).
-
(2012)
Cell
, vol.150
, pp. 1223-1234
-
-
Talchai, C.1
Xuan, S.2
Lin, H.V.3
Sussel, L.4
Accili, D.5
-
155
-
-
0035124874
-
β-cell apoptosis and defense mechanisms: Lessons from type 1 diabetes
-
Eizirik, D.L. & Darville, M.I. β-cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes 50 (Suppl. 1), S64-69 (2001). (Pubitemid 32148222)
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Eizirik, D.L.1
Darville, M.I.2
-
156
-
-
79960038146
-
Using stem cells to study and possibly treat type 1 diabetes
-
Melton, D. A. Using stem cells to study and possibly treat type 1 diabetes. Phil. Trans. R. Soc. B 366, 2307-2311 (2011).
-
(2011)
Phil. Trans. R. Soc B
, vol.366
, pp. 2307-2311
-
-
Melton, D.A.1
-
157
-
-
67049159857
-
Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
-
Patterson, C. C., Dahlquist, G. G., Gyurus, E., Green, A. & Soltesz, G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 373, 2027-2033 (2009).
-
(2009)
Lancet
, vol.373
, pp. 2027-2033
-
-
Patterson, C.C.1
Dahlquist, G.G.2
Gyurus, E.3
Green, A.4
Soltesz, G.5
-
158
-
-
0025011787
-
A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes
-
Riley, W. J. et al. A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N. Engl. J. Med. 323, 1167-1172 (1990). (Pubitemid 20347402)
-
(1990)
New England Journal of Medicine
, vol.323
, Issue.17
, pp. 1167-1172
-
-
Riley, W.J.1
Maclaren, N.K.2
Krischer, J.3
Spillar, R.P.4
Silverstein, J.H.5
Schatz, D.A.6
Schwartz, S.7
Malone, J.8
Shah, S.9
Vadheim, C.10
Rotter, J.I.11
-
159
-
-
0033311156
-
Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes
-
Sabbah, E. et al. Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. J. Clin. Endocrinol. Metab. 84, 1534-1539 (1999). (Pubitemid 30644249)
-
(1999)
Journal of Clinical Endocrinology and Metabolism
, vol.84
, Issue.5
, pp. 1534-1539
-
-
Sabbah, E.1
Savola, K.2
Kulmala, P.3
Veijola, R.4
Vahasalo, P.5
Karjalainen, J.6
Akerblom, H.K.7
Knip, M.8
-
160
-
-
84864381301
-
Fall in Cpeptide during first 2 years from diagnosis: Evidence of at least two distinct phases from composite TrialNet data
-
Greenbaum, C. J. et al. Fall in Cpeptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite TrialNet data. Diabetes 61, 2066-2073 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 2066-2073
-
-
Greenbaum, C.J.1
-
161
-
-
20444485767
-
Cellular and genetic mechanisms of self tolerance and Autoimmunity
-
Goodnow, C. C., Sprent, J., Fazekas de St Groth, B. & Vinuesa, C. G. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 435, 590-597 (2005).
-
(2005)
Nature
, vol.435
, pp. 590-597
-
-
Goodnow, C.C.1
Sprent, J.2
Fazekas De St Groth, B.3
Vinuesa, C.G.4
-
162
-
-
2942652985
-
Receptor editing is the main mechanism of B cell tolerance toward membrane antigens
-
DOI 10.1038/ni1076
-
Halverson, R., Torres, R. M. & Pelanda, R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nature Immunol. 5, 645-650 (2004). (Pubitemid 38811890)
-
(2004)
Nature Immunology
, vol.5
, Issue.6
, pp. 645-650
-
-
Halverson, R.1
Torres, R.M.2
Pelanda, R.3
-
163
-
-
0030981639
-
- bone marrow B cells in vitro
-
Hertz, M. & Nemazee, D. BCR ligation induces receptor editing in IgM+IgD-bone marrow B cells in vitro. Immunity 6, 429-436 (1997). (Pubitemid 27208198)
-
(1997)
Immunity
, vol.6
, Issue.4
, pp. 429-436
-
-
Hertz, M.1
Nemazee, D.2
-
164
-
-
0037364804
-
Natural versus adaptive regulatory T cells
-
DOI 10.1038/nri1032
-
Bluestone, J. A. & Abbas, A. K. Natural versus adaptive regulatory T cells. Nature Rev. Immunol. 3, 253-257 (2003). (Pubitemid 37323210)
-
(2003)
Nature Reviews Immunology
, vol.3
, Issue.3
, pp. 253-257
-
-
Bluestone, J.A.1
Abbas, A.K.2
-
165
-
-
12744277942
-
Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients
-
Harjutsalo, V., Podar, T. & Tuomilehto, J. Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients. Diabetes 54, 563-569 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 563-569
-
-
Harjutsalo, V.1
Podar, T.2
Tuomilehto, J.3
-
166
-
-
79551469699
-
Genetics of type 1 diabetes
-
Steck, A. K. & Rewers, M. J. Genetics of type 1 diabetes. Clin. Chem. 57, 176-185 (2011).
-
(2011)
Clin. Chem
, vol.57
, pp. 176-185
-
-
Steck, A.K.1
Rewers, M.J.2
-
167
-
-
58149096363
-
Concordance for islet autoimmunity among monozygotic twins
-
Redondo, M. J., Jeffrey, J., Fain, P. R., Eisenbarth, G. S. & Orban, T. Concordance for islet autoimmunity among monozygotic twins. N. Engl. J. Med. 359, 2849-2850 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 2849-2850
-
-
Redondo, M.J.1
Jeffrey, J.2
Fain, P.R.3
Eisenbarth, G.S.4
Orban, T.5
-
168
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett, J. C. et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genet. 41, 703-707 (2009).
-
(2009)
Nature Genet
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
-
169
-
-
43249119095
-
Defining the role of the MHC in autoimmunity: A review and pooled analysis
-
Fernando, M. M. et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet. 4, e1000024 (2008).
-
(2008)
PLoS Genet
, vol.4
-
-
Fernando, M.M.1
-
170
-
-
0025837184
-
Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
-
Zhang, Z. J., Davidson, L., Eisenbarth, G. & Weiner, H. L. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl Acad. Sci. USA 88, 10252-10256 (1991). (Pubitemid 21915813)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.22
, pp. 10252-10256
-
-
Zhang, Z.J.1
Davidson, L.2
Eisenbarth, G.3
Weiner, H.L.4
-
171
-
-
16144361909
-
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
-
Tian, J. et al. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nature Med. 2, 1348-1353 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 1348-1353
-
-
Tian, J.1
-
172
-
-
84875464276
-
Interleukin1 antagonism in type 1 diabetes of recent onset: Two multicenter, randomized double-masked, placebo-controlled trials
-
(in the press)
-
Moran, A. et al. Interleukin1 antagonism in type 1 diabetes of recent onset: two multicenter, randomized double-masked, placebo-controlled trials. Lancet (in the press).
-
Lancet
-
-
Moran, A.1
-
173
-
-
23844525846
-
A comprehensive review of interventions in the NOD mouse and implications for translation
-
DOI 10.1016/j.immuni.2005.08.002, PII S1074761305002402
-
Shoda, L. K. et al. A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 23, 115-126 (2005). (Pubitemid 41169282)
-
(2005)
Immunity
, vol.23
, Issue.2
, pp. 115-126
-
-
Shoda, L.K.M.1
Young, D.L.2
Ramanujan, S.3
Whiting, C.C.4
Atkinson, M.A.5
Bluestone, J.A.6
Eisenbarth, G.S.7
Mathis, D.8
Rossini, A.A.9
Campbell, S.E.10
Kahn, R.11
Kreuwel, H.T.C.12
-
174
-
-
0037341252
-
Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
-
DOI 10.2337/diabetes.52.3.734
-
Stoffers, D. A., Desai, B. M., DeLeon, D. D. & Simmons, R. A. Neonatal exendin4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes 52, 734-740 (2003). (Pubitemid 36323581)
-
(2003)
Diabetes
, vol.52
, Issue.3
, pp. 734-740
-
-
Stoffers, D.A.1
Desai, B.M.2
DeLeon, D.D.3
Simmons, R.A.4
-
175
-
-
1342303482
-
Of Mice and Not Men: Differences between Mouse and Human Immunology
-
Mestas, J. & Hughes, C. C. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172, 2731-2738 (2004). (Pubitemid 38263654)
-
(2004)
Journal of Immunology
, vol.172
, Issue.5
, pp. 2731-2738
-
-
Mestas, J.1
Hughes, C.C.W.2
-
176
-
-
10744229777
-
Insulin Secretion in Type 1 Diabetes
-
DOI 10.2337/diabetes.53.2.426
-
Steele, C. et al. Insulin secretion in type 1 diabetes. Diabetes 53, 426-433 (2004). (Pubitemid 38174559)
-
(2004)
Diabetes
, vol.53
, Issue.2
, pp. 426-433
-
-
Steele, C.1
Hagopian, W.A.2
Gitelman, S.3
Masharani, U.4
Cavaghan, M.5
Rother, K.I.6
Donaldson, D.7
Harlan, D.M.8
Bluestone, J.9
Herold, K.C.10
-
177
-
-
33744995996
-
Patterns of metabolic progression to type 1 diabetes in the diabetes prevention trial-type 1
-
Sosenko, J. M. et al. Patterns of metabolic progression to type 1 diabetes in the diabetes prevention trial-type 1. Diabetes Care 29, 643-649 (2006). (Pubitemid 44115367)
-
(2006)
Diabetes Care
, vol.29
, Issue.3
, pp. 643-649
-
-
Sosenko, J.M.1
Palmer, J.P.2
Greenbaum, C.J.3
Mahon, J.4
Cowie, C.5
Krischer, J.P.6
Chase, H.P.7
White, N.H.8
Buckingham, B.9
Herold, K.C.10
Cuthbertson, D.11
Skyler, J.S.12
-
178
-
-
34247154341
-
Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
-
DOI 10.1001/jama.297.14.1568
-
Voltarelli, J. C. et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 297, 1568-1576 (2007). (Pubitemid 46588370)
-
(2007)
Journal of the American Medical Association
, vol.297
, Issue.14
, pp. 1568-1576
-
-
Voltarelli, J.C.1
Couri, C.E.B.2
Stracieri, A.B.P.L.3
Oliveira, M.C.4
Moraes, D.A.5
Pieroni, F.6
Coutinho, M.7
Malmegrim, K.C.R.8
Foss-Freitas, M.C.9
Simoes, B.P.10
Foss, M.C.11
Squiers, E.12
Burt, R.K.13
-
179
-
-
64749084427
-
C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
-
Couri, C. E. et al. C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 301, 1573-1539 (2009).
-
(2009)
JAMA
, vol.301
, pp. 1573-1539
-
-
Couri, C.E.1
-
180
-
-
67650079482
-
Etanercept treatment in children with new-onset type 1 diabetes: Pilot randomized, placebo-controlled, double-blind study
-
Mastrandrea, L. et al. Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study. Diabetes Care 32, 1244-1249 (2009).
-
(2009)
Diabetes Care
, vol.32
, pp. 1244-1249
-
-
Mastrandrea, L.1
|