-
1
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov II1
-
2
-
-
34248572345
-
T(H)-17 cells in the circle of immunity and autoimmunity
-
Bettelli E, Oukka M, Kuchroo VK (2007) T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 8:345-350.
-
(2007)
Nat Immunol
, vol.8
, pp. 345-350
-
-
Bettelli, E.1
Oukka, M.2
Kuchroo, V.K.3
-
3
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4:330-336.
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
4
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
5
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875-1886.
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
-
6
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-189.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
7
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
8
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
Korn T, et al. (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484-487.
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
-
9
-
-
12344312064
-
IL-9 and its receptor: From signal transduction to tumorigenesis
-
Knoops L, Renauld JC, (2004) IL-9 and its receptor: From signal transduction to tumorigenesis. Growth factors (Chur, Switzerland) 22:207-215.
-
(2004)
Growth factors (Chur, Switzerland)
, vol.22
, pp. 207-215
-
-
Knoops, L.1
Renauld, J.C.2
-
10
-
-
33748320914
-
Mast cells are essential intermediaries in regulatory T-cell tolerance
-
Lu LF, et al. (2006) Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442:997-1002.
-
(2006)
Nature
, vol.442
, pp. 997-1002
-
-
Lu, L.F.1
-
11
-
-
56349154943
-
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen M, et al. (2008) Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 9:1341-1346.
-
(2008)
Nat Immunol
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
-
12
-
-
0034660853
-
STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells
-
Demoulin JB, et al. (2000) STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells. Cancer Res 60:3971-3977.
-
(2000)
Cancer Res
, vol.60
, pp. 3971-3977
-
-
Demoulin, J.B.1
-
13
-
-
0029785080
-
A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9
-
Demoulin JB, et al. (1996) A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol 16:4710-4716.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4710-4716
-
-
Demoulin, J.B.1
-
14
-
-
56349093347
-
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
-
Dardalhon V, et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9:1347-1355.
-
(2008)
Nat Immunol
, vol.9
, pp. 1347-1355
-
-
Dardalhon, V.1
-
15
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
Yang XO, et al. (2007) STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282:9358-9363.
-
(2007)
J Biol Chem
, vol.282
, pp. 9358-9363
-
-
Yang, X.O.1
-
16
-
-
0033520477
-
Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9
-
Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC (1999) Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 274:25855-25861.
-
(1999)
J Biol Chem
, vol.274
, pp. 25855-25861
-
-
Demoulin, J.B.1
Van Roost, E.2
Stevens, M.3
Groner, B.4
Renauld, J.C.5
-
17
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish CL, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201:233-240.
-
(2005)
J Exp Med
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
-
18
-
-
34247564147
-
Nonredundant roles for Stat5a/b in directly regulating Foxp3
-
Yao Z, et al. (2007) Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109:4368-4375.
-
(2007)
Blood
, vol.109
, pp. 4368-4375
-
-
Yao, Z.1
-
19
-
-
38949168084
-
Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells
-
Ding Y, Shen S, Lino AC, Curotto de Lafaille MA, Lafaille JJ (2008) Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells. Nat Med 14:162-169.
-
(2008)
Nat Med
, vol.14
, pp. 162-169
-
-
Ding, Y.1
Shen, S.2
Lino, A.C.3
Curotto de Lafaille, M.A.4
Lafaille, J.J.5
-
20
-
-
33847362865
-
IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells
-
Steenwinckel V, et al. (2007) IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. J Immunol 178:3244-3251.
-
(2007)
J Immunol
, vol.178
, pp. 3244-3251
-
-
Steenwinckel, V.1
-
21
-
-
0024530962
-
Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)
-
Van Snick J, et al. (1989) Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40). J Exp Med 169:363-368.
-
(1989)
J Exp Med
, vol.169
, pp. 363-368
-
-
Van Snick, J.1
-
22
-
-
0023739985
-
Functional and structural characterization of P40, amouse glycoprotein with T-cell growth factor activity
-
Uyttenhove C, Simpson RJ, Van Snick J (1988) Functional and structural characterization of P40, amouse glycoprotein with T-cell growth factor activity. Proc Natl Acad Sci USA 85:6934-6938.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 6934-6938
-
-
Uyttenhove, C.1
Simpson, R.J.2
Van Snick, J.3
-
23
-
-
33745321276
-
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
-
Komiyama Y, et al. (2006) IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177:566-573.
-
(2006)
J Immunol
, vol.177
, pp. 566-573
-
-
Komiyama, Y.1
-
24
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, et al. (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Inves 116:1310-1316.
-
(2006)
J Clin Inves
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
-
25
-
-
3142724732
-
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
-
Bettelli E, et al. (2004) Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis J Exp Med 200:79-87.
-
(2004)
J Exp Med
, vol.200
, pp. 79-87
-
-
Bettelli, E.1
-
26
-
-
0034789247
-
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
-
Chitnis T, et al. (2001) Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 108:739-747.
-
(2001)
J Clin Invest
, vol.108
, pp. 739-747
-
-
Chitnis, T.1
-
27
-
-
0029937270
-
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
-
Kaplan MH, Sun YL, Hoey T, Grusby MJ (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174-177.
-
(1996)
Nature
, vol.382
, pp. 174-177
-
-
Kaplan, M.H.1
Sun, Y.L.2
Hoey, T.3
Grusby, M.J.4
-
28
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo SJ, et al. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment Cell 100:655-669.
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
-
29
-
-
36248965294
-
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
-
McGeachy MJ, et al. (2007) TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8:1390-1397.
-
(2007)
Nat Immunol
, vol.8
, pp. 1390-1397
-
-
McGeachy, M.J.1
-
30
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
-
31
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Laurence A, et al. (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371-381.
-
(2007)
Immunity
, vol.26
, pp. 371-381
-
-
Laurence, A.1
-
32
-
-
53149137849
-
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
-
Xiao S, et al. (2008) Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol 181:2277-2284.
-
(2008)
J Immunol
, vol.181
, pp. 2277-2284
-
-
Xiao, S.1
-
33
-
-
0035148616
-
Interleukin 9 induces expression of three cytokine signal inhibitors: Cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling
-
Lejeune D, Demoulin JB, Renauld JC (2001) Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling. Biochem J 353:109-116.
-
(2001)
Biochem J
, vol.353
, pp. 109-116
-
-
Lejeune, D.1
Demoulin, J.B.2
Renauld, J.C.3
-
34
-
-
37849008688
-
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
-
Burchill MA, et al. (2008) Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28:112-121.
-
(2008)
Immunity
, vol.28
, pp. 112-121
-
-
Burchill, M.A.1
-
35
-
-
0036625960
-
The role of STATs in apoptosis
-
Battle TE, Frank DA (2002) The role of STATs in apoptosis. Curr Mol Med 2:381-392.
-
(2002)
Curr Mol Med
, vol.2
, pp. 381-392
-
-
Battle, T.E.1
Frank, D.A.2
-
36
-
-
0038523790
-
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
-
Bettelli E, et al. (2003) Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 197:1073-1081.
-
(2003)
J Exp Med
, vol.197
, pp. 1073-1081
-
-
Bettelli, E.1
|