메뉴 건너뛰기




Volumn 15, Issue 8, 2014, Pages 758-766

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of T H9 cells

Author keywords

[No Author keywords available]

Indexed keywords

CYANIDIN 3 GLUCOSIDE; CYCLOPHOSPHAMIDE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 21; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 9; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE FYN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT INTERLEUKIN 1BETA; SMALL INTERFERING RNA; STAT1 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84904656835     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2925     Document Type: Article
Times cited : (180)

References (50)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A. & Coffman, R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357 (1986).
    • (1986) J. Immunol. , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 3
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621-663 (2011).
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 621-663
    • Crotty, S.1
  • 5
    • 56349093347 scopus 로고    scopus 로고
    • IL-4 inhibits TGF-induced Foxp3+ T cells and, together with TGF-, generates IL-9+IL-10+Foxp3- effector T cells
    • Dardalhon, V. et al. IL-4 inhibits TGF-induced Foxp3+ T cells and, together with TGF-, generates IL-9+IL-10+Foxp3- effector T cells. Nat. Immunol. 9, 1347-1355 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1347-1355
    • Dardalhon, V.1
  • 6
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor- 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen, M. et al. Transforming growth factor- 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9, 1341-1346 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1341-1346
    • Veldhoen, M.1
  • 7
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jäger, A., Dardalhon, V., Sobel, R.A., Bettelli, E. & Kuchroo, V.K. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183, 7169-7177 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 7169-7177
    • Jäger, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 8
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • Staudt, V. et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33, 192-202 (2010).
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1
  • 9
    • 77952584843 scopus 로고    scopus 로고
    • The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
    • Chang, H.C. et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol. 11, 527-534 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 527-534
    • Chang, H.C.1
  • 10
    • 0037089575 scopus 로고    scopus 로고
    • Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
    • Rengarajan, J. et al. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J. Exp. Med. 195, 1003-1012 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1003-1012
    • Rengarajan, J.1
  • 11
    • 0025246676 scopus 로고
    • The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
    • Klemsz, M.J., McKercher, S.R., Celada, A., Van Beveren, C. & Maki, R.A. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61, 113-124 (1990).
    • (1990) Cell , vol.61 , pp. 113-124
    • Klemsz, M.J.1    McKercher, S.R.2    Celada, A.3    Van Beveren, C.4    Maki, R.A.5
  • 12
    • 84864648969 scopus 로고    scopus 로고
    • Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
    • Purwar, R. et al. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat. Med. 18, 1248-1253 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1248-1253
    • Purwar, R.1
  • 13
    • 84868611628 scopus 로고    scopus 로고
    • Th9 cells promote antitumor immune response in vivo
    • Lu, Y. et al. Th9 cells promote antitumor immune responses in vivo. J. Clin. Invest. 122, 4160-4171 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 4160-4171
    • Lu, Y.1
  • 14
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1-dependent adaptive immunity against tumors
    • Ghiringhelli, F. et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1-dependent adaptive immunity against tumors. Nat. Med. 15, 1170-1178 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1
  • 15
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Chung, Y. et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30, 576-587 (2009).
    • (2009) Immunity , vol.30 , pp. 576-587
    • Chung, Y.1
  • 16
    • 84857806891 scopus 로고    scopus 로고
    • The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma
    • Horka, H. et al. The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma. J. Immunol. 188, 2669-2676 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 2669-2676
    • Horka, H.1
  • 17
    • 0030741433 scopus 로고    scopus 로고
    • Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
    • Taki, S. et al. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6, 673-679 (1997).
    • (1997) Immunity , vol.6 , pp. 673-679
    • Taki, S.1
  • 18
    • 0030747793 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo
    • Lohoff, M. et al. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity 6, 681-689 (1997).
    • (1997) Immunity , vol.6 , pp. 681-689
    • Lohoff, M.1
  • 19
    • 70349199467 scopus 로고    scopus 로고
    • Anthocyanins from black soybean seed coats preferentially inhibit TNF-alpha-mediated induction of VCAM-1 over ICAM-1 through the regulation of GATAs and IRF-1
    • Nizamutdinova, I.T. et al. Anthocyanins from black soybean seed coats preferentially inhibit TNF-alpha-mediated induction of VCAM-1 over ICAM-1 through the regulation of GATAs and IRF-1. J. Agric. Food Chem. 57, 7324-7330 (2009).
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 7324-7330
    • Nizamutdinova, I.T.1
  • 20
    • 84880675210 scopus 로고    scopus 로고
    • Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites
    • Kara, E.E. et al. Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites. J. Immunol. 191, 1110-1117 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 1110-1117
    • Kara, E.E.1
  • 21
    • 0032127279 scopus 로고    scopus 로고
    • Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    • Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143-150 (1998).
    • (1998) Immunity , vol.9 , pp. 143-150
    • Adachi, O.1
  • 22
    • 0032524335 scopus 로고    scopus 로고
    • MyD88, an adapter protein involved in interleukin-1 signaling
    • Burns, K. et al. MyD88, an adapter protein involved in interleukin-1 signaling. J. Biol. Chem. 273, 12203-12209 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 12203-12209
    • Burns, K.1
  • 23
    • 0027090310 scopus 로고
    • Jr . Activation of transcription by IFN-: Tyrosine phosphorylation of a 91-kD DNA binding protein
    • Shuai, K., Schindler, C., Prezioso, V.R. & Darnell, J.E. Jr . Activation of transcription by IFN-: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258, 1808-1812 (1992).
    • (1992) Science , vol.258 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell, J.E.4
  • 24
    • 0346792731 scopus 로고    scopus 로고
    • Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity
    • Varinou, L. et al. Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. Immunity 19, 793-802 (2003).
    • (2003) Immunity , vol.19 , pp. 793-802
    • Varinou, L.1
  • 25
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J.E. Jr., Kerr, I.M. & Stark, G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 26
    • 84860870426 scopus 로고    scopus 로고
    • TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia
    • Liu, A. et al. TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia. J. Biol. Chem. 287, 16132-16145 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 16132-16145
    • Liu, A.1
  • 27
    • 0032497642 scopus 로고    scopus 로고
    • Transgenic mouse model for skin malignant melanoma
    • Kato, M. et al. Transgenic mouse model for skin malignant melanoma. Oncogene 17, 1885-1888 (1998).
    • (1998) Oncogene , vol.17 , pp. 1885-1888
    • Kato, M.1
  • 28
    • 10744228869 scopus 로고    scopus 로고
    • Spontaneous vitiligo in an animal model for human melanoma: Role of tumor-specific CD8+ T cells
    • Lengagne, R. et al. Spontaneous vitiligo in an animal model for human melanoma: role of tumor-specific CD8+ T cells. Cancer Res. 64, 1496-1501 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 1496-1501
    • Lengagne, R.1
  • 29
    • 77953225810 scopus 로고    scopus 로고
    • Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma
    • Eyles, J. et al. Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J. Clin. Invest. 120, 2030-2039 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2030-2039
    • Eyles, J.1
  • 30
    • 48149096869 scopus 로고    scopus 로고
    • IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma
    • Frederiksen, K.S. et al. IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma. Cancer Immunol. Immunother. 57, 1439-1449 (2008).
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 1439-1449
    • Frederiksen, K.S.1
  • 31
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: Basic biology and implications for cancer and autoimmunity
    • Spolski, R. & Leonard, W.J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26, 57-79 (2008).
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 32
    • 0028077321 scopus 로고
    • IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF- and IL-4, and is inhibited by IFN
    • Schmitt, E. et al. IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF- and IL-4, and is inhibited by IFN. J. Immunol. 153, 3989-3996 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 3989-3996
    • Schmitt, E.1
  • 33
    • 0023788435 scopus 로고
    • Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN- gene regulatory elements
    • Miyamoto, M. et al. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN- gene regulatory elements. Cell 54, 903-913 (1988).
    • (1988) Cell , vol.54 , pp. 903-913
    • Miyamoto, M.1
  • 34
    • 0035061538 scopus 로고    scopus 로고
    • IRF family of transcription factors as regulators of host defense
    • Taniguchi, T., Ogasawara, K., Takaoka, A. & Tanaka, N. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19, 623-655 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 623-655
    • Taniguchi, T.1    Ogasawara, K.2    Takaoka, A.3    Tanaka, N.4
  • 35
    • 33748051738 scopus 로고    scopus 로고
    • IRFs: Master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
    • Honda, K. & Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6, 644-658 (2006).
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 644-658
    • Honda, K.1    Taniguchi, T.2
  • 36
    • 18744386097 scopus 로고    scopus 로고
    • IFN- represses IL-4 expression via IRF-1 and IRF-2
    • Elser, B. et al. IFN- represses IL-4 expression via IRF-1 and IRF-2. Immunity 17, 703-712 (2002).
    • (2002) Immunity , vol.17 , pp. 703-712
    • Elser, B.1
  • 37
    • 37349040852 scopus 로고    scopus 로고
    • The contribution of transcription factor IRF1 to the interferon- interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
    • Kano, S. et al. The contribution of transcription factor IRF1 to the interferon-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells. Nat. Immunol. 9, 34-41 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 34-41
    • Kano, S.1
  • 38
    • 77955288962 scopus 로고    scopus 로고
    • Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation
    • Jäger, A. & Kuchroo, V.K. Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand. J. Immunol. 72, 173-184 (2010).
    • (2010) Scand. J. Immunol. , vol.72 , pp. 173-184
    • Jäger, A.1    Kuchroo, V.K.2
  • 39
    • 84255215452 scopus 로고    scopus 로고
    • Th17 cells are long lived and retain a stem cell-like molecular signature
    • Muranski, P. et al. Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity 35, 972-985 (2011).
    • (2011) Immunity , vol.35 , pp. 972-985
    • Muranski, P.1
  • 40
    • 77949889567 scopus 로고    scopus 로고
    • Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
    • Okamoto, M. et al. Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. J. Biol. Chem. 285, 6477-6488 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 6477-6488
    • Okamoto, M.1
  • 41
    • 19944434230 scopus 로고    scopus 로고
    • Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    • Zeng, R. et al. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J. Exp. Med. 201, 139-148 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 139-148
    • Zeng, R.1
  • 42
    • 84866772544 scopus 로고    scopus 로고
    • Interleukin-21 has activity in patients with metastatic melanoma: A Phase II study
    • Petrella, T.M. et al. Interleukin-21 has activity in patients with metastatic melanoma: a Phase II study. J. Clin. Oncol. 30, 3396-3401 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 3396-3401
    • Petrella, T.M.1
  • 43
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley, M.E. et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298, 850-854 (2002).
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1
  • 44
    • 65249126905 scopus 로고    scopus 로고
    • Adoptive immunotherapy of cancer using CD4+ T cells
    • Muranski, P. & Restifo, N.P. Adoptive immunotherapy of cancer using CD4+ T cells. Curr. Opin. Immunol. 21, 200-208 (2009).
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 200-208
    • Muranski, P.1    Restifo, N.P.2
  • 45
    • 45549099784 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1
    • Hunder, N.N. et al. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N. Engl. J. Med. 358, 2698-2703 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2698-2703
    • Hunder, N.N.1
  • 46
    • 33847362865 scopus 로고    scopus 로고
    • IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells
    • Steenwinckel, V. et al. IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. J. Immunol. 178, 3244-3251 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 3244-3251
    • Steenwinckel, V.1
  • 48
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 49
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • Trapnell, C., Pachter, L. & Salzberg, S.L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105-1111 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 50
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511-515 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 511-515
    • Trapnell, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.