Selective stimulation of T cell subsets with antibody-cytokine immune complexes

Science

Volumn 311, Issue 5769, 2006, Pages 1924-1927

  Boyman, Onur ^a   Kovar, Marek ^a   Rubinstein, Mark P ^a   Surh, Charles D ^a   Sprent, Jonathan ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELLS; GENETIC ENGINEERING; IMMUNOLOGY; MONOCLONAL ANTIBODIES;

ANTIBODY-CYTOKINE; BIOLOGICAL ACTIVITY; IMMUNE COMPLEXES; LYMPHOCYTES;

ANTIGEN-ANTIBODY REACTIONS;

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; CYTOKINE ANTIBODY; HERMES ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 11B11; MONOCLONAL ANTIBODY 404; MONOCLONAL ANTIBODY 602; MONOCLONAL ANTIBODY JES6 5; MONOCLONAL ANTIBODY S486; PHOSPHATE BUFFERED SALINE; RECOMBINANT INTERLEUKIN 2; UNCLASSIFIED DRUG;

IMMUNE RESPONSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG MECHANISM; IMMUNE RESPONSE; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; RECEPTORS, INTERLEUKIN-2; RECOMBINANT PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 33645465526     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1122927     Document Type: Article

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21. We thank, B. Marchand for typing the manuscript and C. Chahwan, O. Greiner, and V. Martin for helpful discussions. We acknowledge support from the Flow Cytometry and Antibody Core Facility, NIH grants, and the Swiss National Science Foundation and the Novartis Foundation (to O.B.). This is publication no. 17654-IMM from The Scripps Research Institute.