메뉴 건너뛰기




Volumn 109, Issue 10, 2007, Pages 4135-4142

The molecular basis of IL-21-mediated proliferation

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 21; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SHC; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TYROSINE;

EID: 34248364008     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-10-054973     Document Type: Article
Times cited : (242)

References (56)
  • 1
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: The common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H, Okuyama C, Kumaki S, et al. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167:1-5.
    • (2001) J Immunol , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3
  • 2
    • 0037047025 scopus 로고    scopus 로고
    • The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via
    • Habib T, Senadheera S, Weinberg K, Kaushansky K. The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry. 2002;41:8725-8731.
    • (2002) JAK3. Biochemistry , vol.41 , pp. 8725-8731
    • Habib, T.1    Senadheera, S.2    Weinberg, K.3    Kaushansky, K.4
  • 3
    • 0027403374 scopus 로고
    • Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
    • Noguchi M, Yi H, Rosenblatt HM, et al. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell. 1993;73:147-157.
    • (1993) Cell , vol.73 , pp. 147-157
    • Noguchi, M.1    Yi, H.2    Rosenblatt, H.M.3
  • 4
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki K, Spolski R, Feng CG, et al. A critical role for IL-21 in regulating immunoglobulin production. Science. 2002;298:1630-1634.
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1    Spolski, R.2    Feng, C.G.3
  • 5
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol. 2005;5:688-698.
    • (2005) Nat Rev Immunol , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 7
    • 6344269331 scopus 로고    scopus 로고
    • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    • Ozaki K, Spolski R, Ettinger R, et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol. 2004;173:5361-5371.
    • (2004) J Immunol , vol.173 , pp. 5361-5371
    • Ozaki, K.1    Spolski, R.2    Ettinger, R.3
  • 8
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H, Carrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol. 2004;173:657-665.
    • (2004) J Immunol , vol.173 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 9
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    • Ettinger R, Sims GP, Fairhurst AM, et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol. 2005;175:7867-7879.
    • (2005) J Immunol , vol.175 , pp. 7867-7879
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.M.3
  • 10
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3
  • 11
    • 19944434230 scopus 로고    scopus 로고
    • Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    • Zeng R, Spolski R, Finkelstein SE, et al. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med. 2005;201:139-148.
    • (2005) J Exp Med , vol.201 , pp. 139-148
    • Zeng, R.1    Spolski, R.2    Finkelstein, S.E.3
  • 12
    • 0842278642 scopus 로고    scopus 로고
    • IL-21 induces the functional maturation of murine NK cells
    • Brady J, Hayakawa Y, Smyth MJ, Nutt SL. IL-21 induces the functional maturation of murine NK cells. J Immunol. 2004;172:2048-2058.
    • (2004) J Immunol , vol.172 , pp. 2048-2058
    • Brady, J.1    Hayakawa, Y.2    Smyth, M.J.3    Nutt, S.L.4
  • 13
    • 18344394955 scopus 로고    scopus 로고
    • IL-21 limits NK cell responses and promotes antigen-specific T cell activation: A mediator of the transition from innate to adaptive immunity
    • Kasaian MT, Whitters MJ, Carter LL, et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity. 2002;16:559-569.
    • (2002) Immunity , vol.16 , pp. 559-569
    • Kasaian, M.T.1    Whitters, M.J.2    Carter, L.L.3
  • 14
    • 22344451592 scopus 로고    scopus 로고
    • Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    • Smyth MJ, Wallace ME, Nutt SL, Yagita H, Godfrey DI, Hayakawa Y. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J Exp Med. 2005;201:1973-1985.
    • (2005) J Exp Med , vol.201 , pp. 1973-1985
    • Smyth, M.J.1    Wallace, M.E.2    Nutt, S.L.3    Yagita, H.4    Godfrey, D.I.5    Hayakawa, Y.6
  • 15
    • 0041349288 scopus 로고    scopus 로고
    • Cytokine requirements for the growth and development of mouse NK cells in vitro
    • Toomey JA, Gays F, Foster D, Brooks CG. Cytokine requirements for the growth and development of mouse NK cells in vitro. J Leuk Biol. 2003;74:233-242.
    • (2003) J Leuk Biol , vol.74 , pp. 233-242
    • Toomey, J.A.1    Gays, F.2    Foster, D.3    Brooks, C.G.4
  • 16
    • 0347320749 scopus 로고    scopus 로고
    • In vivo antitumor activity of interleukin 21 mediated by natural killer cells
    • Wang G, Tschoi M, Spolski R, et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res. 2003;63:9016-9022.
    • (2003) Cancer Res , vol.63 , pp. 9016-9022
    • Wang, G.1    Tschoi, M.2    Spolski, R.3
  • 17
    • 0345257344 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell activation and maturation
    • Brandt K, Bulfone-Paus S, Foster DC, Ruckert R. Interleukin-21 inhibits dendritic cell activation and maturation. Blood. 2003;102:4090-4098.
    • (2003) Blood , vol.102 , pp. 4090-4098
    • Brandt, K.1    Bulfone-Paus, S.2    Foster, D.C.3    Ruckert, R.4
  • 18
    • 10344238050 scopus 로고    scopus 로고
    • In vivo and in vitro roles of IL-21 in inflammation
    • Pelletier M, Bouchard A, Girard D. In vivo and in vitro roles of IL-21 in inflammation. J Immunol. 2004;173:7521-7530.
    • (2004) J Immunol , vol.173 , pp. 7521-7530
    • Pelletier, M.1    Bouchard, A.2    Girard, D.3
  • 19
    • 0035752146 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases
    • Leonard WJ. Cytokines and immunodeficiency diseases. Nat Rev Immunol. 2001;1:200-208.
    • (2001) Nat Rev Immunol , vol.1 , pp. 200-208
    • Leonard, W.J.1
  • 21
    • 0036784616 scopus 로고    scopus 로고
    • IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    • Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol. 2002;169:3600-3605.
    • (2002) J Immunol , vol.169 , pp. 3600-3605
    • Strengell, M.1    Sareneva, T.2    Foster, D.3    Julkunen, I.4    Matikainen, S.5
  • 22
    • 0037114638 scopus 로고    scopus 로고
    • Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells
    • Suto A, Nakajima H, Hirose K, et al. Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood. 2002;100:4565-4573.
    • (2002) Blood , vol.100 , pp. 4565-4573
    • Suto, A.1    Nakajima, H.2    Hirose, K.3
  • 23
    • 0034614490 scopus 로고    scopus 로고
    • Signaling: 2000 and beyond
    • Hunter T. Signaling: 2000 and beyond. Cell. 2000;100:113-127.
    • (2000) Cell , vol.100 , pp. 113-127
    • Hunter, T.1
  • 24
    • 0842346438 scopus 로고    scopus 로고
    • Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems
    • Pawson T. Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell. 2004;116:191-203.
    • (2004) Cell , vol.116 , pp. 191-203
    • Pawson, T.1
  • 25
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 1996;84:443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 26
    • 0036338213 scopus 로고    scopus 로고
    • STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
    • Lee CK, Raz R, Gimeno R, et al. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 2002;17:63-72.
    • (2002) Immunity , vol.17 , pp. 63-72
    • Lee, C.K.1    Raz, R.2    Gimeno, R.3
  • 27
    • 5844299536 scopus 로고    scopus 로고
    • Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development
    • Wolfer A, Bakker T, Wilson A, et al. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat Immunol. 2001;2:235-241.
    • (2001) Nat Immunol , vol.2 , pp. 235-241
    • Wolfer, A.1    Bakker, T.2    Wilson, A.3
  • 28
    • 20744454264 scopus 로고    scopus 로고
    • Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes
    • Gimeno R, Lee CK, Schindler C, Levy DE. Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes. Mol Cell Biol. 2005;25:5456-5465.
    • (2005) Mol Cell Biol , vol.25 , pp. 5456-5465
    • Gimeno, R.1    Lee, C.K.2    Schindler, C.3    Levy, D.E.4
  • 29
    • 0029887634 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling
    • Itoh T, Muto A, Watanabe S, Miyajima A, Yokota T, Arai K. Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling. J Biol Chem. 1996;271:7587-7592.
    • (1996) J Biol Chem , vol.271 , pp. 7587-7592
    • Itoh, T.1    Muto, A.2    Watanabe, S.3    Miyajima, A.4    Yokota, T.5    Arai, K.6
  • 30
    • 0029955714 scopus 로고    scopus 로고
    • The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses
    • Naviaux RK, Costanzi E, Haas M, Verma IM. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol. 1996;70:5701-5705.
    • (1996) J Virol , vol.70 , pp. 5701-5705
    • Naviaux, R.K.1    Costanzi, E.2    Haas, M.3    Verma, I.M.4
  • 31
    • 0037109077 scopus 로고    scopus 로고
    • IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes
    • Xue HH, Kovanen PE, Pise-Masison CA, et al. IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes. Proc Natl Acad Sci U S A. 2002;99:13759-13764.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13759-13764
    • Xue, H.H.1    Kovanen, P.E.2    Pise-Masison, C.A.3
  • 32
    • 0029875230 scopus 로고    scopus 로고
    • Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation
    • Friedmann MC, Migone TS, Russell SM, Leonard WJ. Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc Natl Acad Sci U S A. 1996;93:2077-2082.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2077-2082
    • Friedmann, M.C.1    Migone, T.S.2    Russell, S.M.3    Leonard, W.J.4
  • 33
    • 0029124056 scopus 로고
    • Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain
    • Goldsmith MA, Lai SY, Xu W, et al. Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain. J Biol Chem. 1995;270:21729-21737.
    • (1995) J Biol Chem , vol.270 , pp. 21729-21737
    • Goldsmith, M.A.1    Lai, S.Y.2    Xu, W.3
  • 35
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin JX, Migone TS, Tsang M, et al. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity. 1995;2:331-339.
    • (1995) Immunity , vol.2 , pp. 331-339
    • Lin, J.X.1    Migone, T.S.2    Tsang, M.3
  • 36
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu CL, Meyer DJ, Campbell GS, et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science. 1995;269:81-83.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3
  • 38
    • 0038152914 scopus 로고    scopus 로고
    • Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma
    • Kelly JA, Spolski R, Kovanen PE, et al. Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma. J Exp Med. 2003;198:79-89.
    • (2003) J Exp Med , vol.198 , pp. 79-89
    • Kelly, J.A.1    Spolski, R.2    Kovanen, P.E.3
  • 39
    • 0031836964 scopus 로고    scopus 로고
    • Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
    • Onishi M, Nosaka T, Misawa K, et al. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol. 1998;18:3871-3879.
    • (1998) Mol Cell Biol , vol.18 , pp. 3871-3879
    • Onishi, M.1    Nosaka, T.2    Misawa, K.3
  • 40
    • 9644295710 scopus 로고    scopus 로고
    • Kovanen PE, Leonard WJ. Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev. 2004;202:67-83.
    • Kovanen PE, Leonard WJ. Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev. 2004;202:67-83.
  • 41
    • 0028926511 scopus 로고
    • The regulation and function of p21ras during T-cell activation and growth
    • Izquierdo Pastor M, Reif K, Cantrell D. The regulation and function of p21ras during T-cell activation and growth. Immunol Today. 1995;16:159-164.
    • (1995) Immunol Today , vol.16 , pp. 159-164
    • Izquierdo Pastor, M.1    Reif, K.2    Cantrell, D.3
  • 42
    • 0037306480 scopus 로고    scopus 로고
    • Role of Shc in T-cell development and function
    • Zhang L, Lorenz U, Ravichandran KS. Role of Shc in T-cell development and function. Immunol Rev. 2003;191:183-195.
    • (2003) Immunol Rev , vol.191 , pp. 183-195
    • Zhang, L.1    Lorenz, U.2    Ravichandran, K.S.3
  • 43
    • 0036849331 scopus 로고    scopus 로고
    • Brazil DP, Park J, Hemmings BA. PKB binding proteins: getting in on the Akt. Cell. 2002;111:293-303.
    • Brazil DP, Park J, Hemmings BA. PKB binding proteins: getting in on the Akt. Cell. 2002;111:293-303.
  • 45
    • 0029046208 scopus 로고
    • Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission
    • Fujii H, Nakagawa Y, Schindler U, et al. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission. Proc Natl Acad Sci U S A. 1995;92:5482-5486.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5482-5486
    • Fujii, H.1    Nakagawa, Y.2    Schindler, U.3
  • 46
    • 0029005549 scopus 로고
    • Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
    • Migone TS, Lin JX, Cereseto A, et al. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science. 1995;269:79-81.
    • (1995) Science , vol.269 , pp. 79-81
    • Migone, T.S.1    Lin, J.X.2    Cereseto, A.3
  • 47
    • 8044231313 scopus 로고    scopus 로고
    • An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT
    • Fujitani Y, Hibi M, Fukada T, et al. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene. 1997;14:751-761.
    • (1997) Oncogene , vol.14 , pp. 751-761
    • Fujitani, Y.1    Hibi, M.2    Fukada, T.3
  • 48
    • 0031774896 scopus 로고    scopus 로고
    • Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
    • Imada K, Bloom ET, Nakajima H, et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med. 1998;188:2067-2074.
    • (1998) J Exp Med , vol.188 , pp. 2067-2074
    • Imada, K.1    Bloom, E.T.2    Nakajima, H.3
  • 49
    • 0031433362 scopus 로고    scopus 로고
    • An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction
    • Nakajima H, Liu XW, Wynshaw-Boris A, et al. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Immunity. 1997;7:691-701.
    • (1997) Immunity , vol.7 , pp. 691-701
    • Nakajima, H.1    Liu, X.W.2    Wynshaw-Boris, A.3
  • 50
    • 32244444750 scopus 로고    scopus 로고
    • Stat5a/b are essential for normal lymphoid development and differentiation
    • Yao Z, Cui Y, Watford WT, et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A. 2006;103:1000-1005.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1000-1005
    • Yao, Z.1    Cui, Y.2    Watford, W.T.3
  • 51
    • 0028931604 scopus 로고    scopus 로고
    • Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE Jr, Yancopoulos GD. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science. 1995;267:1349-1353.
    • Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE Jr, Yancopoulos GD. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science. 1995;267:1349-1353.
  • 52
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
    • Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol. 1998;161:4652-4660.
    • (1998) J Immunol , vol.161 , pp. 4652-4660
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 53
    • 0031758022 scopus 로고    scopus 로고
    • Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes
    • Akaishi H, Takeda K, Kaisho T, et al. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int Immunol. 1998;10:1747-1751.
    • (1998) Int Immunol , vol.10 , pp. 1747-1751
    • Akaishi, H.1    Takeda, K.2    Kaisho, T.3
  • 54
    • 3242742473 scopus 로고    scopus 로고
    • Type I cytokines and interferons and their receptors
    • Paul W, ed, 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins;
    • Leonard W. Type I cytokines and interferons and their receptors. In: Paul W, ed. Fundamental Immunology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2003:701-747.
    • (2003) Fundamental Immunology , pp. 701-747
    • Leonard, W.1
  • 55
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 2002;109(suppl):S121-S131.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 56
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002;3:651-662.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell Jr, J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.