Viral immune evasion due to persistence of activated T cells without effector function

Journal of Experimental Medicine

Volumn 188, Issue 12, 1998, Pages 2205-2213

  Zajac, Allan J ^a   Blattman, Joseph N ^a   Murali Krishna, Kaja ^a   Sourdive, David J D ^a   Suresh, M ^a   Altman, John D ^a   Ahmed, Rafi ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD4 T cells; Chronic infections; Cytotoxic T cells; Major histocompatibility complex tetramers; Unresponsiveness

Indexed keywords

CD69 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; PADGEM PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; HELPER CELL; HOST RESISTANCE; IMMUNOREGULATION; INFECTION RESISTANCE; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS MENINGITIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CLONAL ANERGY; CLONAL DELETION; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNODOMINANT EPITOPES; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; LYMPHOCYTIC CHORIOMENINGITIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES, CYTOTOXIC; VIRAL STRUCTURAL PROTEINS;

EID: 0032416085     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.12.2205     Document Type: Article

References (9)

1. Kägi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K.J. Olsen, E.R. Podack, R.M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 369:31-37.
2. Walsh, C.M., M. Matloubian, C.-C. Liu, R. Ueda, C.G. Kurahara, J.L. Christensen, M.T. Huang, J.D. Young, R. Ahmed, and W.R. Clark. 1994. Immune function in mice lacking the perform gene. Proc. Natl. Acad. Sci. USA. 91:10854-10848.
3. Tishon, A., H. Lewicki, G. Rail, M. Von Herrath, and M.B.A. Oldstone. 1995. An essential role for type 1 interferon-γ in terminating persistent viral infection. Virology. 212:244-250.
4. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science. 272:54-60.
5. Doherty, P.C. 1996. Cytotoxic T cell effector and memory function in viral immunity. Curr. Top. Microbiol. Immunol. 206:1-14.
6. Guidotti, L.G., T. Ishikawa, M.V. Hobbs, B. Matzke, R. Schreiber, and F.V. Chisari. 1996. Intracellular inactivation of hepatitis B virus by cytotoxic T lymphocytes. Immunity. 4:25-36.
7. Riddell, S.R., K.S. Watanabe, J.M. Goodrich, C.R. Li, M.E. Agha, and P.D. Greenberg. 1992. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science. 257:238-241.
8. Heslop, H.E., C.Y. Ng, C. Li, C.A. Smith, S.K. Loftin, R.A. Krance, M.K. Brenner, and C.M. Rooney. 1996. Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nature Med. 2:551-555.
9. Chisari, F.V., and C. Ferrari. 1997. Viral hepatitis. In Viral Pathogenesis. N. Nathanson, editor. Lippincott-Raven, New York. 745-778.