메뉴 건너뛰기




Volumn , Issue , 2007, Pages 353-388

Mechanisms of acetaminophen-induced liver disease

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85049381608     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (14)

References (397)
  • 2
    • 0035132183 scopus 로고    scopus 로고
    • Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches
    • Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol 2001; 31:55-138.
    • (2001) Crit Rev Toxicol , vol.31 , pp. 55-138
    • Bessems, J.G.1    Vermeulen, N.P.2
  • 3
    • 0029094577 scopus 로고
    • Acute renal failure due to acetaminophen ingestion: A case report and review of the literature
    • Blakely P, McDonald BR. Acute renal failure due to acetaminophen ingestion: a case report and review of the literature. J Am Soc Nephrol 1995; 6:48-53.
    • (1995) J Am Soc Nephrol , vol.6 , pp. 48-53
    • Blakely, P.1    McDonald, B.R.2
  • 5
    • 0033671352 scopus 로고    scopus 로고
    • Relationship between nonphenacetin combined analgesics and nephropathy: A review
    • Feinstein AR, Heinemann LAJ, Curham GC, et al. Relationship between nonphenacetin combined analgesics and nephropathy: a review. Kidney Int 2000; 58:2259-64.
    • (2000) Kidney Int , vol.58 , pp. 2259-2264
    • Feinstein, A.R.1    Heinemann, L.A.J.2    Curham, G.C.3
  • 6
    • 0038385359 scopus 로고    scopus 로고
    • Acetaminophen hepatotoxicity
    • Bromer MQ, Black M. Acetaminophen hepatotoxicity. Clin Liver Dis 2003; 7:351-67.
    • (2003) Clin Liver Dis , vol.7 , pp. 351-367
    • Bromer, M.Q.1    Black, M.2
  • 7
    • 0000855767 scopus 로고
    • Biochemical toxicology of acetaminophen
    • Hinson JA. Biochemical toxicology of acetaminophen. Rev Biochem Toxicol 1980; 2:103-30.
    • (1980) Rev Biochem Toxicol , vol.2 , pp. 103-130
    • Hinson, J.A.1
  • 8
    • 30344461594 scopus 로고    scopus 로고
    • The molecular toxicology of acetaminophen
    • Josephy DP. The molecular toxicology of acetaminophen. Drug Metab Rev 2005; 37:581-94.
    • (2005) Drug Metab Rev , vol.37 , pp. 581-594
    • Josephy, D.P.1
  • 9
    • 0036226892 scopus 로고    scopus 로고
    • Acetaminophen hepatotoxicity: The first 35 years
    • Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol 2002; 40:3-20.
    • (2002) J Toxicol Clin Toxicol , vol.40 , pp. 3-20
    • Rumack, B.H.1
  • 10
    • 0002229253 scopus 로고    scopus 로고
    • Paracetamol related deaths in England and Wales
    • Atcha Z, Majeed A. Paracetamol related deaths in England and Wales. Health Stat Q 2000; 7:5-9.
    • (2000) Health Stat Q , vol.7 , pp. 5-9
    • Atcha, Z.1    Majeed, A.2
  • 11
    • 1342310959 scopus 로고    scopus 로고
    • Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit
    • Gow PJ, Jones RM, Dobson JL, Angus PW. Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit. J Gastroenterol Hepatol 2004; 19:154-9.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 154-159
    • Gow, P.J.1    Jones, R.M.2    Dobson, J.L.3    Angus, P.W.4
  • 12
    • 32644474169 scopus 로고    scopus 로고
    • Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study
    • Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42:1364-72.
    • (2005) Hepatology , vol.42 , pp. 1364-1372
    • Larson, A.M.1    Polson, J.2    Fontana, R.J.3
  • 14
    • 0031904834 scopus 로고    scopus 로고
    • 1997 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System
    • Litovitz TL, Klein-Schwartz W, Dyer KS, Shannon M, Lee S, Powers M. 1997 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1998; 16:443-97.
    • (1998) Am J Emerg Med , vol.16 , pp. 443-497
    • Litovitz, T.L.1    Klein-Schwartz, W.2    Dyer, K.S.3    Shannon, M.4    Lee, S.5    Powers, M.6
  • 15
    • 0029124853 scopus 로고
    • Paracetamol (acetaminophen) poisoning
    • Vale JA, Proudfoot AT. Paracetamol (acetaminophen) poisoning. Lancet 1995; 346:547-52.
    • (1995) Lancet , vol.346 , pp. 547-552
    • Vale, J.A.1    Proudfoot, A.T.2
  • 16
    • 33745779244 scopus 로고    scopus 로고
    • Estimates of acetaminophen (paracetomal)-associated overdoses in the United States
    • Nourjah P, Ahmad SR, Karwoski C, Willy M. Estimates of acetaminophen (paracetomal)-associated overdoses in the United States. Pharmacoepidemiol Drug Saf 2006; 15:398-405.
    • (2006) Pharmacoepidemiol Drug Saf , vol.15 , pp. 398-405
    • Nourjah, P.1    Ahmad, S.R.2    Karwoski, C.3    Willy, M.4
  • 17
    • 3042826208 scopus 로고    scopus 로고
    • Acetaminophen hepatoxicity: What do we know, what don’t we know, and what do we do next?
    • Kaplowitz N. Acetaminophen hepatoxicity: what do we know, what don’t we know, and what do we do next? Hepatology 2004; 40:23-6.
    • (2004) Hepatology , vol.40 , pp. 23-26
    • Kaplowitz, N.1
  • 18
    • 3042820284 scopus 로고    scopus 로고
    • Acetaminophen misconceptions
    • Rumack BH. Acetaminophen misconceptions. Hepatology 2004; 40:10-15.
    • (2004) Hepatology , vol.40 , pp. 10-15
    • Rumack, B.H.1
  • 19
    • 33745607004 scopus 로고    scopus 로고
    • Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: A randomized controlled trial
    • Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA 2006; 296:87-93.
    • (2006) JAMA , vol.296 , pp. 87-93
    • Watkins, P.B.1    Kaplowitz, N.2    Slattery, J.T.3    Colonese, C.R.4    Colucci, S.V.5    Stewart, P.W.6    Harris, S.C.7
  • 20
    • 0035912582 scopus 로고    scopus 로고
    • Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: Before and after study
    • Hawton K, Townsend E, Deeks J, Appleby L, Gunnell D, Bennewith O, Cooper J. Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study. Br Med J 2001; 322:1203-7.
    • (2001) Br Med J , vol.322 , pp. 1203-1207
    • Hawton, K.1    Townsend, E.2    Deeks, J.3    Appleby, L.4    Gunnell, D.5    Bennewith, O.6    Cooper, J.7
  • 22
    • 8244226603 scopus 로고
    • Chronic toxicity studies on phenacetin. N-acetyl-p-aminophenol (NAPA) and acetylsalicylic acid on cats
    • Eder H. Chronic toxicity studies on phenacetin. N-acetyl-p-aminophenol (NAPA) and acetylsalicylic acid on cats. Acta Pharmacol Toxicol (Copenh) 1964; 21:197-204.
    • (1964) Acta Pharmacol Toxicol (Copenh) , vol.21 , pp. 197-204
    • Eder, H.1
  • 23
    • 0014029813 scopus 로고
    • Acute liver necrosis following overdose of paracetamol
    • Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J 1966; 5512:497-9.
    • (1966) Br Med J , vol.5512 , pp. 497-499
    • Davidson, D.G.1    Eastham, W.N.2
  • 24
    • 0014029833 scopus 로고
    • Liver damage and impaired glucose tolerance after paracetamol overdosage
    • Thomson JS, Prescott LF. Liver damage and impaired glucose tolerance after paracetamol overdosage. Br Med J 1966; 5512:506-7.
    • (1966) Br Med J , vol.5512 , pp. 506-507
    • Thomson, J.S.1    Prescott, L.F.2
  • 29
    • 0016209023 scopus 로고
    • Acetaminophen-induced hepatic injury: Protective role of glutathione in man and rationale for therapy
    • Mitchell JR, Thorgeirsson SS, Potter WZ, Jollow DJ, Keiser H. Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther 1974; 16:676-84.
    • (1974) Clin Pharmacol Ther , vol.16 , pp. 676-684
    • Mitchell, J.R.1    Thorgeirsson, S.S.2    Potter, W.Z.3    Jollow, D.J.4    Keiser, H.5
  • 30
    • 17844365270 scopus 로고    scopus 로고
    • AASLD position paper: The management of acute liver failure
    • Polson J, Lee WM. AASLD position paper: the management of acute liver failure. Hepatology 2005; 41:1179-97.
    • (2005) Hepatology , vol.41 , pp. 1179-1197
    • Polson, J.1    Lee, W.M.2
  • 31
    • 0032512296 scopus 로고    scopus 로고
    • Paracetamol (acetaminophen) poisoning. No need to change current guidelines to accident departments
    • Routledge P, Vale JA, Bateman DN, et al. Paracetamol (acetaminophen) poisoning. No need to change current guidelines to accident departments. Br Med J 1998; 317:1609-10.
    • (1998) Br Med J , vol.317 , pp. 1609-1610
    • Routledge, P.1    Vale, J.A.2    Bateman, D.N.3
  • 32
    • 0024262737 scopus 로고
    • Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
    • Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med 1988; 319:1557-62.
    • (1988) N Engl J Med , vol.319 , pp. 1557-1562
    • Smilkstein, M.J.1    Knapp, G.L.2    Kulig, K.W.3    Rumack, B.H.4
  • 33
    • 85056689601 scopus 로고    scopus 로고
    • Analgesic-antipyretics
    • Levy RH et al, ed, Philadelphia, PA: Lippincott Williams and Williams
    • Nelson SD. Analgesic-antipyretics. In: Levy RH et al, ed. Metabolic Drug Interactions. Philadelphia, PA: Lippincott Williams and Williams, 2000:447-55.
    • (2000) Metabolic Drug Interactions , pp. 447-455
    • Nelson, S.D.1
  • 34
    • 0025694879 scopus 로고
    • Molecular mechanisms of the hepatotoxicity caused by acetaminophen
    • Nelson SD. Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Semin Liver Dis 1990; 10:267-78.
    • (1990) Semin Liver Dis , vol.10 , pp. 267-278
    • Nelson, S.D.1
  • 35
    • 23944461321 scopus 로고    scopus 로고
    • Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS
    • Johnson KA, Plumb R. Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS. J Pharm Biomed Anal 2005; 39:805-10.
    • (2005) J Pharm Biomed Anal , vol.39 , pp. 805-810
    • Johnson, K.A.1    Plumb, R.2
  • 36
    • 0035197725 scopus 로고    scopus 로고
    • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms
    • Court MH, Duan SX, von Moltke LL, Greenblatt DJ, Patten CJ, Miners JO, Mackenzie PI. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 2001; 299:998-1006.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 998-1006
    • Court, M.H.1    Duan, S.X.2    von Moltke, L.L.3    Greenblatt, D.J.4    Patten, C.J.5    Miners, J.O.6    Mackenzie, P.I.7
  • 37
    • 24044504415 scopus 로고    scopus 로고
    • Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes
    • Kostrubsky SE, Sinclair JF, Strom SC, et al. Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes. Toxicol Sci 2005; 87:146-55.
    • (2005) Toxicol Sci , vol.87 , pp. 146-155
    • Kostrubsky, S.E.1    Sinclair, J.F.2    Strom, S.C.3
  • 38
    • 33744500475 scopus 로고    scopus 로고
    • Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen induced toxicity
    • Mutlib AE, Goosen TC, Bauman JN, Williams JA, Kulkarni S, Kostrubsky SE. Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen induced toxicity. Chem Res Toxicol 2006; 19:701-9.
    • (2006) Chem Res Toxicol , vol.19 , pp. 701-709
    • Mutlib, A.E.1    Goosen, T.C.2    Bauman, J.N.3    Williams, J.A.4    Kulkarni, S.5    Kostrubsky, S.E.6
  • 39
    • 0001005381 scopus 로고    scopus 로고
    • Sulfotransferases
    • Guengerich FP, ed, 3. Oxford:Elsevier
    • Duffel MW. Sulfotransferases. In: Guengerich FP, ed. Comprehensive Toxicology, Vol. 3. Oxford:Elsevier, 1997:365-83.
    • (1997) Comprehensive Toxicology, Vol , pp. 365-383
    • Duffel, M.W.1
  • 40
    • 0026485794 scopus 로고
    • Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase
    • de Morais SM, Chow SY, Wells PG. Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase. Toxicol Appl Pharmacol 1992; 117:81-7.
    • (1992) Toxicol Appl Pharmacol , vol.117 , pp. 81-87
    • de Morais, S.M.1    Chow, S.Y.2    Wells, P.G.3
  • 41
    • 0031009017 scopus 로고    scopus 로고
    • Molecular basis for deficient acetaminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes
    • Court MH, Greenblatt DJ. Molecular basis for deficient acetaminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes. Biochem Pharmacol 1997; 53:1041-7.
    • (1997) Biochem Pharmacol , vol.53 , pp. 1041-1047
    • Court, M.H.1    Greenblatt, D.J.2
  • 42
    • 0026545451 scopus 로고
    • Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert’s syndrome
    • de Morais SM, Uetrecht JP, Wells PG. Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert’s syndrome. Gastroenterology 1992; 102:577-86.
    • (1992) Gastroenterology , vol.102 , pp. 577-586
    • de Morais, S.M.1    Uetrecht, J.P.2    Wells, P.G.3
  • 43
    • 0033049403 scopus 로고    scopus 로고
    • The heterogeneity of paracetamol metabolism in Gilbert’s disease
    • Rodriguez E, Regadera P. The heterogeneity of paracetamol metabolism in Gilbert’s disease. Gastroenterol Hepatol 1999; 22:265-9.
    • (1999) Gastroenterol Hepatol , vol.22 , pp. 265-269
    • Rodriguez, E.1    Regadera, P.2
  • 44
    • 0023268502 scopus 로고
    • The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial
    • Richman DD, Fischl MA, Grieco MH, et al. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med 1987; 317:192-7.
    • (1987) N Engl J Med , vol.317 , pp. 192-197
    • Richman, D.D.1    Fischl, M.A.2    Grieco, M.H.3
  • 45
    • 0026734346 scopus 로고
    • Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure
    • Bray GP, Harrison PM, O’Grady JG, Tredger JM, Williams R. Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. Hum Exp Toxicol 1992; 11:265-70.
    • (1992) Hum Exp Toxicol , vol.11 , pp. 265-270
    • Bray, G.P.1    Harrison, P.M.2    O’Grady, J.G.3    Tredger, J.M.4    Williams, R.5
  • 46
    • 0028861422 scopus 로고
    • A case of paracetamol retard poisoning with fatal outcome
    • Lystback BB, Norregaard P. A case of paracetamol retard poisoning with fatal outcome. Ugeskr Laeger 1995; 157:899-900.
    • (1995) Ugeskr Laeger , vol.157 , pp. 899-900
    • Lystback, B.B.1    Norregaard, P.2
  • 47
  • 48
    • 0021219869 scopus 로고
    • Apparent potentiation of hepatotoxicity from small doses of acetaminophen by phenobarbital
    • Pirotte JH. Apparent potentiation of hepatotoxicity from small doses of acetaminophen by phenobarbital. Ann Intern Med 1984; 101:403.
    • (1984) Ann Intern Med , vol.101 , pp. 403
    • Pirotte, J.H.1
  • 49
    • 0028941897 scopus 로고
    • High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat
    • Nicholls AW, Caddick S, Wilson ID, Farrant RD, Lindon JC, Nicholson JK. High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat. Biochem Pharmacol 1995; 49:1155-64.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1155-1164
    • Nicholls, A.W.1    Caddick, S.2    Wilson, I.D.3    Farrant, R.D.4    Lindon, J.C.5    Nicholson, J.K.6
  • 50
    • 0031578440 scopus 로고    scopus 로고
    • The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats
    • Mugford CA, Tarloff JB. The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats. Toxicol Lett 1997; 93:15-22.
    • (1997) Toxicol Lett , vol.93 , pp. 15-22
    • Mugford, C.A.1    Tarloff, J.B.2
  • 51
    • 0022410466 scopus 로고
    • The role of p-aminophenol in acetaminophen-induced nephrotoxicity: Effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats
    • Newton JF, Kuo CH, DeShone GM, Hoefle D, Bernstein J, Hook JB. The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats. Toxicol Appl Pharmacol 1985; 81:416-30.
    • (1985) Toxicol Appl Pharmacol , vol.81 , pp. 416-430
    • Newton, J.F.1    Kuo, C.H.2    DeShone, G.M.3    Hoefle, D.4    Bernstein, J.5    Hook, J.B.6
  • 52
    • 0032409420 scopus 로고    scopus 로고
    • Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo
    • Rothen JP, Haefeli WE, Meyer UA, Todesco L, Wenk M. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics 1998; 8:553-9.
    • (1998) Pharmacogenetics , vol.8 , pp. 553-559
    • Rothen, J.P.1    Haefeli, W.E.2    Meyer, U.A.3    Todesco, L.4    Wenk, M.5
  • 53
    • 0021345926 scopus 로고
    • N-acetyl-p-benzoquinone imine: A cytochrome P-450- mediated oxidation product of acetaminophen
    • Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-acetyl-p-benzoquinone imine: a cytochrome P-450- mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA 1984; 81:1327-31.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 1327-1331
    • Dahlin, D.C.1    Miwa, G.T.2    Lu, A.Y.3    Nelson, S.D.4
  • 54
    • 0018760363 scopus 로고
    • N-Hydroxyacetaminophen: A microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen
    • Hinson JA, Pohl LR, Gillette JR. N-Hydroxyacetaminophen: a microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen. Life Sci 1979; 24:2133-8.
    • (1979) Life Sci , vol.24 , pp. 2133-2138
    • Hinson, J.A.1    Pohl, L.R.2    Gillette, J.R.3
  • 55
    • 0018849259 scopus 로고
    • Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro
    • Nelson SD, Forte AJ, Dahlin DC. Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro. Biochem Pharmacol 1980; 29:1617-20.
    • (1980) Biochem Pharmacol , vol.29 , pp. 1617-1620
    • Nelson, S.D.1    Forte, A.J.2    Dahlin, D.C.3
  • 56
    • 0019203064 scopus 로고
    • Paracetamol oxidation: Synthesis and reactivity of N-acetyl-p-benzoquinone imine
    • Blair IA, Boobis AR, Davies DJ, Cresp TM. Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinone imine. Tetrahedron Lett 1980; 21:4947-50.
    • (1980) Tetrahedron Lett , vol.21 , pp. 4947-4950
    • Blair, I.A.1    Boobis, A.R.2    Davies, D.J.3    Cresp, T.M.4
  • 57
    • 0020427899 scopus 로고
    • Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen
    • Dahlin DC, Nelson SD. Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen. J Med Chem 1982; 25:885-6.
    • (1982) J Med Chem , vol.25 , pp. 885-886
    • Dahlin, D.C.1    Nelson, S.D.2
  • 59
    • 0019209787 scopus 로고
    • Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine
    • Corcoran GB, Mitchell JR, Vaishnav YN, Horning EC. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. Mol Pharmacol 1980; 18:536-42.
    • (1980) Mol Pharmacol , vol.18 , pp. 536-542
    • Corcoran, G.B.1    Mitchell, J.R.2    Vaishnav, Y.N.3    Horning, E.C.4
  • 60
    • 0021346560 scopus 로고
    • Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol
    • Holme JA, Dahlin DC, Nelson SD, Dybing E. Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol. Biochem Pharmacol 1984; 33:401-6.
    • (1984) Biochem Pharmacol , vol.33 , pp. 401-406
    • Holme, J.A.1    Dahlin, D.C.2    Nelson, S.D.3    Dybing, E.4
  • 61
    • 0018621529 scopus 로고
    • Evidence for the involvement of N-acetyl-p-quinoneimine in acetaminophen metabolism
    • Miner DJ, Kissinger PT. Evidence for the involvement of N-acetyl-p-quinoneimine in acetaminophen metabolism. Biochem Pharmacol 1979; 28:3285-90.
    • (1979) Biochem Pharmacol , vol.28 , pp. 3285-3290
    • Miner, D.J.1    Kissinger, P.T.2
  • 63
    • 0019796044 scopus 로고
    • Comparative electron impact, chemical ionization and field desorption mass spectra of some thioether metabolites of acetaminophen
    • Nelson SD, Vaishnav Y, Kambara H, Baillie TA. Comparative electron impact, chemical ionization and field desorption mass spectra of some thioether metabolites of acetaminophen. Biomed Mass Spectrom 1981; 8:244-51.
    • (1981) Biomed Mass Spectrom , vol.8 , pp. 244-251
    • Nelson, S.D.1    Vaishnav, Y.2    Kambara, H.3    Baillie, T.A.4
  • 65
    • 0023124537 scopus 로고
    • Dose-dependent pharmacokinetics of acetaminophen: Evidence of glutathione depletion in humans
    • Slattery JT, Wilson JM, Kalhorn TF, Nelson SD. Dose-dependent pharmacokinetics of acetaminophen:evidence of glutathione depletion in humans. Clin Pharmacol Ther 1987; 41:413-8.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 413-418
    • Slattery, J.T.1    Wilson, J.M.2    Kalhorn, T.F.3    Nelson, S.D.4
  • 66
    • 0023204051 scopus 로고
    • Quinoneimines as substrates for quinone reductase (NAD(P)H: (quinone-acceptor)oxidoreductase) and the effect of dicumarol on their cytotoxicity
    • Powis G, See KL, Santone KS, Melder DC, Hodnett EM. Quinoneimines as substrates for quinone reductase (NAD(P)H: (quinone-acceptor)oxidoreductase) and the effect of dicumarol on their cytotoxicity. Biochem Pharmacol 1987; 36:2473-9.
    • (1987) Biochem Pharmacol , vol.36 , pp. 2473-2479
    • Powis, G.1    See, K.L.2    Santone, K.S.3    Melder, D.C.4    Hodnett, E.M.5
  • 67
    • 0021266813 scopus 로고
    • Enzymatic and non-enzymatic reduction of N-acetylp- benzoquinone imine and some properties of the N-acetyl-p-benzosemiquinone imine radical
    • Powis G, Svingen BA, Dahlin DC, Nelson SD. Enzymatic and non-enzymatic reduction of N-acetylp- benzoquinone imine and some properties of the N-acetyl-p-benzosemiquinone imine radical. Biochem Pharmacol 1984; 33:2367-70.
    • (1984) Biochem Pharmacol , vol.33 , pp. 2367-2370
    • Powis, G.1    Svingen, B.A.2    Dahlin, D.C.3    Nelson, S.D.4
  • 68
    • 0033594991 scopus 로고    scopus 로고
    • Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct
    • Chen W, Shockcor JP, Tonge R, Hunter A, Gartner C, Nelson SD. Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct. Biochemistry 1999; 38:8159-66.
    • (1999) Biochemistry , vol.38 , pp. 8159-8166
    • Chen, W.1    Shockcor, J.P.2    Tonge, R.3    Hunter, A.4    Gartner, C.5    Nelson, S.D.6
  • 69
    • 0024044003 scopus 로고
    • The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study
    • Coles B, Wilson I, Wardman P, Hinson JA, Nelson SD, Ketterer B. The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study. Arch Biochem Biophys 1988; 264:253-60.
    • (1988) Arch Biochem Biophys , vol.264 , pp. 253-260
    • Coles, B.1    Wilson, I.2    Wardman, P.3    Hinson, J.A.4    Nelson, S.D.5    Ketterer, B.6
  • 70
    • 0018965180 scopus 로고
    • 3-Hydroxyacetaminophen: A microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen
    • Hinson JA, Pohl LR, Monks TJ, Gillette JR, Guengerich FP. 3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen. Drug Metab Dispos 1980; 8:289-94.
    • (1980) Drug Metab Dispos , vol.8 , pp. 289-294
    • Hinson, J.A.1    Pohl, L.R.2    Monks, T.J.3    Gillette, J.R.4    Guengerich, F.P.5
  • 71
    • 0021268110 scopus 로고
    • The formation and toxicity of catechol metabolites of acetaminophen in mice
    • Forte AJ, Wilson JM, Slattery JT, Nelson SD. The formation and toxicity of catechol metabolites of acetaminophen in mice. Drug Metab Dispos 1984; 12:484-91.
    • (1984) Drug Metab Dispos , vol.12 , pp. 484-491
    • Forte, A.J.1    Wilson, J.M.2    Slattery, J.T.3    Nelson, S.D.4
  • 73
    • 0031949068 scopus 로고    scopus 로고
    • Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirusexpressed and purified human cytochromes P450 2E1 and 2A6
    • Chen W, Koenigs LL, Thompson SJ, Peter RM, Rettie AE, Trager WF, Nelson SD. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirusexpressed and purified human cytochromes P450 2E1 and 2A6. Chem Res Toxicol 1998; 11:295-301.
    • (1998) Chem Res Toxicol , vol.11 , pp. 295-301
    • Chen, W.1    Koenigs, L.L.2    Thompson, S.J.3    Peter, R.M.4    Rettie, A.E.5    Trager, W.F.6    Nelson, S.D.7
  • 77
  • 78
    • 0024401849 scopus 로고
    • Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2
    • Raucy JL, Lasker JM, Lieber CS, Black M. Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys 1989; 271:270-83.
    • (1989) Arch Biochem Biophys , vol.271 , pp. 270-283
    • Raucy, J.L.1    Lasker, J.M.2    Lieber, C.S.3    Black, M.4
  • 79
    • 0020619673 scopus 로고
    • Acetaminophen metabolism in subjects fed charcoalbroiled beef
    • Anderson KE, Schneider J, Pantuck EJ, et al. Acetaminophen metabolism in subjects fed charcoalbroiled beef. Clin Pharmacol Ther 1983; 34:369-74.
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 369-374
    • Anderson, K.E.1    Schneider, J.2    Pantuck, E.J.3
  • 80
    • 0023112104 scopus 로고
    • Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking
    • Bock KW, Wiltfang J, Blume R, Ullrich D, Bircher J. Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking. Eur J Clin Pharmacol 1987; 31:677-83.
    • (1987) Eur J Clin Pharmacol , vol.31 , pp. 677-683
    • Bock, K.W.1    Wiltfang, J.2    Blume, R.3    Ullrich, D.4    Bircher, J.5
  • 81
    • 0021269529 scopus 로고
    • Determinants of acetaminophen metabolism: Effect of inducers and inhibitors of drug metabolism on acetaminophen’s metabolic pathways
    • Miners JO, Attwood J, Birkett DJ. Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen’s metabolic pathways. Clin Pharmacol Ther 1984; 35:480-6.
    • (1984) Clin Pharmacol Ther , vol.35 , pp. 480-486
    • Miners, J.O.1    Attwood, J.2    Birkett, D.J.3
  • 82
    • 0030748504 scopus 로고    scopus 로고
    • The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin
    • Sarich T, Kalhorn T, Magee S, et al. The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. Clin Pharmacol Ther 1997; 62:21-8.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 21-28
    • Sarich, T.1    Kalhorn, T.2    Magee, S.3
  • 85
    • 0031765730 scopus 로고    scopus 로고
    • Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice
    • Zaher H, Buters JT, Ward JM, et al. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicol Appl Pharmacol 1998; 152:193-9.
    • (1998) Toxicol Appl Pharmacol , vol.152 , pp. 193-199
    • Zaher, H.1    Buters, J.T.2    Ward, J.M.3
  • 88
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993; 90:11825-9.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3    Dahl, M.L.4    Sjoqvist, F.5    Ingelman-Sundberg, M.6
  • 89
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 1996; 278:441-6.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3    Johansson, I.4    Rodrigues, F.5    Ingelman-Sundberg, M.6
  • 90
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270:414-23.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 91
  • 93
    • 0021263980 scopus 로고
    • Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases
    • Rumack BH. Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases. Am J Dis Child 1984; 138:428-33.
    • (1984) Am J Dis Child , vol.138 , pp. 428-433
    • Rumack, B.H.1
  • 94
    • 0017228166 scopus 로고
    • Acetaminophen elimination kinetics in neonates, children, and adults
    • Miller RP, Roberts RJ, Fischer LJ. Acetaminophen elimination kinetics in neonates, children, and adults. Clin Pharmacol Ther 1976; 19:284-94.
    • (1976) Clin Pharmacol Ther , vol.19 , pp. 284-294
    • Miller, R.P.1    Roberts, R.J.2    Fischer, L.J.3
  • 95
    • 0018822416 scopus 로고
    • The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis
    • Lauterburg BH, Vaishnav Y, Stillwell WG, Mitchell JR. The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis. J Pharmacol Exp Ther 1980; 213:54-8.
    • (1980) J Pharmacol Exp Ther , vol.213 , pp. 54-58
    • Lauterburg, B.H.1    Vaishnav, Y.2    Stillwell, W.G.3    Mitchell, J.R.4
  • 96
    • 0033208794 scopus 로고    scopus 로고
    • The safety of acetaminophen and ibuprofen among children younger than two years old
    • Lesko SM, Mitchell AA. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics 1999; 104:e39.
    • (1999) Pediatrics , vol.104 , pp. e39
    • Lesko, S.M.1    Mitchell, A.A.2
  • 98
    • 0034047901 scopus 로고    scopus 로고
    • Unintentional acetaminophen ingestion in children and the potential for hepatotoxicity
    • Caravati EM. Unintentional acetaminophen ingestion in children and the potential for hepatotoxicity. J Toxicol Clin Toxicol 2000; 38:291-6.
    • (2000) J Toxicol Clin Toxicol , vol.38 , pp. 291-296
    • Caravati, E.M.1
  • 99
    • 0031917313 scopus 로고    scopus 로고
    • Therapeutic misadventures with acetaminophen: Hepatoxicity after multiple doses in children
    • Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. J Pediatr 1998; 132:22-7.
    • (1998) J Pediatr , vol.132 , pp. 22-27
    • Heubi, J.E.1    Barbacci, M.B.2    Zimmerman, H.J.3
  • 100
    • 0033230869 scopus 로고    scopus 로고
    • Childhood hepatotoxicity with paracetamol doses less than 150 mg/kg per day
    • Hynson JL, South M. Childhood hepatotoxicity with paracetamol doses less than 150 mg/kg per day. Med J Aust 1999; 171:497.
    • (1999) Med J Aust , vol.171 , pp. 497
    • Hynson, J.L.1    South, M.2
  • 102
    • 0030687996 scopus 로고    scopus 로고
    • Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity
    • Rivera-Penera T, Gugig R, Davis J, et al. Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity. J Pediatr 1997; 130:300-4.
    • (1997) J Pediatr , vol.130 , pp. 300-304
    • Rivera-Penera, T.1    Gugig, R.2    Davis, J.3
  • 103
    • 0034693779 scopus 로고    scopus 로고
    • Accidental paracetamol overdosing and fulminant hepatic failure in children
    • Daly FF, Dart RC, Prescott LF. Accidental paracetamol overdosing and fulminant hepatic failure in children. Med J Aust 2000; 173:558-60.
    • (2000) Med J Aust , vol.173 , pp. 558-560
    • Daly, F.F.1    Dart, R.C.2    Prescott, L.F.3
  • 104
    • 4143151596 scopus 로고    scopus 로고
    • Hepatotoxicity possibly due to paracetamol with carbamazepine
    • Parikh S, Dillon LC, Scharf SL. Hepatotoxicity possibly due to paracetamol with carbamazepine. Intern Med J 2004; 34:441-2.
    • (2004) Intern Med J , vol.34 , pp. 441-442
    • Parikh, S.1    Dillon, L.C.2    Scharf, S.L.3
  • 105
    • 0018243232 scopus 로고
    • Death in an adolescent following an overdose of acetaminophen and phenobarbital
    • Wilson JT, Kasantikul V, Harbison R, Martin D. Death in an adolescent following an overdose of acetaminophen and phenobarbital. Am J Dis Child 1978; 132:466-73.
    • (1978) Am J Dis Child , vol.132 , pp. 466-473
    • Wilson, J.T.1    Kasantikul, V.2    Harbison, R.3    Martin, D.4
  • 106
    • 0015595664 scopus 로고
    • Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage
    • Wright N, Prescott LF. Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott Med J 1973; 18:56-8.
    • (1973) Scott Med J , vol.18 , pp. 56-58
    • Wright, N.1    Prescott, L.F.2
  • 107
    • 0031763259 scopus 로고    scopus 로고
    • Fulminant hepatic failure from acetaminophen in an anorexic patient treated with carbamazepine
    • Young CR, Mazure CM. Fulminant hepatic failure from acetaminophen in an anorexic patient treated with carbamazepine. J Clin Psychiatry 1998; 59:622.
    • (1998) J Clin Psychiatry , vol.59 , pp. 622
    • Young, C.R.1    Mazure, C.M.2
  • 109
    • 27844540822 scopus 로고    scopus 로고
    • Retinoid X receptor alpha regulates the expression of glutathione S-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver
    • Dai G, Chou N, He L, et al. Retinoid X receptor alpha regulates the expression of glutathione S-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol 2005; 68:1590-6.
    • (2005) Mol Pharmacol , vol.68 , pp. 1590-1596
    • Dai, G.1    Chou, N.2    He, L.3
  • 110
    • 0036765785 scopus 로고    scopus 로고
    • Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
    • Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 2002; 62:638-46.
    • (2002) Mol Pharmacol , vol.62 , pp. 638-646
    • Maglich, J.M.1    Stoltz, C.M.2    Goodwin, B.3    Hawkins-Brown, D.4    Moore, J.T.5    Kliewer, S.A.6
  • 111
    • 10744223848 scopus 로고    scopus 로고
    • Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver
    • Wu Y, Zhang X, Bardag-Gorce F, et al. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol 2004; 65:550-7.
    • (2004) Mol Pharmacol , vol.65 , pp. 550-557
    • Wu, Y.1    Zhang, X.2    Bardag-Gorce, F.3
  • 112
    • 0037064177 scopus 로고    scopus 로고
    • Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
    • Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 2002; 298:422-4.
    • (2002) Science , vol.298 , pp. 422-424
    • Zhang, J.1    Huang, W.2    Chua, S.S.3    Wei, P.4    Moore, D.D.5
  • 113
    • 10044229222 scopus 로고    scopus 로고
    • Enhanced acetaminophen toxicity by activation of the pregnane X receptor
    • Guo GL, Moffit JS, Nicol CJ, et al. Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol Sci 2004; 82:374-80.
    • (2004) Toxicol Sci , vol.82 , pp. 374-380
    • Guo, G.L.1    Moffit, J.S.2    Nicol, C.J.3
  • 114
    • 10344224570 scopus 로고    scopus 로고
    • The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
    • Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 2004; 279:49517-22.
    • (2004) J Biol Chem , vol.279 , pp. 49517-49522
    • Zhang, J.1    Huang, W.2    Qatanani, M.3    Evans, R.M.4    Moore, D.D.5
  • 116
    • 84883271384 scopus 로고    scopus 로고
    • CAR unlikely to significantly modulate acetaminophen hepatotoxicity in most humans
    • Nelson SD, Slattery JT, Thummel KE, Watkins PB. CAR unlikely to significantly modulate acetaminophen hepatotoxicity in most humans. Hepatology 2003; 38:254-7.
    • (2003) Hepatology , vol.38 , pp. 254-257
    • Nelson, S.D.1    Slattery, J.T.2    Thummel, K.E.3    Watkins, P.B.4
  • 117
    • 0033776410 scopus 로고    scopus 로고
    • Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats
    • Xiong H, Turner KC, Ward ES, Jansen PL, Brouwer KL. Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats. J Pharmacol Exp Ther 2000; 295:512-8.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 512-518
    • Xiong, H.1    Turner, K.C.2    Ward, E.S.3    Jansen, P.L.4    Brouwer, K.L.5
  • 118
    • 22944456884 scopus 로고    scopus 로고
    • Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: Role of Mrp2 and Bcrp1
    • Zamek-Gliszczynski MJ, Hoffmaster KA, Tian X, et al. Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1. Drug Metab Dispos 2005; 33:1158-65.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1158-1165
    • Zamek-Gliszczynski, M.J.1    Hoffmaster, K.A.2    Tian, X.3
  • 120
    • 27744499524 scopus 로고    scopus 로고
    • Shift from biliary to urinary elimination of acetaminophen- glucuronide in acetaminophen-pretreated rats
    • Ghanem CI, Ruiz ML, Villanueva SS, et al. Shift from biliary to urinary elimination of acetaminophen- glucuronide in acetaminophen-pretreated rats. J Pharmacol Exp Ther 2005; 315:987-95.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 987-995
    • Ghanem, C.I.1    Ruiz, M.L.2    Villanueva, S.S.3
  • 121
    • 0017658897 scopus 로고
    • Forensic toxicology of some deaths associated with the combined use of propoxyphene and acetaminophen (paracetamol)
    • Robinson AE, Sattar H, McDowall RD, Holder AT, Powell R. Forensic toxicology of some deaths associated with the combined use of propoxyphene and acetaminophen (paracetamol). J Forensic Sci 1977; 22:708-17.
    • (1977) J Forensic Sci , vol.22 , pp. 708-717
    • Robinson, A.E.1    Sattar, H.2    McDowall, R.D.3    Holder, A.T.4    Powell, R.5
  • 123
    • 0019966536 scopus 로고
    • Massive intoxication with acetaminophen and propoxyphene: Unexpected survival and unusual pharmacokinetics of acetaminophen
    • Pond SM, Tong TG, Kaysen GA, Menke DJ, Galinsky RE, Roberts SM, Levy G. Massive intoxication with acetaminophen and propoxyphene: unexpected survival and unusual pharmacokinetics of acetaminophen. J Toxicol Clin Toxicol 1982; 19:1-16.
    • (1982) J Toxicol Clin Toxicol , vol.19 , pp. 1-16
    • Pond, S.M.1    Tong, T.G.2    Kaysen, G.A.3    Menke, D.J.4    Galinsky, R.E.5    Roberts, S.M.6    Levy, G.7
  • 124
    • 0031036790 scopus 로고    scopus 로고
    • Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid
    • Chien JY, Peter RM, Nolan CM, et al. Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid. Clin Pharmacol Ther 1997; 61:24-34.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 24-34
    • Chien, J.Y.1    Peter, R.M.2    Nolan, C.M.3
  • 126
  • 128
    • 0030802792 scopus 로고    scopus 로고
    • Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization
    • Chien JY, Thummel KE, Slattery JT. Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization. Drug Metab Dispos 1997; 25:1165-75.
    • (1997) Drug Metab Dispos , vol.25 , pp. 1165-1175
    • Chien, J.Y.1    Thummel, K.E.2    Slattery, J.T.3
  • 131
    • 0025027886 scopus 로고
    • Severe acetaminophen toxicity in a patient receiving isoniazid
    • Murphy R, Swartz R, Watkins PB. Severe acetaminophen toxicity in a patient receiving isoniazid. Ann Intern Med 1990; 113:799-800.
    • (1990) Ann Intern Med , vol.113 , pp. 799-800
    • Murphy, R.1    Swartz, R.2    Watkins, P.B.3
  • 132
    • 0027958433 scopus 로고
    • Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis
    • Nolan CM, Sandblom RE, Thummel KE, Slattery JT, Nelson SD. Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. Chest 1994; 105:408-11.
    • (1994) Chest , vol.105 , pp. 408-411
    • Nolan, C.M.1    Sandblom, R.E.2    Thummel, K.E.3    Slattery, J.T.4    Nelson, S.D.5
  • 135
    • 0029083319 scopus 로고
    • Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: Analysis of instances of therapeutic misadventure
    • Zimmerman HJ, Maddrey WC. Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology 1995; 22:767-73.
    • (1995) Hepatology , vol.22 , pp. 767-773
    • Zimmerman, H.J.1    Maddrey, W.C.2
  • 136
    • 0034046306 scopus 로고    scopus 로고
    • Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose
    • Makin A, Williams R. Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose. QJM 2000; 93:341-9.
    • (2000) QJM , vol.93 , pp. 341-349
    • Makin, A.1    Williams, R.2
  • 137
    • 0034117815 scopus 로고    scopus 로고
    • Paracetamol, alcohol and the liver
    • Prescott LF. Paracetamol, alcohol and the liver. Br J Clin Pharmacol 2000; 49:291-301.
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 291-301
    • Prescott, L.F.1
  • 138
    • 0035829077 scopus 로고    scopus 로고
    • Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: A randomized, double-blind, placebo-controlled trial
    • Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L. Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial. Arch Intern Med 2001; 161:2247-52.
    • (2001) Arch Intern Med , vol.161 , pp. 2247-2252
    • Kuffner, E.K.1    Dart, R.C.2    Bogdan, G.M.3    Hill, R.E.4    Casper, E.5    Darton, L.6
  • 139
    • 0027499273 scopus 로고
    • Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA
    • Takahashi T, Lasker JM, Rosman AS, Lieber CS. Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 1993; 17:236-45.
    • (1993) Hepatology , vol.17 , pp. 236-245
    • Takahashi, T.1    Lasker, J.M.2    Rosman, A.S.3    Lieber, C.S.4
  • 140
    • 0028229899 scopus 로고
    • Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
    • Garcia-Ruiz C, Morales A, Ballesta A, Rodes J, Kaplowitz N, Fernandez-Checa JC. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest 1994; 94:193-201.
    • (1994) J Clin Invest , vol.94 , pp. 193-201
    • Garcia-Ruiz, C.1    Morales, A.2    Ballesta, A.3    Rodes, J.4    Kaplowitz, N.5    Fernandez-Checa, J.C.6
  • 141
    • 0026493715 scopus 로고
    • Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats
    • Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 1992; 16:1423-7.
    • (1992) Hepatology , vol.16 , pp. 1423-1427
    • Hirano, T.1    Kaplowitz, N.2    Tsukamoto, H.3    Kamimura, S.4    Fernandez-Checa, J.C.5
  • 142
    • 0036322172 scopus 로고    scopus 로고
    • Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver
    • Zhao P, Kalhorn TF, Slattery JT. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology 2002; 36:326-35.
    • (2002) Hepatology , vol.36 , pp. 326-335
    • Zhao, P.1    Kalhorn, T.F.2    Slattery, J.T.3
  • 143
    • 0029041637 scopus 로고
    • Induction mechanisms of cytochrome P450 2E1 in liver: Interplay between ethanol treatment and starvation
    • Hu Y, Ingelman-Sundberg M, Lindros KO. Induction mechanisms of cytochrome P450 2E1 in liver:interplay between ethanol treatment and starvation. Biochem Pharmacol 1995; 50:155-61.
    • (1995) Biochem Pharmacol , vol.50 , pp. 155-161
    • Hu, Y.1    Ingelman-Sundberg, M.2    Lindros, K.O.3
  • 144
    • 0023748625 scopus 로고
    • Glutathione deficiency in alcoholics: Risk factor for paracetamol hepatotoxicity
    • Lauterburg BH, Velez ME. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988; 29:1153-7.
    • (1988) Gut , vol.29 , pp. 1153-1157
    • Lauterburg, B.H.1    Velez, M.E.2
  • 146
    • 0028149489 scopus 로고
    • Association of acetaminophen hepatotoxicity with fasting and ethanol use
    • Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994; 272:1840-5.
    • (1994) JAMA , vol.272 , pp. 1840-1845
    • Whitcomb, D.C.1    Block, G.D.2
  • 147
    • 0036891947 scopus 로고    scopus 로고
    • Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: Implication of potentiated acetaminophen toxicity in alcoholics
    • Zhao P, Slattery JT. Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics. Drug Metab Dispos 2002; 30:1413-7.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1413-1417
    • Zhao, P.1    Slattery, J.T.2
  • 148
    • 0033976076 scopus 로고    scopus 로고
    • Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: Protection by triacetyloleandomycin
    • Sinclair JF, Szakacs JG, Wood SG, et al. Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin. Biochem Pharmacol 2000; 59:445-54.
    • (2000) Biochem Pharmacol , vol.59 , pp. 445-454
    • Sinclair, J.F.1    Szakacs, J.G.2    Wood, S.G.3
  • 149
    • 0034667503 scopus 로고    scopus 로고
    • Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice
    • Sinclair JF, Szakacs JG, Wood SG, et al. Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice. Toxicol Appl Pharmacol 2000; 168:114-22.
    • (2000) Toxicol Appl Pharmacol , vol.168 , pp. 114-122
    • Sinclair, J.F.1    Szakacs, J.G.2    Wood, S.G.3
  • 150
    • 0036145889 scopus 로고    scopus 로고
    • Retroperitoneal haematoma after paracetamol increased anticoagulation
    • Andrews FJ. Retroperitoneal haematoma after paracetamol increased anticoagulation. Emerg Med J 2002; 19:84-5.
    • (2002) Emerg Med J , vol.19 , pp. 84-85
    • Andrews, F.J.1
  • 151
  • 152
    • 0026065890 scopus 로고
    • Potentiation of warfarin anticoagulation by acetaminophen
    • Bartle WR, Blakely JA. Potentiation of warfarin anticoagulation by acetaminophen. JAMA 1991; 265:1260.
    • (1991) JAMA , vol.265 , pp. 1260
    • Bartle, W.R.1    Blakely, J.A.2
  • 155
    • 15244346051 scopus 로고    scopus 로고
    • Paracetamol: A haemorrhagic risk factor in patients on warfarin
    • Mahé I, Bertrand N, Drouet L, et al. Paracetamol: a haemorrhagic risk factor in patients on warfarin. Br J Clin Pharmacol 2005; 59:371-4.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 371-374
    • Mahé, I.1    Bertrand, N.2    Drouet, L.3
  • 156
    • 0000184344 scopus 로고
    • Potentiation of anticoagulant effect of warfarin by acetaminophen (Tylenol)
    • Rubin RN, Mentzer RL, Budzynski AZ. Potentiation of anticoagulant effect of warfarin by acetaminophen (Tylenol). Clin Res 1984; 32:698a.
    • (1984) Clin Res , vol.32 , pp. 698
    • Rubin, R.N.1    Mentzer, R.L.2    Budzynski, A.Z.3
  • 157
    • 0142197163 scopus 로고    scopus 로고
    • Sustained intake of paracetamol (acetaminophen) during oral anticoagulant therapy with coumarins does not cause clinically important INR changes: A randomized double-blind clinical trial
    • Gadisseur AP, Van Der Meer FJ, Rosendaal FR. Sustained intake of paracetamol (acetaminophen) during oral anticoagulant therapy with coumarins does not cause clinically important INR changes:a randomized double-blind clinical trial. J Thromb Haemost 2003; 1:714-7.
    • (2003) J Thromb Haemost , vol.1 , pp. 714-717
    • Gadisseur, A.P.1    Van Der Meer, F.J.2    Rosendaal, F.R.3
  • 158
    • 0032945551 scopus 로고    scopus 로고
    • The effects of acetaminophen on pharmacokinetics and pharmacodynamics of warfarin
    • Kwan D, Bartle WR, Walker SE. The effects of acetaminophen on pharmacokinetics and pharmacodynamics of warfarin. J Clin Pharmacol 1999; 39:68-75.
    • (1999) J Clin Pharmacol , vol.39 , pp. 68-75
    • Kwan, D.1    Bartle, W.R.2    Walker, S.E.3
  • 159
    • 0032881464 scopus 로고    scopus 로고
    • Warfarin-acetaminophen drug interaction revisited
    • Shek KL, Chan LN, Nutescu E. Warfarin-acetaminophen drug interaction revisited. Pharmacotherapy 1999; 19:1153-8.
    • (1999) Pharmacotherapy , vol.19 , pp. 1153-1158
    • Shek, K.L.1    Chan, L.N.2    Nutescu, E.3
  • 160
    • 0032481644 scopus 로고    scopus 로고
    • Acetaminophen and other risk factors for excessive warfarin anticoagulation
    • Hylek EM, Heiman H, Skates SJ, Sheehan MA, Singer DE. Acetaminophen and other risk factors for excessive warfarin anticoagulation. JAMA 1998; 279:657-62.
    • (1998) JAMA , vol.279 , pp. 657-662
    • Hylek, E.M.1    Heiman, H.2    Skates, S.J.3    Sheehan, M.A.4    Singer, D.E.5
  • 161
    • 85057680169 scopus 로고    scopus 로고
    • Does paracetamol (acetaminophen) potentiate the effects of oral anticoagulants?
    • Mahé I, Caulin C, Bergmann JF. Does paracetamol (acetaminophen) potentiate the effects of oral anticoagulants? A literature review Drug Saf 2004; 27:283-352.
    • (2004) A literature review Drug Saf , vol.27 , pp. 283-352
    • Mahé, I.1    Caulin, C.2    Bergmann, J.F.3
  • 162
    • 0031862325 scopus 로고    scopus 로고
    • Inhibition of S-warfarin metabolism by nonsteroidal antiinflammatory drugs in human liver microsomes in vitro
    • Takigawa T, Tainaka H, Mihara K, Ogata H. Inhibition of S-warfarin metabolism by nonsteroidal antiinflammatory drugs in human liver microsomes in vitro. Biol Pharm Bull 1998; 21:541-3.
    • (1998) Biol Pharm Bull , vol.21 , pp. 541-543
    • Takigawa, T.1    Tainaka, H.2    Mihara, K.3    Ogata, H.4
  • 163
    • 0033653694 scopus 로고    scopus 로고
    • Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII
    • Whyte IM, Buckley NA, Reith DM, Goodhew I, Seldon M, Dawson AH. Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII. Ther Drug Monit 2000; 22:742-8.
    • (2000) Ther Drug Monit , vol.22 , pp. 742-748
    • Whyte, I.M.1    Buckley, N.A.2    Reith, D.M.3    Goodhew, I.4    Seldon, M.5    Dawson, A.H.6
  • 164
    • 6344230026 scopus 로고    scopus 로고
    • Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle
    • Thijssen HH, Soute BA, Vervoort LM, Claessens JG. Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. Thromb Haemost 2004; 92:797-802.
    • (2004) Thromb Haemost , vol.92 , pp. 797-802
    • Thijssen, H.H.1    Soute, B.A.2    Vervoort, L.M.3    Claessens, J.G.4
  • 165
    • 0029053262 scopus 로고
    • Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury
    • Nelson SD. Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury. Drug Metab Rev 1995; 27:147-77.
    • (1995) Drug Metab Rev , vol.27 , pp. 147-177
    • Nelson, S.D.1
  • 166
    • 0028346020 scopus 로고
    • Preferred orientations in the binding of 4'- hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies
    • Myers TG, Thummel KE, Kalhorn TF, Nelson SD. Preferred orientations in the binding of 4'- hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem 1994; 37:860-7.
    • (1994) J Med Chem , vol.37 , pp. 860-867
    • Myers, T.G.1    Thummel, K.E.2    Kalhorn, T.F.3    Nelson, S.D.4
  • 167
    • 0034088779 scopus 로고    scopus 로고
    • The catalytic pathway of cytochrome p450cam at atomic resolution
    • Schlichting I, Berendzen J, Chu K, et al. The catalytic pathway of cytochrome p450cam at atomic resolution. Science 2000; 287:1615-22.
    • (2000) Science , vol.287 , pp. 1615-1622
    • Schlichting, I.1    Berendzen, J.2    Chu, K.3
  • 169
    • 0029116115 scopus 로고
    • NMR studies of substrate binding to cytochrome P450 BM3: Comparisons to cytochrome P450 cam
    • Modi S, Primrose WU, Boyle JM, Gibson CF, Lian LY, Roberts GC. NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam. Biochemistry 1995; 34:8982-8.
    • (1995) Biochemistry , vol.34 , pp. 8982-8988
    • Modi, S.1    Primrose, W.U.2    Boyle, J.M.3    Gibson, C.F.4    Lian, L.Y.5    Roberts, G.C.6
  • 170
    • 0033958217 scopus 로고    scopus 로고
    • Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: Investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform
    • Lewis DF, Bird MG, Dickins M, Lake BG, Eddershaw PJ, Tarbit MH, Goldfarb PS. Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform. Xenobiotica 2000; 30:1-25.
    • (2000) Xenobiotica , vol.30 , pp. 1-25
    • Lewis, D.F.1    Bird, M.G.2    Dickins, M.3    Lake, B.G.4    Eddershaw, P.J.5    Tarbit, M.H.6    Goldfarb, P.S.7
  • 171
    • 0025113960 scopus 로고
    • Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in the mouse
    • Rashed MS, Myers TG, Nelson SD. Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in the mouse. Drug Metab Dispos 1990; 18:765-70.
    • (1990) Drug Metab Dispos , vol.18 , pp. 765-770
    • Rashed, M.S.1    Myers, T.G.2    Nelson, S.D.3
  • 172
    • 0025009272 scopus 로고
    • Acetaminophen structure-toxicity studies: In vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide
    • Roberts SA, Price VF, Jollow DJ. Acetaminophen structure-toxicity studies: in vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide. Toxicol Appl Pharmacol 1990; 105:195-208.
    • (1990) Toxicol Appl Pharmacol , vol.105 , pp. 195-208
    • Roberts, S.A.1    Price, V.F.2    Jollow, D.J.3
  • 173
    • 0024345539 scopus 로고
    • Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide
    • Tirmenstein MA, Nelson SD. Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide. J Biol Chem 1989; 264:9814-9.
    • (1989) J Biol Chem , vol.264 , pp. 9814-9819
    • Tirmenstein, M.A.1    Nelson, S.D.2
  • 174
    • 0025274623 scopus 로고
    • Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals
    • Nelson SD, Pearson PG. Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals. Annu Rev Pharmacol Toxicol 1990; 30:169-95.
    • (1990) Annu Rev Pharmacol Toxicol , vol.30 , pp. 169-195
    • Nelson, S.D.1    Pearson, P.G.2
  • 175
    • 0033800819 scopus 로고    scopus 로고
    • Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo
    • Rogers LK, Valentine CJ, Szczpyka M, Smith CV. Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo. Chem Res Toxicol 2000; 13:873-82.
    • (2000) Chem Res Toxicol , vol.13 , pp. 873-882
    • Rogers, L.K.1    Valentine, C.J.2    Szczpyka, M.3    Smith, C.V.4
  • 176
    • 0025250140 scopus 로고
    • Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides
    • Tirmenstein MA, Nelson SD. Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides. J Biol Chem 1990; 265:3059-65.
    • (1990) J Biol Chem , vol.265 , pp. 3059-3065
    • Tirmenstein, M.A.1    Nelson, S.D.2
  • 177
    • 0028893334 scopus 로고
    • Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: Correspondence of covalent binding with toxicity
    • Hart SG, Cartun RW, Wyand DS, Khairallah EA, Cohen SD. Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity. Fundam Appl Toxicol 1995; 24:260-74.
    • (1995) Fundam Appl Toxicol , vol.24 , pp. 260-274
    • Hart, S.G.1    Cartun, R.W.2    Wyand, D.S.3    Khairallah, E.A.4    Cohen, S.D.5
  • 178
    • 0025981219 scopus 로고
    • Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity
    • Roberts DW, Bucci TJ, Benson RW, Warbritton AR, McRae TA, Pumford NR, Hinson JA. Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol 1991; 138:359-71.
    • (1991) Am J Pathol , vol.138 , pp. 359-371
    • Roberts, D.W.1    Bucci, T.J.2    Benson, R.W.3    Warbritton, A.R.4    McRae, T.A.5    Pumford, N.R.6    Hinson, J.A.7
  • 181
    • 0034916119 scopus 로고    scopus 로고
    • Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses
    • James LP, Farrar HC, Sullivan JE, et al. Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. J Clin Pharmacol 2001; 41:846-51.
    • (2001) J Clin Pharmacol , vol.41 , pp. 846-851
    • James, L.P.1    Farrar, H.C.2    Sullivan, J.E.3
  • 182
    • 0036206777 scopus 로고    scopus 로고
    • Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection
    • Muldrew KL, James LP, Coop L, McCullough SS, Hendrickson HP, Hinson JA, Mayeux PR. Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug Metab Dispos 2002; 30:446-51.
    • (2002) Drug Metab Dispos , vol.30 , pp. 446-451
    • Muldrew, K.L.1    James, L.P.2    Coop, L.3    McCullough, S.S.4    Hendrickson, H.P.5    Hinson, J.A.6    Mayeux, P.R.7
  • 183
    • 0342601372 scopus 로고    scopus 로고
    • Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide
    • Dietze EC, Schafer A, Omichinski JG, Nelson SD. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide. Chem Res Toxicol 1997; 10:1097-103.
    • (1997) Chem Res Toxicol , vol.10 , pp. 1097-1103
    • Dietze, E.C.1    Schafer, A.2    Omichinski, J.G.3    Nelson, S.D.4
  • 184
    • 0021950344 scopus 로고
    • Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins
    • Hoffmann KJ, Streeter AJ, Axworthy DB, Baillie TA. Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins. Mol Pharmacol 1985; 27:566-73.
    • (1985) Mol Pharmacol , vol.27 , pp. 566-573
    • Hoffmann, K.J.1    Streeter, A.J.2    Axworthy, D.B.3    Baillie, T.A.4
  • 185
    • 0024554249 scopus 로고
    • Epitope characterization of acetaminophen bound to protein and nonprotein sulfhydryl groups by an enzyme-linked immunosorbent assay
    • Potter DW, Pumford NR, Hinson JA, Benson RW, Roberts DW. Epitope characterization of acetaminophen bound to protein and nonprotein sulfhydryl groups by an enzyme-linked immunosorbent assay. J Pharmacol Exp Ther 1989; 248:182-9.
    • (1989) J Pharmacol Exp Ther , vol.248 , pp. 182-189
    • Potter, D.W.1    Pumford, N.R.2    Hinson, J.A.3    Benson, R.W.4    Roberts, D.W.5
  • 186
    • 0021333072 scopus 로고
    • The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro
    • Streeter AJ, Dahlin DC, Nelson SD, Baillie TA. The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro. Chem Biol Interact 1984; 48:349-66.
    • (1984) Chem Biol Interact , vol.48 , pp. 349-366
    • Streeter, A.J.1    Dahlin, D.C.2    Nelson, S.D.3    Baillie, T.A.4
  • 187
    • 0029658060 scopus 로고    scopus 로고
    • The covalent binding of [14C]acetaminophen to mouse hepatic microsomal proteins: The specific binding to calreticulin and the two forms of the thiol: Protein disulfide oxidoreductases
    • Zhou L, McKenzie BA, Eccleston ED, Jr., Srivastava SP, Chen N, Erickson RR, Holtzman JL. The covalent binding of [14C]acetaminophen to mouse hepatic microsomal proteins: the specific binding to calreticulin and the two forms of the thiol:protein disulfide oxidoreductases. Chem Res Toxicol 1996; 9:1176-82.
    • (1996) Chem Res Toxicol , vol.9 , pp. 1176-1182
    • Zhou, L.1    McKenzie, B.A.2    Eccleston, E.D.3    Srivastava, S.P.4    Chen, N.5    Erickson, R.R.6    Holtzman, J.L.7
  • 188
    • 0030459693 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine
    • Matthews AM, Roberts DW, Hinson JA, Pumford NR. Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine. Drug Metab Dispos 1996; 24:1192-6.
    • (1996) Drug Metab Dispos , vol.24 , pp. 1192-1196
    • Matthews, A.M.1    Roberts, D.W.2    Hinson, J.A.3    Pumford, N.R.4
  • 189
    • 0030744291 scopus 로고    scopus 로고
    • Selective protein arylation and acetaminophen-induced hepatotoxicity
    • Cohen SD, Khairallah EA. Selective protein arylation and acetaminophen-induced hepatotoxicity. Drug Metab Rev 1997; 29:59-77.
    • (1997) Drug Metab Rev , vol.29 , pp. 59-77
    • Cohen, S.D.1    Khairallah, E.A.2
  • 190
    • 7544222053 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity: Role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition
    • Hinson JA, Reid AB, McCullough SS, James LP. Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab Rev 2004; 36:805-22.
    • (2004) Drug Metab Rev , vol.36 , pp. 805-822
    • Hinson, J.A.1    Reid, A.B.2    McCullough, S.S.3    James, L.P.4
  • 191
    • 0030927213 scopus 로고    scopus 로고
    • Protein targets of xenobiotic reactive intermediates
    • Pumford NR, Halmes NC. Protein targets of xenobiotic reactive intermediates. Annu Rev Pharmacol Toxicol 1997; 37:91-117.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 91-117
    • Pumford, N.R.1    Halmes, N.C.2
  • 192
    • 0032504193 scopus 로고    scopus 로고
    • Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry
    • Qiu Y, Benet LZ, Burlingame AL. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem 1998; 273:17940-53.
    • (1998) J Biol Chem , vol.273 , pp. 17940-17953
    • Qiu, Y.1    Benet, L.Z.2    Burlingame, A.L.3
  • 194
    • 0026581374 scopus 로고
    • A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein
    • Pumford NR, Martin BM, Hinson JA. A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein. Biochem Biophys Res Commun 1992; 182:1348-55.
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 1348-1355
    • Pumford, N.R.1    Martin, B.M.2    Hinson, J.A.3
  • 197
    • 0028832745 scopus 로고
    • Identification of the mouse liver 44-kDa acetaminophen- binding protein as a subunit of glutamine synthetase
    • Bulera SJ, Birge RB, Cohen SD, Khairallah EA. Identification of the mouse liver 44-kDa acetaminophen- binding protein as a subunit of glutamine synthetase. Toxicol Appl Pharmacol 1995; 134:313-20.
    • (1995) Toxicol Appl Pharmacol , vol.134 , pp. 313-320
    • Bulera, S.J.1    Birge, R.B.2    Cohen, S.D.3    Khairallah, E.A.4
  • 198
    • 0030808812 scopus 로고    scopus 로고
    • Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice
    • Gupta S, Rogers LK, Taylor SK, Smith CV. Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice. Toxicol Appl Pharmacol 1997; 146:317-27.
    • (1997) Toxicol Appl Pharmacol , vol.146 , pp. 317-327
    • Gupta, S.1    Rogers, L.K.2    Taylor, S.K.3    Smith, C.V.4
  • 199
    • 0030296545 scopus 로고    scopus 로고
    • Identification of a 54-kDa mitochondrial acetaminophenbinding protein as aldehyde dehydrogenase
    • Landin JS, Cohen SD, Khairallah EA. Identification of a 54-kDa mitochondrial acetaminophenbinding protein as aldehyde dehydrogenase. Toxicol Appl Pharmacol 1996; 141:299-307.
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 299-307
    • Landin, J.S.1    Cohen, S.D.2    Khairallah, E.A.3
  • 200
    • 0029935673 scopus 로고    scopus 로고
    • Glutamate dehydrogenase covalently binds to a reactive metabolite of acetaminophen
    • Halmes NC, Hinson JA, Martin BM, Pumford NR. Glutamate dehydrogenase covalently binds to a reactive metabolite of acetaminophen. Chem Res Toxicol 1996; 9:541-6.
    • (1996) Chem Res Toxicol , vol.9 , pp. 541-546
    • Halmes, N.C.1    Hinson, J.A.2    Martin, B.M.3    Pumford, N.R.4
  • 202
    • 0033920278 scopus 로고    scopus 로고
    • Two-dimensional database of mouse liver proteins: Changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol
    • Fountoulakis M, Berndt P, Boelsterli UA, Crameri F, Winter M, Albertini S, Suter L. Two-dimensional database of mouse liver proteins: changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol. Electrophoresis 2000; 21:2148-61.
    • (2000) Electrophoresis , vol.21 , pp. 2148-2161
    • Fountoulakis, M.1    Berndt, P.2    Boelsterli, U.A.3    Crameri, F.4    Winter, M.5    Albertini, S.6    Suter, L.7
  • 203
    • 0028950762 scopus 로고
    • A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide
    • Myers TG, Dietz EC, Anderson NL, Khairallah EA, Cohen SD, Nelson SD. A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide. Chem Res Toxicol 1995; 8:403-13.
    • (1995) Chem Res Toxicol , vol.8 , pp. 403-413
    • Myers, T.G.1    Dietz, E.C.2    Anderson, N.L.3    Khairallah, E.A.4    Cohen, S.D.5    Nelson, S.D.6
  • 204
    • 0035697715 scopus 로고    scopus 로고
    • Identification of hepatic protein targets of the reactive metabolites of the nonhepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry
    • Qiu Y, Benet LZ, Burlingame AL. Identification of hepatic protein targets of the reactive metabolites of the nonhepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry. Adv Exp Med Biol 2001; 500:663-73.
    • (2001) Adv Exp Med Biol , vol.500 , pp. 663-673
    • Qiu, Y.1    Benet, L.Z.2    Burlingame, A.L.3
  • 205
    • 0034640255 scopus 로고    scopus 로고
    • A 56-kDa selenium-binding protein participates in intra-Golgi protein transport
    • Porat A, Sagiv Y, Elazar Z. A 56-kDa selenium-binding protein participates in intra-Golgi protein transport. J Biol Chem 2000; 275:14457-65.
    • (2000) J Biol Chem , vol.275 , pp. 14457-14465
    • Porat, A.1    Sagiv, Y.2    Elazar, Z.3
  • 207
    • 0029973142 scopus 로고    scopus 로고
    • Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene
    • Gladyshev VN, Jeang KT, Stadtman TC. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci USA 1996; 93:6146-51.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6146-6151
    • Gladyshev, V.N.1    Jeang, K.T.2    Stadtman, T.C.3
  • 208
    • 0020488534 scopus 로고
    • Rat liver thioredoxin and thioredoxin reductase: Purification and characterization
    • Luthman M, Holmgren A. Rat liver thioredoxin and thioredoxin reductase: purification and characterization. Biochemistry 1982; 21:6628-33.
    • (1982) Biochemistry , vol.21 , pp. 6628-6633
    • Luthman, M.1    Holmgren, A.2
  • 209
    • 0031013960 scopus 로고    scopus 로고
    • Comparison of covalent binding of acetaminophen and the regioisomer 3'-hydroxyacetanilide to mouse liver protein
    • Matthews AM, Hinson JA, Roberts DW, Pumford NR. Comparison of covalent binding of acetaminophen and the regioisomer 3'-hydroxyacetanilide to mouse liver protein. Toxicol Lett 1997; 90:77-82.
    • (1997) Toxicol Lett , vol.90 , pp. 77-82
    • Matthews, A.M.1    Hinson, J.A.2    Roberts, D.W.3    Pumford, N.R.4
  • 210
    • 0025963773 scopus 로고
    • Hepatotoxicity after 3'-hydroxyacetanilide administration to buthionine sulfoximine pretreated mice
    • Tirmenstein MA, Nelson SD. Hepatotoxicity after 3'-hydroxyacetanilide administration to buthionine sulfoximine pretreated mice. Chem Res Toxicol 1991; 4:214-7.
    • (1991) Chem Res Toxicol , vol.4 , pp. 214-217
    • Tirmenstein, M.A.1    Nelson, S.D.2
  • 211
    • 0016738541 scopus 로고
    • Experimental paracetamol-induced hepatic necrosis: A light- and electron-microscope, and histochemical study
    • Dixon MF, Dixon B, Aparicio SR, Loney DP. Experimental paracetamol-induced hepatic necrosis: a light- and electron-microscope, and histochemical study. J Pathol 1975; 116:17-29.
    • (1975) J Pathol , vol.116 , pp. 17-29
    • Dixon, M.F.1    Dixon, B.2    Aparicio, S.R.3    Loney, D.P.4
  • 212
    • 0018874083 scopus 로고
    • Acetaminophen-induced hepatotoxicity in mice
    • Walker RM, Racz WJ, McElligott TF. Acetaminophen-induced hepatotoxicity in mice. Lab Invest 1980; 42:181-9.
    • (1980) Lab Invest , vol.42 , pp. 181-189
    • Walker, R.M.1    Racz, W.J.2    McElligott, T.F.3
  • 213
    • 0025774993 scopus 로고
    • Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes
    • Burcham PC, Harman AW. Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J Biol Chem 1991; 266:5049-54.
    • (1991) J Biol Chem , vol.266 , pp. 5049-5054
    • Burcham, P.C.1    Harman, A.W.2
  • 214
    • 0027976561 scopus 로고
    • Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity
    • Donnelly PJ, Walker RM, Racz WJ. Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity. Arch Toxicol 1994; 68:110-8.
    • (1994) Arch Toxicol , vol.68 , pp. 110-118
    • Donnelly, P.J.1    Walker, R.M.2    Racz, W.J.3
  • 215
    • 0024531786 scopus 로고
    • Impaired mitochondrial oxidative energy metabolism following paracetamolinduced hepatotoxicity in the rat
    • Katyare SS, Satav JG. Impaired mitochondrial oxidative energy metabolism following paracetamolinduced hepatotoxicity in the rat. Br J Pharmacol 1989; 96:51-8.
    • (1989) Br J Pharmacol , vol.96 , pp. 51-58
    • Katyare, S.S.1    Satav, J.G.2
  • 217
    • 0024454385 scopus 로고
    • In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria
    • Ramsay RR, Rashed MS, Nelson SD. In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria. Arch Biochem Biophys 1989; 273:449-57.
    • (1989) Arch Biochem Biophys , vol.273 , pp. 449-457
    • Ramsay, R.R.1    Rashed, M.S.2    Nelson, S.D.3
  • 218
    • 0026634039 scopus 로고
    • The toxicological relevance of paracetamol-induced inhibition of hepatic respiration and ATP depletion
    • Strubelt O, Younes M. The toxicological relevance of paracetamol-induced inhibition of hepatic respiration and ATP depletion. Biochem Pharmacol 1992; 44:163-70.
    • (1992) Biochem Pharmacol , vol.44 , pp. 163-170
    • Strubelt, O.1    Younes, M.2
  • 219
    • 0030601829 scopus 로고    scopus 로고
    • Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat
    • Vendemiale G, Grattagliano I, Altomare E, Turturro N, Guerrieri F. Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat. Biochem Pharmacol 1996; 52:1147-54.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1147-1154
    • Vendemiale, G.1    Grattagliano, I.2    Altomare, E.3    Turturro, N.4    Guerrieri, F.5
  • 220
    • 0025673837 scopus 로고
    • Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: The protective effect of allopurinol
    • Jaeschke H. Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. J Pharmacol Exp Ther 1990; 255:935-41.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 935-941
    • Jaeschke, H.1
  • 221
    • 0029584277 scopus 로고
    • Adenosine triphosphate (ATP) levels in paracetamol-induced cell injury in the rat in vivo and in vitro
    • Martin FL, McLean AE. Adenosine triphosphate (ATP) levels in paracetamol-induced cell injury in the rat in vivo and in vitro. Toxicology 1995; 104:91-7.
    • (1995) Toxicology , vol.104 , pp. 91-97
    • Martin, F.L.1    McLean, A.E.2
  • 222
    • 58149209522 scopus 로고
    • Mitochondrial ATPase: A target for paracetamolinduced hepatotoxicity
    • Parmar DV, Ahmed G, Khandkar MA, Katyare SS. Mitochondrial ATPase: a target for paracetamolinduced hepatotoxicity. Eur J Pharmacol 1995; 293:225-9.
    • (1995) Eur J Pharmacol , vol.293 , pp. 225-229
    • Parmar, D.V.1    Ahmed, G.2    Khandkar, M.A.3    Katyare, S.S.4
  • 223
    • 0023718622 scopus 로고
    • Effect of acetaminophen hepatotoxicity on hepatic mitochondrial and microsomal calcium contents in mice
    • Burcham PC, Harman AW. Effect of acetaminophen hepatotoxicity on hepatic mitochondrial and microsomal calcium contents in mice. Toxicol Lett 1988; 44:91-9.
    • (1988) Toxicol Lett , vol.44 , pp. 91-99
    • Burcham, P.C.1    Harman, A.W.2
  • 224
    • 0023598396 scopus 로고
    • Early disturbance of calcium translocation across the plasma membrane in toxic liver injury
    • Lauterburg BH. Early disturbance of calcium translocation across the plasma membrane in toxic liver injury. Hepatology 1987; 7:1179-83.
    • (1987) Hepatology , vol.7 , pp. 1179-1183
    • Lauterburg, B.H.1
  • 225
    • 0022381689 scopus 로고
    • The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+
    • Moore M, Thor H, Moore G, Nelson S, Moldeus P, Orrenius S. The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. J Biol Chem 1985; 260:13035-40.
    • (1985) J Biol Chem , vol.260 , pp. 13035-13040
    • Moore, M.1    Thor, H.2    Moore, G.3    Nelson, S.4    Moldeus, P.5    Orrenius, S.6
  • 227
    • 0021839389 scopus 로고
    • ATP-dependent calcium uptake by rat liver plasma membrane vesicles. Effect of alkylating hepatotoxins in vivo
    • Tsokos-Kuhn JO, Todd EL, McMillin-Wood JB, Mitchell JR. ATP-dependent calcium uptake by rat liver plasma membrane vesicles. Effect of alkylating hepatotoxins in vivo. Mol Pharmacol 1985; 28:56-61.
    • (1985) Mol Pharmacol , vol.28 , pp. 56-61
    • Tsokos-Kuhn, J.O.1    Todd, E.L.2    McMillin-Wood, J.B.3    Mitchell, J.R.4
  • 228
    • 0023193249 scopus 로고
    • Early inhibition of the Na+/K+-ATPase ion pump during acetaminophen-induced hepatotoxicity in rat
    • Corcoran GB, Chung SJ, Salazar DE. Early inhibition of the Na+/K+-ATPase ion pump during acetaminophen-induced hepatotoxicity in rat. Biochem Biophys Res Commun 1987; 149:203-7.
    • (1987) Biochem Biophys Res Commun , vol.149 , pp. 203-207
    • Corcoran, G.B.1    Chung, S.J.2    Salazar, D.E.3
  • 229
    • 0032210811 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase activity and changes in protein phosphorylation following acetaminophen exposure in cultured mouse hepatocytes
    • Bruno MK, Khairallah EA, Cohen SD. Inhibition of protein phosphatase activity and changes in protein phosphorylation following acetaminophen exposure in cultured mouse hepatocytes. Toxicol Appl Pharmacol 1998; 153:119-32.
    • (1998) Toxicol Appl Pharmacol , vol.153 , pp. 119-132
    • Bruno, M.K.1    Khairallah, E.A.2    Cohen, S.D.3
  • 230
    • 0017369326 scopus 로고
    • Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine
    • Labadarios D, Davis M, Portmann B, Williams R. Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine. Biochem Pharmacol 1977; 26:31-5.
    • (1977) Biochem Pharmacol , vol.26 , pp. 31-35
    • Labadarios, D.1    Davis, M.2    Portmann, B.3    Williams, R.4
  • 232
    • 0022516425 scopus 로고
    • Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol
    • Tee LB, Boobis AR, Huggett AC, Davies DS. Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol. Toxicol Appl Pharmacol 1986; 83:294-314.
    • (1986) Toxicol Appl Pharmacol , vol.83 , pp. 294-314
    • Tee, L.B.1    Boobis, A.R.2    Huggett, A.C.3    Davies, D.S.4
  • 233
    • 0021335173 scopus 로고
    • Biliary excretion of glutathione and glutathione disulfide in the rat. Regulation and response to oxidative stress
    • Lauterburg BH, Smith CV, Hughes H, Mitchell JR. Biliary excretion of glutathione and glutathione disulfide in the rat. Regulation and response to oxidative stress. J Clin Invest 1984; 73:124-33.
    • (1984) J Clin Invest , vol.73 , pp. 124-133
    • Lauterburg, B.H.1    Smith, C.V.2    Hughes, H.3    Mitchell, J.R.4
  • 234
    • 0026101849 scopus 로고
    • Correlations and apparent contradictions in assessment of oxidant stress status in vivo
    • Smith CV. Correlations and apparent contradictions in assessment of oxidant stress status in vivo. Free Radic Biol Med 1991; 10:217-24.
    • (1991) Free Radic Biol Med , vol.10 , pp. 217-224
    • Smith, C.V.1
  • 235
    • 0022371112 scopus 로고
    • Acetaminophen hepatotoxicity in vivo is not accompanied by oxidant stress
    • Smith CV, Mitchell JR. Acetaminophen hepatotoxicity in vivo is not accompanied by oxidant stress. Biochem Biophys Res Commun 1985; 133:329-36.
    • (1985) Biochem Biophys Res Commun , vol.133 , pp. 329-336
    • Smith, C.V.1    Mitchell, J.R.2
  • 236
    • 0029074260 scopus 로고
    • Acetaminophen-induced hepatic injury in mice: The role of lipid peroxidation and effects of pretreatment with coenzyme and alpha-tocopherol
    • Amimoto T, Matsura T, Koyama SY, Nakanishi T, Yamada K, Kajiyama G. Acetaminophen-induced hepatic injury in mice: the role of lipid peroxidation and effects of pretreatment with coenzyme and alpha-tocopherol. Free Radic Biol Med 1995; 19:169-76.
    • (1995) Free Radic Biol Med , vol.19 , pp. 169-176
    • Amimoto, T.1    Matsura, T.2    Koyama, S.Y.3    Nakanishi, T.4    Yamada, K.5    Kajiyama, G.6
  • 238
    • 0018763569 scopus 로고
    • Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo
    • Wendel A, Feuerstein S, Konz KH. Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochem Pharmacol 1979; 28:2051-5.
    • (1979) Biochem Pharmacol , vol.28 , pp. 2051-2055
    • Wendel, A.1    Feuerstein, S.2    Konz, K.H.3
  • 239
    • 0018611635 scopus 로고
    • Ethane production and liver necrosis in rats after administration of drugs and other chemicals
    • Burk RF, Lane JM. Ethane production and liver necrosis in rats after administration of drugs and other chemicals. Toxicol Appl Pharmacol 1979; 50:467-78.
    • (1979) Toxicol Appl Pharmacol , vol.50 , pp. 467-478
    • Burk, R.F.1    Lane, J.M.2
  • 240
    • 0027446269 scopus 로고
    • Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: Comparison with carbon tetrachloride
    • Kamiyama T, Sato C, Liu J, Tajiri K, Miyakawa H, Marumo F. Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: comparison with carbon tetrachloride. Toxicol Lett 1993; 66:7-12.
    • (1993) Toxicol Lett , vol.66 , pp. 7-12
    • Kamiyama, T.1    Sato, C.2    Liu, J.3    Tajiri, K.4    Miyakawa, H.5    Marumo, F.6
  • 241
    • 0027064479 scopus 로고
    • Formation of novel noncyclooxygenase- derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation
    • Morrow JD, Awad JA, Kato T, Takahashi K, Badr KF, Roberts LJ, II, Burk RF. Formation of novel noncyclooxygenase- derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. J Clin Invest 1992; 90:2502-7.
    • (1992) J Clin Invest , vol.90 , pp. 2502-2507
    • Morrow, J.D.1    Awad, J.A.2    Kato, T.3    Takahashi, K.4    Badr, K.F.5    Roberts, L.J.6    Burk, R.F.7
  • 243
    • 0032970909 scopus 로고    scopus 로고
    • The isoprostanes: Unique prostaglandin-like products of freeradical- initiated lipid peroxidation
    • Morrow JD, Chen Y, Brame CJ, et al. The isoprostanes: unique prostaglandin-like products of freeradical- initiated lipid peroxidation. Drug Metab Rev 1999; 31:117-39.
    • (1999) Drug Metab Rev , vol.31 , pp. 117-139
    • Morrow, J.D.1    Chen, Y.2    Brame, C.J.3
  • 244
    • 0028265812 scopus 로고
    • Biliary excretion of lysosomal enzymes, iron, and oxidized protein in Fischer-344 and Sprague-Dawley rats and the effects of diquat and acetaminophen
    • Gupta S, Rogers LK, Smith CV. Biliary excretion of lysosomal enzymes, iron, and oxidized protein in Fischer-344 and Sprague-Dawley rats and the effects of diquat and acetaminophen. Toxicol Appl Pharmacol 1994; 125:42-50.
    • (1994) Toxicol Appl Pharmacol , vol.125 , pp. 42-50
    • Gupta, S.1    Rogers, L.K.2    Smith, C.V.3
  • 245
    • 0029961590 scopus 로고    scopus 로고
    • Mechanism of acetaminophen-induced hepatotoxicity: Covalent binding versus oxidative stress
    • Gibson JD, Pumford NR, Samokyszyn VM, Hinson JA. Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress. Chem Res Toxicol 1996; 9:580-5.
    • (1996) Chem Res Toxicol , vol.9 , pp. 580-585
    • Gibson, J.D.1    Pumford, N.R.2    Samokyszyn, V.M.3    Hinson, J.A.4
  • 247
    • 0023733865 scopus 로고
    • Effect of deferrioxamine and diethyldithiocarbamate on paracetamol-induced hepato- and nephrotoxicity. The role of lipid peroxidation
    • Younes M, Sause C, Siegers CP, Lemoine R. Effect of deferrioxamine and diethyldithiocarbamate on paracetamol-induced hepato- and nephrotoxicity. The role of lipid peroxidation. J Appl Toxicol 1988; 8:261-5.
    • (1988) J Appl Toxicol , vol.8 , pp. 261-265
    • Younes, M.1    Sause, C.2    Siegers, C.P.3    Lemoine, R.4
  • 248
    • 0022359224 scopus 로고
    • The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity
    • Younes M, Siegers CP. The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity. Chem Biol Interact 1985; 55:327-34.
    • (1985) Chem Biol Interact , vol.55 , pp. 327-334
    • Younes, M.1    Siegers, C.P.2
  • 249
    • 0027420167 scopus 로고
    • Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury
    • ElSisi AE, Hall P, Sim WL, Earnest DL, Sipes IG. Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. Toxicol Appl Pharmacol 1993; 119:280-8.
    • (1993) Toxicol Appl Pharmacol , vol.119 , pp. 280-288
    • ElSisi, A.E.1    Hall, P.2    Sim, W.L.3    Earnest, D.L.4    Sipes, I.G.5
  • 250
    • 0030062401 scopus 로고    scopus 로고
    • Sinusoidal lining cells and hepatotoxicity
    • Laskin DL. Sinusoidal lining cells and hepatotoxicity. Toxicol Pathol 1996; 24:112-8.
    • (1996) Toxicol Pathol , vol.24 , pp. 112-118
    • Laskin, D.L.1
  • 253
    • 0023113523 scopus 로고
    • The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase
    • Potter DW, Hinson JA. The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase. J Biol Chem 1987; 262:974-80.
    • (1987) J Biol Chem , vol.262 , pp. 974-980
    • Potter, D.W.1    Hinson, J.A.2
  • 254
    • 0022389679 scopus 로고
    • Identification of acetaminophen polymerization products catalyzed by horseradish peroxidase
    • Potter DW, Miller DW, Hinson JA. Identification of acetaminophen polymerization products catalyzed by horseradish peroxidase. J Biol Chem 1985; 260:12174-80.
    • (1985) J Biol Chem , vol.260 , pp. 12174-12180
    • Potter, D.W.1    Miller, D.W.2    Hinson, J.A.3
  • 255
    • 0021196036 scopus 로고
    • Acetaminophen: Enzymatic formation of a transient phenoxyl free radical
    • West PR, Harman LS, Josephy PD, Mason RP. Acetaminophen: enzymatic formation of a transient phenoxyl free radical. Biochem Pharmacol 1984; 33:2933-6.
    • (1984) Biochem Pharmacol , vol.33 , pp. 2933-2936
    • West, P.R.1    Harman, L.S.2    Josephy, P.D.3    Mason, R.P.4
  • 256
    • 0022251549 scopus 로고
    • Formation of 4-aminophenoxyl free radical from the acetaminophen metabolite N-acetyl-p-benzoquinone imine
    • Fischer V, West PR, Nelson SD, Harvison PJ, Mason RP. Formation of 4-aminophenoxyl free radical from the acetaminophen metabolite N-acetyl-p-benzoquinone imine. J Biol Chem 1985; 260:11446-50.
    • (1985) J Biol Chem , vol.260 , pp. 11446-11450
    • Fischer, V.1    West, P.R.2    Nelson, S.D.3    Harvison, P.J.4    Mason, R.P.5
  • 257
    • 0023917210 scopus 로고
    • Properties of the radicals formed by one-electron oxidation of acetaminophen- a pulse radiolysis study
    • Bisby RH, Tabassum N. Properties of the radicals formed by one-electron oxidation of acetaminophen- a pulse radiolysis study. Biochem Pharmacol 1988; 37:2731-8.
    • (1988) Biochem Pharmacol , vol.37 , pp. 2731-2738
    • Bisby, R.H.1    Tabassum, N.2
  • 258
    • 0026092267 scopus 로고
    • Mechanism of acetaminophen-stimulated NADPH oxidation catalyzed by the peroxidase-H2O2 system
    • Keller RJ, Hinson JA. Mechanism of acetaminophen-stimulated NADPH oxidation catalyzed by the peroxidase-H2O2 system. Drug Metab Dispos 1991; 19:184-7.
    • (1991) Drug Metab Dispos , vol.19 , pp. 184-187
    • Keller, R.J.1    Hinson, J.A.2
  • 259
    • 0021705694 scopus 로고
    • Thiyl radicals-formation during peroxidase-catalyzed metabolism of acetaminophen in the presence of thiols
    • Ross D, Albano E, Nilsson U, Moldeus P. Thiyl radicals-formation during peroxidase-catalyzed metabolism of acetaminophen in the presence of thiols. Biochem Biophys Res Commun 1984; 125:109-15.
    • (1984) Biochem Biophys Res Commun , vol.125 , pp. 109-115
    • Ross, D.1    Albano, E.2    Nilsson, U.3    Moldeus, P.4
  • 260
    • 0023113250 scopus 로고
    • Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen
    • van de Straat R, de Vries J, Vermeulen NP. Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen. Biochem Pharmacol 1987; 36:613-9.
    • (1987) Biochem Pharmacol , vol.36 , pp. 613-619
    • van de Straat, R.1    de Vries, J.2    Vermeulen, N.P.3
  • 261
    • 0037039457 scopus 로고    scopus 로고
    • Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites
    • Senter PD, Al-Abed Y, Metz CN, et al. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites. Proc Natl Acad Sci USA 2002; 99:144-9.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 144-149
    • Senter, P.D.1    Al-Abed, Y.2    Metz, C.N.3
  • 262
    • 0043135016 scopus 로고    scopus 로고
    • The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity
    • Jaeschke H, Knight TR, Bajt ML. The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 2003; 144:279-88.
    • (2003) Toxicol Lett , vol.144 , pp. 279-288
    • Jaeschke, H.1    Knight, T.R.2    Bajt, M.L.3
  • 264
    • 0036828064 scopus 로고    scopus 로고
    • Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: Protection by glutathione
    • Knight TR, Ho YS, Farhood A, Jaeschke H. Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione. J Pharmacol Exp Ther 2002; 303:468-75.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 468-475
    • Knight, T.R.1    Ho, Y.S.2    Farhood, A.3    Jaeschke, H.4
  • 265
    • 85057667168 scopus 로고    scopus 로고
    • Methods and approaches to study metabolism and toxicity of acetaminophen
    • Lash LH, ed, Molecular Methods and Mechanisms. Totowa, NJ:Humana
    • Bruschi SA. Methods and approaches to study metabolism and toxicity of acetaminophen. In: Lash LH, ed. Drug Metabolism and Transport. Molecular Methods and Mechanisms. Totowa, NJ:Humana, 2005:387.
    • (2005) Drug Metabolism and Transport , pp. 387
    • Bruschi, S.A.1
  • 266
    • 0035977838 scopus 로고    scopus 로고
    • The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis
    • Gonzalez FJ. The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis. Toxicol Lett 2001; 120:199-208.
    • (2001) Toxicol Lett , vol.120 , pp. 199-208
    • Gonzalez, F.J.1
  • 267
    • 0037336009 scopus 로고    scopus 로고
    • Adult toxicology in critical care: Part II: Specific poisonings
    • Mokhlesi B, Leikin JB, Murray P, Corbridge TC. Adult toxicology in critical care: part II: specific poisonings. Chest 2003; 123:897-922.
    • (2003) Chest , vol.123 , pp. 897-922
    • Mokhlesi, B.1    Leikin, J.B.2    Murray, P.3    Corbridge, T.C.4
  • 268
    • 32944472713 scopus 로고    scopus 로고
    • Broadening the view of acetaminophen hepatotoxicity
    • O’Grady JG. Broadening the view of acetaminophen hepatotoxicity. Hepatology 2005; 42:1252-4.
    • (2005) Hepatology , vol.42 , pp. 1252-1254
    • O’Grady, J.G.1
  • 269
    • 0036730173 scopus 로고    scopus 로고
    • Serum phosphate is an early predictor of outcome in severe acetaminopheninduced hepatotoxicity
    • Schmidt LE, Dalhoff K. Serum phosphate is an early predictor of outcome in severe acetaminopheninduced hepatotoxicity. Hepatology 2002; 36:659-65.
    • (2002) Hepatology , vol.36 , pp. 659-665
    • Schmidt, L.E.1    Dalhoff, K.2
  • 270
    • 3242742968 scopus 로고    scopus 로고
    • Gene expression profiling of rat livers reveals indicators of potential adverse effects
    • Heinloth AN, Irwin RD, Boorman GA, et al. Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicol Sci 2004; 80:193-202.
    • (2004) Toxicol Sci , vol.80 , pp. 193-202
    • Heinloth, A.N.1    Irwin, R.D.2    Boorman, G.A.3
  • 271
    • 0034764653 scopus 로고    scopus 로고
    • Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2
    • Adams ML, Pierce RH, Vail ME, et al. Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2. Mol Pharmacol 2001; 60:907-15.
    • (2001) Mol Pharmacol , vol.60 , pp. 907-915
    • Adams, M.L.1    Pierce, R.H.2    Vail, M.E.3
  • 272
    • 20844462088 scopus 로고    scopus 로고
    • From point B to point A: Applying toxicogenomics to biological inference
    • Freeman K. From point B to point A: applying toxicogenomics to biological inference. Environ Health Perspect 2005; 113:A388-93.
    • (2005) Environ Health Perspect , vol.113 , pp. A388-A393
    • Freeman, K.1
  • 273
    • 0037330948 scopus 로고    scopus 로고
    • Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamolinduced toxicity in the liver
    • Kitteringham NR, Powell H, Jenkins RE, et al. Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamolinduced toxicity in the liver. Proteomics 2003; 3:191-207.
    • (2003) Proteomics , vol.3 , pp. 191-207
    • Kitteringham, N.R.1    Powell, H.2    Jenkins, R.E.3
  • 274
    • 0036147966 scopus 로고    scopus 로고
    • Genomics and proteomics analysis of acetaminophen toxicity in mouse liver
    • Ruepp SU, Tonge RP, Shaw J, Wallis N, Pognan F. Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. Toxicol Sci 2002; 65:135-50.
    • (2002) Toxicol Sci , vol.65 , pp. 135-150
    • Ruepp, S.U.1    Tonge, R.P.2    Shaw, J.3    Wallis, N.4    Pognan, F.5
  • 275
    • 21144438395 scopus 로고    scopus 로고
    • Proteomic identification of potential susceptibility factors in drug-induced liver disease
    • Welch KD, Wen B, Goodlett DR, et al. Proteomic identification of potential susceptibility factors in drug-induced liver disease. Chem Res Toxicol 2005; 18:924-33.
    • (2005) Chem Res Toxicol , vol.18 , pp. 924-933
    • Welch, K.D.1    Wen, B.2    Goodlett, D.R.3
  • 276
    • 33744999177 scopus 로고    scopus 로고
    • Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity
    • Zhu JH, Lei XG. Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity. Exp Biol Med (Maywood) 2006; 231:545-52.
    • (2006) Exp Biol Med (Maywood) , vol.231 , pp. 545-552
    • Zhu, J.H.1    Lei, X.G.2
  • 277
    • 33644864832 scopus 로고    scopus 로고
    • Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: Toxicity differentiation in hepatotoxicants
    • Yamamoto T, Kikkawa R, Yamada H, Horii I. Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants. J Toxicol Sci 2006; 31:49-60.
    • (2006) J Toxicol Sci , vol.31 , pp. 49-60
    • Yamamoto, T.1    Kikkawa, R.2    Yamada, H.3    Horii, I.4
  • 278
    • 26444588758 scopus 로고    scopus 로고
    • Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity
    • Ho HK, White CC, Fernandez C, Fausto N, Kavanagh TJ, Nelson SD, Bruschi SA. Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity. Toxicol Sci 2005; 86:354-64.
    • (2005) Toxicol Sci , vol.86 , pp. 354-364
    • Ho, H.K.1    White, C.C.2    Fernandez, C.3    Fausto, N.4    Kavanagh, T.J.5    Nelson, S.D.6    Bruschi, S.A.7
  • 279
    • 0037201949 scopus 로고    scopus 로고
    • Role of antioxidants in paraquat toxicity
    • Suntres ZE. Role of antioxidants in paraquat toxicity. Toxicology 2002; 180:65-77.
    • (2002) Toxicology , vol.180 , pp. 65-77
    • Suntres, Z.E.1
  • 280
    • 0020505821 scopus 로고
    • Covalent binding and the mechanism of paracetamol toxicity
    • Devalia JL, McLean AE. Covalent binding and the mechanism of paracetamol toxicity. Biochem Pharmacol 1983; 32:2602-3.
    • (1983) Biochem Pharmacol , vol.32 , pp. 2602-2603
    • Devalia, J.L.1    McLean, A.E.2
  • 281
    • 0020371002 scopus 로고
    • Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system
    • Devalia JL, Ogilvie RC, McLean AE. Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system. Biochem Pharmacol 1982; 31:3745-9.
    • (1982) Biochem Pharmacol , vol.31 , pp. 3745-3749
    • Devalia, J.L.1    Ogilvie, R.C.2    McLean, A.E.3
  • 282
    • 0021146055 scopus 로고
    • The microsomal metabolism and site of covalent binding to protein of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen
    • Streeter AJ, Bjorge SM, Axworthy DB, Nelson SD, Baillie TA. The microsomal metabolism and site of covalent binding to protein of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen. Drug Metab Dispos 1984; 12:565-76.
    • (1984) Drug Metab Dispos , vol.12 , pp. 565-576
    • Streeter, A.J.1    Bjorge, S.M.2    Axworthy, D.B.3    Nelson, S.D.4    Baillie, T.A.5
  • 283
    • 85057671407 scopus 로고    scopus 로고
    • Mechanisms of acetaminophen-induced liver disease
    • Kaplowitz N, DeLeve LD, eds, 1st ed. New York: Marcel Dekker
    • Nelson SD, Bruschi S. Mechanisms of acetaminophen-induced liver disease. In: Kaplowitz N, DeLeve LD, eds. Drug Induced Liver Disease. 1st ed. New York: Marcel Dekker, 2003:773.
    • (2003) Drug Induced Liver Disease , pp. 773
    • Nelson, S.D.1    Bruschi, S.2
  • 284
    • 33644857006 scopus 로고    scopus 로고
    • Neuroprotection by pharmacologic blockade of the GAPDH death cascade
    • Hara MR, Thomas B, Cascio MB, et al. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci USA 2006; 103:3887-9.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3887-3889
    • Hara, M.R.1    Thomas, B.2    Cascio, M.B.3
  • 285
    • 22144477159 scopus 로고    scopus 로고
    • S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
    • Hara MR, Agrawal N, Kim SF, et al. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol 2005; 7:665-74.
    • (2005) Nat Cell Biol , vol.7 , pp. 665-674
    • Hara, M.R.1    Agrawal, N.2    Kim, S.F.3
  • 286
    • 0032973950 scopus 로고    scopus 로고
    • New insights into an old protein: The functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase
    • Sirover MA. New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase. Biochim Biophys Acta 1999; 1432:159-84.
    • (1999) Biochim Biophys Acta , vol.1432 , pp. 159-184
    • Sirover, M.A.1
  • 288
    • 0023583835 scopus 로고
    • Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen
    • Kyle ME, Miccadei S, Nakae D, Farber JL. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem Biophys Res Commun 1987; 149:889-96.
    • (1987) Biochem Biophys Res Commun , vol.149 , pp. 889-896
    • Kyle, M.E.1    Miccadei, S.2    Nakae, D.3    Farber, J.L.4
  • 290
    • 0025343905 scopus 로고
    • Evidence for a direct role of intracellular calcium in paracetamol toxicity
    • Boobis AR, Seddon CE, Nasseri-Sina P, Davies DS. Evidence for a direct role of intracellular calcium in paracetamol toxicity. Biochem Pharmacol 1990; 39:1277-81.
    • (1990) Biochem Pharmacol , vol.39 , pp. 1277-1281
    • Boobis, A.R.1    Seddon, C.E.2    Nasseri-Sina, P.3    Davies, D.S.4
  • 291
    • 0021783158 scopus 로고
    • The biochemical pathology of toxic cell death
    • Farber JL. The biochemical pathology of toxic cell death. Monogr Pathol 1985;19-31.
    • (1985) Monogr Pathol , pp. 19-31
    • Farber, J.L.1
  • 292
    • 0024345539 scopus 로고
    • Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver
    • Tirmenstein MA, Nelson SD. Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver. J Biol Chem 1989; 264:9814-9.
    • (1989) J Biol Chem , vol.264 , pp. 9814-9819
    • Tirmenstein, M.A.1    Nelson, S.D.2
  • 293
    • 0025675750 scopus 로고
    • Implications of alterations in intracellular calcium ion homeostasis in the advent of paracetamol-induced cytotoxicity in primary mouse hepatocyte cultures
    • Bruschi SA, Priestly BG. Implications of alterations in intracellular calcium ion homeostasis in the advent of paracetamol-induced cytotoxicity in primary mouse hepatocyte cultures. Toxicol In Vitro 1990; 4:743-9.
    • (1990) Toxicol In Vitro , vol.4 , pp. 743-749
    • Bruschi, S.A.1    Priestly, B.G.2
  • 294
    • 0037348405 scopus 로고    scopus 로고
    • An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy
    • Coen M, Lenz EM, Nicholson JK, Wilson ID, Pognan F, Lindon JC. An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy. Chem Res Toxicol 2003; 16:295-303.
    • (2003) Chem Res Toxicol , vol.16 , pp. 295-303
    • Coen, M.1    Lenz, E.M.2    Nicholson, J.K.3    Wilson, I.D.4    Pognan, F.5    Lindon, J.C.6
  • 295
    • 1642345498 scopus 로고    scopus 로고
    • Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse
    • Coen M, Ruepp SU, Lindon JC, Nicholson JK, Pognan F, Lenz EM, Wilson ID. Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse. J Pharm Biomed Anal 2004; 35:93-105.
    • (2004) J Pharm Biomed Anal , vol.35 , pp. 93-105
    • Coen, M.1    Ruepp, S.U.2    Lindon, J.C.3    Nicholson, J.K.4    Pognan, F.5    Lenz, E.M.6    Wilson, I.D.7
  • 296
    • 33644512085 scopus 로고    scopus 로고
    • Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice
    • Welch KD, Reilly TP, Bourdi M, et al. Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice. Chem Res Toxicol 2006; 19:223-33.
    • (2006) Chem Res Toxicol , vol.19 , pp. 223-233
    • Welch, K.D.1    Reilly, T.P.2    Bourdi, M.3
  • 297
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • Clayton TA, Lindon JC, Cloarec O, et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 2006; 440:1073-7.
    • (2006) Nature , vol.440 , pp. 1073-1077
    • Clayton, T.A.1    Lindon, J.C.2    Cloarec, O.3
  • 298
    • 33644865721 scopus 로고    scopus 로고
    • In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system
    • Kikkawa R, Fujikawa M, Yamamoto T, Hamada Y, Yamada H, Horii I. In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system. J Toxicol Sci 2006; 31:23-34.
    • (2006) J Toxicol Sci , vol.31 , pp. 23-34
    • Kikkawa, R.1    Fujikawa, M.2    Yamamoto, T.3    Hamada, Y.4    Yamada, H.5    Horii, I.6
  • 299
    • 24044477893 scopus 로고    scopus 로고
    • Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats
    • Minami K, Saito T, Narahara M, et al. Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats. Toxicol Sci 2005; 87:296-305.
    • (2005) Toxicol Sci , vol.87 , pp. 296-305
    • Minami, K.1    Saito, T.2    Narahara, M.3
  • 302
    • 20844432350 scopus 로고    scopus 로고
    • Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
    • Williams DP, Garcia-Allan C, Hanton G, et al. Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration. Chem Res Toxicol 2004; 17:1551-61.
    • (2004) Chem Res Toxicol , vol.17 , pp. 1551-1561
    • Williams, D.P.1    Garcia-Allan, C.2    Hanton, G.3
  • 303
    • 24944469203 scopus 로고    scopus 로고
    • Identification of oxidative stress-related proteins for predictive screening of hepatotoxicity using a proteomic approach
    • Yamamoto T, Kikkawa R, Yamada H, Horii I. Identification of oxidative stress-related proteins for predictive screening of hepatotoxicity using a proteomic approach. J Toxicol Sci 2005; 30:213-27.
    • (2005) J Toxicol Sci , vol.30 , pp. 213-227
    • Yamamoto, T.1    Kikkawa, R.2    Yamada, H.3    Horii, I.4
  • 304
    • 0036304261 scopus 로고    scopus 로고
    • Mode of cell death after acetaminophen overdose in mice: Apoptosis or oncotic necrosis?
    • Gujral JS, Knight TR, Farhood A, Bajt ML, Jaeschke H. Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci 2002; 67:322-8.
    • (2002) Toxicol Sci , vol.67 , pp. 322-328
    • Gujral, J.S.1    Knight, T.R.2    Farhood, A.3    Bajt, M.L.4    Jaeschke, H.5
  • 305
    • 0041733598 scopus 로고    scopus 로고
    • Involvement of mitochondria in acetaminopheninduced apoptosis and hepatic injury: Roles of cytochrome c, Bax, Bid, and caspases
    • El-Hassan H, Anwar K, Macanas-Pirard P, et al. Involvement of mitochondria in acetaminopheninduced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases. Toxicol Appl Pharmacol 2003; 191:118-29.
    • (2003) Toxicol Appl Pharmacol , vol.191 , pp. 118-129
    • El-Hassan, H.1    Anwar, K.2    Macanas-Pirard, P.3
  • 308
    • 1842472069 scopus 로고    scopus 로고
    • Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis
    • Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J 2004; 23:1207-16.
    • (2004) EMBO J , vol.23 , pp. 1207-1216
    • Bassik, M.C.1    Scorrano, L.2    Oakes, S.A.3    Pozzan, T.4    Korsmeyer, S.J.5
  • 311
    • 0037386258 scopus 로고    scopus 로고
    • Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70
    • Sawada M, Hayes P, Matsuyama S. Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat Cell Biol 2003; 5:352-7.
    • (2003) Nat Cell Biol , vol.5 , pp. 352-357
    • Sawada, M.1    Hayes, P.2    Matsuyama, S.3
  • 315
    • 18144399957 scopus 로고    scopus 로고
    • Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak
    • Zhai D, Luciano F, Zhu X, Guo B, Satterthwait AC, Reed JC. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J Biol Chem 2005; 280:15815-24.
    • (2005) J Biol Chem , vol.280 , pp. 15815-15824
    • Zhai, D.1    Luciano, F.2    Zhu, X.3    Guo, B.4    Satterthwait, A.C.5    Reed, J.C.6
  • 317
    • 3242806002 scopus 로고    scopus 로고
    • BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives
    • Huckelhoven R. BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives. Apoptosis 2004; 9:299-307.
    • (2004) Apoptosis , vol.9 , pp. 299-307
    • Huckelhoven, R.1
  • 319
    • 0030592172 scopus 로고    scopus 로고
    • The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
    • Bernardi P. The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death. Biochim Biophys Acta 1996; 1275:5-9.
    • (1996) Biochim Biophys Acta , vol.1275 , pp. 5-9
    • Bernardi, P.1
  • 320
    • 26444468146 scopus 로고    scopus 로고
    • Mitochondria: Pharmacological manipulation of cell death
    • Bouchier-Hayes L, Lartigue L, Newmeyer DD. Mitochondria: pharmacological manipulation of cell death. J Clin Invest 2005; 115:2640-7.
    • (2005) J Clin Invest , vol.115 , pp. 2640-2647
    • Bouchier-Hayes, L.1    Lartigue, L.2    Newmeyer, D.D.3
  • 321
    • 7044226521 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in acetaminopheninduced necrosis and apoptosis of cultured mouse hepatocytes
    • Kon K, Kim JS, Jaeschke H, Lemasters JJ. Mitochondrial permeability transition in acetaminopheninduced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 2004; 40:1170-9.
    • (2004) Hepatology , vol.40 , pp. 1170-1179
    • Kon, K.1    Kim, J.S.2    Jaeschke, H.3    Lemasters, J.J.4
  • 322
    • 11144310166 scopus 로고    scopus 로고
    • Involvement of mitochondrial permeability transition in acetaminophen- induced liver injury in mice
    • Masubuchi Y, Suda C, Horie T. Involvement of mitochondrial permeability transition in acetaminophen- induced liver injury in mice. J Hepatol 2005; 42:110-6.
    • (2005) J Hepatol , vol.42 , pp. 110-116
    • Masubuchi, Y.1    Suda, C.2    Horie, T.3
  • 323
    • 13244292321 scopus 로고    scopus 로고
    • Mechanisms of acetaminopheninduced hepatotoxicity: Role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes
    • Reid AB, Kurten RC, McCullough SS, Brock RW, Hinson JA. Mechanisms of acetaminopheninduced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Pharmacol Exp Ther 2005; 312:509-16.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 509-516
    • Reid, A.B.1    Kurten, R.C.2    McCullough, S.S.3    Brock, R.W.4    Hinson, J.A.5
  • 324
    • 0036792660 scopus 로고    scopus 로고
    • Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo
    • Haouzi D, Cohen I, Vieira HL, et al. Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo. Apoptosis 2002; 7:395-405.
    • (2002) Apoptosis , vol.7 , pp. 395-405
    • Haouzi, D.1    Cohen, I.2    Vieira, H.L.3
  • 325
    • 4644257565 scopus 로고    scopus 로고
    • Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice
    • Fiorucci S, Antonelli E, Distrutti E, Mencarelli A, Farneti S, Del Soldato P, Morelli A. Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol 2004; 143:33-42.
    • (2004) Br J Pharmacol , vol.143 , pp. 33-42
    • Fiorucci, S.1    Antonelli, E.2    Distrutti, E.3    Mencarelli, A.4    Farneti, S.5    Del Soldato, P.6    Morelli, A.7
  • 326
    • 21244446551 scopus 로고    scopus 로고
    • Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D
    • Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, Bernardi P. Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem 2005; 280:18558-61.
    • (2005) J Biol Chem , vol.280 , pp. 18558-18561
    • Basso, E.1    Fante, L.2    Fowlkes, J.3    Petronilli, V.4    Forte, M.A.5    Bernardi, P.6
  • 327
    • 15844375853 scopus 로고    scopus 로고
    • Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
    • Baines CP, Kaiser RA, Purcell NH, et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005; 434:658-62.
    • (2005) Nature , vol.434 , pp. 658-662
    • Baines, C.P.1    Kaiser, R.A.2    Purcell, N.H.3
  • 328
    • 24744460273 scopus 로고    scopus 로고
    • Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
    • Schinzel AC, Takeuchi O, Huang Z, et al. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci USA 2005; 102:12005-10.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12005-12010
    • Schinzel, A.C.1    Takeuchi, O.2    Huang, Z.3
  • 329
    • 15844407874 scopus 로고    scopus 로고
    • Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
    • Nakagawa T, Shimizu S, Watanabe T, et al. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005; 434:652-8.
    • (2005) Nature , vol.434 , pp. 652-658
    • Nakagawa, T.1    Shimizu, S.2    Watanabe, T.3
  • 330
    • 26444560960 scopus 로고    scopus 로고
    • Caspases: Pharmacological manipulation of cell death
    • Lavrik IN, Golks A, Krammer PH. Caspases: pharmacological manipulation of cell death. J Clin Invest 2005; 115:2665-72.
    • (2005) J Clin Invest , vol.115 , pp. 2665-2672
    • Lavrik, I.N.1    Golks, A.2    Krammer, P.H.3
  • 331
    • 33244469737 scopus 로고    scopus 로고
    • Role of caspases in acetaminophen-induced liver injury
    • Jaeschke H, Cover C, Bajt ML. Role of caspases in acetaminophen-induced liver injury. Life Sci 2006; 78:1670-6.
    • (2006) Life Sci , vol.78 , pp. 1670-1676
    • Jaeschke, H.1    Cover, C.2    Bajt, M.L.3
  • 332
    • 0036683708 scopus 로고    scopus 로고
    • Cell culture model for acetaminophen-induced hepatocyte death in vivo
    • Pierce RH, Franklin CC, Campbell JS, et al. Cell culture model for acetaminophen-induced hepatocyte death in vivo. Biochem Pharmacol 2002; 64:413-24.
    • (2002) Biochem Pharmacol , vol.64 , pp. 413-424
    • Pierce, R.H.1    Franklin, C.C.2    Campbell, J.S.3
  • 333
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts:requirement for dATP and cytochrome c. Cell 1996; 86:147-57.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 334
    • 0030900980 scopus 로고    scopus 로고
    • Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
    • Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185:1481-6.
    • (1997) J Exp Med , vol.185 , pp. 1481-1486
    • Leist, M.1    Single, B.2    Castoldi, A.F.3    Kuhnle, S.4    Nicotera, P.5
  • 335
    • 22544432640 scopus 로고    scopus 로고
    • Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death
    • Kroemer G, El-Deiry WS, Golstein P, et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ 2005; 12(Suppl. 2):1463-7.
    • (2005) Cell Death Differ , vol.12 , pp. 1463-1467
    • Kroemer, G.1    El-Deiry, W.S.2    Golstein, P.3
  • 336
    • 2342613543 scopus 로고    scopus 로고
    • Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice
    • Goldring CE, Kitteringham NR, Elsby R, et al. Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice. Hepatology 2004; 39:1267-76.
    • (2004) Hepatology , vol.39 , pp. 1267-1276
    • Goldring, C.E.1    Kitteringham, N.R.2    Elsby, R.3
  • 337
    • 19644386887 scopus 로고    scopus 로고
    • Assessment of hepatotoxic liabilities by transcript profiling
    • Ruepp S, Boess F, Suter L, et al. Assessment of hepatotoxic liabilities by transcript profiling. Toxicol Appl Pharmacol 2005; 207:161-70.
    • (2005) Toxicol Appl Pharmacol , vol.207 , pp. 161-170
    • Ruepp, S.1    Boess, F.2    Suter, L.3
  • 338
    • 0034802130 scopus 로고    scopus 로고
    • Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway
    • Bae MA, Pie JE, Song BJ. Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway. Mol Pharmacol 2001; 60:847-56.
    • (2001) Mol Pharmacol , vol.60 , pp. 847-856
    • Bae, M.A.1    Pie, J.E.2    Song, B.J.3
  • 340
    • 29244492360 scopus 로고    scopus 로고
    • Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice
    • Napirei M, Basnakian AG, Apostolov EO, Mannherz HG. Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. Hepatology 2006; 43:297-305.
    • (2006) Hepatology , vol.43 , pp. 297-305
    • Napirei, M.1    Basnakian, A.G.2    Apostolov, E.O.3    Mannherz, H.G.4
  • 341
    • 29544448331 scopus 로고    scopus 로고
    • Intracellular signaling mechanisms of acetaminophen-induced liver cell death
    • Jaeschke H, Bajt ML. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 2006; 89:31-41.
    • (2006) Toxicol Sci , vol.89 , pp. 31-41
    • Jaeschke, H.1    Bajt, M.L.2
  • 343
    • 0033558892 scopus 로고    scopus 로고
    • Expression and structure of senescence marker protein-30 (SMP30) and its biological significance
    • Fujita T, Shirasawa T, Maruyama N. Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. Mech Ageing Dev 1999; 107:271-80.
    • (1999) Mech Ageing Dev , vol.107 , pp. 271-280
    • Fujita, T.1    Shirasawa, T.2    Maruyama, N.3
  • 344
    • 0033534765 scopus 로고    scopus 로고
    • Senescence marker protein-30 (SMP30): Structure and biological function
    • Fujita T. Senescence marker protein-30 (SMP30): structure and biological function. Biochem Biophys Res Commun 1999; 254:1-4.
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 1-4
    • Fujita, T.1
  • 345
    • 0032544727 scopus 로고    scopus 로고
    • Senescence marker protein-30 (SMP30) rescues cell death by enhancing plasma membrane Ca(2+)-pumping activity in Hep G2 cells
    • Fujita T, Inoue H, Kitamura T, Sato N, Shimosawa T, Maruyama N. Senescence marker protein-30 (SMP30) rescues cell death by enhancing plasma membrane Ca(2+)-pumping activity in Hep G2 cells. Biochem Biophys Res Commun 1998; 250:374-80.
    • (1998) Biochem Biophys Res Commun , vol.250 , pp. 374-380
    • Fujita, T.1    Inoue, H.2    Kitamura, T.3    Sato, N.4    Shimosawa, T.5    Maruyama, N.6
  • 346
    • 3242813768 scopus 로고    scopus 로고
    • Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells
    • Matsuyama S, Kitamura T, Enomoto N, et al. Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. Biochem Biophys Res Commun 2004; 321:386-90.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 386-390
    • Matsuyama, S.1    Kitamura, T.2    Enomoto, N.3
  • 347
    • 33645819801 scopus 로고    scopus 로고
    • Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy
    • Kondo Y, Inai Y, Sato Y, et al. Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci USA 2006; 103:5723-8.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5723-5728
    • Kondo, Y.1    Inai, Y.2    Sato, Y.3
  • 348
    • 3142604667 scopus 로고    scopus 로고
    • Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver
    • Kondo Y, Ishigami A, Kubo S, et al. Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver. FEBS Lett 2004; 570:57-62.
    • (2004) FEBS Lett , vol.570 , pp. 57-62
    • Kondo, Y.1    Ishigami, A.2    Kubo, S.3
  • 350
    • 0031802829 scopus 로고    scopus 로고
    • Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice
    • Hinson JA, Pike SL, Pumford NR, Mayeux PR. Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol 1998; 11:604-7.
    • (1998) Chem Res Toxicol , vol.11 , pp. 604-607
    • Hinson, J.A.1    Pike, S.L.2    Pumford, N.R.3    Mayeux, P.R.4
  • 351
    • 29344465714 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    • Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 2005; 310:1966-70.
    • (2005) Science , vol.310 , pp. 1966-1970
    • Kim, S.F.1    Huri, D.A.2    Snyder, S.H.3
  • 352
    • 14844295448 scopus 로고    scopus 로고
    • Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice
    • Cover C, Fickert P, Knight TR, Fuchsbichler A, Farhood A, Trauner M, Jaeschke H. Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice. Toxicol Sci 2005; 84:201-8.
    • (2005) Toxicol Sci , vol.84 , pp. 201-208
    • Cover, C.1    Fickert, P.2    Knight, T.R.3    Fuchsbichler, A.4    Farhood, A.5    Trauner, M.6    Jaeschke, H.7
  • 353
    • 2642536197 scopus 로고    scopus 로고
    • Alkylating DNA damage stimulates a regulated form of necrotic cell death
    • Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 2004; 18:1272-82.
    • (2004) Genes Dev , vol.18 , pp. 1272-1282
    • Zong, W.X.1    Ditsworth, D.2    Bauer, D.E.3    Wang, Z.Q.4    Thompson, C.B.5
  • 354
    • 0030793294 scopus 로고    scopus 로고
    • Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains
    • DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA, van der Hoek A. Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol 1997; 53:1339-45.
    • (1997) Biochem Pharmacol , vol.53 , pp. 1339-1345
    • DeLeve, L.D.1    Wang, X.2    Kaplowitz, N.3    Shulman, H.M.4    Bart, J.A.5    van der Hoek, A.6
  • 357
    • 14044277429 scopus 로고    scopus 로고
    • The molecular machinery of autophagy: Unanswered questions
    • Klionsky DJ. The molecular machinery of autophagy: unanswered questions. J Cell Sci 2005; 118:7-18.
    • (2005) J Cell Sci , vol.118 , pp. 7-18
    • Klionsky, D.J.1
  • 358
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • Levine B, Yuan J. Autophagy in cell death: an innocent convict? J Clin Invest 2005; 115:2679-88.
    • (2005) J Clin Invest , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 359
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306:990-5.
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 361
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy. Cell 2005; 122:927-39.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3
  • 363
    • 19944434059 scopus 로고    scopus 로고
    • Inhibition of macroautophagy triggers apoptosis
    • Boya P, Gonzalez-Polo RA, Casares N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25:1025-40.
    • (2005) Mol Cell Biol , vol.25 , pp. 1025-1040
    • Boya, P.1    Gonzalez-Polo, R.A.2    Casares, N.3
  • 364
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: Apoptosis, necrosis and autophagy
    • Edinger AL, Thompson CB. Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 2004; 16:663-9.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 365
    • 0035487007 scopus 로고    scopus 로고
    • The mitochondrial permeability transition initiates autophagy in rat hepatocytes
    • Elmore SP, Qian T, Grissom SF, Lemasters JJ. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J 2001; 15:2286-7.
    • (2001) FASEB J , vol.15 , pp. 2286-2287
    • Elmore, S.P.1    Qian, T.2    Grissom, S.F.3    Lemasters, J.J.4
  • 367
    • 33645521571 scopus 로고    scopus 로고
    • Autophagic programmed cell death by selective catalase degradation
    • Yu L, Wan F, Dutta S, et al. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci USA 2006; 103:4952-7.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4952-4957
    • Yu, L.1    Wan, F.2    Dutta, S.3
  • 369
    • 0242266921 scopus 로고    scopus 로고
    • Formation of stacked ER cisternae by low affinity protein interactions
    • Snapp EL, Hegde RS, Francolini M, et al. Formation of stacked ER cisternae by low affinity protein interactions. J Cell Biol 2003; 163:257-69.
    • (2003) J Cell Biol , vol.163 , pp. 257-269
    • Snapp, E.L.1    Hegde, R.S.2    Francolini, M.3
  • 370
    • 33644868070 scopus 로고    scopus 로고
    • Measurement of serum acetaminophen-protein adducts in patients with acute liver failure
    • Davern TJ, II, James LP, Hinson JA, et al. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology 2006; 130:687-94.
    • (2006) Gastroenterology , vol.130 , pp. 687-694
    • Davern, T.J.1    James, L.P.2    Hinson, J.A.3
  • 371
    • 0042733742 scopus 로고    scopus 로고
    • Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants
    • Limaye PB, Apte UM, Shankar K, Bucci TJ, Warbritton A, Mehendale HM. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol Appl Pharmacol 2003; 191:211-26.
    • (2003) Toxicol Appl Pharmacol , vol.191 , pp. 211-226
    • Limaye, P.B.1    Apte, U.M.2    Shankar, K.3    Bucci, T.J.4    Warbritton, A.5    Mehendale, H.M.6
  • 372
    • 32544432347 scopus 로고    scopus 로고
    • Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity
    • Dambach DM, Durham SK, Laskin JD, Laskin DL. Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity. Toxicol Appl Pharmacol 2006; 211:157-65.
    • (2006) Toxicol Appl Pharmacol , vol.211 , pp. 157-165
    • Dambach, D.M.1    Durham, S.K.2    Laskin, J.D.3    Laskin, D.L.4
  • 373
    • 0036242256 scopus 로고    scopus 로고
    • Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse
    • Dambach DM, Watson LM, Gray KR, Durham SK, Laskin DL. Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse. Hepatology 2002; 35:1093-103.
    • (2002) Hepatology , vol.35 , pp. 1093-1103
    • Dambach, D.M.1    Watson, L.M.2    Gray, K.R.3    Durham, S.K.4    Laskin, D.L.5
  • 374
    • 33645971964 scopus 로고    scopus 로고
    • Clinical medicine. Accident prompts a closer look at antibody trials
    • Marshall E. Clinical medicine. Accident prompts a closer look at antibody trials. Science 2006; 312:172.
    • (2006) Science , vol.312 , pp. 172
    • Marshall, E.1
  • 376
    • 0029434216 scopus 로고
    • Acetaminopheninduced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity
    • Blazka ME, Germolec DR, Simeonova P, Bruccoleri A, Pennypacker KR, Luster MI. Acetaminopheninduced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity. J Inflamm 1995; 47:138-50.
    • (1995) J Inflamm , vol.47 , pp. 138-150
    • Blazka, M.E.1    Germolec, D.R.2    Simeonova, P.3    Bruccoleri, A.4    Pennypacker, K.R.5    Luster, M.I.6
  • 378
    • 0842282902 scopus 로고    scopus 로고
    • The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice
    • Ishida Y, Kondo T, Tsuneyama K, Lu P, Takayasu T, Mukaida N. The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice. J Leukoc Biol 2004; 75:59-67.
    • (2004) J Leukoc Biol , vol.75 , pp. 59-67
    • Ishida, Y.1    Kondo, T.2    Tsuneyama, K.3    Lu, P.4    Takayasu, T.5    Mukaida, N.6
  • 379
    • 0141503509 scopus 로고    scopus 로고
    • Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators
    • Gardner CR, Laskin JD, Dambach DM, et al. Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators. Toxicol Appl Pharmacol 2003; 192:119-30.
    • (2003) Toxicol Appl Pharmacol , vol.192 , pp. 119-130
    • Gardner, C.R.1    Laskin, J.D.2    Dambach, D.M.3
  • 381
    • 0032125487 scopus 로고    scopus 로고
    • Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure
    • Bernal W, Donaldson P, Underhill J, Wendon J, Williams R. Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. J Hepatol 1998; 29:53-9.
    • (1998) J Hepatol , vol.29 , pp. 53-59
    • Bernal, W.1    Donaldson, P.2    Underhill, J.3    Wendon, J.4    Williams, R.5
  • 383
    • 0029871839 scopus 로고    scopus 로고
    • Histopathology of acetaminopheninduced liver changes: Role of interleukin 1 alpha and tumor necrosis factor alpha
    • Blazka ME, Elwell MR, Holladay SD, Wilson RE, Luster MI. Histopathology of acetaminopheninduced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha. Toxicol Pathol 1996; 24:181-9.
    • (1996) Toxicol Pathol , vol.24 , pp. 181-189
    • Blazka, M.E.1    Elwell, M.R.2    Holladay, S.D.3    Wilson, R.E.4    Luster, M.I.5
  • 384
    • 0036154452 scopus 로고    scopus 로고
    • Protection against acetaminophen-induced liver injury and lethality by interleukin 10: Role of inducible nitric oxide synthase
    • Bourdi M, Masubuchi Y, Reilly TP, et al. Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology 2002; 35:289-98.
    • (2002) Hepatology , vol.35 , pp. 289-298
    • Bourdi, M.1    Masubuchi, Y.2    Reilly, T.P.3
  • 385
    • 0032931621 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury
    • Hogaboam CM, Simpson KJ, Chensue SW, et al. Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury. Gene Ther 1999; 6:573-84.
    • (1999) Gene Ther , vol.6 , pp. 573-584
    • Hogaboam, C.M.1    Simpson, K.J.2    Chensue, S.W.3
  • 386
    • 0032867463 scopus 로고    scopus 로고
    • Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines
    • Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. FASEB J 1999; 13:1565-74.
    • (1999) FASEB J , vol.13 , pp. 1565-1574
    • Hogaboam, C.M.1    Bone-Larson, C.L.2    Steinhauser, M.L.3
  • 387
    • 0037308128 scopus 로고    scopus 로고
    • The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice
    • Liu J, Li C, Waalkes MP, Clark J, Myers P, Saavedra JE, Keefer LK. The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. Hepatology 2003; 37:324-33.
    • (2003) Hepatology , vol.37 , pp. 324-333
    • Liu, J.1    Li, C.2    Waalkes, M.P.3    Clark, J.4    Myers, P.5    Saavedra, J.E.6    Keefer, L.K.7
  • 388
    • 0036408857 scopus 로고    scopus 로고
    • Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: Potential role of tumor necrosis factor-alpha and interleukin-10
    • Gardner CR, Laskin JD, Dambach DM, et al. Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol Appl Pharmacol 2002; 184:27-36.
    • (2002) Toxicol Appl Pharmacol , vol.184 , pp. 27-36
    • Gardner, C.R.1    Laskin, J.D.2    Dambach, D.M.3
  • 389
    • 0036330839 scopus 로고    scopus 로고
    • Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice
    • Hinson JA, Bucci TJ, Irwin LK, Michael SL, Mayeux PR. Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric Oxide 2002; 6:160-7.
    • (2002) Nitric Oxide , vol.6 , pp. 160-167
    • Hinson, J.A.1    Bucci, T.J.2    Irwin, L.K.3    Michael, S.L.4    Mayeux, P.R.5
  • 391
    • 0033891369 scopus 로고    scopus 로고
    • Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis
    • Zhang H, Cook J, Nickel J, Yu R, Stecker K, Myers K, Dean NM. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nat Biotechnol 2000; 18:862-7.
    • (2000) Nat Biotechnol , vol.18 , pp. 862-867
    • Zhang, H.1    Cook, J.2    Nickel, J.3    Yu, R.4    Stecker, K.5    Myers, K.6    Dean, N.M.7
  • 392
    • 0034129863 scopus 로고    scopus 로고
    • Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells
    • Boulares AH, Giardina C, Inan MS, Khairallah EA, Cohen SD. Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells. Toxicol Sci 2000; 55:370-5.
    • (2000) Toxicol Sci , vol.55 , pp. 370-375
    • Boulares, A.H.1    Giardina, C.2    Inan, M.S.3    Khairallah, E.A.4    Cohen, S.D.5
  • 394
    • 0036181113 scopus 로고    scopus 로고
    • A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the fas pathway
    • Fiorucci S, Antonelli E, Mencarelli A, et al. A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the fas pathway. Br J Pharmacol 2002; 135:589-99.
    • (2002) Br J Pharmacol , vol.135 , pp. 589-599
    • Fiorucci, S.1    Antonelli, E.2    Mencarelli, A.3
  • 395
    • 1942515459 scopus 로고    scopus 로고
    • Nitric oxide releasing acetaminophen (nitroacetaminophen)
    • Moore PK, Marshall M. Nitric oxide releasing acetaminophen (nitroacetaminophen). Dig Liver Dis 2003; 35(Suppl. 2):S49-60.
    • (2003) Dig Liver Dis , vol.35 , pp. S49-S60
    • Moore, P.K.1    Marshall, M.2
  • 396
    • 0017576559 scopus 로고
    • Treatment of acetaminophen overdosage with N-acetylcysteine
    • Lyons L, Studdiford JS, Sommaripa AM. Treatment of acetaminophen overdosage with N-acetylcysteine. N Engl J Med 1977; 296:174-5.
    • (1977) N Engl J Med , vol.296 , pp. 174-175
    • Lyons, L.1    Studdiford, J.S.2    Sommaripa, A.M.3
  • 397
    • 0017084677 scopus 로고
    • Reversal of experimental paracetamol toxicosis with N-acetylcysteine
    • Piperno E, Berssenbruegge DA. Reversal of experimental paracetamol toxicosis with N-acetylcysteine. Lancet 1976; 2:738-9.
    • (1976) Lancet , vol.2 , pp. 738-739
    • Piperno, E.1    Berssenbruegge, D.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.