Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide

Chemical Research in Toxicology

Volumn 10, Issue 10, 1997, Pages 1097-1103

  Dietze, Eric C ^a   Schäfer, Andrea ^a,b   Omichinski, James G ^a   Nelson, Sidney D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLBENZOQUINONE IMINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PARACETAMOL; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME INACTIVATION; LIVER CELL DAMAGE; LIVER NECROSIS; LIVER TOXICITY; MASS SPECTROMETRY; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BENZOQUINONES; BINDING SITES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; IMINES; MASS SPECTROMETRY; MICE; RABBITS; SWINE;

EID: 0342601372     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx970090u     Document Type: Article

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