Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

Toxicological Sciences

Volumn 65, Issue 1, 2002, Pages 135-150

  Ruepp, Stefan U ^a   Tonge, Robert P ^a   Shaw, Joanne ^a   Wallis, Nicola ^a   Pognan, François ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Acetaminophen; APAP; Genomics; In vivo; Kupffer cells; Mitochondria; Mouse; Oxidative stress; Paracetamol; Proteomics

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALANINE AMINOTRANSFERASE; CHAPERONE; GLUTATHIONE SYNTHASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN 60; MESSENGER RNA; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL REGENERATION; CONTROLLED STUDY; CYTOPLASM; DRUG OVERDOSE; ELECTRON MICROSCOPY; ENERGY YIELD; GENE CONTROL; GENOMICS; KUPFFER CELL; LIVER MITOCHONDRION; LIVER NECROSIS; LIVER TOXICITY; METABOLITE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROTEOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ACETAMINOPHEN; ANIMALS; BLOTTING, WESTERN; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENOMICS; GLUTATHIONE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEPATOCYTES; KUPFFER CELLS; LIVER; MALE; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA, LIVER; OVERDOSE; OXIDATIVE STRESS; PROTEOME; RNA, MESSENGER; TIME FACTORS;

ANIMALIA;

EID: 0036147966     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/65.1.135     Document Type: Article

References (70)

1. Ionizing radiation-inducible apoptosis in the absence of p53 linked to transcription factor EGR-1
2. Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes
3. N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes
4. Mitochondria and cell death. Mechanistic aspects and methodological issues
5. Cleavage of the serum response factor during death receptor-induced apoptosis results in an inhibition of the c-FOS promoter transcriptional activity
6. Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity
7. Acetaminophen-induced hepatotoxicity is associated with early changes in NF-κB and NF-IL6 DNA binding activity
8. Morphometry of liver sinusoidal cells
9. Liver necrosis from paracetamol
10. Selective alterations in the patterns of newly synthesized proteins by acetaminophen and its dimethylated analogues in primary cultures of mouse hepatocytes
11. Short technical reports. Modification of the TRI reagent procedure for isolation of RNA from polysaccharide- and proteoglycan-rich sources
12. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine
13. Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice
14. N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
15. C-Myc target genes involved in cell growth, apoptosis and metabolism
16. Acute liver necrosis following overdose of paracetamol
17. Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen
18. Immobilization stress induces c-fos accumulation in liver
19. Oxidative stress: Role of mitochondria and protection by glutathione
20. Δ3,5-Δ2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization
21. Two-dimensional database of mouse liver proteins: Changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol
22. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
23. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology
24. Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: Correspondence of covalent binding with toxicity
25. Role of covalent and non-covalent interactions in cell toxicity: Effects on proteins
26. Direct cell-to-cell contact between Kupffer cells and hepatocytes augments endotoxin-induced hepatic injury
27. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo
28. Induction of megamitochondria by some chemicals inducing oxidative stress in primary cultured rat hepatocytes
29. Free radical-induced megamitochondria formation and apoptosis
30. Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation
31. Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor κB activation
32. Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and gamma-glutamylcysteine synthetase
33. Acute renal failure associated with acetaminophen ingestion: Report of a case and review of the literature
34. Identification of a 54-kDa mitochondrial acetaminophen-binding protein as aldehyde dehydrogenase
35. Effects of acetaminophen on preimplantation embryo glutathione concentration and development in vivo and in vitro
36. Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice
37. Suppression of growth and transformation and induction of apoptosis by EGR-1
38. An in vitro model of liver injury using paracetamol treatment of liver slices and prevention of injury by some antioxidants
39. Specificity, diversity, and convergence in VEGF and TNF-α signaling events leading to tissue factor upregulation via EGR-1 in endothelial cells
40. Mechanism of action of paracetamol protective agents in mice in vivo
41. Acetaminophen toxicity. Opposite effects of two forms of glutathione peroxidase
42. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism
43. Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione
44. A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3′-hydroxyacetanilide
45. Apoptosis by death factor
46. Early growth response-1-dependent apoptosis is mediated by p53
47. Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250
48. The zinc finger transcription factor Egr- 1 is essential for and restricts differentiation along the macrophage lineage
49. Signaling networks-Do all roads lead to the same genes?
50. The principles and practice of toxicogenomics: Applications and opportunities
51. Role of oxidants and antioxidants in the induction of AP-1, NF-αB, and glutathione S-transferase gene expression
52. Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: A time and dose study
53. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry
54. Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a non-hepatotoxic regioisomer, 3′-hydroxyacetanilide, in the mouse
55. Expression profiling of acetaminophen liver toxicity in mice using microarray technology
56. Subcellular fractionation of mitochondria
57. Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity
58. Acute acetaminophen toxicity in transgenic mice with elevated hepatic glutathione
59. Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver
60. Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells
61. Inhibition of tumour necrosis factor-α does not prevent experimental paracetamol-induced hepatic necrosis
62. Construction and characterization of a normalized cDNA library
63. Role of CYP1A2 in the hepatotoxicity of acetaminophen: Investigations using Cyp1a2 null mice
64. Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology
65. Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat
66. Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention
67. Acetaminophen-induced hepatotoxicity in mice
68. Calcium: Outside/inside homeostasis and signalling
69. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice