Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6

Chemical Research in Toxicology

Volumn 11, Issue 4, 1998, Pages 295-301

  Chen, Weiqiao ^a   Koenigs, Luke L ^a   Thompson, Stella J ^a   Peter, Raimund M ^a   Rettie, Allan E ^a   Trager, William F ^a   Nelson, Sidney D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYPARACETAMOL; CYTOCHROME P450; DRUG METABOLITE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PARACETAMOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACULOVIRUS; CHEMICAL REACTION KINETICS; DRUG OXIDATION; ENZYME INACTIVATION; ENZYME MECHANISM; EXPRESSION VECTOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LETHAL DOSE; LIVER CLEARANCE; LIVER MICROSOME METABOLISM; LIVER TOXICITY; PH;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ARYL HYDROCARBON HYDROXYLASES; BACULOVIRIDAE; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MIXED FUNCTION OXYGENASES;

UNIDENTIFIED BACULOVIRUS;

EID: 0031949068     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9701687     Document Type: Article

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